{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:31:35Z","timestamp":1785785495931,"version":"3.56.0"},"reference-count":71,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interreg Sudoe 2021\u20132027 program","award":["S1\/1.1\/E0116"],"award-info":[{"award-number":["S1\/1.1\/E0116"]}]},{"name":"Interreg Sudoe 2021\u20132027 program","award":["0623-137919"],"award-info":[{"award-number":["0623-137919"]}]},{"name":"Interreg Sudoe 2021\u20132027 program","award":["ED481B-2022-020"],"award-info":[{"award-number":["ED481B-2022-020"]}]},{"name":"Conseller\u00eda de Educaci\u00f3n, Ciencia, Universidades e Formaci\u00f3n Profesional of Xunta de Galicia and the University of Vigo","award":["S1\/1.1\/E0116"],"award-info":[{"award-number":["S1\/1.1\/E0116"]}]},{"name":"Conseller\u00eda de Educaci\u00f3n, Ciencia, Universidades e Formaci\u00f3n Profesional of Xunta de Galicia and the University of Vigo","award":["0623-137919"],"award-info":[{"award-number":["0623-137919"]}]},{"name":"Conseller\u00eda de Educaci\u00f3n, Ciencia, Universidades e Formaci\u00f3n Profesional of Xunta de Galicia and the University of Vigo","award":["ED481B-2022-020"],"award-info":[{"award-number":["ED481B-2022-020"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n, Formaci\u00f3n Profesional e Universidades of Xunta de Galicia","award":["S1\/1.1\/E0116"],"award-info":[{"award-number":["S1\/1.1\/E0116"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n, Formaci\u00f3n Profesional e Universidades of Xunta de Galicia","award":["0623-137919"],"award-info":[{"award-number":["0623-137919"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n, Formaci\u00f3n Profesional e Universidades of Xunta de Galicia","award":["ED481B-2022-020"],"award-info":[{"award-number":["ED481B-2022-020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Plant flowers are recognized as a rich source of bioactive phenolic compounds. In this study, for the first time, the recovery of antioxidant phenolic compounds from Cytisus striatus flowers (CF) was optimized using microwave-assisted extraction (MAE). The variables (% of ethanol, temperature, and time) were studied using a response surface methodology (RSM). Extraction efficiency was assessed by total phenol content, total flavonoid content, and the antioxidant capacity through DPPH, ABTS, FRAP, and CUPRAC assays. Additionally, cytotoxicity and anti-inflammatory properties were evaluated in different cell lines. The optimal extraction conditions (87.6% ethanol, 160.8 \u00b0C and 8.76 min) yielded extracts rich in phenolics (85.9 mg GAE\/g CF) and flavonoids (120.3 mg RE\/g CF), with strong antioxidant capacity. LC-MS\/MS analysis identified 27 phenolic compounds, including chrysin, apigenin, and quercetin derivatives. Cytotoxicity tests showed that CF extract maintained high viability (&gt;80%) in human embryonic kidney (HEK293T) and human lung adenocarcinoma (A549) cells up to 2000 \u00b5g\/mL, indicating low cytotoxicity. The anti-inflammatory potential was evidenced by a decrease in IL-1\u03b2 levels and an increase in IL-10 cytokine production in LPS-stimulated macrophages. These results highlight the great potential of CF as a promising bioresource to obtain value-added compounds for the development of functional foods, nutraceuticals, and cosmetic products.<\/jats:p>","DOI":"10.3390\/ijms26157100","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T14:22:44Z","timestamp":1753280564000},"page":"7100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of Cytisus Flower Extracts with Antioxidant and Anti-Inflammatory Properties for Nutraceutical and Food Uses"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2333-1113","authenticated-orcid":false,"given":"Adela","family":"Alvaredo-L\u00f3pez-Vizca\u00edno","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Science, University of Vigo (Campus Ourense), As Lagoas, 32004 Ourense, Spain"},{"name":"Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA), University of Vigo (Campus Auga), As Lagoas, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-8491","authenticated-orcid":false,"given":"Augusto","family":"Costa-Barbosa","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Institute of Science and Innovation for Sustainability (IB-S), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-4428","authenticated-orcid":false,"given":"Paula","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Institute of Science and Innovation for Sustainability (IB-S), Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-8961","authenticated-orcid":false,"given":"Pablo G.","family":"del R\u00edo","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Science, University of Vigo (Campus Ourense), As Lagoas, 32004 Ourense, Spain"},{"name":"Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA), University of Vigo (Campus Auga), As Lagoas, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8221-419X","authenticated-orcid":false,"given":"Claudia","family":"Botelho","sequence":"additional","affiliation":[{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-4605","authenticated-orcid":false,"given":"Pedro","family":"Ferreira-Santos","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Science, University of Vigo (Campus Ourense), As Lagoas, 32004 Ourense, Spain"},{"name":"Instituto de Agroecolox\u00eda e Alimentaci\u00f3n (IAA), University of Vigo (Campus Auga), As Lagoas, 32004 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"ref_1","unstructured":"(2025, January 19). 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