{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:41:38Z","timestamp":1778643698576,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RSU internal and RSU with LASE external consolidation","award":["5.2.1.1.i.0\/2\/24\/I\/CFLA\/005"],"award-info":[{"award-number":["5.2.1.1.i.0\/2\/24\/I\/CFLA\/005"]}]},{"name":"RSU internal and RSU with LASE external consolidation","award":["857287"],"award-info":[{"award-number":["857287"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["5.2.1.1.i.0\/2\/24\/I\/CFLA\/005"],"award-info":[{"award-number":["5.2.1.1.i.0\/2\/24\/I\/CFLA\/005"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["857287"],"award-info":[{"award-number":["857287"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Metabolome studies have already been carried out in patients with systemic sclerosis (SSc). However, polyneuropathy (PNP) as a complication of SSc has been overlooked in these studies. To the best of our knowledge, this is the first study to examine metabolic changes in SSc patients with PNP. Patients with SSc (n = 62) and a healthy control group (HC) (n = 72) were recruited from two Latvian hospitals. Blood plasma samples were collected and analyzed using an LC-MS-based targeted metabolomics workflow. Our plasma sample cohort consisted of 62 patients with SSc, 42% of whom had PNP. Differences between SSc patients and the HC group with fold changes &gt; 2 were observed for aspartic acid, glutamic acid, valine, and citrulline, all of which were reduced. In contrast to the SSc to HC discrimination, no metabolites had a high fold change; only minor changes were observed using FC &gt; 1.3. We identified elevated concentrations of kynurenine, asparagine, and alanine. Changes in metabolite regulation in patients with SSc, compared to controls, are not identical to those observed in SSc patients with PNP, with elevated concentrations of kynurenine and alanine specific to the SSc subgroup. SSc patients with PNP should probably be considered a distinct population with important metabolomic features.<\/jats:p>","DOI":"10.3390\/ijms26157133","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T10:28:09Z","timestamp":1753352889000},"page":"7133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Metabolomic Profiling Reveals Differences Between Systemic Sclerosis Patients with Polyneuropathy"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-2948","authenticated-orcid":false,"given":"Kristine","family":"Ivanova","sequence":"first","affiliation":[{"name":"Department of Doctoral Studies, R\u012bga Stradin\u0161 University, LV-1050 R\u012bga, Latvia"},{"name":"Institute of Oncology and Molecular Genetics, R\u012bga Stradin\u0161 University, LV-1050 R\u012bga, Latvia"},{"name":"Department of Rheumatology, Pauls Stradi\u0146\u0161 Clinical University Hospital, LV-1002 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Schiemer","sequence":"additional","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1048 R\u012bga, Latvia"},{"name":"Institute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, LV-1048 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8724-6630","authenticated-orcid":false,"given":"Annija","family":"Vaska","sequence":"additional","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1048 R\u012bga, Latvia"},{"name":"Institute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, LV-1048 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nata\u013cja","family":"Kurj\u0101ne","sequence":"additional","affiliation":[{"name":"Institute of Oncology and Molecular Genetics, R\u012bga Stradin\u0161 University, LV-1050 R\u012bga, Latvia"},{"name":"Department of Biology and Microbiology, R\u012bga Stradin\u0161 University, LV-1050 R\u012bga, Latvia"},{"name":"Centre for Clinical Immunology and Allergy, Pauls Stradi\u0146\u0161 Clinical University Hospital, LV-1002 R\u012bga, Latvia"},{"name":"Clinic of Medical Genetics and Prenatal Diagnostics, Children\u2019s Clinical University Hospital, LV-1004 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktorija","family":"Kenina","sequence":"additional","affiliation":[{"name":"Institute of Oncology and Molecular Genetics, R\u012bga Stradin\u0161 University, LV-1050 R\u012bga, Latvia"},{"name":"Department of Biology and Microbiology, R\u012bga Stradin\u0161 University, LV-1050 R\u012bga, Latvia"},{"name":"Department of Neurology, Pauls Stradi\u0146\u0161 Clinical University Hospital, LV-1002 R\u012bga, Latvia"},{"name":"European Reference Network for Rare Neuromuscular Diseases, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristaps","family":"Klavins","sequence":"additional","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1048 R\u012bga, Latvia"},{"name":"Institute of Biomaterials and Bioengineering, Faculty of Natural Sciences and Technology, Riga Technical University, LV-1048 R\u012bga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/1346-8138.14153","article-title":"Systemic sclerosis","volume":"45","author":"Asano","year":"2018","journal-title":"J. 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