{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:20:36Z","timestamp":1791390036048,"version":"4.3.3"},"reference-count":248,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Spinal cord injury (SCI) is a debilitating condition that results from a culmination of acute and chronic damage to neural tissue, specifically the myelin sheath, thus impacting neurons\u2019 abilities to synergistically perform their physiological roles. This review explores the molecular underpinnings of myelination, demyelination, and remyelination, emphasizing the role of oligodendrocyte progenitor cells (OPCs), astrocytes, and microglia in physiological, and pathophysiological, healing. Furthermore, we link these processes with emerging therapeutic strategies currently under investigation in animal and human models, underscoring areas of translational medicine that remain underutilized. The goal of this review is to provide a framework for developing more advanced interventions to restore function and improve outcomes for individuals with SCI.<\/jats:p>","DOI":"10.3390\/ijms26157249","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:51:14Z","timestamp":1753699874000},"page":"7249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Spinal Cord Injury Remyelination: Pathways to Therapies"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8326-502X","authenticated-orcid":false,"given":"Julia K.","family":"Kaniuk","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, 240 E Huron Street, Suite 1-200, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8434-7224","authenticated-orcid":false,"given":"Divy","family":"Kumar","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, 240 E Huron Street, Suite 1-200, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-1943","authenticated-orcid":false,"given":"Joshua","family":"Tennyson","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, 240 E Huron Street, Suite 1-200, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn L.","family":"Hurka","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, 240 E Huron Street, Suite 1-200, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Margolis","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, 240 E Huron Street, Suite 1-200, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3763-3032","authenticated-orcid":false,"given":"Andrei","family":"Bucaloiu","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University, 240 E Huron Street, Suite 1-200, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Selner","sequence":"additional","affiliation":[{"name":"Northwestern Medicine Department of Neurological Surgery, 676 N St Clair Street, Suite 2210, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9910-148X","authenticated-orcid":false,"given":"Christopher S.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Northwestern Medicine Department of Neurological Surgery, 676 N St Clair Street, Suite 2210, Chicago, IL 60611, USA"},{"name":"Simpson-Querrey Research Institute, 303 E. Superior St., Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Narine, M., and Colognato, H. (2022). Current Insights into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.892968"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Simons, M., and Nave, K.-A. (2016). Oligodendrocytes: Myelination and Axonal Support. Cold Spring Harb. Perspect. Biol., 8.","DOI":"10.1101\/cshperspect.a020479"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1016\/j.cub.2006.11.042","article-title":"Rapid Conduction and the Evolution of Giant Axons and Myelinated Fibers","volume":"17","author":"Hartline","year":"2007","journal-title":"Curr. 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