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As third-party synapses in brain networks, astrocytes play an important role in maintaining the normal function of neural networks, which contribute to the abnormal function of networks in AD. In recent years, numerous studies have shown that clusterin, a protein expressed by astrocytes, can participate in the progression of AD. Clusterin plays a significant role in many pathological processes of AD, such as lipid metabolism, AD pathological features, the imbalance in neural circuit excitatory inhibition, and neuroinflammation. Therefore, delving deeper into the association between clusterin and AD will help us to understand the mechanisms of disease better and provide a theoretical basis for early diagnosis and the development of treatment strategies for AD.<\/jats:p>","DOI":"10.3390\/ijms26157271","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:51:14Z","timestamp":1753699874000},"page":"7271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clusterin Regulates the Mechanisms of Neuroinflammation and Neuronal Circuit Impairment in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Yihang","family":"Yu","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjian","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Hebei Medical University, Shijiazhuang 050017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University, Shijiazhuang 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University, Shijiazhuang 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qain","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University, Shijiazhuang 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University, Shijiazhuang 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University, Shijiazhuang 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/s41593-023-01448-8","article-title":"A conceptual framework for astrocyte function","volume":"26","author":"Ching","year":"2023","journal-title":"Nat. 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