{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:01:36Z","timestamp":1787907696371,"version":"build-2784847793"},"reference-count":42,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RC 26\/22"],"award-info":[{"award-number":["RC 26\/22"]}]},{"name":"Italian Ministry of Health","award":["RC06\/23"],"award-info":[{"award-number":["RC06\/23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Metabolic and bariatric surgery (MBS) is an effective treatment for severe obesity, though individual responses vary widely, partly due to genetic predisposition. This study investigates the association of a body mass index (BMI) polygenic score (PGS) with weight loss and metabolic outcomes following surgery. A cohort of 225 patients undergoing MBS was analyzed at baseline (T0), six (T6), and twelve (T12) months, with anthropometric and biochemical parameters recorded at each time point. Total weight loss (TWL) and excess weight loss (EWL) percentages were calculated. PGS was computed using the LDpred-grid Bayesian method. The mean age was 45.9 \u00b1 9.4 years. Males had a higher baseline prevalence of type 2 diabetes (T2D) and comorbidities (p &lt; 0.001). Linear regression analysis confirmed an association between PGS and baseline BMI (p = 0.012). Moreover, mediation analysis revealed that baseline BMI mediated the effect of the PGS on %TWL at T12, with an indirect effect (p-value = 0.018). In contrast, high-density lipoprotein-cholesterol (HDL-C) at T6 and triglycerides (TG) at T12 showed direct associations with the PGS (p-value = 0.004 and p-value = 0.08, respectively), with no significant mediation by BMI. This study showed a BMI-mediated association of PGS with %TWL and a direct association with lipid changes, suggesting its potential integration into personalized obesity treatment.<\/jats:p>","DOI":"10.3390\/ijms26157337","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T16:16:10Z","timestamp":1753805770000},"page":"7337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polygenic Score for Body Mass Index Is Associated with Weight Loss and Lipid Outcomes After Metabolic and Bariatric Surgery"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9116-2685","authenticated-orcid":false,"given":"Luana","family":"Aldegheri","sequence":"first","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cipullo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-3547","authenticated-orcid":false,"given":"Natalia","family":"Rosso","sequence":"additional","affiliation":[{"name":"Metabolic Liver Disease Unit, Fondazione Italiana Fegato\u2014ONLUS, Area Science Park, Basovizza, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4701-9134","authenticated-orcid":false,"given":"Eulalia","family":"Catamo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4280-1725","authenticated-orcid":false,"given":"Biagio","family":"Casagranda","sequence":"additional","affiliation":[{"name":"Surgical Clinic Division, Cattinara Hospital, Azienda Sanitaria Universitaria Giuliano Isontina, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-6648","authenticated-orcid":false,"given":"Pablo","family":"Giraudi","sequence":"additional","affiliation":[{"name":"Metabolic Liver Disease Unit, Fondazione Italiana Fegato\u2014ONLUS, Area Science Park, Basovizza, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"de Manzini","sequence":"additional","affiliation":[{"name":"Surgical Clinic Division, Cattinara Hospital, Azienda Sanitaria Universitaria Giuliano Isontina, 34149 Trieste, Italy"},{"name":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Surgical Clinic Division, Cattinara Hospital, Azienda Sanitaria Universitaria Giuliano Isontina, 34149 Trieste, Italy"},{"name":"Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2152-2353","authenticated-orcid":false,"given":"Antonietta","family":"Robino","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2014IRCCS Burlo Garofolo, 34137 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Maxim, M., Soroceanu, R.P., Vl\u0103sceanu, V.I., Platon, R.L., Toader, M., Miler, A.A., Onofriescu, A., Abdulan, I.M., Ciuntu, B.-M., and Balan, G. 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