{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T15:54:42Z","timestamp":1776614082023,"version":"3.51.2"},"reference-count":144,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression and are involved in diverse physiological and pathological processes, including carcinogenesis. In bladder cancer (BCa), dysregulation of NR signaling pathways has been linked to tumor initiation, progression, therapy resistance, and immune evasion. Recent evidence highlights the intricate crosstalk between NRs and microRNAs (miRNAs), which are small non-coding RNAs that posttranscriptionally modulate gene expression. This review provides an integrated overview of the molecular interactions between key NRs and miRNAs in BCa. We investigated how miRNAs regulate NR expression and function and, conversely, how NRs influence miRNA biogenesis, thereby forming regulatory feedback loops that shape tumor behavior. Specific miRNA\u2013NR interactions affecting epithelial-to-mesenchymal transition, metabolic reprogramming, angiogenesis, and chemoresistance are discussed in detail. Additionally, we highlight therapeutic strategies targeting NR\u2013miRNA networks, including selective NR modulators, miRNA mimics and inhibitors, as well as RNA-based combinatorial approaches focusing on their utility as diagnostic biomarkers and personalized treatment targets. Understanding the molecular complexity of NR\u2013miRNA regulation in BCa may open new avenues for improving therapeutic outcomes and advancing precision oncology in urological cancers.<\/jats:p>","DOI":"10.3390\/ijms26157340","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T16:16:10Z","timestamp":1753805770000},"page":"7340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nuclear Receptors in Bladder Cancer: Insights into miRNA-Mediated Regulation and Potential Therapeutic Implications"],"prefix":"10.3390","volume":"26","author":[{"given":"Jos\u00e9 Javier","family":"Flores-Estrada","sequence":"first","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez De M\u00e9xico, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez De M\u00e9xico, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-9406","authenticated-orcid":false,"given":"Georgina","family":"Victoria-Acosta","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez De M\u00e9xico, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6240-3468","authenticated-orcid":false,"given":"Enoc Mariano","family":"Cort\u00e9s-Malag\u00f3n","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez De M\u00e9xico, Mexico City 07760, Mexico"},{"name":"Genetics Laboratory, Hospital Nacional Homeop\u00e1tico, Mexico City 06800, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-6861","authenticated-orcid":false,"given":"Mar\u00eda Guadalupe","family":"Ortiz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez De M\u00e9xico, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-4451","authenticated-orcid":false,"given":"Mar\u00eda Elizbeth","family":"Alvarez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Celular Humana y Veterinaria Posgrado en Ciencias Gen\u00f3micas, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico (UACM), San Lorenzo 290, Col. Del Valle, Mexico City 03100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie I.","family":"Nu\u00f1ez-Olvera","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-3001","authenticated-orcid":false,"given":"Yussel Fernando","family":"P\u00e9rez-Navarro","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Celular Humana y Veterinaria Posgrado en Ciencias Gen\u00f3micas, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico (UACM), San Lorenzo 290, Col. Del Valle, Mexico City 03100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5538-9374","authenticated-orcid":false,"given":"Marcos","family":"Morales-Reyna","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis Celular Humana y Veterinaria Posgrado en Ciencias Gen\u00f3micas, Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico (UACM), San Lorenzo 290, Col. Del Valle, Mexico City 03100, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Puente-Rivera","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez De M\u00e9xico, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41572-023-00468-9","article-title":"Bladder cancer","volume":"9","author":"Hansel","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s11764-016-0533-8","article-title":"Lifestyle factors and health-related quality of life in bladder cancer survivors: A systematic review","volume":"10","author":"Gopalakrishna","year":"2016","journal-title":"J. Cancer Surviv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/bju.15209","article-title":"Recurrence- and progression-free survival in intermediate-risk non-muscle-invasive bladder cancer: The impact of conditional evaluation and subclassification","volume":"127","author":"Kohada","year":"2021","journal-title":"BJU Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3233\/BLC-190249","article-title":"Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions","volume":"6","author":"Zuniga","year":"2020","journal-title":"Bladder Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lee, C.U., Song, W., Koo, M.J., Boo, Y., Chung, J.H., Kang, M., Sung, H.H., Jeon, H.G., Jeong, B.C., and Seo, S.I. (2022). Utility of Contemporary Health Screening in the Diagnosis of Bladder Cancer. Diagnostics, 12.","DOI":"10.3390\/diagnostics12051040"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S44-51","DOI":"10.4111\/icu.2016.57.S1.S44","article-title":"How do we manage high-grade T1 bladder cancer? Conservative or aggressive therapy?","volume":"57","author":"Yun","year":"2016","journal-title":"Investig. Clin. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.critrevonc.2015.05.005","article-title":"Emerging concepts on drug resistance in bladder cancer: Implications for future strategies","volume":"96","author":"Massari","year":"2015","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0955-0674(98)80015-X","article-title":"The nuclear receptor ligand-binding domain: Structure and function","volume":"10","author":"Moras","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev.biophys.30.1.329","article-title":"Binding of ligands and activation of transcription by nuclear receptors","volume":"30","author":"Steinmetz","year":"2001","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.trecan.2020.11.007","article-title":"Targeting Nuclear Receptors for Cancer Therapy: Premises, Promises, and Challenges","volume":"7","author":"Yang","year":"2021","journal-title":"Trends Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"154316","DOI":"10.1016\/j.prp.2023.154316","article-title":"miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay\u2014A review","volume":"242","author":"Elsakka","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.canlet.2020.04.023","article-title":"Non-coding RNA in bladder cancer","volume":"485","author":"Li","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"6940","DOI":"10.1158\/0008-5472.CAN-11-2091","article-title":"A comprehensive view of nuclear receptor cancer cistromes","volume":"71","author":"Tang","year":"2011","journal-title":"Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrg.2017.102","article-title":"Nuclear receptors in cancer\u2014Uncovering new and evolving roles through genomic analysis","volume":"19","author":"Dhiman","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2133\/dmpk.21.437","article-title":"Nuclear receptor-mediated transcriptional regulation in Phase I, II, and III xenobiotic metabolizing systems","volume":"21","author":"Nakata","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/apha.12681","article-title":"MicroRNAs in metabolism","volume":"219","author":"Vienberg","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ceb.2009.04.009","article-title":"Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells","volume":"21","author":"Chekulaeva","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2147\/IJN.S72904","article-title":"Clinical and pathological implications of miRNA in bladder cancer","volume":"10","author":"Braicu","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4331\/wjbc.v8.i1.45","article-title":"Role of microRNAs in translation regulation and cancer","volume":"8","author":"Oliveto","year":"2017","journal-title":"World J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2174\/138920210793175895","article-title":"MicroRNA: Biogenesis, Function and Role in Cancer","volume":"11","author":"Macfarlane","year":"2010","journal-title":"Curr. Genom."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/1568009617666170630142725","article-title":"MicroRNA Key to Angiogenesis Regulation: MiRNA Biology and Therapy","volume":"18","author":"Tiwari","year":"2018","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/prm2.12119","article-title":"miRNAs involvement in the etiology and targeted therapy of bladder cancer: Interaction between signaling pathway","volume":"12","author":"Sharma","year":"2023","journal-title":"Precis. Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.1073\/pnas.0800650105","article-title":"The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene","volume":"105","author":"Kong","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/modpathol.2013.125","article-title":"CCND1\/CyclinD1 status in metastasizing bladder cancer: A prognosticator and predictor of chemotherapeutic response","volume":"27","author":"Seiler","year":"2014","journal-title":"Mod. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Polo, A., Marchese, S., De Petro, G., Montella, M., Ciliberto, G., Budillon, A., and Costantini, S. (2018). Identifying a panel of genes\/proteins\/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-28739-6"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1158\/0008-5472.CAN-09-0744","article-title":"Distinct microRNA alterations characterize high- and low-grade bladder cancer","volume":"69","author":"Catto","year":"2009","journal-title":"Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/j.1464-410X.2012.11748.x","article-title":"Predicting progression of bladder urothelial carcinoma using microRNA expression","volume":"112","author":"Rosenberg","year":"2013","journal-title":"BJU Int."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Awadalla, A., Abol-Enein, H., Hamam, E.T., Ahmed, A.E., Khirallah, S.M., El-Assmy, A., Mostafa, S.A., Babalghith, A.O., Ali, M., and Abdel-Rahim, M. (2022). Identification of Epigenetic Interactions between miRNA and Gene Expression as Potential Prognostic Markers in Bladder Cancer. Genes, 13.","DOI":"10.3390\/genes13091629"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Otmani, K., and Lewalle, P. (2021). Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.708765"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s13046-019-1406-6","article-title":"Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression","volume":"38","author":"Braicu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1515\/oncologie-2022-1030","article-title":"Differential expression and functions of miRNAs in bladder cancer","volume":"25","author":"Huang","year":"2023","journal-title":"Oncologie"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10555-017-9712-y","article-title":"MicroRNAs and metastasis: Small RNAs play big roles","volume":"37","author":"Kim","year":"2018","journal-title":"Cancer Metastasis Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.4111\/icu.2016.57.S1.S60","article-title":"The role of microRNAs in bladder cancer","volume":"57","author":"Enokida","year":"2016","journal-title":"Investig. Clin. Urol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Das, S., Hayden, J., Sullivan, T., and Rieger-Christ, K. (2023). The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24020964"},{"key":"ref_36","first-page":"5549","article-title":"MicroRNA-34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression","volume":"18","author":"Ding","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"156926","DOI":"10.1016\/j.cyto.2025.156926","article-title":"MiR-125b suppresses bladder Cancer cell growth and triggers apoptosis by regulating IL-6\/IL-6R\/STAT3 axis in vitro and in vivo","volume":"190","author":"Lin","year":"2025","journal-title":"Cytokine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0155-5","article-title":"Estrogen receptor \u03b2 promotes bladder cancer growth and invasion via alteration of miR-92a\/DAB2IP signals","volume":"50","author":"Ou","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"40832","DOI":"10.18632\/oncotarget.16586","article-title":"Cell-free microRNA expression signatures in urine serve as novel noninvasive biomarkers for diagnosis and recurrence prediction of bladder cancer","volume":"8","author":"Du","year":"2017","journal-title":"Oncotarget"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1186\/s13046-014-0115-4","article-title":"MicroRNA-34a functions as an anti-metastatic microRNA and suppresses angiogenesis in bladder cancer by directly targeting CD44","volume":"33","author":"Yu","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhu, J., Li, Y., Luo, Y., Xu, J., Liufu, H., Tian, Z., Huang, C., and Li, J. (2019). A Feedback Loop Formed by ATG7\/Autophagy, FOXO3a\/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer. Cancers, 11.","DOI":"10.3390\/cancers11030349"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"33064","DOI":"10.18632\/oncotarget.16524","article-title":"MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells","volume":"8","author":"Minami","year":"2017","journal-title":"Oncotarget"},{"key":"ref_43","first-page":"6355","article-title":"miR-145-5p inhibits the proliferation and migration of bladder cancer cells by targeting TAGLN2","volume":"16","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.urolonc.2007.01.019","article-title":"Micro-RNA profiling in kidney and bladder cancers","volume":"25","author":"Gottardo","year":"2007","journal-title":"Urol. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12672-023-00808-x","article-title":"Delineating the role of nuclear receptors in colorectal cancer, a focused review","volume":"15","author":"Manickasamy","year":"2024","journal-title":"Discov. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s13577-019-00285-x","article-title":"MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K\/AKT pathway","volume":"33","author":"Liu","year":"2020","journal-title":"Hum. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/ijc.25509","article-title":"MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3","volume":"128","author":"Huang","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2018.11.005","article-title":"Long non-coding RNA HOXA-AS2 promotes the migration, invasion and stemness of bladder cancer via regulating miR-125b\/Smad2 axis","volume":"375","author":"Wang","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.7150\/jca.21228","article-title":"LncRNA MALAT1 Inhibits Apoptosis and Promotes Invasion by Antagonizing miR-125b in Bladder Cancer Cells","volume":"8","author":"Xie","year":"2017","journal-title":"J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.7150\/jca.35710","article-title":"LncRNA00518 promotes cell proliferation through regulating miR-101 in bladder cancer","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4149\/neo_2018_180512N312","article-title":"MiR-203a functions as a tumor suppressor in bladder cancer by targeting SIX4","volume":"66","author":"Na","year":"2019","journal-title":"Neoplasma"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.canlet.2019.12.018","article-title":"Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p\/SLPI-mediated vasculogenic mimicry formation","volume":"473","author":"Yang","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"27313","DOI":"10.18632\/oncotarget.8430","article-title":"Glucocorticoid receptor beta increases migration of human bladder cancer cells","volume":"7","author":"McBeth","year":"2016","journal-title":"Oncotarget"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12935-014-0070-3","article-title":"MiR-133b regulates bladder cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1","volume":"14","author":"Chen","year":"2014","journal-title":"Cancer Cell Int."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.canlet.2014.11.002","article-title":"MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene","volume":"357","author":"Lv","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_56","first-page":"1382","article-title":"MiRNA-29c regulates cell growth and invasion by targeting CDK6 in bladder cancer","volume":"7","author":"Zhao","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.biopha.2018.09.100","article-title":"MiR-125a-5p suppresses bladder cancer progression through targeting FUT4","volume":"108","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.12659\/MSM.906836","article-title":"Androgen Receptor Is Inactivated and Degraded in Bladder Cancer Cells by Phenyl Glucosamine via miR-449a Restoration","volume":"24","author":"Guo","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2012.01.027","article-title":"MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins","volume":"320","author":"Chen","year":"2012","journal-title":"Cancer Lett."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Han, Y., Chen, J., Zhao, X., Liang, C., Wang, Y., Sun, L., Jiang, Z., Zhang, Z., Yang, R., and Li, Z. (2011). MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018286"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41419-019-1827-3","article-title":"ER\u03b1-mediated alterations in circ_0023642 and miR-490-5p signaling suppress bladder cancer invasion","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101115","DOI":"10.1016\/j.tranon.2021.101115","article-title":"Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease","volume":"14","author":"Maylin","year":"2021","journal-title":"Transl. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1210\/me.2011-1281","article-title":"Allosteric conversation in the androgen receptor ligand-binding domain surfaces","volume":"26","author":"Grosdidier","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/bs.vh.2023.01.001","article-title":"The androgen receptor","volume":"123","author":"Blair","year":"2023","journal-title":"Vitam. Horm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1111\/cas.13002","article-title":"Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer","volume":"107","author":"Yonemori","year":"2016","journal-title":"Cancer Sci."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Barsky, S.T., and Monks, D.A. (2025). The role of androgens and global and tissue-specific androgen receptor expression on body composition, exercise adaptation, and performance. Biol. Sex Differ., 16.","DOI":"10.1186\/s13293-025-00707-6"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Chaudhary, P., Singha, B., Abdel-Hafiz, H.A., Velegraki, M., Sundi, D., Satturwar, S., Parwani, A.V., Grivennikov, S.I., You, S., and Goodridge, H.S. (2025). Sex differences in bladder cancer: Understanding biological and clinical implications. Biol. Sex Differ., 16.","DOI":"10.1186\/s13293-025-00715-6"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41389-023-00489-9","article-title":"Biological differences underlying sex and gender disparities in bladder cancer: Current synopsis and future directions","volume":"12","author":"Doshi","year":"2023","journal-title":"Oncogenesis"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1038\/onc.2013.274","article-title":"Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver","volume":"33","author":"Chang","year":"2014","journal-title":"Oncogene"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"100645","DOI":"10.1016\/j.ijso.2023.100645","article-title":"Expression of androgen receptor in bladder cancer: A tertiary care center study","volume":"56","author":"Obeidat","year":"2023","journal-title":"Int. J. Surg. Open"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.3892\/or.2013.2792","article-title":"Epidermal growth factor enhances androgen receptor-mediated bladder cancer progression and invasion via potentiation of AR transactivation","volume":"30","author":"Hsieh","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/ERC-12-0328","article-title":"Androgen activates \u03b2-catenin signaling in bladder cancer cells","volume":"20","author":"Li","year":"2013","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_73","unstructured":"Laval University (2025, July 19). A Phase II Trial of Bicalutamide in Patients Receiving Intravesical BCG for Non-muscle Invasive Bladder Cancer (BicaBCa). Available online: https:\/\/ctv.veeva.com\/study\/a-phase-ii-trial-of-bicalutamide-in-patients-receiving-intravesical-bcg-for-non-muscle-invasive-blad."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1038\/s41418-021-00743-w","article-title":"Targeting androgen receptor (AR) with antiandrogen Enzalutamide increases prostate cancer cell invasion yet decreases bladder cancer cell invasion via differentially altering the AR\/circRNA-ARC1\/miR-125b-2-3p or miR-4736\/PPAR\u03b3\/MMP-9 signals","volume":"28","author":"Deng","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.euf.2020.10.002","article-title":"Switching Cancers: A Systematic Review Assessing the Role of Androgen Suppressive Therapy in Bladder Cancer","volume":"7","author":"Kourbanhoussen","year":"2021","journal-title":"Eur. Urol. Focus"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Xiang, P., Du, Z., Hao, Y., Guan, D., Liu, D., Yan, W., Wang, M., Liu, Y., and Ping, H. (2021). Impact of Androgen Suppression Therapy on the Risk and Prognosis of Bladder Cancer: A Systematic Review and Meta-Analysis. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.784627"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Li, P., Chen, J., and Miyamoto, H. (2017). Androgen Receptor Signaling in Bladder Cancer. Cancers, 9.","DOI":"10.3390\/cancers9020020"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1159\/000480419","article-title":"The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR)","volume":"43","author":"Xiong","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.2147\/OTT.S193661","article-title":"The functions of microRNA-124 on bladder cancer","volume":"12","author":"Cao","year":"2019","journal-title":"Onco Targets Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"16205","DOI":"10.18632\/oncotarget.7578","article-title":"miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4\/E2F1 signal activation","volume":"7","author":"Feng","year":"2016","journal-title":"Oncotarget"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.omtn.2020.03.003","article-title":"The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics","volume":"20","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/CAD.0000000000000555","article-title":"miR-449a: A potential therapeutic agent for cancer","volume":"28","author":"Chen","year":"2017","journal-title":"Anticancer Drugs"},{"key":"ref_83","first-page":"724","article-title":"miR-200a-3p predicts prognosis and inhibits bladder cancer cell proliferation by targeting STAT4","volume":"19","author":"Li","year":"2023","journal-title":"Arch. Med. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1038\/s41417-022-00506-w","article-title":"Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2\/circ_0001005\/PD-L1 signaling","volume":"29","author":"Liu","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.ircmb.2024.08.005","article-title":"Expanding frontiers in liquid biopsy-discovery and validation of circulating biomarkers in renal cell carcinoma and bladder cancer","volume":"391","author":"Krishnan","year":"2025","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/BLC-160052","article-title":"Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression","volume":"2","author":"Godoy","year":"2016","journal-title":"Bladder Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Huang, W., Chen, Y., Liu, Y., Zhang, Q., Yu, Z., Mou, L., Wu, H., Zhao, L., Long, T., and Qin, D. (2015). Roles of ER\u03b2 and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen. Biomed Res. Int., 2015.","DOI":"10.1155\/2015\/251780"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrc3093","article-title":"The different roles of ER subtypes in cancer biology and therapy","volume":"11","author":"Thomas","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/carcin\/bgt348","article-title":"Suppression of ER\u03b2 signaling via ER\u03b2 knockout or antagonist protects against bladder cancer development","volume":"35","author":"Hsu","year":"2014","journal-title":"Carcinogenesis"},{"key":"ref_90","first-page":"2523","article-title":"Estrogen receptor-\u03b2 signaling induces cisplatin resistance in bladder cancer","volume":"10","author":"Goto","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.18632\/oncotarget.1421","article-title":"Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo","volume":"5","author":"Hsu","year":"2014","journal-title":"Oncotarget"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Lappano, R., Todd, L.A., Stanic, M., Cai, Q., Maggiolini, M., Marincola, F., and Pietrobon, V. (2022). Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment. Cancers, 14.","DOI":"10.3390\/cancers14030539"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"589649","DOI":"10.3389\/pore.2021.589649","article-title":"Clinicopathological Significance of Estrogen Receptor","volume":"27","author":"Sato","year":"2021","journal-title":"Pathol. Oncol. Res."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Ide, H., and Miyamoto, H. (2021). Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy. Cells, 10.","DOI":"10.3390\/cells10051169"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1002\/ijc.32036","article-title":"miR-4324-RACGAP1-STAT3-ESR1 feedback loop inhibits proliferation and metastasis of bladder cancer","volume":"144","author":"Ge","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_96","first-page":"4705","article-title":"MicroRNA-206 acts as a tumor suppressor in bladder cancer via targeting YRDC","volume":"8","author":"Huang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3892\/ijo.2015.2837","article-title":"MiR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells","volume":"46","author":"Fu","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_98","first-page":"23","article-title":"The emerging roles of orphan nuclear receptors in prostate cancer","volume":"1866","author":"Wu","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1158\/0008-5472.CAN-18-3842","article-title":"Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1\/ITGB6\/STAT3 Signaling Axis in Bladder Cancer","volume":"79","author":"Cao","year":"2019","journal-title":"Cancer Res."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Fan, J., Lv, Z., Yang, G., Liao, T.T., Xu, J., Wu, F., Huang, Q., Guo, M., Hu, G., and Zhou, M. (2018). Retinoic Acid Receptor-Related Orphan Receptors: Critical Roles in Tumorigenesis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01187"},{"key":"ref_101","first-page":"4793","article-title":"Characteristics of Nur77 and its ligands as potential anticancer compounds (Review)","volume":"18","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1124\/mol.109.061143","article-title":"Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth","volume":"77","author":"Cho","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/mc.23411","article-title":"Aldehyde dehydrogenase 6 family member A1 negatively regulates cell growth and to cisplatin sensitivity in bladder cancer","volume":"61","author":"Guo","year":"2022","journal-title":"Mol. Carcinog."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s12276-020-00551-1","article-title":"Hepatocyte nuclear factor 4\u03b1 and cancer-related cell signaling pathways: A promising insight into cancer treatment","volume":"53","author":"Lv","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Oh, M., Kim, S.Y., Gil, J.E., Byun, J.S., Cha, D.W., Ku, B., Lee, W., Kim, W.K., Oh, K.J., and Lee, E.W. (2020). Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-67549-7"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Mao, W., Xiong, G., Wu, Y., Wang, C., St. Clair, D., Li, J.D., and Xu, R. (2021). ROR\u03b1 Suppresses Cancer-Associated Inflammation by Repressing Respiratory Complex I-Dependent ROS Generation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910665"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"879254","DOI":"10.1155\/2015\/879254","article-title":"miR-34a inhibits proliferation and invasion of bladder cancer cells by targeting orphan nuclear receptor HNF4G","volume":"2015","author":"Sun","year":"2015","journal-title":"Dis. Markers"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13046-019-1059-5","article-title":"MicroRNA-34 family: A potential tumor suppressor and therapeutic candidate in cancer","volume":"38","author":"Zhang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s10555-021-09973-3","article-title":"The comprehensive landscape of miR-34a in cancer research","volume":"40","author":"Li","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3109\/07357907.2013.853077","article-title":"Nur77 inhibits androgen-induced bladder cancer growth","volume":"31","author":"Wu","year":"2013","journal-title":"Cancer Invest."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"13841","DOI":"10.1002\/jcb.28657","article-title":"The enhanced expression of estrogen-related receptor \u03b1 in human bladder cancer tissues and the effects of estrogen-related receptor \u03b1 knockdown on bladder cancer cells","volume":"120","author":"Ye","year":"2019","journal-title":"J. Cell Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1749-6632.1996.tb18619.x","article-title":"PPAR tissue distribution and interactions with other hormone-signaling pathways","volume":"804","author":"Lemberger","year":"1996","journal-title":"Ann. N. Y. Acad Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1038\/s41467-021-26421-6","article-title":"Pparg signaling controls bladder cancer subtype and immune exclusion","volume":"12","author":"Tate","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0002-9440(10)63737-6","article-title":"Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells","volume":"164","author":"Varley","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1038\/s41467-019-12307-1","article-title":"Urothelial organoids originating from Cd49f","volume":"10","author":"Santos","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPARgamma","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.celrep.2014.10.035","article-title":"Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes","volume":"9","author":"Biton","year":"2014","journal-title":"Cell Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41467-017-00147-w","article-title":"Evasion of immunosurveillance by genomic alterations of PPAR\u03b3\/RXR\u03b1 in bladder cancer","volume":"8","author":"Korpal","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1158\/0008-5472.CAN-17-1701","article-title":"Genomic activation of PPARG reveals a candidate therapeutic axis in bladder cancer","volume":"77","author":"Goldstein","year":"2017","journal-title":"Cancer Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1158\/1078-0432.CCR-08-0457","article-title":"Peroxisome proliferator-activated receptor gamma overexpression suppresses growth and induces apoptosis in human multiple myeloma cells","volume":"14","author":"Bernstein","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23534","DOI":"10.1074\/jbc.M200172200","article-title":"Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells","volume":"277","author":"Fauconnet","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrc3214","article-title":"The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention","volume":"12","author":"Peters","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"114271","DOI":"10.1016\/j.yexcr.2024.114271","article-title":"Long noncoding RNA UCA1 inhibits epirubicin-induced apoptosis by activating PPAR\u03b1-mediated lipid metabolism","volume":"442","author":"Sun","year":"2024","journal-title":"Exp. Cell Res."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Ide, H., Inoue, S., and Miyamoto, H. (2018). The Role of Glucocorticoid Receptor Signaling in Bladder Cancer Progression. Cancers, 10.","DOI":"10.3390\/cancers10120484"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1002\/mc.23118","article-title":"Role of glucocorticoid signaling in urothelial tumorigenesis: Inhibition by prednisone presumably through inducing glucocorticoid receptor transrepression","volume":"58","author":"Ide","year":"2019","journal-title":"Mol. Carcinog."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1210\/endrev\/bnae008","article-title":"The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity","volume":"45","author":"Lockett","year":"2024","journal-title":"Endocr. Rev."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Ramos-Ram\u00edrez, P., and Tliba, O. (2021). Glucocorticoid Receptor \u03b2 (GR\u03b2): Beyond Its Dominant-Negative Function. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073649"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/jmcb\/mjz001","article-title":"Glucocorticoid receptor-IRS-1 axis controls EMT and the metastasis of breast cancers","volume":"11","author":"Shi","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.mce.2016.10.002","article-title":"AKT1 has dual actions on the glucocorticoid receptor by cooperating with 14-3-3","volume":"439","author":"Habib","year":"2017","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1742-4658.2010.07997.x","article-title":"microRNA-203 suppresses bladder cancer development by repressing bcl-w expression","volume":"278","author":"Bo","year":"2011","journal-title":"FEBS J."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1158\/1940-6207.CAPR-11-0267","article-title":"Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer","volume":"4","author":"Saini","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1476-4598-9-38","article-title":"The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression","volume":"9","author":"Lynch","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10555-024-10171-0","article-title":"Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics","volume":"43","author":"BharathwajChetty","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/1541-7786.MCR-20-0189","article-title":"Cell-Intrinsic Tumorigenic Functions of PPAR\u03b3 in Bladder Urothelial Carcinoma","volume":"19","author":"Sanchez","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/me.2013-1291","article-title":"Minireview: Role of orphan nuclear receptors in cancer and potential as drug targets","volume":"28","author":"Safe","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1038\/oncsis.2013.25","article-title":"Orphan nuclear receptor HNF4G promotes bladder cancer growth and invasion through the regulation of the hyaluronan synthase 2 gene","volume":"2","author":"Okegawa","year":"2013","journal-title":"Oncogenesis"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.urology.2009.10.041","article-title":"Androgen receptor is a potential therapeutic target for bladder cancer","volume":"75","author":"Wu","year":"2010","journal-title":"Urology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12672-012-0123-9","article-title":"Raloxifene inhibits growth of RT4 urothelial carcinoma cells via estrogen receptor-dependent induction of apoptosis and inhibition of proliferation","volume":"4","author":"Hoffman","year":"2013","journal-title":"Horm. Cancer"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Goto, T., and Miyamoto, H. (2021). The Role of Estrogen Receptors in Urothelial Cancer. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.643870"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"53168","DOI":"10.18632\/oncotarget.18230","article-title":"MEK inhibition enhances efficacy of bacillus Calmette-Gu\u00e9rin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides","volume":"8","author":"Whang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.2147\/DDDT.S158518","article-title":"Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro","volume":"12","author":"Bourn","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_142","first-page":"5875","article-title":"miR-124 regulates STAT3-mediated cell proliferation, migration and apoptosis in bladder cancer","volume":"16","author":"Wang","year":"2018","journal-title":"Oncol Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1038\/onc.2011.543","article-title":"MiR-27b targets PPAR\u03b3 to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells","volume":"31","author":"Lee","year":"2012","journal-title":"Oncogene"},{"key":"ref_144","unstructured":"Alexa, F. (2016). The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation. [Ph.D. Thesis, University of Tennessee Health Science Center]."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/15\/7340\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:18:28Z","timestamp":1760033908000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/15\/7340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":144,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ijms26157340"],"URL":"https:\/\/doi.org\/10.3390\/ijms26157340","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]}}}