{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:26:40Z","timestamp":1777332400204,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis is a serious public health problem. sTREM-1 is a marker of inflammatory and infectious processes that has the potential to become a useful tool for predicting the evolution of sepsis. A prediction model for sepsis was constructed by combining sTREM-1, CRP, and a leukogram via a Bayesian network. A translational study carried out with 32 children with congenital heart disease who had undergone surgical correction at a public referral hospital in Northeast Brazil. In the postoperative period, the mean value of sTREM-1 was greater among patients diagnosed with sepsis than among those not diagnosed with sepsis (394.58 pg\/mL versus 239.93 pg\/mL, p &lt; 0.001). Analysis of the ROC curve for sTREM-1 and sepsis revealed that the area under the curve was 0.761, with a 95% CI (0.587\u20130.935) and p = 0.013. With the Bayesian model, we found that a 100% probability of sepsis was related to postoperative blood concentrations of CRP above 71 mg\/dL, a leukogram above 14,000 cells\/\u03bcL, and sTREM-1 concentrations above the cutoff point (283.53 pg\/mL). The proposed model using the Bayesian network approach with the combination of CRP, leukocyte count, and postoperative sTREM-1 showed promise for the diagnosis of sepsis.<\/jats:p>","DOI":"10.3390\/ijms26157379","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:00:41Z","timestamp":1753884041000},"page":"7379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sepsis Prediction: Biomarkers Combined in a Bayesian Approach"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-7875","authenticated-orcid":false,"given":"Jo\u00e3o V. B.","family":"Cabral","sequence":"first","affiliation":[{"name":"Postgraduate Program in Therapeutic Innovation, Federal University of Pernambuco-UFPE, Professor Moraes Rego Avenue, SN, University City, Recife 50670-420, Brazil"},{"name":"Postgraduate Program in Nursing, Federal University of Para\u00edba-UFPB, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7570-8199","authenticated-orcid":false,"given":"Maria M. B. M.","family":"da Silveira","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Pernambuco-UPE, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-0478","authenticated-orcid":false,"given":"Wilma T. F.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Nursing, Federal University of Para\u00edba-UFPB, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-1078","authenticated-orcid":false,"given":"Amanda T.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Academic Center of Vit\u00f3ria, Federal University of Pernambuco-UFPE, Recife 50670-420, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-3489","authenticated-orcid":false,"given":"F\u00e1bio H. P. C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Federal Rural University of Pernambuco-UFRPE, Recife 52171-030, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7525-9445","authenticated-orcid":false,"given":"Thaysa M. G. A. 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F.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"College of Nursing, State University of Para\u00edba-UEPB, Campina Grande 58429-500, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-5815","authenticated-orcid":false,"given":"Thaisa R.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Pernambuco-UPE, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1609-1125","authenticated-orcid":false,"given":"Jabiael C.","family":"da Silva Filho","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Pernambuco-UPE, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-4640","authenticated-orcid":false,"given":"Tamara","family":"Silva","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Pernambuco-UPE, Recife 50670-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-6615","authenticated-orcid":false,"given":"Leuridan C.","family":"Torres","sequence":"additional","affiliation":[{"name":"Institute of Integral Medicine Professor Fernando Figueira-IMIP, Recife 50070-550, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-7741","authenticated-orcid":false,"given":"D\u00e1rio C. Sobral","family":"Filho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Sciences, University of Pernambuco-UPE, Recife 50670-420, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2734-2284","authenticated-orcid":false,"given":"Dinaldo C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Therapeutic Innovation, Federal University of Pernambuco-UFPE, Professor Moraes Rego Avenue, SN, University City, Recife 50670-420, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","unstructured":"Latin American Sepsis Institute (2025, July 10). Care for Pediatric Patients with Sepsis, Severe Sepsis, and Septic Shock. 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