{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:26:36Z","timestamp":1792823196287,"version":"4.5.0"},"reference-count":438,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Schizophrenia is a challenging multifactorial neuropsychiatric disease that involves interactions between genetic susceptibility and environmental insults. Increasing evidence implicates viral infections as significant environmental contributors, particularly during sensitive neurodevelopmental periods. This review synthesises current findings on the viral hypothesis of schizophrenia, encompassing a wide array of neurotropic viruses, including influenza viruses, herpesviruses (HSV-1 and 2, CMV, VZV, EBV, HHV-6 and 8), hepatitis B and C viruses, HIV, HERVs, HTLV, Zika virus, BoDV, coronaviruses (including SARS-CoV-2), and others. These pathogens can contribute to schizophrenia through mechanisms such as direct microinvasion, persistent central nervous system infection, immune-mediated neuroinflammation, molecular mimicry, and the disturbance of the blood\u2013brain barrier. Prenatal exposure to viral infections can trigger maternal immune activation, resulting in cytokine-mediated alterations in the neurological development of the foetus that persist into adulthood. Genetic studies highlight the role of immune-related loci, including major histocompatibility complex polymorphisms, in modulating susceptibility to infection and neurodevelopmental outcomes. Clinical data also support the \u201cmild encephalitis\u201d hypothesis, suggesting that a subset of schizophrenia cases involve low-grade chronic neuroinflammation. Although antipsychotics have some immunomodulatory effects, adjunctive anti-inflammatory therapies show promise, particularly in treatment-resistant cases. Despite compelling associations, pathogen-specific links remain inconsistent, emphasising the need for longitudinal studies and integrative approaches such as viromics to unravel causal relationships. This review supports a \u201cmulti-hit\u201d model in which viral infections interfere with hereditary and immunological susceptibilities, enhancing schizophrenia risk. Elucidating these virus\u2013immune\u2013brain interactions may facilitate the discovery of biomarkers, targeted prevention, and novel therapeutic strategies for schizophrenia.<\/jats:p>","DOI":"10.3390\/ijms26157429","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T15:56:16Z","timestamp":1754409376000},"page":"7429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence"],"prefix":"10.3390","volume":"26","author":[{"given":"M\u0103d\u0103lina Georgeta","family":"Sighencea","sequence":"first","affiliation":[{"name":"Doctoral School, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-4669","authenticated-orcid":false,"given":"Simona Corina","family":"Trifu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, \u201cCarol Davila\u201d University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wahbeh, M.H., and Avramopoulos, D. (2021). Gene-Environment Interactions in Schizophrenia: A Literature Review. Genes, 12.","DOI":"10.3390\/genes12121850"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sj.mp.4001925","article-title":"Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10","volume":"12","author":"Fellerhoff","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pnpbp.2012.06.014","article-title":"Schizophrenia: Linking Prenatal Infection to Cytokines, the Tryptophan Catabolite (TRYCAT) Pathway, NMDA Receptor Hypofunction, Neurodevelopment and Neuroprogression","volume":"42","author":"Anderson","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e2191","DOI":"10.1002\/rmv.2191","article-title":"Type B Coxsackieviruses and Central Nervous System Disorders: Critical Review of Reported Associations","volume":"31","author":"Jmii","year":"2021","journal-title":"Rev. Med. Virol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rantala, M.J., Luoto, S., Borr\u00e1z-Le\u00f3n, J.I., and Krams, I. (2022). Schizophrenia: The New Etiological Synthesis. Neurosci. Biobehav. Rev., 142.","DOI":"10.1016\/j.neubiorev.2022.104894"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/schbul\/sbp052","article-title":"Coronavirus Immunoreactivity in Individuals with a Recent Onset of Psychotic Symptoms","volume":"37","author":"Severance","year":"2011","journal-title":"Schizophr. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1566-2772(03)00098-7","article-title":"Modeling the Role of Infections in the Etiology of Mental Illness","volume":"3","author":"Pearce","year":"2003","journal-title":"Clin. Neurosci. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2015.02.043","article-title":"Abnormal Immune System Development and Function in Schizophrenia Helps Reconcile Diverse Findings and Suggests New Treatment and Prevention Strategies","volume":"1617","author":"Anders","year":"2015","journal-title":"Brain Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Jansen van Vuren, E., Steyn, S.F., Brink, C.B., M\u00f6ller, M., Viljoen, F.P., and Harvey, B.H. (2021). The Neuropsychiatric Manifestations of COVID-19: Interactions with Psychiatric Illness and Pharmacological Treatment. Biomed. Pharmacother., 135.","DOI":"10.1016\/j.biopha.2020.111200"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bbr.2008.12.022","article-title":"Neural Basis of Psychosis-Related Behaviour in the Infection Model of Schizophrenia","volume":"204","author":"Meyer","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.psychres.2015.08.025","article-title":"Viral Metagenomics in Drug-Na\u00efve, First-Onset Schizophrenia Patients with Prominent Negative Symptoms","volume":"229","author":"Canuti","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neubiorev.2016.03.017","article-title":"A Review of Vulnerability and Risks for Schizophrenia: Beyond the Two Hit Hypothesis","volume":"65","author":"Davis","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/npp.2012.253","article-title":"Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis","volume":"38","author":"Anacker","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/13550289609146888","article-title":"Detection of Herpesviridae in Postmortem Multiple Sclerosis Brain Tissue and Controls by Polymerase Chain Reaction","volume":"2","author":"Sanders","year":"1996","journal-title":"J. Neurovirol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1152\/ajpregu.00087.2015","article-title":"Long-Term Pathological Consequences of Prenatal Infection: Beyond Brain Disorders","volume":"309","author":"Labouesse","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/mp.2008.5","article-title":"Are Some Cases of Psychosis Caused by Microbial Agents? A Review of the Evidence","volume":"13","author":"Yolken","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF00452786","article-title":"Human Cytomegalovirus DNA in the Temporal Cortex of a Schizophrenic Patient","volume":"238","author":"Moises","year":"1988","journal-title":"Eur. Arch. Psychiatry Neurol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/jcla.20261","article-title":"RNA from Borna Disease Virus in Patients with Schizophrenia, Schizoaffective Patients, and in Their Biological Relatives","volume":"22","author":"Nunes","year":"2008","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Faustmann, T.J., Kamp, D., R\u00e4uber, S., Dukart, J., Melzer, N., and Schilbach, L. (2023). Social Interaction, Psychotic Disorders and Inflammation: A Triangle of Interest. Prog. Neuropsychopharmacol. Biol. Psychiatry, 122.","DOI":"10.1016\/j.pnpbp.2022.110697"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S2215-0366(17)30293-6","article-title":"The Blood-Brain Barrier in Psychosis","volume":"5","author":"Pollak","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1358\/dot.2009.45.4.1353924","article-title":"Potential Microbial Origins of Schizophrenia and Their Treatments","volume":"45","author":"Fatemi","year":"2009","journal-title":"Drugs Today"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bbi.2012.08.011","article-title":"Behaviour and Hippocampus-Specific Changes in Spiny Mouse Neonates after Treatment of the Mother with the Viral-Mimetic Poly I:C at Mid-Pregnancy","volume":"26","author":"Ratnayake","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbi.2012.09.011","article-title":"Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat","volume":"27","author":"Lukasz","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41398-019-0622-3","article-title":"A large-scale genomic investigation of susceptibility to infection and its association with mental disorders in the Danish population","volume":"9","author":"Nudel","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/schbul\/sbn054","article-title":"Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: Cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii","volume":"35","author":"Carter","year":"2009","journal-title":"Schizophr. Bull."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuron.2009.09.002","article-title":"Cytokines and CNS development","volume":"64","author":"Deverman","year":"2009","journal-title":"Neuron"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5498\/wjp.v2.i6.124","article-title":"Platelets: A possible glance into brain biological processes in schizophrenia","volume":"2","author":"Asor","year":"2012","journal-title":"World J. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1749-6632.2012.06638.x","article-title":"Autoimmune diseases and infections as risk factors for schizophrenia","volume":"1262","author":"Benros","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.schres.2014.07.025","article-title":"Neuroimmune biomarkers in schizophrenia","volume":"176","author":"Tomasik","year":"2016","journal-title":"Schizophr. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421\u2013427.","DOI":"10.1038\/nature13595"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/ijnp\/pyy062","article-title":"Kinetics of cytokine levels during antipsychotic treatment in schizophrenia: A meta-analysis","volume":"21","author":"Romeo","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1176\/appi.ajp.2014.13121579","article-title":"Elevated maternal C-reactive protein and increased risk of schizophrenia in a national birth cohort","volume":"171","author":"Canetta","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pnpbp.2012.06.019","article-title":"Updating the mild encephalitis hypothesis of schizophrenia","volume":"42","author":"Bechter","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4088\/JCP.10r06823","article-title":"Nonsteroidal anti-inflammatory drugs in schizophrenia: Ready for practice or a good start? A meta-analysis","volume":"73","author":"Sommer","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/157339511794474271","article-title":"The role of microbial agents in the etiology of schizophrenia: An infectious hypothesis for psychosis?","volume":"7","author":"Heiber","year":"2011","journal-title":"Curr. Immunol. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/sj.mp.4001915","article-title":"Brain morphological changes associated with exposure to HSV1 in first-episode schizophrenia","volume":"12","author":"Prasad","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1176\/ajp.2006.163.12.2178","article-title":"No evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia?","volume":"163","author":"Brown","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/2049-632X.12077","article-title":"Susceptibility genes are enriched in those of the herpes simplex virus 1\/host interactome in psychiatric and neurological disorders","volume":"69","author":"Carter","year":"2013","journal-title":"Pathog. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/ajmg.b.31234","article-title":"Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk","volume":"156B","author":"Demontis","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.1017\/S0033291723000430","article-title":"Antiviral treatment in schizophrenia: A randomized pilot PET study on the effects of valaciclovir on neuroinflammation","volume":"53","author":"Jonker","year":"2023","journal-title":"Psychol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.schres.2015.05.012","article-title":"Maternal exposure to sexually transmitted infections and schizophrenia among offspring","volume":"166","author":"Brown","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Desforges, M., Le Coupanec, A., Dubeau, P., Bourgouin, A., Lajoie, L., Dub\u00e9, M., and Talbot, P.J. (2019). Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?. Viruses, 12.","DOI":"10.3390\/v12010014"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1176\/appi.ajp.2011.10101423","article-title":"Progressive gray matter loss and changes in cognitive functioning associated with exposure to herpes simplex virus 1 in schizophrenia: A longitudinal study","volume":"168","author":"Prasad","year":"2011","journal-title":"Am. J. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3233\/HAB-170325","article-title":"Determining the IgM and IgG antibodies titer against HSV1, HSV2 and CMV in the serum of schizophrenia patients","volume":"26","author":"Mohagheghi","year":"2018","journal-title":"Hum. Antibodies"},{"key":"ref_46","first-page":"132","article-title":"Seropositivity of neurotropic infectious agents in first-episode schizophrenia patients and the relationship with positive and negative symptoms","volume":"28","author":"Bolu","year":"2016","journal-title":"Psychiatr. Danub."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Yong, S.J., Yong, M.H., Teoh, S.L., Soga, T., Parhar, I., Chew, J., and Lim, W.L. (2021). The Hippocampal Vulnerability to Herpes Simplex Virus Type I Infection: Relevance to Alzheimer\u2019s Disease and Memory Impairment. Front. Cell. Neurosci., 15.","DOI":"10.3389\/fncel.2021.695738"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.schres.2018.11.002","article-title":"Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study","volume":"206","author":"Breier","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.schres.2010.06.010","article-title":"A Danish National Birth Cohort study of maternal HSV-2 antibodies as a risk factor for schizophrenia in their offspring","volume":"122","author":"Mortensen","year":"2010","journal-title":"Schizophr. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1128\/JVI.02110-06","article-title":"Herpes simplex virus type 2 (HSV-2) establishes latent infection in a different population of ganglionic neurons than HSV-1: Role of latency-associated transcripts","volume":"81","author":"Margolis","year":"2007","journal-title":"J. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archpsyc.58.11.1032","article-title":"Maternal infections and subsequent psychosis among offspring","volume":"58","author":"Buka","year":"2001","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.biopsych.2006.05.024","article-title":"Toxoplasma gondii as a risk factor for early-onset schizophrenia: Analysis of filter paper blood samples obtained at birth","volume":"61","author":"Mortensen","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"120856","DOI":"10.1016\/j.jns.2023.120856","article-title":"Herpes simplex virus 2 serology is associated with thinner whole-brain cortex in community-dwelling older adults","volume":"454","author":"Roberts","year":"2023","journal-title":"J. Neurol. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Otth, C., Acu\u00f1a-Hinrichsen, F., Leyton, L., Martin, C., and Concha, M.I. (2016). Herpes Simplex Virus Type 1 at the Central Nervous System. Herpesviridae, InTech.","DOI":"10.5772\/64130"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1750-3639.2011.00485.x","article-title":"Chronic Progressive Deficits in Neuron Size, Density and Number in the Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus","volume":"21","author":"Dosa","year":"2011","journal-title":"Brain Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0006-8993(00)02149-1","article-title":"Neonatal Herpes Simplex Virus Type 1 Brain Infection Affects the Development of Sensorimotor Gating in Rats","volume":"863","author":"Engel","year":"2000","journal-title":"Brain Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archpsyc.1990.01810140081011","article-title":"Sensorimotor Gating and Schizophrenia: Human and Animal Model Studies","volume":"47","author":"Braff","year":"1990","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41398-022-02044-3","article-title":"Herpes Simplex Virus 1 Infection on Grey Matter and General Intelligence in Severe Mental Illness","volume":"12","author":"Andreou","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/13550280600760594","article-title":"Spatiotemporal Changes of the Herpes Simplex Virus Entry Receptor Nectin-1 in Murine Brain during Postnatal Development","volume":"12","author":"Prandovszky","year":"2006","journal-title":"J. Neurovirol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1093\/schbul\/sbs125","article-title":"Neurotropic Infectious Agents and Cognitive Impairment in Schizophrenia","volume":"38","author":"Nimgaonkar","year":"2012","journal-title":"Schizophr. Bull."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Duarte, L.F., Farias, M.A., Alvarez, D.M., Bueno, S.M., Riedel, C.A., and Gonzalez, P.A. (2019). Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights into Proposed Interrelationships with Neurodegenerative Disorders. Front. Cell. Neurosci., 13.","DOI":"10.3389\/fncel.2019.00046"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Harris, S.A., and Harris, E.A. (2018). Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer\u2019s Disease. Front. Aging Neurosci., 10.","DOI":"10.3389\/fnagi.2018.00048"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/schbul\/sbs046","article-title":"Exposure to Herpes Simplex Virus Type 1 and Cognitive Impairments in Individuals with Schizophrenia","volume":"38","author":"Prasad","year":"2012","journal-title":"Schizophr. Bull."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.jpsychires.2013.07.010","article-title":"Exposure to herpes simplex virus, type 1 and reduced cognitive function","volume":"47","author":"Thomas","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Oliveira Neto, N.F., Caixeta, R.A.V., Zerbinati, R.M., Zarpellon, A.C., Caetano, M.W., Pallos, D., Junges, R., Costa, A.L.F., Aitken-Saavedra, J., and Giannecchini, S. (2024). The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections. Viruses, 16.","DOI":"10.3390\/v16111759"},{"key":"ref_66","first-page":"243","article-title":"Microglia Activation, Herpes Infection, and NMDA Receptor Inhibition: Common Pathways to Psychosis?","volume":"Volume 8","author":"Myint","year":"2015","journal-title":"Immunology and Psychiatry: From Basic Research to Therapeutic Interventions"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.schres.2015.08.036","article-title":"The impact of Herpes simplex virus type 1 on cognitive impairments in young, healthy individuals\u2014A historical prospective study","volume":"168","author":"Fruchter","year":"2015","journal-title":"Schizophr. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.bbi.2008.04.156","article-title":"Association between cognitive functioning, exposure to Herpes Simplex Virus type 1, and the COMT Val158Met genetic polymorphism in adults without a psychiatric disorder","volume":"22","author":"Dickerson","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1161\/01.STR.0000086754.32238.DA","article-title":"Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases","volume":"34","author":"Strandberg","year":"2003","journal-title":"Stroke"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1017\/S003329171200195X","article-title":"Persistent infection with neurotropic herpes viruses and cognitive impairment","volume":"43","author":"Watson","year":"2013","journal-title":"Psychol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Jonker, I., Klein, H.C., Duivis, H.E., Yolken, R.H., Rosmalen, J.G.M., and Schoevers, R.A. (2014). Association between exposure to HSV1 and cognitive functioning in a general population of adolescents. The TRAILS study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0101549"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.schres.2010.01.008","article-title":"Neuroanatomic and Cognitive Abnormalities Related to Herpes Simplex Virus Type 1 in Schizophrenia","volume":"118","author":"Schretlen","year":"2010","journal-title":"Schizophr. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0920-9964(94)90018-3","article-title":"Brain Structure Changes in Schizophrenics with High Serum Titers of Antibodies to Herpes Virus","volume":"11","author":"Pandurangi","year":"1994","journal-title":"Schizophr. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ajmg.b.30603","article-title":"Comprehensive Evaluation of Positional Candidates in the IL-18 Pathway Reveals Suggestive Associations with Schizophrenia and Herpes Virus Seropositivity","volume":"147","author":"Shirts","year":"2008","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/1040841X.2019.1660615","article-title":"Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: Friends or foes?","volume":"45","author":"Wang","year":"2019","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.schres.2010.01.007","article-title":"Grey matter changes associated with host genetic variation and exposure to Herpes Simplex Virus 1 (HSV1) in first episode schizophrenia","volume":"118","author":"Prasad","year":"2010","journal-title":"Schizophr. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"26331055231166411","DOI":"10.1177\/26331055231166411","article-title":"Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level","volume":"18","author":"James","year":"2023","journal-title":"Neurosci. Insights"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Huang, Y.C., Ping, L.Y., Hsu, S.H., Tsai, H.Y., and Cheng, M.C. (2023). Indicators of HSV1 Infection, ECM-Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia. J. Pers. Med., 13.","DOI":"10.3390\/jpm13091392"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/schbul\/sby164","article-title":"Schizophrenia is associated with an aberrant immune response to Epstein-Barr virus","volume":"45","author":"Dickerson","year":"2019","journal-title":"Schizophr. Bull."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pnpbp.2013.09.003","article-title":"Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder","volume":"48","author":"Houenou","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000408323","article-title":"Cytomegalovirus as a possible etiological agent in schizophrenia","volume":"12","author":"Torrey","year":"1983","journal-title":"Adv. Biol. Psychiatry"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.tins.2006.06.002","article-title":"Viral infections in the developing and mature brain","volume":"29","year":"2006","journal-title":"Trends Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.schres.2014.05.019","article-title":"Childhood Epstein-Barr Virus infection and subsequent risk of psychotic experiences in adolescence: A population-based prospective serological study","volume":"158","author":"Khandaker","year":"2014","journal-title":"Schizophr. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/postgradmedj-2012-131337","article-title":"Cognitive dysfunction: An important extrahepatic manifestation of hepatitis C infection?","volume":"89","author":"Kennelly","year":"2013","journal-title":"Postgrad. Med. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.schres.2012.06.035","article-title":"Maternal antibodies to infectious agents and risk for non-affective psychoses in the offspring\u2014A matched case-control study","volume":"140","author":"Karlsson","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1038\/s41380-023-02162-4","article-title":"Cytomegalovirus antibodies are associated with mood disorders, suicide, markers of neuroinflammation, and microglia activation in postmortem brain samples","volume":"28","author":"Zheng","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7852","DOI":"10.1128\/JVI.78.14.7852-7860.2004","article-title":"Epstein-Barr virus latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovirus HERV-K18 superantigen","volume":"78","author":"Sutkowski","year":"2004","journal-title":"J. Virol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/schbul\/sbu032","article-title":"Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC-derived neurons and brain activation patterns underlying working memory performance","volume":"41","author":"Prasad","year":"2015","journal-title":"Schizophr. Bull."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/CMR.00023-08","article-title":"Neuropathogenesis of congenital cytomegalovirus infection: Disease mechanisms and prospects for intervention","volume":"22","author":"Cheeran","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0002-9440(10)63691-7","article-title":"Neuron-specific activation of murine cytomegalovirus early gene e1 promoter in transgenic mice","volume":"163","author":"Arai","year":"2003","journal-title":"Am. J. Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.schres.2011.03.013","article-title":"Antibodies to infectious agents and the positive symptom dimension of subclinical psychosis: The TRAILS study","volume":"129","author":"Wang","year":"2011","journal-title":"Schizophr. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00702-014-1193-3","article-title":"Glutamate receptor antibodies in neurological diseases: Anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A\/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with various neurological disorders","volume":"121","author":"Levite","year":"2014","journal-title":"J. Neural Transm."},{"key":"ref_93","unstructured":"Segundo, M. (2019, January 14\u201315). Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for schizophrenia. Proceedings of the 5th World Congress on Health Economics, Health Policy and Healthcare Management, Copenhagen, Denmark."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"12750","DOI":"10.1128\/JVI.05878-11","article-title":"Inhibition of inflammatory interleukin-6 activity via extracellular signal-regulated kinase\u2013mitogen-activated protein kinase signaling antagonizes human cytomegalovirus reactivation from dendritic cells","volume":"85","author":"Reeves","year":"2011","journal-title":"J. Virol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Lucchese, G., Fl\u00f6el, A., and Stahl, B. (2020). A Peptide Link Between Human Cytomegalovirus Infection, Neuronal Migration, and Psychosis. Front. Psychiatry, 11.","DOI":"10.3389\/fpsyt.2020.00349"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.2967\/jnumed.109.066647","article-title":"Neuroinflammation in schizophrenia-related psychosis: A PET study","volume":"50","author":"Doorduin","year":"2009","journal-title":"J. Nucl. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1086\/344272","article-title":"Glial Cell Responses to Herpesvirus Infections: Role in Defense and Immunopathogenesis","volume":"186","author":"Lokensgard","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.schres.2011.10.003","article-title":"Additive Effects of Elevated C-Reactive Protein and Exposure to Herpes Simplex Virus Type 1 on Cognitive Impairment in Individuals with Schizophrenia","volume":"134","author":"Dickerson","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.schres.2021.02.001","article-title":"Complement C4 associations with altered microbial biomarkers exemplify gene-by-environment interactions in schizophrenia","volume":"234","author":"Severance","year":"2021","journal-title":"Schizophr. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/mp.2013.2","article-title":"Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci","volume":"19","author":"Demontis","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e12680","DOI":"10.1111\/gbb.12680","article-title":"From conifers to cognition: Microbes, brain and behavior","volume":"19","author":"Lathe","year":"2020","journal-title":"Genes Brain Behav."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.neuropharm.2011.01.011","article-title":"The Viral Theory of Schizophrenia Revisited: Abnormal Placental Gene Expression and Structural Changes with Lack of Evidence for H1N1 Viral Presence in Placentae of Infected Mice or Brains of Exposed Offspring","volume":"62","author":"Fatemi","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1523\/JNEUROSCI.3376-06.2006","article-title":"Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers","volume":"26","author":"Sparkman","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1128\/JVI.01616-14","article-title":"In vivo reactivation of latent herpes simplex virus 1 in mice can occur in the brain before occurring in the trigeminal ganglion","volume":"88","author":"Yao","year":"2014","journal-title":"J. Virol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.schres.2011.11.003","article-title":"Structural Abnormalities in the Cuneus Associated with Herpes Simplex Virus (Type 1) Infection in People at Ultra High Risk of Developing Psychosis","volume":"135","author":"Whitford","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/brain\/124.10.2014","article-title":"In Vivo Visualization of Activated Glia by 11C-PK11195-PET Following Herpes Encephalitis Reveals Projected Neuronal Damage Beyond the Primary Focal Lesion","volume":"124","author":"Cagnin","year":"2001","journal-title":"Brain"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.schres.2011.01.020","article-title":"Serological Evidence of Exposure to Herpes Simplex Virus Type 1 Is Associated with Cognitive Deficits in the CATIE Schizophrenia Sample","volume":"128","author":"Yolken","year":"2011","journal-title":"Schizophr. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"113157","DOI":"10.1016\/j.psychres.2020.113157","article-title":"The Association Between Exposure to Herpes Simplex Virus Type 1 (HSV-1) and Cognitive Functioning in Schizophrenia: A Meta-Analysis","volume":"291","author":"Dickerson","year":"2020","journal-title":"Psychiatry Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.schres.2017.08.001","article-title":"Emotion discrimination in humans: Its association with HSV-1 infection and its improvement with antiviral treatment","volume":"193","author":"Bhatia","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1176\/appi.ajp.163.3.442","article-title":"Impairment in the specificity of emotion processing in schizophrenia","volume":"163","author":"Schneider","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1093\/schbul\/sbl029","article-title":"The functional significance of social cognition in schizophrenia: A review","volume":"32","author":"Couture","year":"2006","journal-title":"Schizophr. Bull."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01701811","article-title":"HSV-1 brain infection by the olfactory nerve route and virus latency and reactivation may cause learning and behavioral deficiencies and violence in children and adults: A point of view","volume":"10","author":"Becker","year":"1995","journal-title":"Virus Genes"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jns.2007.08.010","article-title":"Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis","volume":"264","author":"Karatas","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.schres.2007.04.021","article-title":"Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk","volume":"94","author":"Shirts","year":"2007","journal-title":"Schizophr. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"112502","DOI":"10.1016\/j.psychres.2019.112502","article-title":"Infection with Herpes Simplex Virus Type 1 (HSV-1) and Sleep: The Dog That Did Not Bark","volume":"280","author":"Meshreky","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.psyneuen.2019.06.015","article-title":"Herpes Simplex Virus Type 1 Infection Is Associated with Suicidal Behavior and First Registered Psychiatric Diagnosis in a Healthy Population","volume":"108","author":"Nissen","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.chom.2013.03.010","article-title":"Virus infections in the nervous system","volume":"13","author":"Koyuncu","year":"2013","journal-title":"Cell Host Microbe"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e05645","DOI":"10.1016\/j.heliyon.2020.e05645","article-title":"Infections, inflammation, and risk of neuropsychiatric disorders: The neglected role of \u201cco-infection\u201d","volume":"6","author":"Abdoli","year":"2020","journal-title":"Heliyon"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1128\/jvi.66.4.2150-2156.1992","article-title":"Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia","volume":"66","author":"Sawtell","year":"1992","journal-title":"J. Virol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1750-3639.2001.tb00414.x","article-title":"Polymerase chain reaction as a diagnostic adjunct in herpesvirus infections of the nervous system","volume":"11","author":"DeBiasi","year":"2001","journal-title":"Brain Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/WCO.0000000000000556","article-title":"Viruses have multiple paths to central nervous system pathology","volume":"31","author":"Agner","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41577-021-00543-w","article-title":"Autoantibodies in neurological disease","volume":"21","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF03391675","article-title":"Anxiety and Depression: Linkages with Viral Diseases","volume":"34","author":"Coughlin","year":"2012","journal-title":"Public Health Rev."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Wang, X., Zhang, L., Lei, Y., Liu, X., Zhou, X., Liu, Y., Wang, M., Yang, L., Zhang, L., and Fan, S. (2014). Meta-analysis of infectious agents and depression. Sci. Rep., 4.","DOI":"10.1038\/srep04530"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/CMR.8.1.131","article-title":"Viruses, schizophrenia, and bipolar disorder","volume":"8","author":"Yolken","year":"1995","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/070674370905400809","article-title":"No association between prenatal viral infection and depression in later life\u2014A long-term cohort study of 6152 subjects","volume":"54","author":"Pang","year":"2009","journal-title":"Can. J. Psychiatry"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbi.2022.02.020","article-title":"Lifetime pathogen burden, inflammatory markers, and depression in community-dwelling older adults","volume":"102","author":"Lu","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.semcdb.2017.09.010","article-title":"Perinatal inflammation and adult psychopathology: From preclinical models to humans","volume":"77","author":"Depino","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0920-9964(88)90043-6","article-title":"Schizophrenic births and viral diseases in two states","volume":"1","author":"Torrey","year":"1988","journal-title":"Schizophr. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.schres.2011.10.026","article-title":"Infectious agents associated with schizophrenia: A meta-analysis","volume":"136","author":"Arias","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_131","first-page":"843","article-title":"Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: Meta-analysis and analytical study","volume":"11","author":"Cervilla","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1192\/bjp.124.3.273","article-title":"A serological study on mentally ill patients with particular reference to the prevalence of herpesvirus infections","volume":"124","author":"Lycke","year":"1974","journal-title":"Br. J. Psychiatry"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s00406-004-0481-6","article-title":"Antibodies to infectious agents in individuals with recent onset schizophrenia","volume":"254","author":"Leweke","year":"2004","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000026597","article-title":"No changes in paired viral antibody titers during the course of acute schizophrenia","volume":"40","author":"Fukuda","year":"1999","journal-title":"Neuropsychobiology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.schres.2021.06.012","article-title":"Toxoplasma gondii, Herpesviridae and long-term risk of transition to first-episode psychosis in an ultra high-risk sample","volume":"233","author":"Burkhardt","year":"2021","journal-title":"Schizophr. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1600-0447.1992.tb03290.x","article-title":"Search for evidence of herpes simplex virus, type 1, or varicella-zoster virus infection in postmortem brain tissue from schizophrenic patients","volume":"86","author":"Alexander","year":"1992","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/archpsyc.1996.01830010034006","article-title":"Search for viral nucleic acid sequences in brain tissues of patients with schizophrenia using nested polymerase chain reaction","volume":"53","author":"Taller","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/jnnp.50.3.247","article-title":"Search for viral nucleic acid sequences in the post mortem brains of patients with schizophrenia and individuals who have committed suicide","volume":"50","author":"Carter","year":"1987","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_139","first-page":"e301","article-title":"Role of Chronic Bacterial and Viral Infections in Neurodegenerative, Neurobehavioral, Psychiatric, Autoimmune and Fatiguing Illnesses: Part 2","volume":"3","author":"Nicolson","year":"2010","journal-title":"Br. J. Med. Pract."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s11910-007-0038-y","article-title":"Epstein\u2013Barr Virus and Multiple Sclerosis","volume":"7","year":"2007","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_141","first-page":"362","article-title":"Epstein-Barr Virus-Associated Lymphoproliferative Disorders","volume":"7","author":"Ambinder","year":"2003","journal-title":"Rev. Clin. Exp. Hematol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1086\/491746","article-title":"Mononucleosis in the Laboratory","volume":"192","author":"Ambinder","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJM197606172942501","article-title":"Infectious Mononucleosis: Epstein-Barr Virus Shedding in Saliva and the Oropharynx","volume":"294","author":"Niederman","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Martelius, T., Lappalainen, M., Palom\u00e4ki, M., and Anttila, V.J. (2011). Clinical Characteristics of Patients with Epstein-Barr Virus in Cerebrospinal Fluid. BMC Infect. Dis., 11.","DOI":"10.1186\/1471-2334-11-281"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/WNL.0b013e31823ed057","article-title":"Association of Innate Immune Activation with Latent Epstein-Barr Virus in Active MS Lesions","volume":"78","author":"Tzartos","year":"2012","journal-title":"Neurology"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e946","DOI":"10.1038\/tp.2016.212","article-title":"Neuropathology of Mood Disorders: Do We See the Stigmata of Inflammation?","volume":"6","author":"Mechawar","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/jmv.23713","article-title":"Randomized Clinical Trial to Evaluate the Efficacy and Safety of Valganciclovir in a Subset of Patients with Chronic Fatigue Syndrome","volume":"85","author":"Montoya","year":"2013","journal-title":"J. Med. Virol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Hassani, A., Corboy, J.R., Al-Salam, S., and Khan, G. (2018). Epstein-Barr Virus Is Present in the Brain of Most Cases of Multiple Sclerosis and May Engage More Than Just B Cells. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192109"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/jid.2013.423","article-title":"Epstein-Barr Virus Infection Induces Aberrant TLR Activation Pathway and Fibroblast\u2013Myofibroblast Conversion in Scleroderma","volume":"134","author":"Farina","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"993","DOI":"10.4088\/JCP.11r07425","article-title":"Psychiatric Symptoms in Systemic Lupus Erythematosus: A Systematic Review","volume":"73","author":"Perl","year":"2012","journal-title":"J. Clin. Psychiatry"},{"key":"ref_151","first-page":"55","article-title":"Clinical Features and Predictive Factors in Neuropsychiatric Lupus","volume":"30","author":"Chiewthanakul","year":"2012","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/1352458513504249","article-title":"Psychiatric Diagnoses and Cognitive Impairment in Pediatric Multiple Sclerosis","volume":"20","author":"Weisbrot","year":"2014","journal-title":"Mult. Scler."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Brenner, P., Alexanderson, K., Bj\u00f6rkenstam, C., Jokinen, J., Hillert, J., Friberg, E., and Tingh\u00f6g, P. (2014). Psychiatric Diagnoses, Medication and Risk for Disability Pension in Multiple Sclerosis Patients: A Population-Based Register Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104165"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/09540261003589612","article-title":"Psychotic Features Associated with Multiple Sclerosis","volume":"22","author":"Kosmidis","year":"2010","journal-title":"Int. Rev. Psychiatry"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1002\/jmv.27995","article-title":"Relationship of herpesvirus (HSV1, EBV, CMV, HHV6) seropositivity with depressive disorder and its clinical aspects: The first study in children","volume":"94","author":"Bayturan","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbi.2019.12.001","article-title":"Association of exposure to Toxoplasma gondii, Epstein-Barr Virus, Herpes Simplex virus Type 1 and Cytomegalovirus with new-onset depressive and anxiety disorders: An 11-year follow-up study","volume":"87","author":"Markkula","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/AOG.0b013e31820f3a30","article-title":"Maternal depression and Epstein-Barr virus reactivation in early pregnancy","volume":"117","author":"Haeri","year":"2011","journal-title":"Obstet. Gynecol."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Zhu, P., Chen, Y.J., Hao, J.H., Ge, J.F., Huang, K., Tao, R.X., Jiang, X.M., and Tao, F.B. (2013). Maternal depressive symptoms related to Epstein-Barr virus reactivation in late pregnancy. Sci. Rep., 3.","DOI":"10.1038\/srep03096"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.psyneuen.2017.09.009","article-title":"Depressive symptoms are associated with salivary shedding of Epstein-Barr virus in female adolescents: The role of sex differences","volume":"86","author":"Ford","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/BF01314836","article-title":"Antibodies to Epstein\u2013Barr virus, herpes simplex type 1, cytomegalovirus and measles virus in psychiatric patients","volume":"67","author":"Zonis","year":"1981","journal-title":"Arch. Virol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1017\/S0033291700011764","article-title":"Herpes simplex virus, cytomegalovirus and Epstein\u2013Barr virus antibody titres in sera from schizophrenic patients","volume":"16","author":"Delisi","year":"1986","journal-title":"Psychol. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2165\/00023210-200620110-00001","article-title":"Cytomegalovirus and schizophrenia","volume":"20","author":"Torrey","year":"2006","journal-title":"CNS Drugs"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nature08186","article-title":"Common variants conferring risk of schizophrenia","volume":"460","author":"Stefansson","year":"2009","journal-title":"Nature"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archpsyc.57.11.1053","article-title":"Children\u2019s self-reported psychotic symptoms and adult schizophreniform disorder: A 15-year longitudinal study","volume":"57","author":"Poulton","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1176\/appi.ajp.2013.12060768","article-title":"Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study","volume":"170","author":"Zammit","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/msj.20240","article-title":"Environmental factors in multiple sclerosis: Epstein-Barr virus, vitamin D, and cigarette smoking","volume":"78","author":"Wingerchuk","year":"2011","journal-title":"Mt. Sinai J. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/brbi.2001.0644","article-title":"Maternal cytokine levels during pregnancy and adult psychosis","volume":"15","author":"Buka","year":"2001","journal-title":"Brain Behav. Immun."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1176\/appi.ajp.161.5.889","article-title":"Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring","volume":"161","author":"Brown","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.biopsych.2008.04.025","article-title":"Microglia activation in recent-onset schizophrenia: A quantitative (R)-[11C]PK11195 positron emission tomography study","volume":"64","author":"Bossong","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.schres.2020.12.018","article-title":"Exposure to Epstein Barr virus and cognitive functioning in individuals with schizophrenia","volume":"228","author":"Dickerson","year":"2021","journal-title":"Schizophr. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"15041","DOI":"10.1038\/npjschz.2015.41","article-title":"The association between antibodies to neurotropic pathogens and schizophrenia: A case-control study","volume":"1","author":"Litjens","year":"2015","journal-title":"NPJ Schizophr."},{"key":"ref_174","first-page":"102332","article-title":"Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model","volume":"102","author":"Jog","year":"2019","journal-title":"J. Autoimmun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molimm.2015.11.007","article-title":"Antibodies specific for Epstein-Barr virus nuclear antigen-1 cross-react with human heterogeneous nuclear ribonucleoprotein L.","volume":"69","author":"Lindsey","year":"2016","journal-title":"Mol. Immunol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jad.2019.11.150","article-title":"Atypical immune response to Epstein-Barr virus in major depressive disorder","volume":"264","author":"Dickerson","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13073-020-00790-x","article-title":"The landscape of host genetic factors involved in infection to common viruses and SARS-CoV-2","volume":"12","author":"Kachuri","year":"2020","journal-title":"Genome Med."},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Vistarop, A., Jimenez, O., Cohen, M., De Matteo, E., Preciado, M.V., and Chabay, P. (2020). Differences in Epstein-Barr virus characteristics and viral-related microenvironment could be responsible for lymphomagenesis in children. Pathogens, 9.","DOI":"10.3390\/pathogens9010068"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3233\/JAD-140822","article-title":"Herpes viruses increase the risk of Alzheimer\u2019s disease: A meta-analysis","volume":"47","author":"Steel","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Dickerson, F., Stallings, C., Origoni, A., Katsafanas, E., Schweinfurth, L.A., Savage, C.L., and Yolken, R. (2014). Association between cytomegalovirus antibody levels and cognitive functioning in non-elderly adults. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095510"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1001\/archpsyc.60.5.466","article-title":"Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia","volume":"60","author":"Dickerson","year":"2003","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.bbi.2018.01.006","article-title":"Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population: 11-year follow-up study","volume":"69","author":"Suvisaari","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0954579417000529","article-title":"Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study","volume":"30","author":"Vanyukov","year":"2018","journal-title":"Dev. Psychopathol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12987-022-00355-7","article-title":"Antibody indices of infectious pathogens from serum and cerebrospinal fluid in patients with schizophrenia spectrum disorders","volume":"19","author":"Runge","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.biopsych.2006.09.034","article-title":"Antibodies to infectious agents in individuals at ultra-high risk for psychosis","volume":"61","author":"Amminger","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jad.2017.12.069","article-title":"Are infectious agents involved in the pathogenesis of postpartum psychosis?","volume":"229","author":"Snijders","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.molmed.2019.11.003","article-title":"Epstein-Barr virus in multiple sclerosis: Theory and emerging immunotherapies","volume":"26","author":"Pender","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Anderson, A.G., Gaffy, C.B., Weseli, J.R., and Gorres, K.L. (2019). Inhibition of Epstein-Barr virus lytic reactivation by the atypical antipsychotic drug clozapine. Viruses, 11.","DOI":"10.3390\/v11050450"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/rmv.1862","article-title":"Cytomegalovirus latency and reactivation: Recent insights into an age old problem","volume":"26","author":"Dupont","year":"2016","journal-title":"Rev. Med. Virol."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/cmi.2014.75","article-title":"The immunology of human cytomegalovirus latency: Could latent infection be cleared by novel immunotherapeutic strategies?","volume":"12","author":"Wills","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/pin.12502","article-title":"Pathogenesis of developmental anomalies of the central nervous system induced by congenital cytomegalovirus infection","volume":"67","author":"Kawasaki","year":"2017","journal-title":"Pathol. Int."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/NEN.0000000000000038","article-title":"Cytomegalovirus-induced brain malformations in fetuses","volume":"73","author":"Teissier","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.euroneuro.2010.08.006","article-title":"Effect of cytomegalovirus infection on temporal lobe development in utero: Quantitative MRI studies","volume":"20","author":"Hoffmann","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1093\/schbul\/sbi054","article-title":"Deficit Schizophrenia: Association with Serum Antibodies to Cytomegalovirus","volume":"32","author":"Dickerson","year":"2006","journal-title":"Schizophr. Bull."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3109\/15622971003653246","article-title":"The association of infectious agents and schizophrenia","volume":"11","author":"Krause","year":"2010","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pnpbp.2012.02.001","article-title":"Viral infection, inflammation and schizophrenia","volume":"42","author":"Kneeland","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_197","unstructured":"Toroudi, H.P., Nazer, Y., and Shamsabadi, S. (2024). The Potential Link between Cytomegalovirus Infection and the Onset and Symptoms of Schizophrenia. Clin. Schizophr. Relat. Psychoses, 18."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.schres.2008.07.017","article-title":"Antibodies to Cytomegalovirus and Herpes Simplex Virus 1 Associated with Cognitive Function in Schizophrenia","volume":"106","author":"Shirts","year":"2008","journal-title":"Schizophr. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(80)90386-4","article-title":"Raised Cytomegalovirus-Antibody Level in Cerebrospinal Fluid of Schizophrenic Patients","volume":"316","author":"Albrecht","year":"1980","journal-title":"Lancet"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1600-0447.1986.tb02737.x","article-title":"Serum and Cerebrospinal Fluid Antibodies to Cytomegalovirus in Schizophrenia","volume":"73","author":"Ahokas","year":"1986","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1126\/science.6281883","article-title":"Cytomegalovirus Antibody in Cerebrospinal Fluid of Schizophrenic Patients Detected by Enzyme Immunoassay","volume":"216","author":"Torrey","year":"1982","journal-title":"Science"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0140-6736(83)90645-1","article-title":"Viruses and Schizophrenia","volume":"322","author":"Kaufmann","year":"1983","journal-title":"Lancet"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"113929","DOI":"10.1016\/j.psychres.2021.113929","article-title":"Cytomegalovirus Infection and IQ in Patients with Severe Mental Illness and Healthy Individuals","volume":"300","author":"Andreou","year":"2021","journal-title":"Psychiatry Res."},{"key":"ref_204","first-page":"103","article-title":"Complement-Fixing Antibodies Against Cytomegalovirus in Different Parts of the World","volume":"49","author":"Krech","year":"1973","journal-title":"Bull. World Health Organ."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jpsychires.2016.11.011","article-title":"Suicide attempts and markers of immune response in individuals with serious mental illness","volume":"87","author":"Dickerson","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbi.2023.05.015","article-title":"Immune cell subsets in patients with bipolar disorder or schizophrenia with history of childhood maltreatment","volume":"112","author":"Foiselle","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Solana, C., Pereira, D., and Tarazona, R. (2018). Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?. Brain Sci., 8.","DOI":"10.3390\/brainsci8100188"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1176\/appi.ajp.160.12.2234","article-title":"Reduction of symptoms by valacyclovir in cytomegalovirus-seropositive individuals with schizophrenia","volume":"160","author":"Dickerson","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/schbul\/sbs040","article-title":"Antiherpes virus\u2013specific treatment and cognition in schizophrenia: A test-of-concept randomized double-blind placebo-controlled trial","volume":"39","author":"Prasad","year":"2013","journal-title":"Schizophr. Bull."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1176\/appi.ajp.159.6.1029","article-title":"Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia","volume":"159","author":"Riedel","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1432-2277.2002.tb00119.x","article-title":"Induction of cyclo-oxygenase-2 by acute liver allograft rejection and cytomegalovirus infection in the rat","volume":"15","author":"Martelius","year":"2002","journal-title":"Transpl. Int."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1073\/pnas.052713799","article-title":"Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication","volume":"99","author":"Zhu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Craighead, J.E. (2000). Cytomegalovirus. Pathology and Pathogenesis of Human Viral Disease, Academic Press.","DOI":"10.1016\/B978-012195160-3\/50009-1"},{"key":"ref_214","first-page":"445","article-title":"Iatrogenic modification of tissue responses to infectious agents in the central nervous system","volume":"44","author":"Bailey","year":"1968","journal-title":"Res. Publ. Assoc. Res. Nerv. Ment. Dis."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1212\/WNL.23.2.136","article-title":"Cytomegalovirus encephalitis in adults","volume":"23","author":"Dorfman","year":"1973","journal-title":"Neurology"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/07853890601083808","article-title":"Are exposure to cytomegalovirus and genetic variation on chromosome 6p joint risk factors for schizophrenia?","volume":"39","author":"Kim","year":"2007","journal-title":"Ann. Med."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/gr.101956.109","article-title":"Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia","volume":"20","author":"Torkamani","year":"2010","journal-title":"Genome Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1756-6606-7-41","article-title":"Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia","volume":"7","author":"Hagihara","year":"2014","journal-title":"Mol. Brain"},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Komaroff, A.L., Rizzo, R., and Ecker, J.L. (2021). Human Herpesviruses 6A and 6B in Reproductive Diseases. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.648945"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Santpere, G., Telford, M., Andr\u00e9s-Benito, P., Navarro, A., and Ferrer, I. (2020). The Presence of Human Herpesvirus 6 in the Brain in Health and Disease. Biomolecules, 10.","DOI":"10.3390\/biom10111520"},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Prusty, B.K., Gulve, N., Govind, S., Krueger, G.R.F., Feichtinger, J., Larcombe, L., Aspinall, R., Ablashi, D.V., and Toro, C.T. (2018). Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01955"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3029","article-title":"Microbes\u2019 roadmap to neurons","volume":"12","author":"Kristensson","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"5563","DOI":"10.1073\/pnas.0913586107","article-title":"The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro","volume":"107","author":"Arbuckle","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/1673-5374.226380","article-title":"Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology","volume":"13","author":"Hogestyn","year":"2018","journal-title":"Neural Regen. Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/PRA.0000000000000677","article-title":"Recurrent Catatonia: Infection and Immunity in an Idiopathic Illness","volume":"29","author":"Tiwari","year":"2023","journal-title":"J. Psychiatr. Pract."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.schres.2013.10.004","article-title":"Association between antibodies to multiple infectious and food antigens and new onset schizophrenia among US military personnel","volume":"151","author":"Li","year":"2013","journal-title":"Schizophr. Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1176\/appi.ajp.2007.06081254","article-title":"Selected infectious agents and risk of schizophrenia among U.S. military personnel","volume":"165","author":"Niebuhr","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/schbul\/sbm139","article-title":"Results from a hypothesis generating case-control study: Herpes family viruses and schizophrenia among military personnel","volume":"34","author":"Niebuhr","year":"2008","journal-title":"Schizophr. Bull."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0920-9964(02)00160-3","article-title":"Herpesviruses and Toxoplasma gondii in orbital frontal cortex of psychiatric patients","volume":"60","author":"Torrey","year":"2003","journal-title":"Schizophr. Res."},{"key":"ref_230","first-page":"21cr02944","article-title":"HHV-6 and schizophrenia: An unusual presentation or an unproven etiology?","volume":"24","author":"Deshpande","year":"2022","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.psychres.2013.12.035","article-title":"High prevalence of Human Herpesvirus 8 in schizophrenic patients","volume":"216","author":"Hannachi","year":"2014","journal-title":"Psychiatry Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"e220200","DOI":"10.1590\/0074-02760220200","article-title":"Family Herpesviridae and neuroinfections: Current status and research in progress","volume":"117","author":"Carneiro","year":"2022","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2005.08.014","article-title":"Investigating the presence of human herpesvirus 7 and 8 in multiple sclerosis and normal control brain tissue","volume":"240","author":"Opsahl","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1743-422X-2-78","article-title":"Human herpesvirus 8\u2014A novel human pathogen","volume":"2","author":"Edelman","year":"2005","journal-title":"Virol. J."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.biopsych.2007.09.024","article-title":"Inflammatory cytokine alterations in schizophrenia: A systematic quantitative review","volume":"63","author":"Potvin","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1054\/mehy.2000.1203","article-title":"The Th2-hypothesis of schizophrenia: A strategy to identify a subgroup of schizophrenia caused by immune mechanisms","volume":"56","author":"Schwarz","year":"2001","journal-title":"Med. Hypotheses"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ejcb.2010.10.016","article-title":"Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization","volume":"90","author":"Suthaus","year":"2011","journal-title":"Eur. J. Cell Biol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1182\/blood-2002-01-0015","article-title":"Rta of the human herpesvirus 8\/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression","volume":"100","author":"Deng","year":"2002","journal-title":"Blood"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Zhao, J., Punj, V., Matta, H., Mazzacurati, L., Schamus, S., Yang, Y., Yang, T., Hong, Y., and Chaudhary, P.M. (2007). K13 blocks KSHV lytic replication and deregulates vIL6 and hIL6 expression: A model of lytic replication induced clonal selection in viral oncogenesis. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0001067"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1385\/MN:25:3:233","article-title":"Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system","volume":"25","author":"Nakashima","year":"2002","journal-title":"Mol. Neurobiol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.09.003","article-title":"The environment and susceptibility to schizophrenia","volume":"93","author":"Brown","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1192\/bjp.158.6.764","article-title":"Season of birth in schizophrenia. Evidence for confinement of an excess of winter births to patients without a family history of mental disorder","volume":"158","author":"Gibson","year":"1991","journal-title":"Br. J. Psychiatry"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1176\/appi.ajp.2009.09030361","article-title":"Prenatal infection and schizophrenia: A review of epidemiologic and translational studies","volume":"167","author":"Brown","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref_244","doi-asserted-by":"crossref","unstructured":"K\u0119pi\u0144ska, A.P., Iyegbe, C.O., Vernon, A.C., Yolken, R., Murray, R.M., and Pollak, T.A. (2020). Schizophrenia and influenza at the centenary of the 1918\u20131919 Spanish influenza pandemic: Mechanisms of psychosis risk. Front. Psychiatry, 11.","DOI":"10.3389\/fpsyt.2020.00072"},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archpsyc.1988.01800260109013","article-title":"Adult schizophrenia following prenatal exposure to an influenza epidemic","volume":"45","author":"Mednick","year":"1988","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1034\/j.1600-0447.2003.00052.x","article-title":"Prenatal exposure to influenza as a risk factor for adult schizophrenia","volume":"107","author":"Limosin","year":"2003","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.mehy.2011.02.019","article-title":"Season of birth in schizophrenia: A maternal-fetal chronobiological hypothesis","volume":"76","author":"Schwartz","year":"2011","journal-title":"Med. Hypotheses"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.mehy.2014.10.014","article-title":"Can the season of birth risk factor for schizophrenia be prevented by bright light treatment for the second trimester mother around the winter solstice?","volume":"83","author":"Schwartz","year":"2014","journal-title":"Med. Hypotheses"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/archpsyc.61.8.774","article-title":"Serologic evidence of prenatal influenza in the etiology of schizophrenia","volume":"61","author":"Brown","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003","article-title":"Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring","volume":"23","author":"Shi","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.mp.4002042","article-title":"Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling","volume":"13","author":"Meyer","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.mp.4001545","article-title":"Influenza A virus infection causes alterations in expression of synaptic regulatory genes combined with changes in cognitive and emotional behaviors in mice","volume":"10","author":"Beraki","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1093\/schbul\/sbz114","article-title":"A Network Analysis of Epigenetic and Transcriptional Regulation in a Neurodevelopmental Rat Model of Schizophrenia with Implications for Translational Research","volume":"46","author":"Du","year":"2020","journal-title":"Schizophr. Bull."},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Andreau, F., Galeano, P., Caltana, L.R., Masciotra, L., Chertcoff, A., Pontoriero, A., Baumeister, E., Amoroso, M., Brusco, H.A., and Tous, M.I. (2012). Effects of Two Commonly Found Strains of Influenza A Virus on Developing Dopaminergic Neurons, in Relation to the Pathophysiology of Schizophrenia. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051068"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"S1329","DOI":"10.1016\/j.euroneuro.2018.08.480","article-title":"SU116: Peptide sharing between schizophrenia-related proteins and the Influenza A virus may offer a link between immunity and psychotic disorders","volume":"29","author":"Kepinska","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.euroneuro.2021.07.144","article-title":"55. Multi-modal evidence that pandemic influenza influences schizophrenia risk","volume":"51","author":"Iyegbe","year":"2021","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.euroneuro.2017.12.034","article-title":"Molecular linking of influenza infection to cellular pathology of protein misassembly: The case of Disrupted-in-Schizophrenia 1 (DISC1)","volume":"28","author":"Marreiros","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1002\/jnr.21799","article-title":"Induction of the kynurenine pathway by neurotropic influenza A virus infection","volume":"86","author":"Holtze","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00023210-200923020-00001","article-title":"Pharmacological manipulation of kynurenic acid: Potential in the treatment of psychiatric disorders","volume":"23","author":"Erhardt","year":"2009","journal-title":"CNS Drugs"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1176\/ajp.155.6.761","article-title":"Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort","volume":"155","author":"Gil","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/schbul\/sbp147","article-title":"Schizophrenia and 1957 pandemic of influenza: Meta-analysis","volume":"36","author":"Selten","year":"2010","journal-title":"Schizophr. Bull."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0920-9964(97)00033-9","article-title":"Influenza epidemics and incidence of schizophrenia, affective disorders and mental retardation in Western Australia: No evidence of a major effect","volume":"26","author":"Morgan","year":"1997","journal-title":"Schizophr. Res."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.reprotox.2022.09.002","article-title":"Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: A systematic review","volume":"113","author":"Fung","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0140-6736(07)61515-3","article-title":"H5N1 infection of the respiratory tract and beyond: A molecular pathology study","volume":"370","author":"Gu","year":"2007","journal-title":"Lancet"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.schres.2007.09.031","article-title":"Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin","volume":"98","author":"Fatemi","year":"2008","journal-title":"Schizophr. Res."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1600-0447.1993.tb03468.x","article-title":"Does prenatal influenza divert susceptible females from later affective psychosis to schizophrenia?","volume":"88","author":"Takei","year":"1993","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2003.09.002","article-title":"What causes seasonality of birth in schizophrenia?","volume":"48","author":"Tochigi","year":"2004","journal-title":"Neurosci. Res."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1741-4520.2007.00151.x","article-title":"Hyperthermia in utero due to maternal influenza is an environmental risk factor for schizophrenia","volume":"47","author":"Edwards","year":"2007","journal-title":"Congenit. Anom."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1523\/JNEUROSCI.6389-11.2012","article-title":"Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice","volume":"32","author":"Jurgens","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1523\/JNEUROSCI.1740-17.2018","article-title":"Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function","volume":"38","author":"Hosseini","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/syn.20162","article-title":"Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: A potential animal model for schizophrenia and autism","volume":"57","author":"Fatemi","year":"2005","journal-title":"Synapse"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1523\/JNEUROSCI.4230-10.2011","article-title":"Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring","volume":"31","author":"Moreno","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Suschana, E., Anderson, T., Hong, C., Narikatte, A., Silverberg, J., and Sharma, M.S. (2025). The Role of Anti-Inflammatory Diets and Supplementation in Metabolic Syndrome and Symptom Remission in Adults with Schizophrenia: A Systematic Review. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1506353"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"E583","DOI":"10.1503\/jpn.200154","article-title":"Hepatitis C-associated late-onset schizophrenia: A nationwide, population-based cohort study","volume":"46","author":"Cheng","year":"2021","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s41983-022-00568-5","article-title":"Impact of direct-acting antivirals on neuropsychiatric and neurocognitive dysfunction in chronic hepatitis C patients","volume":"58","author":"Shehata","year":"2022","journal-title":"Egypt. J. Neurol. Psychiatry Neurosurg."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3748\/wjg.v21.i8.2269","article-title":"Chronic hepatitis C virus infection and neurological and psychiatric disorders: An overview","volume":"21","author":"Adinolfi","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"M\u00fcller, N. (2015). The Role of Infections and Autoimmune Diseases for Schizophrenia and Depression: Findings from Large-Scale Epidemiological Studies. Immunology and Psychiatry, Springer.","DOI":"10.1007\/978-3-319-13602-8"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.2174\/187152731307141015122638","article-title":"The role of viruses in neurodegenerative and neurobehavioral diseases","volume":"13","author":"Karim","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.genhosppsych.2011.03.006","article-title":"Prevalence of liver disease in veterans with bipolar disorder or schizophrenia","volume":"33","author":"Fuller","year":"2011","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S2215-0366(14)00122-9","article-title":"Inflammation and immunity in schizophrenia: Implications for pathophysiology and treatment","volume":"2","author":"Khandaker","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1176\/appi.psy.50.1.30","article-title":"Understanding associations between serious mental illness and hepatitis C virus among veterans: A national multivariate analysis","volume":"50","author":"Himelhoch","year":"2009","journal-title":"Psychosomatics"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcma.2012.03.002","article-title":"Prevalence of hepatitis B and hepatitis C in patients with chronic schizophrenia living in institutions","volume":"75","author":"Hung","year":"2012","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.schres.2008.11.008","article-title":"Prevalence of HIV and hepatitis C infection among patients with schizophrenia","volume":"108","author":"Franic","year":"2009","journal-title":"Schizophr. Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.genhosppsych.2019.10.007","article-title":"Rates of hepatitis B and C in patients with schizophrenia: A meta-analysis","volume":"61","author":"Lluch","year":"2019","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1600-0447.2007.01095.x","article-title":"Physical illness and schizophrenia: A review of the literature","volume":"116","author":"Leucht","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.pnpbp.2004.01.018","article-title":"High prevalence of the hepatitis C virus infection among the inpatients of schizophrenia and psychoactive substance abuse in Japan","volume":"28","author":"Nakamura","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1176\/appi.psy.48.5.405","article-title":"Hepatitis C in schizophrenia: Screening experience in a community-dwelling clozapine cohort","volume":"48","author":"Freudenreich","year":"2007","journal-title":"Psychosomatics"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.26141","article-title":"Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence","volume":"57","author":"Groeger","year":"2013","journal-title":"Hepatology"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.psychres.2017.08.036","article-title":"Increased risk of concurrent hepatitis C among male patients with schizophrenia","volume":"258","author":"Chiu","year":"2017","journal-title":"Psychiatry Res."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/bmj.321.7256.263","article-title":"Psychiatric disorders and risky sexual behaviour in young adulthood: Cross sectional study in birth cohort","volume":"321","author":"Ramrakha","year":"2000","journal-title":"BMJ"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/08820139409066822","article-title":"Depressed natural killer cell activity in schizophrenic patients","volume":"23","author":"Abdeljaber","year":"1994","journal-title":"Immunol. Investig."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S2352-3018(15)00089-2","article-title":"Associations between HIV and schizophrenia and their effect on HIV treatment outcomes: A nationwide population-based cohort study in Denmark","volume":"2","author":"Helleberg","year":"2015","journal-title":"Lancet HIV"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"8910396","DOI":"10.1155\/2016\/8910396","article-title":"Oxidative Stress during HIV Infection: Mechanisms and Consequences","volume":"2016","author":"Ivanov","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/wps.20001","article-title":"Secondary psychoses: An update","volume":"12","author":"Keshavan","year":"2013","journal-title":"World Psychiatry"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neubiorev.2014.06.004","article-title":"Refining and integrating schizophrenia pathophysiology\u2014Relevance of the allostatic load concept","volume":"45","author":"Misiak","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0006-3223(98)00229-7","article-title":"Antiretroviral antibodies: Implications for schizophrenia, schizophrenia spectrum disorders, and bipolar disorder","volume":"45","author":"Hart","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/014107688808100610","article-title":"Testing the retrovirus hypothesis of manic depression and schizophrenia with molecular genetic techniques","volume":"81","author":"Gurling","year":"1988","journal-title":"J. R. Soc. Med."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jpsychires.2009.08.008","article-title":"Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: Identification of subgroups with immune responses and blood-CSF barrier dysfunction","volume":"44","author":"Bechter","year":"2010","journal-title":"J. Psychiatr. Res."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/mrdd.1028","article-title":"Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models","volume":"7","author":"Hornig","year":"2001","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/bph.13364","article-title":"Microglial activation and progressive brain changes in schizophrenia","volume":"173","author":"Laskaris","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2174\/187152707783399229","article-title":"Kynurenine pathway and disease: An overview","volume":"6","year":"2007","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bbi.2006.02.005","article-title":"Acute psychotic symptoms in HIV-1 infected patients are associated with increased levels of kynurenic acid in cerebrospinal fluid","volume":"21","author":"Atlas","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jpsychires.2013.08.008","article-title":"Activation of kynurenine pathway in ex vivo fibroblasts from patients with bipolar disorder or schizophrenia: Cytokine challenge increases production of 3-hydroxykynurenine","volume":"47","author":"Johansson","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_305","first-page":"159","article-title":"Serotonin and human immunodeficiency viruses","volume":"31","author":"Launay","year":"1989","journal-title":"Nouvelle Rev. Fr. Hematol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1192\/bjp.166.1.55","article-title":"Polymerase chain reaction (PCR) search for viral nucleic acid sequences in schizophrenia","volume":"166","author":"Carbone","year":"1995","journal-title":"Br. J. Psychiatry"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/15622975.2010.601760","article-title":"Human Endogenous Retrovirus Type W (HERV-W) in Schizophrenia: A New Avenue of Research at the Gene\u2013Environment Interface","volume":"14","author":"Leboyer","year":"2013","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/schbul\/sbp166","article-title":"Implication of the env Gene of the Human Endogenous Retrovirus W Family in the Expression of BDNF and DRD3 and Development of Recent-Onset Schizophrenia","volume":"37","author":"Huang","year":"2011","journal-title":"Schizophr. Bull."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00702-006-0599-y","article-title":"Reduced Expression of Human Endogenous Retrovirus (HERV)-W GAG Protein in the Cingulate Gyrus and Hippocampus in Schizophrenia, Bipolar Disorder, and Depression","volume":"114","author":"Weis","year":"2007","journal-title":"J. Neural Transm."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1176\/appi.neuropsych.15030059","article-title":"Pathophysiological Role of HERV-W in Schizophrenia","volume":"28","author":"Aftab","year":"2016","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_311","doi-asserted-by":"crossref","unstructured":"Slokar, G., and Hasler, G. (2016). Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia. Front. Psychiatry, 6.","DOI":"10.3389\/fpsyt.2015.00183"},{"key":"ref_312","doi-asserted-by":"crossref","unstructured":"Li, F., Sabunciyan, S., Yolken, R.H., Lee, D., Kim, S., and Karlsson, H. (2019). Transcription of Human Endogenous Retroviruses in Human Brain by RNA-Seq Analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0207353"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"4634","DOI":"10.1073\/pnas.061021998","article-title":"Retroviral RNA Identified in the Cerebrospinal Fluids and Brains of Individuals with Schizophrenia","volume":"98","author":"Karlsson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1601-183X.2007.00334.x","article-title":"Elevated Levels of Human Endogenous Retrovirus-W Transcripts in Blood Cells from Patients with First Episode Schizophrenia","volume":"7","author":"Yao","year":"2008","journal-title":"Genes Brain Behav."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.schres.2006.01.007","article-title":"Human Endogenous Retroviral pol RNA and Protein Detected and Identified in the Blood of Individuals with Schizophrenia","volume":"83","author":"Huang","year":"2006","journal-title":"Schizophr. Res."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.schres.2012.03.037","article-title":"Antibodies to Retroviruses in Recent Onset Psychosis and Multi-Episode Schizophrenia","volume":"138","author":"Dickerson","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.psychres.2018.12.012","article-title":"First-Episode Schizophrenia Is Associated with a Reduction of HERV-K Methylation in Peripheral Blood","volume":"271","author":"Mak","year":"2019","journal-title":"Psychiatry Res."},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/apm.12486","article-title":"Human Endogenous Retroviruses in Neurologic Disease","volume":"124","author":"Christensen","year":"2016","journal-title":"APMIS"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/apm.12478","article-title":"Expression and Regulation of Human Endogenous Retrovirus W Elements","volume":"124","author":"Li","year":"2016","journal-title":"APMIS"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"19472","DOI":"10.1073\/pnas.1318172110","article-title":"Human-Specific Endogenous Retroviral Insert Serves as an Enhancer for the Schizophrenia-Linked Gene PRODH","volume":"110","author":"Suntsova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bihy.2009.04.006","article-title":"Human Endogenous Retroviruses, Hormones and APOBEC3G: A Connection to Explore in Schizophrenia","volume":"2","year":"2009","journal-title":"Biosci. Hypotheses"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000450581","article-title":"Activated Phosphorylated STAT1 Levels as a Biologically Relevant Immune Signal in Schizophrenia","volume":"23","author":"Sharma","year":"2016","journal-title":"Neuroimmunomodulation"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.biopsych.2008.10.018","article-title":"The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia","volume":"65","author":"Song","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.molmed.2018.02.007","article-title":"Human Endogenous Retroviruses in Neurological Diseases","volume":"24","author":"Nath","year":"2018","journal-title":"Trends Mol. Med."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.biopsych.2008.06.028","article-title":"Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients","volume":"64","author":"Perron","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_326","doi-asserted-by":"crossref","unstructured":"Balestrieri, E., Matteucci, C., Cipriani, C., Grelli, S., Ricceri, L., Calamandrei, G., and Vallebona, P.S. (2019). Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236050"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virs.2022.08.005","article-title":"Domesticated HERV-W env Contributes to the Activation of the Small Conductance Ca2+-Activated K+ Type 2 Channels via Decreased 5-HT4 Receptor in Recent-Onset Schizophrenia","volume":"38","author":"Wu","year":"2023","journal-title":"Virol. Sin."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s13365-018-0692-7","article-title":"HERV-W env Regulates Calcium Influx via Activating TRPC3 Channel Together with Depressing DISC1 in Human Neuroblastoma Cells","volume":"25","author":"Chen","year":"2019","journal-title":"J. Neurovirol."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuroscience.2013.05.033","article-title":"Human Endogenous Retrovirus W Family Envelope Gene Activates the Small Conductance Ca2+-Activated K+ Channel in Human Neuroblastoma Cells through CREB","volume":"247","author":"Li","year":"2013","journal-title":"Neuroscience"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/emmm.201100135","article-title":"A CAG Repeat Polymorphism of KCNN3 Predicts SK3 Channel Function and Cognitive Performance in Schizophrenia","volume":"3","author":"Grube","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virs.2023.09.001","article-title":"Ancient Dormant Virus Remnant ERVW-1 Drives Ferroptosis via Degradation of GPX4 and SLC3A2 in Schizophrenia","volume":"39","author":"Zhang","year":"2024","journal-title":"Virol. Sin."},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1128\/JVI.76.2.600-608.2002","article-title":"Search for Hepatitis C Virus Negative-Strand RNA Sequences and Analysis of Viral Sequences in the Central Nervous System: Evidence of Replication","volume":"76","author":"Radkowski","year":"2002","journal-title":"J. Virol."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1016\/j.euroneuro.2023.08.159","article-title":"Integrating Human Endogenous Retroviruses in Transcriptome-Wide Association Studies Highlights Novel Risk Factors for Major Psychiatric Conditions","volume":"75","author":"Powell","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"10890","DOI":"10.1128\/JVI.79.17.10890-10901.2005","article-title":"Human Endogenous Retrovirus Expression Profiles in Samples from Brains of Patients with Schizophrenia and Bipolar Disorders","volume":"79","author":"Frank","year":"2005","journal-title":"J. Virol."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"109404","DOI":"10.1016\/j.mehy.2019.109404","article-title":"A Model of Human Endogenous Retrovirus (HERV) Activation in Mental Health and Illness","volume":"133","author":"Canli","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"110178","DOI":"10.1016\/j.isci.2024.110178","article-title":"Immunosuppression-induced Zika virus reactivation causes brain inflammation and behavioral deficits in mice","volume":"27","author":"Nogueira","year":"2024","journal-title":"iScience"},{"key":"ref_337","doi-asserted-by":"crossref","unstructured":"Elgueta, D., Murgas, P., Riquelme, E., Yang, G., and Cancino, G.I. (2022). Consequences of Viral Infection and Cytokine Production During Pregnancy on Brain Development in Offspring. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.816619"},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12974-022-02460-8","article-title":"Zika virus-induced TNF-\u03b1 signaling dysregulates expression of neurologic genes associated with psychiatric disorders","volume":"19","author":"Kung","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/15622975.2018.1500027","article-title":"Can in utero Zika virus exposure be a risk factor for schizophrenia in the offspring?","volume":"21","author":"Pierson","year":"2020","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_340","doi-asserted-by":"crossref","unstructured":"Klase, Z.A., Khakhina, S., Schneider, A.D.B., Callahan, M.V., Glasspool-Malone, J., and Malone, R. (2016). Zika fetal neuropathogenesis: Etiology of a viral syndrome. PLoS Negl. Trop. Dis., 10.","DOI":"10.1101\/050674"},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"eaar2749","DOI":"10.1126\/scitranslmed.aar2749","article-title":"Acute and chronic neurological consequences of early-life Zika virus infection in mice","volume":"10","author":"Souza","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/jamapediatrics.2017.0002","article-title":"Bridging knowledge gaps to understand how Zika virus exposure and infection affect child development","volume":"171","author":"Kapogiannis","year":"2017","journal-title":"JAMA Pediatr."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"e00217","DOI":"10.1128\/msystems.00219-17","article-title":"Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain","volume":"3","author":"Janssens","year":"2018","journal-title":"mSystems"},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/1516-4446-2017-2308","article-title":"Zika virus infection followed by a first episode of psychosis: Another flavivirus leading to pure psychiatric symptomatology","volume":"39","year":"2017","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3201\/eid2306.162029","article-title":"Zika virus-associated cognitive impairment in adolescent, 2016","volume":"23","author":"Zucker","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1056\/NEJMc1602964","article-title":"Zika virus associated with meningoencephalitis","volume":"374","author":"Carteaux","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_347","doi-asserted-by":"crossref","unstructured":"Aguilar Ticona, J.P., Nery, N., Ladines-Lim, J.B., Gambrah, C., Sacramento, G., de Paula Freitas, B., Bouzon, J., Oliveira-Filho, J., Borja, A., and Adhikarla, H. (2021). Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009162"},{"key":"ref_348","first-page":"e14","article-title":"Neurodevelopmental outcomes of children following in utero exposure to Zika in Nicaragua","volume":"73","author":"Stringer","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_349","doi-asserted-by":"crossref","unstructured":"Grant, R., Fl\u00e9chelles, O., Tressi\u00e8res, B., Dialo, M., Elenga, N., Mediamolle, N., Mallard, A., Hebert, J.C., Lachaume, N., and Couchy, E. (2021). In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: A cohort study. BMC Med., 19.","DOI":"10.1186\/s12916-020-01888-0"},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s11065-018-9388-2","article-title":"Cognitive deficits in psychotic disorders: A lifespan perspective","volume":"28","author":"Sheffield","year":"2018","journal-title":"Neuropsychol. Rev."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbi.2020.10.024","article-title":"Prenatal exposure to viral infection and neuropsychiatric disorders in offspring: A review of the literature and recommendations for the COVID-19 pandemic","volume":"91","author":"Zimmer","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1038\/s41467-024-52192-x","article-title":"Lethal Borna disease virus 1 infections of humans and animals\u2014In-depth molecular epidemiology and phylogeography","volume":"15","author":"Ebinger","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2009.09.023","article-title":"Viral infection leading to brain dysfunction: More prevalent than appreciated?","volume":"64","year":"2009","journal-title":"Neuron"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s15010-024-02337-3","article-title":"Clinical analysis of Bornavirus Encephalitis cases demonstrates a small time window for etiological diagnostics and treatment attempts, a large case series from Germany 1996\u20132022","volume":"53","author":"Wilking","year":"2025","journal-title":"Infection"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neures.2006.06.002","article-title":"Recent progress in animal modeling of immune inflammatory processes in schizophrenia: Implication of specific cytokines","volume":"56","author":"Nawa","year":"2006","journal-title":"Neurosci. Res."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2004.01.001","article-title":"Animal models of obstetric complications in relation to schizophrenia","volume":"45","author":"Boksa","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1750-3639.1995.tb00598.x","article-title":"Presence of CD4+ and CD8+ T cells and expression of MHC class I and MHC class II antigen in horses with Borna disease virus-induced encephalitis","volume":"5","author":"Bilzer","year":"1995","journal-title":"Brain Pathol."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbi.2008.07.012","article-title":"Activation of the maternal immune system alters cerebellar development in the offspring","volume":"23","author":"Shi","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1128\/JVI.02245-06","article-title":"Spatiotemporal analysis of Purkinje cell degeneration relative to parasagittal expression domains in a model of neonatal viral infection","volume":"81","author":"Williams","year":"2007","journal-title":"J. Virol."},{"key":"ref_360","first-page":"1","article-title":"The role of the immune system in the pathophysiology of schizophrenia","volume":"19","author":"Kim","year":"2005","journal-title":"Brain Behav. Immun."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jad.2005.10.008","article-title":"Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients","volume":"90","author":"Miranda","year":"2006","journal-title":"J. Affect. Disord."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1128\/CMR.16.3.534-545.2003","article-title":"Borna disease virus infection, a human mental-health risk","volume":"16","author":"Bode","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1073\/pnas.0405965102","article-title":"Genome trimming: A unique strategy for replication control employed by Borna disease virus","volume":"102","author":"Schneider","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1440-1819.2010.02073.x","article-title":"Anti-Borna disease virus antibody responses in psychiatric patients: Long-term follow up","volume":"64","author":"Heinrich","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/zoonoticdis3040023","article-title":"Clinical Features of BoDV-1 Encephalitis: A Systematic Review","volume":"3","author":"Corrado","year":"2023","journal-title":"Zoonotic Dis."},{"key":"ref_366","first-page":"4899364","article-title":"Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset","volume":"2023","author":"Matsunaga","year":"2023","journal-title":"Case Rep. Psychiatry"},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1128\/CDLI.6.5.696-700.1999","article-title":"Detection of Borna Disease Virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay","volume":"6","author":"Yamaguchi","year":"1999","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ajp.2017.11.026","article-title":"The association between Borna Disease Virus and schizophrenia: A systematic review and meta-analysis","volume":"34","author":"Azami","year":"2018","journal-title":"Asian J. Psychiatr."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.5897\/AJMR11.031","article-title":"Does borna disease virus (BDV) have a role in the etiopathogenesis of schizophrenia?","volume":"5","author":"Karakose","year":"2011","journal-title":"Afr. J. Microbiol. Res."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0165-1781(94)02600-N","article-title":"Borna disease virus and schizophrenia","volume":"56","author":"Waltrip","year":"1995","journal-title":"Psychiatry Res."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-0447.1997.tb09941.x","article-title":"Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan","volume":"96","author":"Iwahashi","year":"1997","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000150545","article-title":"The neuropathogenesis of Borna disease virus infections","volume":"40","author":"Ludwig","year":"1997","journal-title":"Intervirology"},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jaut.2006.07.006","article-title":"Schizophrenia, autoimmunity and immune system dysregulation: A comprehensive model updated and revisited","volume":"27","author":"Strous","year":"2006","journal-title":"J. Autoimmun."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1353\/pbm.2003.0038","article-title":"Genes, germs, and schizophrenia: An evolutionary perspective","volume":"46","author":"Ledgerwood","year":"2003","journal-title":"Perspect. Biol. Med."},{"key":"ref_375","first-page":"190","article-title":"Increased psychiatric comorbidity in Borna disease virus seropositive psychiatric patients","volume":"98","author":"Bechter","year":"1998","journal-title":"Acta Psychiatr. Belg."},{"key":"ref_376","doi-asserted-by":"crossref","unstructured":"M\u00fcller, N. (1999). Cerebrospinal fluid filtration in a case of schizophrenia related to \u201csubclinical\u201d Borna disease virus encephalitis. Key Topics in Brain Research. Psychiatry, Psychoimmunology, and Viruses, Springer-Verlag.","DOI":"10.1007\/978-3-7091-6404-4"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0165-1781(03)00190-2","article-title":"Detection of anti-Borna disease virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan","volume":"120","author":"Terayama","year":"2003","journal-title":"Psychiatry Res."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/JCM.39.2.419-429.2001","article-title":"Immunological and PCR analyses for Borna Disease Virus in psychiatric patients and blood donors in Japan","volume":"39","author":"Fukuda","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/sj.mp.4000568","article-title":"Detection of Borna Disease Virus RNA from peripheral blood cells in schizophrenic patients and mental health workers","volume":"4","author":"Chen","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.mp.4000484","article-title":"High seroprevalence of Borna Virus infection in schizophrenic patients, family members and mental health workers in Taiwan","volume":"4","author":"Chen","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4306\/pi.2009.6.4.306","article-title":"Failure to detect Borna Disease Virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients","volume":"6","author":"Na","year":"2009","journal-title":"Psychiatry Investig."},{"key":"ref_382","first-page":"85","article-title":"Detection of Borna disease virus-p24 specific antibody in the sera of schizophrenic patients of China by means of Western-blot","volume":"17","author":"Yang","year":"2003","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"10044","DOI":"10.1128\/JVI.72.12.10044-10049.1998","article-title":"Detection and sequence analysis of Borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors","volume":"72","author":"Iwata","year":"1998","journal-title":"J. Virol."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0920-9964(97)00105-9","article-title":"Prenatal exposure to influenza and schizophrenia in Surinamese and Dutch Antillean immigrants to The Netherlands","volume":"30","author":"Selten","year":"1998","journal-title":"Schizophr. Res."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0966-842X(01)02071-6","article-title":"Borna disease virus and neuropsychiatric disease\u2014A reappraisal","volume":"9","author":"Lipkin","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_386","first-page":"257","article-title":"Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia","volume":"11","author":"Soltani","year":"2016","journal-title":"Iran. J. Psychiatry"},{"key":"ref_387","first-page":"19","article-title":"Borna Disease Virus in Caribbean immigrants to the Netherlands, diagnosed with schizophrenia","volume":"1","author":"Selten","year":"1998","journal-title":"Schizophr. Res."},{"key":"ref_388","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1034\/j.1601-5215.2003.00043.x","article-title":"Borna disease virus and deficit schizophrenia","volume":"15","author":"Kim","year":"2003","journal-title":"Acta Neuropsychiatr."},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/mp.2011.179","article-title":"Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder","volume":"17","author":"Hornig","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1742-2094-5-50","article-title":"Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection","volume":"5","author":"Ovanesov","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/sj.mp.4001558","article-title":"Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence","volume":"10","author":"Harrison","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"ref_392","doi-asserted-by":"crossref","unstructured":"Nagy, M.A., and Mahmoud, M.M. (2022). Schizophrenia and Viruses: A Focus on Coronavirus Disease (COVID-19). Clin. Med. Rev. Rep., 4.","DOI":"10.31579\/2690-8794\/114"},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.psc.2021.11.001","article-title":"Emerging Knowledge of the Neurobiology of COVID-19","volume":"45","author":"Butler","year":"2022","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.neubiorev.2021.05.008","article-title":"Viral Respiratory Infections and Psychosis: A Review of the Literature and the Implications of COVID-19","volume":"127","author":"Kulaga","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.schres.2018.02.048","article-title":"TNF-\u03b1 and IL-6 Are Associated with the Deficit Syndrome and Negative Symptoms in Patients with Chronic Schizophrenia","volume":"199","author":"Goldsmith","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cnp.2020.06.001","article-title":"Electroencephalographic (EEG) Features of Encephalopathy in the Setting of COVID-19: A Case Series","volume":"5","author":"Canham","year":"2020","journal-title":"Clin. Neurophysiol. Pract."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"113573","DOI":"10.1016\/j.psychres.2020.113573","article-title":"A Commentary Revisiting the Viral Hypothesis of Schizophrenia: Onset of a Schizophreniform Disorder Subsequent to SARS-CoV-2 Infection","volume":"295","author":"DeLisi","year":"2021","journal-title":"Psychiatry Res."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jpsychires.2023.09.017","article-title":"From \u2018Mental Fog\u2019 to Post-Acute COVID-19 Syndrome\u2019s Executive Function Alteration: Implications for Clinical Approach","volume":"167","author":"Pallanti","year":"2023","journal-title":"J. Psychiatr. Res."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S2215-0366(21)00084-5","article-title":"6-Month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19: A Retrospective Cohort Study Using Electronic Health Records","volume":"8","author":"Taquet","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"112982","DOI":"10.1016\/j.psychres.2020.112982","article-title":"COVID-19: Considering the Prevalence of Schizophrenia in the Coming Decades","volume":"288","author":"Zandifar","year":"2020","journal-title":"Psychiatry Res."},{"key":"ref_401","doi-asserted-by":"crossref","first-page":"135491","DOI":"10.1016\/j.neulet.2020.135491","article-title":"COVID-19 and Psychosis Risk: Real or Delusional Concern?","volume":"741","author":"Watson","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"114809","DOI":"10.1016\/j.psychres.2022.114809","article-title":"Severe COVID-19 Increases the Risk of Schizophrenia","volume":"317","author":"Baranova","year":"2022","journal-title":"Psychiatry Res."},{"key":"ref_403","doi-asserted-by":"crossref","unstructured":"Amin, M.M., Futrawan, R., and Husada, M.S. (2022). Correlation Between Schizophrenia and Coronavirus Disease in North Sumatera, Indonesia: A Correlative Analytical Study. Front. Psychiatry, 13.","DOI":"10.3389\/fpsyt.2022.896623"},{"key":"ref_404","doi-asserted-by":"crossref","first-page":"e978","DOI":"10.1002\/hsr2.978","article-title":"COVID-19 and the Increase in Schizophrenia Incidence in the Future: A Hypothesis and a Serious Warning","volume":"6","author":"Pourfridoni","year":"2022","journal-title":"Health Sci. Rep."},{"key":"ref_405","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s11469-021-00671-3","article-title":"Risk of First-Episode Schizophrenia in Aged Adults Increased During COVID-19 Outbreak","volume":"21","author":"Hu","year":"2021","journal-title":"Int. J. Ment. Health Addict."},{"key":"ref_406","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.genhosppsych.2021.10.003","article-title":"COVID-19-Associated Psychosis: A Systematic Review of Case Reports","volume":"73","author":"Smith","year":"2021","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S2215-0366(20)30287-X","article-title":"Neurological and Neuropsychiatric Complications of COVID-19 in 153 Patients: A UK-Wide Surveillance Study","volume":"7","author":"Varatharaj","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s12035-020-02134-7","article-title":"Neurological Complications Associated with the Blood-Brain Barrier Damage Induced by the Inflammatory Response During SARS-CoV-2 Infection","volume":"58","author":"Aguilera","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_409","doi-asserted-by":"crossref","first-page":"100196","DOI":"10.1016\/j.bbih.2020.100196","article-title":"COVID-19 Impacts the Expression of Molecular Markers Associated with Neuropsychiatric Disorders","volume":"11","author":"Rosa","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_410","doi-asserted-by":"crossref","unstructured":"Kotsiri, I., Resta, P., Spyrantis, A., Panotopoulos, C., Chaniotis, D., Beloukas, A., and Magiorkinis, E. (2023). Viral Infections and Schizophrenia: A Comprehensive Review. Viruses, 15.","DOI":"10.3390\/v15061345"},{"key":"ref_411","doi-asserted-by":"crossref","unstructured":"Patlola, S.R., Donohoe, G., and McKernan, D.P. (2023). Counting the Toll of Inflammation on Schizophrenia\u2014A Potential Role for Toll-like Receptors. Biomolecules, 13.","DOI":"10.3390\/biom13081188"},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.rpsm.2023.04.002","article-title":"Schizophrenia and the COVID-19 Pandemic: A Narrative Review from the Biomedical Perspective","volume":"18","author":"Kowalski","year":"2025","journal-title":"Span. J. Psychiatry Ment Health"},{"key":"ref_413","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neures.2021.04.009","article-title":"Causal Impact of Local Inflammation in the Nasal Cavity on Higher Brain Function and Cognition","volume":"172","author":"Hasegawa","year":"2021","journal-title":"Neurosci. Res."},{"key":"ref_414","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.schres.2021.07.016","article-title":"Volumetric Alteration of Olfactory Bulb and Immune-Related Molecular Changes in Olfactory Epithelium in First Episode Psychosis Patients","volume":"235","author":"Yang","year":"2021","journal-title":"Schizophr. Res."},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/13550280600827351","article-title":"Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex","volume":"12","author":"Hobbs","year":"2006","journal-title":"J. Neurovirol."},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"103250","DOI":"10.1016\/j.jri.2020.103250","article-title":"Maternal immune responses and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring","volume":"143","author":"Cavalcante","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.schres.2009.12.010","article-title":"Antibodies to measles in individuals with recent onset psychosis","volume":"119","author":"Dickerson","year":"2010","journal-title":"Schizophr. Res."},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1192\/bjp.160.5.598","article-title":"Are polioviruses a cause of schizophrenia?","volume":"160","author":"Eagles","year":"1992","journal-title":"Br. J. Psychiatry"},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/inf.1970.2.issue-1.03","article-title":"Coxsackie B5 outbreak in a newborn nursery with 17 cases of serous meningitis","volume":"2","author":"Rantakallio","year":"1970","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0006-3223(01)01068-X","article-title":"Prenatal rubella, premorbid abnormalities, and adult schizophrenia","volume":"49","author":"Brown","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"ref_421","first-page":"22cr03379","article-title":"Psychosis and catatonia associated with West Nile virus","volume":"25","author":"Mahato","year":"2023","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4103\/0975-2870.202104","article-title":"Psychosis in dengue fever","volume":"10","author":"Chaudhury","year":"2017","journal-title":"Med. J. Dr. D.Y. Patil Univ."},{"key":"ref_423","first-page":"e47425","article-title":"Acute Psychosis and Mania: An Uncommon Complication of Dengue Fever","volume":"15","author":"Elavia","year":"2023","journal-title":"Cureus"},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S1413-86702009000100003","article-title":"Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil","volume":"13","author":"Carvalho","year":"2009","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_425","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mehy.2006.11.023","article-title":"Parvovirus B19 infection of brain: Possible role of gender in determining mental illness and autoimmune thyroid disorders","volume":"69","author":"Hammond","year":"2007","journal-title":"Med. Hypotheses"},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0140-6736(73)91952-1","article-title":"Slow and latent viruses in schizophrenia","volume":"2","author":"Torrey","year":"1973","journal-title":"Lancet"},{"key":"ref_427","doi-asserted-by":"crossref","unstructured":"Kurstak, E., Lipowski, Z.J., and Morozov, P.V. (1987). Paramyxoviruses in the Brain in Febrile Schizophrenia. Viruses, Immunity, and Mental Disorders, Springer.","DOI":"10.1007\/978-1-4613-1799-9"},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1086\/522866","article-title":"Seroprevalence of measles antibody in the US population, 1999\u20132004","volume":"196","author":"McQuillan","year":"2007","journal-title":"J. Infect. Dis."},{"key":"ref_429","first-page":"E5","article-title":"National serologic survey of measles immunity among persons 6 years of age or older, 1988\u20131994","volume":"3","author":"Hutchins","year":"2001","journal-title":"MedGenMed"},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1192\/bjp.150.6.861","article-title":"Schizophreniform episode following measles infection","volume":"150","author":"Stoler","year":"1987","journal-title":"Br. J. Psychiatry"},{"key":"ref_431","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1176\/ajp.156.7.1100","article-title":"Association between prenatal exposure to poliovirus infection and adult schizophrenia","volume":"156","author":"Suvisaari","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1440-1614.2001.01006.x","article-title":"No significant association between prenatal exposure to poliovirus epidemics and psychosis","volume":"36","author":"Cahill","year":"2002","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/acps.13295","article-title":"Incidence of schizophrenia and influence of prenatal and infant exposure to viral infectious diseases","volume":"143","author":"Tanskanen","year":"2021","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1176\/appi.ajp.157.3.438","article-title":"Nonaffective psychosis after prenatal exposure to rubella","volume":"157","author":"Brown","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/0006-3223(94)00219-S","article-title":"Brain dysmorphology in adults with congenital rubella plus schizophrenialike symptoms","volume":"37","author":"Lim","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1742-2094-10-43","article-title":"Neuroinflammation and psychiatric illness","volume":"10","author":"Najjar","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/ije\/26.4.837","article-title":"Association between central nervous system infections during childhood and adult onset schizophrenia and other psychoses: A 28-year follow-up","volume":"26","author":"Rantakallio","year":"1997","journal-title":"Int. J. Epidemiol."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00406-004-0485-2","article-title":"Childhood central nervous system infections and risk for schizophrenia","volume":"254","author":"Koponen","year":"2004","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/15\/7429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:20:48Z","timestamp":1760034048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/15\/7429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":438,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ijms26157429"],"URL":"https:\/\/doi.org\/10.3390\/ijms26157429","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}