{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:44:15Z","timestamp":1791524655025,"version":"4.3.4"},"reference-count":83,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Small- and Medium-sized Enterprises (SMEs)","award":["RS-2023-00264947"],"award-info":[{"award-number":["RS-2023-00264947"]}]},{"name":"Ministry of Small- and Medium-sized Enterprises (SMEs)","award":["2025-52-0007"],"award-info":[{"award-number":["2025-52-0007"]}]},{"name":"Yonsei University Mirae Campus (Republic of Korea)","award":["RS-2023-00264947"],"award-info":[{"award-number":["RS-2023-00264947"]}]},{"name":"Yonsei University Mirae Campus (Republic of Korea)","award":["2025-52-0007"],"award-info":[{"award-number":["2025-52-0007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sarcopenia is characterized by a reduction in muscle function and skeletal muscle mass relative to that of healthy individuals. In older adults and those who are less resistant to sarcopenia, glucocorticoid secretion or accumulation during treatment exacerbates muscle protein degradation, potentially causing sarcopenia. This study assessed the preventive effects and mechanisms of heat-killed Lactobacillus plantarum postbiotic beLP-K (beLP-K) against dexamethasone (DEX)-induced sarcopenia in C2C12 myotubes and Sprague-Dawley rats. The administration of beLP-K did not induce cytotoxicity and mitigated cell damage caused by DEX. Furthermore, beLP-K significantly reduced the expression of forkhead box O3 \u03b1 (FoxO3\u03b1), muscle atrophy f-box (MAFbx)\/atrogin-1, and muscle RING-finger protein-1 (MuRF1), which are associated with muscle protein degradation. DEX induced weight loss in rats; however, in the beLP-K group, weight gain was observed. Micro-computed tomography analysis revealed that beLP-K increased muscle mass, correlating with weight and grip strength. beLP-K alleviated the DEX-induced reduction in grip strength and increased the mass of hind leg muscles. The correlation between beLP-K administration and increased muscle mass was associated with decreased expression levels of muscle degradation-related proteins such as MAFbx\/atrogin-1 and MuRF1. Therefore, beLP-K may serve as a treatment for sarcopenia or as functional food material.<\/jats:p>","DOI":"10.3390\/ijms26157504","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:45:11Z","timestamp":1754466311000},"page":"7504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protective Efficacy of Lactobacillus plantarum Postbiotic beLP-K in a Dexamethasone-Induced Sarcopenia Model"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3400-4611","authenticated-orcid":false,"given":"Juyeong","family":"Moon","sequence":"first","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8144-6989","authenticated-orcid":false,"given":"Eunwoo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harang","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Yeong","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6575-6765","authenticated-orcid":false,"given":"Jinsu","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-2301","authenticated-orcid":false,"given":"Min-ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5352-2822","authenticated-orcid":false,"given":"Kwon-Il","family":"Han","sequence":"additional","affiliation":[{"name":"Research & Development Center, bereum Co. Ltd., Wonju 26362, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-3263","authenticated-orcid":false,"given":"Doyong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1697-3232","authenticated-orcid":false,"given":"Tack-Joong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Biological Science and Technology, Yonsei University, Wonju 26493, Republic of Korea"},{"name":"Research & Development Center, Doctor TJ Co. 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