{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T02:08:17Z","timestamp":1770084497027,"version":"3.49.0"},"reference-count":22,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Gastric adenocarcinoma is a malignant tumor that develops from the glandular cells of the inner wall of the stomach. The prevalence of this type of disease varies from 90 to 95% of all types of gastric cancer. The aim of our study was to investigate the differences in the content of cytokines and oxidative stress markers in patients with gastric adenocarcinoma associated with H. pylori infection depending on the stage. The study included 281 patients with gastric cancer. At stage I of the disease\u201475 people, stage II\u201470 people, stage III\u201469 people, and stage IV of the disease\u201467 people. The levels of TNF-\u03b1, IL-2, IL-8, IFN\u03b3, TNF-\u03b2, IL-17A, IL-6, IL-10, and IL-4 in the blood serum of patients and healthy individuals were determined by enzyme immunoassay and plasma oxidative stress scores (MDA, SOD, CAT, GST, GPO, CP). The present study revealed that H. pylori-infected gastric adenocarcinoma at different stages is associated with different plasma levels of cytokines, lipid peroxidation products, and antioxidant defense factors. Further studies are needed to evaluate the effectiveness of therapeutic strategies combining cytokine regulation and oxidative stress to improve clinical outcomes in gastric cancer.<\/jats:p>","DOI":"10.3390\/ijms26157609","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:09:53Z","timestamp":1754492993000},"page":"7609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytokine Regulation and Oxidative Stress in Helicobacter Pylori-Associated Gastric Adenocarcinoma at Different Stages: Insights from a Cross-Sectional Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-9207","authenticated-orcid":false,"given":"Olga","family":"Smirnova","sequence":"first","affiliation":[{"name":"Federal Research Center \u201cKrasnoyarsk Science Center\u201d, Siberian Branch of the Russian Academy of Sciences \u201cScientific Research Institute of Medical Problems of the North\u201d, St. Partizan Zheleznyaka, 3 \u201cG\u201d, 660022 Krasnoyarsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-1893","authenticated-orcid":false,"given":"Aleksander","family":"Sinyakov","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cKrasnoyarsk Science Center\u201d, Siberian Branch of the Russian Academy of Sciences \u201cScientific Research Institute of Medical Problems of the North\u201d, St. Partizan Zheleznyaka, 3 \u201cG\u201d, 660022 Krasnoyarsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard","family":"Kasparov","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cKrasnoyarsk Science Center\u201d, Siberian Branch of the Russian Academy of Sciences \u201cScientific Research Institute of Medical Problems of the North\u201d, St. Partizan Zheleznyaka, 3 \u201cG\u201d, 660022 Krasnoyarsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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