{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T21:38:30Z","timestamp":1774042710708,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the immune system attacking the central nervous system, leading to demyelination and neurodegeneration. This work investigates the relationship between specific human leukocyte antigen (HLA) polymorphisms and MS, aiming to reveal the immunogenetic background of this disease for more individualized management approaches. This study employed a case\u2013control design, analyzing HLA allele frequencies in 179 MS patients and 200 control subjects using next-generation sequencing, The key findings indicate significant associations between several HLA Class I and II alleles and MS, including HLA-B*35:03:01:03, HLA-C*04:01:01:14, HLA-DRB1*15:01:01:26, and HLA-DQA1*05:05:01:02. These findings emphasize the critical role of HLA molecules in MS Romanian patients.<\/jats:p>","DOI":"10.3390\/ijms26157628","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:09:53Z","timestamp":1754492993000},"page":"7628","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data"],"prefix":"10.3390","volume":"26","author":[{"given":"Alexandra Elena","family":"Constantinescu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d Medical University Bucharest, 020021 Bucharest, Romania"},{"name":"\u201dEmil Palade\u201d Center of Excellence for Young People in Scientific Research (EP-CEYR), Academy of Romanian Scientists, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-8654","authenticated-orcid":false,"given":"Ion","family":"M\u0103run\u021belu","sequence":"additional","affiliation":[{"name":"Fundeni Centre for Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Ple\u0219a","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d Medical University Bucharest, 020021 Bucharest, Romania"},{"name":"Neurology Department, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-1066","authenticated-orcid":false,"given":"Carmen Adella","family":"S\u00eerbu","sequence":"additional","affiliation":[{"name":"Neurology Department, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 030167 Bucharest, Romania"},{"name":"Clinical Neuroscience Department, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florentina Cristina","family":"Ple\u0219a","sequence":"additional","affiliation":[{"name":"Neurology Department, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania"},{"name":"Clinical Neuroscience Department, University of Medicine and Pharmacy \u201cCarol Davila\u201d, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia Ioana","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Fundeni Centre for Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5828-2694","authenticated-orcid":false,"given":"Ileana","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d Medical University Bucharest, 020021 Bucharest, Romania"},{"name":"\u201dEmil Palade\u201d Center of Excellence for Young People in Scientific Research (EP-CEYR), Academy of Romanian Scientists, 030167 Bucharest, Romania"},{"name":"Fundeni Centre for Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Karamyan, A., D\u00fcnser, M.W., Wiebe, D.J., Pilz, G., Wipfler, P., Chroust, V., Novak, H.F., Hauer, L., Trinka, E., and Sellner, J. 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