{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:16:03Z","timestamp":1789229763854,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health (NIH)","award":["R01AT005076"],"award-info":[{"award-number":["R01AT005076"]}]},{"name":"National Institutes of Health (NIH)","award":["R35GM145331"],"award-info":[{"award-number":["R35GM145331"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Human dermcidin (DCD) is synthesized as a 110-amino acid precursor (pre-dermcidin, pre-DCD) containing a 19-residue leader signal sequence, which is removed to produce a leader-less pro-domain-containing peptide termed as pro-dermcidin, pro-DCD. Pro-DCD can be secreted by human eccrine sweat glands and then cleaved into antimicrobial peptides, such as dermcidin (DCD). Emerging evidence suggests that pro-DCD has broader physiological roles beyond antimicrobial defense, potentially serving as a therapeutic agent for inflammatory diseases like sepsis. In this review, we summarize recent evidence supporting pro-DCD as a regulator of innate immunity in sepsis.<\/jats:p>","DOI":"10.3390\/ijms26157643","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T09:56:42Z","timestamp":1754647002000},"page":"7643","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pro-Dermcidin as an Emerging Regulator of Innate Immunity in Sepsis"],"prefix":"10.3390","volume":"26","author":[{"given":"Li","family":"Lou","sequence":"first","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA"},{"name":"Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, 500 Hofstra Blvd., Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie Shu","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA"},{"name":"Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, 500 Hofstra Blvd., Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-7407","authenticated-orcid":false,"given":"Xiaoling","family":"Qiang","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA"},{"name":"Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, 500 Hofstra Blvd., Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haichao","family":"Wang","sequence":"additional","affiliation":[{"name":"The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY 11030, USA"},{"name":"Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, 500 Hofstra Blvd., Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/14728222.2023.2239495","article-title":"A two-decade journey in identifying high mobility group box 1 (HMGB1) and procathepsin L (pCTS-L) as potential therapeutic targets for sepsis","volume":"27","author":"Li","year":"2023","journal-title":"Expert Opin. 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