{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:34:55Z","timestamp":1785886495902,"version":"3.56.0"},"reference-count":83,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research and Innovation in Romania through Core Program","award":["PN 23.16.01.03\/2023"],"award-info":[{"award-number":["PN 23.16.01.03\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>As obesity and Western diet consumption are key factors contributing to gut dysbiosis, we investigated the relationship between intestinal microbiota, obesity, and psoriasis in an imiquimod-based model. C57BL\/6 mice were used as follows: psoriasis-induced groups fed continuously with a standard or Western diet, psoriasis-induced group fed with a Western diet and then returned to a standard diet, and controls. For each group, clinicopathological, immune, and metabolic parameters were integrated with microbiome data. The imiquimod-based models displayed human psoriasis features and significant changes in immune parameters. Hence, psoriatic mice on prolonged high-fat intake presented decreased microbial richness and evenness and a gut microbiome composition resembling that of obese mice. Ruminococcus, Clostridium, Desulfovibrio, and Enterorhabdus were the most abundant genera in the obesity-enhanced psoriasis group. Raoultella abundance was linked with psoriasis. Yet, the same pathobionts over-represented in the obese psoriatic mice displayed positive correlations with metabolic stress indicators and proinflammatory factors, indicating potential biomarkers of disease severity. Conversely, Lactobacillus taiwanensis, Alistipes putredinis, and Eubacterium hadrum might be potential taxa for attenuating the metabolic burden in obesity-enhanced psoriasis. Here, we depict the microbial signatures associated with inflammation and metabolic stress in an obesity-aggravated psoriasis mouse model.<\/jats:p>","DOI":"10.3390\/ijms26167697","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T15:30:52Z","timestamp":1754667052000},"page":"7697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microbial Signatures of Obesity-Aggravated Psoriasis: Insights from an Imiquimod-Based Mouse Model"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-5497","authenticated-orcid":false,"given":"Carolina","family":"Constantin","sequence":"first","affiliation":[{"name":"Immunology Department, \u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena-Georgiana","family":"Dobre","sequence":"additional","affiliation":[{"name":"Immunology Department, \u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Istvan","sequence":"additional","affiliation":[{"name":"European Virus Bioinformatics Center, University of Jena, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-6351","authenticated-orcid":false,"given":"Adriana Narcisa","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Immunology Department, \u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-4378","authenticated-orcid":false,"given":"Mihaela","family":"Surcel","sequence":"additional","affiliation":[{"name":"Immunology Department, \u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-019X","authenticated-orcid":false,"given":"Gheorghita","family":"Isvoranu","sequence":"additional","affiliation":[{"name":"Animal Husbandry, \u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-2805","authenticated-orcid":false,"given":"Monica","family":"Neagu","sequence":"additional","affiliation":[{"name":"Immunology Department, \u201cVictor Babes\u201d National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Colentina Clinical Hospital, 020125 Bucharest, Romania"},{"name":"Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sun, C., Chen, L., Yang, H., Sun, H., Xie, Z., Zhao, B., Jiang, X., Qin, B., and Shen, Z. (2021). Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.761978"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri1373","article-title":"Interactions between commensal intestinal bacteria and the immune system","volume":"4","author":"Macpherson","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.micpath.2016.02.005","article-title":"Akkermansia muciniphila and its role in regulating host functions","volume":"106","author":"Derrien","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","article-title":"An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice","volume":"63","author":"Shin","year":"2014","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Codo\u00f1er, F.M., Ram\u00edrez-Bosca, A., Climent, E., Carri\u00f3n-Gutierrez, M., Guerrero, M., P\u00e9rez-Orqu\u00edn, J.M., Horga de la Parte, J., Genov\u00e9s, S., Ram\u00f3n, D., and Navarro-L\u00f3pez, V. (2018). Gut microbial composition in patients with psoriasis. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-22125-y"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/exd.13463","article-title":"The Akkermansia muciniphila is a gut microbiota signature in psoriasis","volume":"27","author":"Tan","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopha.2018.02.103","article-title":"The potential pathogenic role of IL-17\/Th17 cells in both type 1 and type 2 diabetes mellitus","volume":"101","author":"Bakery","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Sch\u00e4kel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.rdc.2015.07.013","article-title":"Etiology and Pathogenesis of Psoriasis","volume":"41","author":"Boehncke","year":"2015","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00403-010-1065-0","article-title":"Evidence for the presence of bacteria in the blood of psoriasis patients","volume":"302","author":"Munz","year":"2010","journal-title":"Arch. Dermatol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/jamadermatol.2014.5585","article-title":"Identification of Bacterial DNA in the Peripheral Blood of Patients with Active Psoriasis","volume":"151","author":"Such","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mosca, A., Leclerc, M., and Hugot, J.P. (2016). Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00455"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Okada, K., Matsushima, Y., Mizutani, K., and Yamanaka, K. (2020). The Role of Gut Microbiome in Psoriasis: Oral Administration of Staphylococcus aureus and Streptococcus danieliae Exacerbates Skin Inflammation of Imiquimod-Induced Psoriasis-Like Dermatitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093303"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Z\u00e1kostelsk\u00e1, Z., M\u00e1lkov\u00e1, J., Klime\u0161ov\u00e1, K., Rossmann, P., Hornov\u00e1, M., Novos\u00e1dov\u00e1, I., Stehl\u00edkov\u00e1, Z., Kostov\u010d\u00edk, M., Hudcovic, T., and \u0160tep\u00e1nkov\u00e1, R. (2016). Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159539"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lundquist, P., Hagforsen, E., Wagner, M., Alimohammadi, M., Melo, F.R., Pejler, G., Artursson, P., Carlson, M., Rollman, O., and Lampinen, M. (2025). Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier. Biochim. Biophys. Acta. Mol. Basis Dis., 1871.","DOI":"10.1016\/j.bbadis.2024.167634"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/exd.12487","article-title":"Cellular sources of IL-17 in psoriasis: A paradigm shift?","volume":"23","author":"Keijsers","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Guerra, E.S., Lee, C.K., Specht, C.A., Yadav, B., Huang, H., Akalin, A., Huh, J.R., Mueller, C., and Levitz, S.M. (2017). Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006175"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1002\/eji.201242569","article-title":"IL-17-producing \u03b3\u03b4 T cells and innate lymphoid cells","volume":"42","author":"Sutton","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ebiom.2019.02.050","article-title":"NCR(-) group 3 innate lymphoid cells orchestrate IL-23\/IL-17 axis to promote hepatocellular carcinoma development","volume":"41","author":"Liu","year":"2019","journal-title":"eBioMedicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41385-020-0273-y","article-title":"IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia","volume":"13","author":"Lu","year":"2020","journal-title":"Mucosal Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/sj.jid.5700310","article-title":"Prominent production of IL-20 by CD68+\/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects","volume":"126","author":"Wang","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/jid.2012.456","article-title":"CD8+ T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-\u03b3, IL-13, IL-17, and IL-22","volume":"133","author":"Hijnen","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/nutd.2012.26","article-title":"The association between psoriasis and obesity: A systematic review and meta-analysis of observational studies","volume":"2","author":"Armstrong","year":"2012","journal-title":"Nutr. Diabetes"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40744-020-00215-6","article-title":"Obesity and Psoriatic Arthritis: A Narrative Review","volume":"7","author":"Kumthekar","year":"2020","journal-title":"Rheumatol. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2147\/CCID.S411636","article-title":"A Comparison of Clinical Characteristics in Overweight\/Obese and Normal Weight Patients with Psoriasis Vulgaris: A Bicentric Retrospective Observational Study","volume":"16","author":"Li","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_29","first-page":"4095789","article-title":"The Gut Microbiome Profile in Obesity: A Systematic Review","volume":"2018","author":"Castaner","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chen, L., Li, J., Zhu, W., Kuang, Y., Liu, T., Zhang, W., Chen, X., and Peng, C. (2020). Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.589726"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sikora, M., Stec, A., Chrabaszcz, M., Knot, A., Waskiel-Burnat, A., Rakowska, A., Olszewska, M., and Rudnicka, L. (2020). Gut Microbiome in Psoriasis: An Updated Review. Pathogens, 9.","DOI":"10.3390\/pathogens9060463"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Vetrani, C., Di Nisio, A., Paschou, S.A., Barrea, L., Muscogiuri, G., Graziadio, C., Savastano, S., Colao, A., and on behalf of the Obesity Programs of Nutrition, Education, Research and Assessment (OPERA) Group (2022). From Gut Microbiota through Low-Grade Inflammation to Obesity: Key Players and Potential Targets. Nutrients, 14.","DOI":"10.3390\/nu14102103"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41430-020-0607-6","article-title":"Profile of the gut microbiota of adults with obesity: A systematic review","volume":"74","author":"Crovesy","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Thye, A.Y.-K., Bah, Y.-R., Law, J.W.-F., Tan, L.T.-H., He, Y.-W., Wong, S.-H., Thurairajasingam, S., Chan, K.-G., Lee, L.-H., and Letchumanan, V. (2022). Gut-Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051037"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Stojanov, S., Berlec, A., and \u0160trukelj, B. (2020). The Influence of Probiotics on the Firmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111715"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Al Bander, Z., Nitert, M.D., Mousa, A., and Naderpoor, N. (2020). The Gut Microbiota and Inflammation: An Overview. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17207618"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10753-021-01559-z","article-title":"Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance","volume":"45","author":"Prince","year":"2022","journal-title":"Inflammation"},{"key":"ref_38","first-page":"S25","article-title":"The Role of the Gut Microbiome in Psoriasis: From Pathogens to Pathology","volume":"15","author":"Wilchowski","year":"2022","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s13555-020-00466-9","article-title":"Gut-Brain-Skin Axis in Psoriasis: A Review","volume":"11","author":"Chen","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1002\/eji.201343801","article-title":"TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis","volume":"43","author":"Flutter","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1038\/ncomms9424","article-title":"Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis","volume":"6","author":"Zanvit","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jcmgh.2018.09.010","article-title":"Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells","volume":"7","author":"Kiyohara","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Stehlikova, Z., Kostovcikova, K., Kverka, M., Rossmann, P., Dvorak, J., Novosadova, I., Kostovcik, M., Coufal, S., Srutkova, D., and Prochazkova, P. (2019). Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00236"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Shinno-Hashimoto, H., Hashimoto, Y., Wei, Y., Chang, L., Fujita, Y., Ishima, T., Matsue, H., and Hashimoto, K. (2021). Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-90480-4"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.2147\/JIR.S337031","article-title":"Gut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice","volume":"14","author":"Chen","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Surcel, M., Munteanu, A., Isvoranu, G., Ibram, A., Caruntu, C., Constantin, C., and Neagu, M. (2021). Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome. J. Pers. Med., 11.","DOI":"10.3390\/jpm11090841"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2147\/DMSO.S348800","article-title":"Serum Levels of Free Fatty Acids in Obese Mice and Their Associations with Routine Lipid Profiles","volume":"15","author":"Sun","year":"2022","journal-title":"Diabetes. Metab. Syndr. Obes."},{"key":"ref_48","first-page":"4956","article-title":"Reinforcing involvement of NK cells in psoriasiform dermatitis animal model","volume":"18","author":"Surcel","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1582-4934.2003.tb00206.x","article-title":"Imbalance of peripheral B lymphocytes and NK cells in rheumatoid arthritis","volume":"7","author":"Manda","year":"2003","journal-title":"J. Cell. Mol. Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Caldirola, M.S., Mart\u00ednez, M.P., Bezrodnik, L., Zwirner, N.W., and Gaillard, M.I. (2020). Immune Monitoring of Patients with Primary Immune Regulation Disorders Unravels Higher Frequencies of Follicular T Cells with Different Profiles That Associate with Alterations in B Cell Subsets. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.576724"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2328218","DOI":"10.1155\/2021\/2328218","article-title":"Assessment of Immune Cell Populations in Tumor Tissue and Peripheral Blood Samples from Head and Neck Squamous Cell Carcinoma Patients","volume":"2021","author":"Caruntu","year":"2021","journal-title":"Anal. Cell. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Neagu, M., Constantin, C., and Zurac, S. (2013). Immune parameters in the prognosis and therapy monitoring of cutaneous melanoma patients: Experience, role, and limitations. Biomed Res. Int., 2013.","DOI":"10.1155\/2013\/107940"},{"key":"ref_53","first-page":"1693","article-title":"Peripheral immune cell markers in children with recurrent respiratory infections in the absence of primary immunodeficiency","volume":"18","author":"Munteanu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Manickam, C., Upadhyay, A.A., Woolley, G., Kroll, K.W., Terry, K., Broedlow, C.A., Klatt, N.R., Bosinger, S.E., and Reeves, R.K. (2024). Natural killer-like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques. PLoS Pathog., 20.","DOI":"10.1371\/journal.ppat.1012223"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","article-title":"Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"Turner","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1007\/s13555-023-01007-w","article-title":"Causal Associations Between Gut Microbiota and Psoriasis: A Mendelian Randomization Study","volume":"13","author":"Zang","year":"2023","journal-title":"Dermatol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41564-024-01912-6","article-title":"Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations","volume":"10","author":"Yin","year":"2025","journal-title":"Nat. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"pbad023","DOI":"10.1093\/pcmedi\/pbad023","article-title":"Investigating the gut microbiota\u2019s influence on psoriasis and psoriatic arthritis risk: A Mendelian randomization analysis","volume":"6","author":"Yu","year":"2023","journal-title":"Precis. Clin. Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Li, Y., Chen, G., Hu, X., Bao, Y., Wu, C., Zeng, N., and Jiang, F. (2024). Assessing causal relationships between gut microbiota and psoriasis: Evidence from two sample Mendelian randomization analysis. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-59603-5"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1084\/jem.20181639","article-title":"Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification","volume":"216","author":"Sorbara","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"112088","DOI":"10.1016\/j.exger.2023.112088","article-title":"Gut Enterobacteriaceae and uraemic toxins\u2014Perpetrators for ageing","volume":"173","author":"Boopathi","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.anaerobe.2012.09.002","article-title":"Anaerostipes hadrus comb. nov., a dominant species within the human colonic microbiota; reclassification of Eubacterium hadrum Moore et al. 1976","volume":"18","author":"Daigneault","year":"2012","journal-title":"Anaerobe"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2147\/PTT.S505283","article-title":"Metagenomics Analysis of Altered Gut Microbiome in Psoriasis and the Mediation Analysis: A Case-Control Study","volume":"15","author":"Xiao","year":"2025","journal-title":"Psoriasis"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105970","DOI":"10.1016\/j.micpath.2023.105970","article-title":"Altered gut microbiome composition in nontreated plaque psoriasis patients","volume":"175","author":"Wen","year":"2023","journal-title":"Microb. Pathog."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Stec, A., Sikora, M., Maciejewska, M., Paralusz-Stec, K., Michalska, M., Sikorska, E., and Rudnicka, L. (2023). Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24043494"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Buha\u0219, M.C., Candrea, R., Gavrila\u0219, L.I., Miere, D., T\u0103taru, A., Boca, A., and C\u0103tinean, A. (2023). Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311225"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Choy, C.T., Chan, U.K., Siu, P.L.K., Zhou, J., Wong, C.H., Lee, Y.W., Chan, H.W., Tsui, J.C.C., Loo, S.K.F., and Tsui, S.K.W. (2023). A Novel E3 Probiotics Formula Restored Gut Dysbiosis and Remodelled Gut Microbial Network and Microbiome Dysbiosis Index (MDI) in Southern Chinese Adult Psoriasis Patients. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076571"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Surcel, M., Constantin, C., Munteanu, A.N., Costea, D.A., Isvoranu, G., Codrici, E., Popescu, I.D., T\u0103nase, C., Ibram, A., and Neagu, M. (2023). Immune Portrayal of a New Therapy Targeting Microbiota in an Animal Model of Psoriasis. J. Pers. Med., 13.","DOI":"10.3390\/jpm13111556"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2405781","DOI":"10.1002\/advs.202405781","article-title":"Postbiotics from Lactobacillus johnsonii Activates Gut Innate Immunity to Mitigate Alcohol-Associated Liver Disease","volume":"12","author":"Yin","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.vetmic.2019.02.003","article-title":"Lactobacillus johnsonii L531 reduces pathogen load and helps maintain short-chain fatty acid levels in the intestines of pigs challenged with Salmonella enterica Infantis","volume":"230","author":"He","year":"2019","journal-title":"Vet. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Valladares, R., Sankar, D., Li, N., Williams, E., Lai, K.-K., Abdelgeliel, A.S., Gonzalez, C.F., Wasserfall, C.H., Larkin, J., and Schatz, D. (2010). Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0010507"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2145843","DOI":"10.1080\/19490976.2022.2145843","article-title":"Lactobacillus johnsonii alleviates colitis by TLR1\/2-STAT3 mediated CD206+ macrophagesIL-10 activation","volume":"14","author":"Jia","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Wang, K., Mehta, R.S., Ma, W., Nguyen, L.H., Wang, D.D., Ghazi, A.R., Yan, Y., Al-Shaar, L., Wang, Y., and Hang, D. (2023). The gut microbiome modifies the associations of short- and long-term physical activity with body weight changes. Microbiome, 11.","DOI":"10.1186\/s40168-023-01542-w"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-023-06466-x","article-title":"Gut microbial carbohydrate metabolism contributes to insulin resistance","volume":"621","author":"Takeuchi","year":"2023","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zhang, S., Wang, R., Zhao, R., Lu, Y., Xu, M., Lin, X., Lan, R., Zhang, S., Tang, H., and Fan, Q. (2025). Alistipes putredinis Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats via Gut Microbiota Remodeling and Inflammatory Suppression. Nutrients, 17.","DOI":"10.3390\/nu17122013"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Wu, J., Peng, Y., Tian, R., Yu, H., Hu, H., Huang, Q., Xu, Y., Liu, L., and Pan, H. (2025). Investigating Correlation Between Gut Microbiota and Rheumatoid Arthritis Subtypes by Mendelian Randomization. Pathogens, 14.","DOI":"10.3390\/pathogens14040385"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"113995","DOI":"10.1016\/j.jep.2021.113995","article-title":"Berberis kansuensis extract alleviates type 2 diabetes in rats by regulating gut microbiota composition","volume":"273","author":"Xu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Fraillon, E., J\u00e9gou, J.-F., Rabeony, H., Lecron, J.-C., Lebonvallet, N., Marie-Joseph, E., Josset-Lamaugarny, A., Aimond, G., Misery, L., and Morel, F. (2025). Comparative analysis of cutaneous features of psoriasis in acute and chronic imiquimod-induced mouse models. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-12111-6"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Toh, S., and Hern\u00e1n, M.A. (2008). Causal inference from longitudinal studies with baseline randomization. Int. J. Biostat., 4.","DOI":"10.2202\/1557-4679.1117"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Zhu, Q., Wu, K., Yang, Q., Meng, B., Niu, Y., and Zhao, F. (2023). Advances in psoriasis and gut microorganisms with co-metabolites. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1192543"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"Mourits","year":"2009","journal-title":"J. Immunol."},{"key":"ref_83","unstructured":"(2023, October 18). Ion 16STM Metagenomics Kit. Available online: https:\/\/assets.thermofisher.com\/TFS-Assets\/LSG\/manuals\/MAN0010799_Ion_16S_Metagenomics_UG.pdf."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/7697\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:26:55Z","timestamp":1760034415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/7697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":83,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ijms26167697"],"URL":"https:\/\/doi.org\/10.3390\/ijms26167697","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]}}}