{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:33:26Z","timestamp":1789443206771,"version":"build-2803163510"},"reference-count":157,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472358"],"award-info":[{"award-number":["32472358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024A1515010054"],"award-info":[{"award-number":["2024A1515010054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023B03J1275"],"award-info":[{"award-number":["2023B03J1275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["32472358"],"award-info":[{"award-number":["32472358"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024A1515010054"],"award-info":[{"award-number":["2024A1515010054"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2023B03J1275"],"award-info":[{"award-number":["2023B03J1275"]}]},{"name":"Guangzhou Key Research and Development Program","award":["32472358"],"award-info":[{"award-number":["32472358"]}]},{"name":"Guangzhou Key Research and Development Program","award":["2024A1515010054"],"award-info":[{"award-number":["2024A1515010054"]}]},{"name":"Guangzhou Key Research and Development Program","award":["2023B03J1275"],"award-info":[{"award-number":["2023B03J1275"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Folate is an essential vitamin involved in one-carbon metabolism. It can be acquired from many food sources or in synthetic form. A wide range of processing methods have been studied to improve the bioaccessibility and bioavailability of folate in foods, yet this is often accompanied by a decrease in stability. Encapsulation technology has emerged as an effective solution for protecting folate from degradation and liberation while also improving its bioavailability. Folate deficiency is a prevalent phenomenon worldwide, particularly in underprivileged countries, leading to various health problems, such as neural tube defects. Thus, folate was fortified through both exogenous addition and biofortification. Gene editing technology, especially CRISPR-Cas9, has great promise in this field when compared to transgenic engineering, because transgenic engineering may pose safety concerns and environmental risks. While ongoing research has identified additional potential effects of folate, the dosage and duration remain important factors to consider for optimal health outcomes. The mechanisms of how folate promotes the production of neurotransmitters associated with the gut microbiota\u2013brain axis and reduces depression are not well understood. In addition to folate alone, there may be synergistic effects of combined supplementation of folate and other nutrients or medications, but this is not yet fully clarified and requires further examination. This review summarizes the food sources, enrichment, bioaccessibility, and bioavailability of folate. Furthermore, the health benefits of folate, including neural tube protection, cardiovascular protection, neuroprotection, anti-cancer, immune response augmentation, and gut homeostasis maintenance, with their potential bioactivity mechanisms, are discussed.<\/jats:p>","DOI":"10.3390\/ijms26167703","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T11:02:09Z","timestamp":1754910129000},"page":"7703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Comprehensive Review of Fortification, Bioavailability, and Health Benefits of Folate"],"prefix":"10.3390","volume":"26","author":[{"given":"Jiarun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanying","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0049-8892","authenticated-orcid":false,"given":"Hosahalli","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Food Science and Agricultural Chemistry, Macdonald Campus of McGill University, Montr\u00e9al, QC H9X 3V9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13568-018-0592-5","article-title":"Folate promotes S-adenosyl methionine reactions and the microbial methylation cycle and boosts ruminants production and reproduction","volume":"8","author":"Abbasi","year":"2018","journal-title":"AMB. 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