{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:37:05Z","timestamp":1760060225194,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Early stages of chronic kidney disease (CKD) are closely associated with vascular remodeling and coronary artery calcification. The aim of this study is to determine whether adropin is associated with asymptomatic coronary calcification in patients in the early stages of CKD. This study enrolled 337 individuals fulfilling the inclusion criteria of the early stages of CKD (G1\u20132, A1\u20133) and divided them into two subgroups with (n = 196) and without (n = 141) asymptomatic coronary artery calcification. Native coronary multi-detector computed tomography angiography was conducted to determine coronary artery calcification, which was stratified into four grades according to the Agatston method. Serum levels of adropin were measured by ELISA. The patients with known asymptomatic coronary artery calcification had significantly lower levels of adropin than those without this condition. The levels of adropin in individuals with mild (130\u2013199 HU), moderate (200\u2013299 HU), severe (300\u2013399 HU) and very severe (\u2265400 HU) calcification were 3.13 (95% CI = 1.92\u20134.21) ng\/mL, 2.3 (95% CI = 1.45\u20133.6) ng\/mL, 2.1 (95% CI = 1.22\u20133.25) ng\/mL and 1.26 (95% CI = 1.13\u20131.98) ng\/mL, respectively. In multivariate logistic regression low adropin (&lt;2.95 ng\/mL), a presence of hypertension, type 2 diabetes mellitus (T2DM) exerted their independent potencies to predict asymptomatic coronary calcification. Moreover, adropin demonstrated better discriminative potency than concomitant hypertension and T2DM. Conclusions: Low levels of circulating adropin significantly predicted a risk of coronary artery calcification in patients in the early stages of CKD.<\/jats:p>","DOI":"10.3390\/ijms26167816","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:53:27Z","timestamp":1755100407000},"page":"7816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association of Adropin with Asymptomatic Coronary Calcification in Patients in Early Stages of Chronic Kidney Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Tetiana A.","family":"Berezina","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Nephrology, VitaCenter, 69000 Zaporozhye, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr O.","family":"Berezin","sequence":"additional","affiliation":[{"name":"Luzerner Psychiatrie AG, 4915 St. Urban, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-0604","authenticated-orcid":false,"given":"Evgen V.","family":"Novikov","sequence":"additional","affiliation":[{"name":"Department of Functional Diagnostics, Shupyk National Healthcare University of Ukraine, 04136 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0446-3999","authenticated-orcid":false,"given":"Alexander E.","family":"Berezin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Nephrology, VitaCenter, 69000 Zaporozhye, Ukraine"},{"name":"Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1681\/ASN.2015050542","article-title":"CKD Prevalence Varies across the European General Population","volume":"27","author":"Stel","year":"2016","journal-title":"J. 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