{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:21:13Z","timestamp":1792804873835,"version":"4.5.0"},"reference-count":260,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health","award":["R01 HL132899"],"award-info":[{"award-number":["R01 HL132899"]}]},{"name":"National Institutes of Health","award":["R01 HL147954"],"award-info":[{"award-number":["R01 HL147954"]}]},{"name":"National Institutes of Health","award":["R01 HL164584"],"award-info":[{"award-number":["R01 HL164584"]}]},{"name":"National Institutes of Health","award":["R01 HL169432"],"award-info":[{"award-number":["R01 HL169432"]}]},{"name":"National Institutes of Health","award":["24EIA1255341"],"award-info":[{"award-number":["24EIA1255341"]}]},{"name":"National Institutes of Health","award":["25POST1371944"],"award-info":[{"award-number":["25POST1371944"]}]},{"name":"National Institutes of Health","award":["GM135134"],"award-info":[{"award-number":["GM135134"]}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["R01 HL132899"],"award-info":[{"award-number":["R01 HL132899"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["R01 HL147954"],"award-info":[{"award-number":["R01 HL147954"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["R01 HL164584"],"award-info":[{"award-number":["R01 HL164584"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["R01 HL169432"],"award-info":[{"award-number":["R01 HL169432"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["24EIA1255341"],"award-info":[{"award-number":["24EIA1255341"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["25POST1371944"],"award-info":[{"award-number":["25POST1371944"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002584","name":"American Heart Association Established Investigator","doi-asserted-by":"publisher","award":["GM135134"],"award-info":[{"award-number":["GM135134"]}],"id":[{"id":"10.13039\/100002584","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["R01 HL132899"],"award-info":[{"award-number":["R01 HL132899"]}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["R01 HL147954"],"award-info":[{"award-number":["R01 HL147954"]}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["R01 HL164584"],"award-info":[{"award-number":["R01 HL164584"]}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["R01 HL169432"],"award-info":[{"award-number":["R01 HL169432"]}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["24EIA1255341"],"award-info":[{"award-number":["24EIA1255341"]}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["25POST1371944"],"award-info":[{"award-number":["25POST1371944"]}]},{"name":"Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research","award":["GM135134"],"award-info":[{"award-number":["GM135134"]}]},{"name":"American Heart Association postdoctoral fellowship","award":["R01 HL132899"],"award-info":[{"award-number":["R01 HL132899"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association postdoctoral fellowship","award":["R01 HL147954"],"award-info":[{"award-number":["R01 HL147954"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association postdoctoral fellowship","award":["R01 HL164584"],"award-info":[{"award-number":["R01 HL164584"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association postdoctoral fellowship","award":["R01 HL169432"],"award-info":[{"award-number":["R01 HL169432"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association postdoctoral fellowship","award":["24EIA1255341"],"award-info":[{"award-number":["24EIA1255341"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association postdoctoral fellowship","award":["25POST1371944"],"award-info":[{"award-number":["25POST1371944"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"American Heart Association postdoctoral fellowship","award":["GM135134"],"award-info":[{"award-number":["GM135134"]}],"id":[{"id":"https:\/\/ror.org\/013kjyp64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH T32 predoctoral fellowship","award":["R01 HL132899"],"award-info":[{"award-number":["R01 HL132899"]}]},{"name":"NIH T32 predoctoral fellowship","award":["R01 HL147954"],"award-info":[{"award-number":["R01 HL147954"]}]},{"name":"NIH T32 predoctoral fellowship","award":["R01 HL164584"],"award-info":[{"award-number":["R01 HL164584"]}]},{"name":"NIH T32 predoctoral fellowship","award":["R01 HL169432"],"award-info":[{"award-number":["R01 HL169432"]}]},{"name":"NIH T32 predoctoral fellowship","award":["24EIA1255341"],"award-info":[{"award-number":["24EIA1255341"]}]},{"name":"NIH T32 predoctoral fellowship","award":["25POST1371944"],"award-info":[{"award-number":["25POST1371944"]}]},{"name":"NIH T32 predoctoral fellowship","award":["GM135134"],"award-info":[{"award-number":["GM135134"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Cardiac physiology and pathology have been extensively explored at the transcriptional level. Still, they are less understood at the translational level, including three major knowledge gaps: pathophysiological impact, molecular mechanisms, and therapeutic implications of translational control in cardiac biology and heart disease. This review aims to provide a summary of the most recent key findings in this emerging field of translational control in heart health and disease, covering the physiological functions, disease pathogenesis, biochemical mechanisms, and development of potential RNA-based, translation-manipulating drugs. Translation of mRNA to protein is the final step in the central dogma for protein synthesis. Translation machinery includes a family of essential \u201chousekeeping\u201d factors and enzymes required for mRNA translation. These translation factors ensure the accurate processing of mRNA to protein according to the genetic code and maintain the optimal quality and quantity of cellular proteins for normal cardiac function. Translation factors also regulate the efficiency, speed, and fidelity of protein production and play a role in cardiac pathological remodeling under stress conditions. This review first introduces the techniques and methods used to study the translational regulation of gene expression in the cardiac system. We then summarize discoveries of a variety of pathophysiological functions and molecular mechanisms of translational control in cardiac health and disease, focusing on two primary symptoms, cardiac hypertrophy and fibrosis. In these sessions, we discuss the translational regulation directed by specific regulatory factors in cardiac physiology and how their genetic mutations, expression dysregulation, or functional alterations contribute to the etiology of heart disease. Notably, translational control exhibits extensive crosstalk with other processes, including transcriptional regulation, mitochondrial metabolism, and sarcomere homeostasis. Furthermore, recent findings have revealed the role of translational regulation in cardiomyocyte proliferation and heart regeneration, providing new approaches for creating regenerative medicine. Because transcript-specific translational regulation of both pathological and protective proteins occurs in heart disease, target-selective translation inhibitors and enhancers can be developed. These inhibitors and enhancers offer valuable insights into novel therapeutic targets and the development of RNA-based drugs for heart disease treatment.<\/jats:p>","DOI":"10.3390\/ijms26167863","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T15:44:21Z","timestamp":1755186261000},"page":"7863","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Translational Control in Cardiac Pathophysiology and Therapeutic Development: When mRNA Meets the Heart"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-8645","authenticated-orcid":false,"given":"Uday K.","family":"Baliga","sequence":"first","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-0401","authenticated-orcid":false,"given":"Aleksandr","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0155-4427","authenticated-orcid":false,"given":"Jack L.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"},{"name":"Department of Biochemistry & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-6498","authenticated-orcid":false,"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"},{"name":"Department of Biochemistry & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Soon","family":"Khor","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0147-8826","authenticated-orcid":false,"given":"Debojyoti","family":"Das","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Wainwright","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"},{"name":"Department of Biochemistry & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-3967","authenticated-orcid":false,"given":"Peng","family":"Yao","sequence":"additional","affiliation":[{"name":"Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"},{"name":"Department of Biochemistry & Biophysics, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"},{"name":"The Center for RNA Biology, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"},{"name":"The Center for Biomedical Informatics, University of Rochester School of Medicine & Dentistry, Rochester, NY 14586, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics: A Report of US and Global Data from the American Heart Association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Simmonds, S.J., Cuijpers, I., Heymans, S., and Jones, E.A.V. (2020). Cellular and Molecular Differences between HFpEF and HFrEF: A Step Ahead in an Improved Pathological Understanding. Cells, 9.","DOI":"10.3390\/cells9010242"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.bi.56.070187.001013","article-title":"Aminoacyl tRNA synthetases: General scheme of structure-function relationships in the polypeptides and recognition of transfer RNAs","volume":"56","author":"Schimmel","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.biochem.69.1.617","article-title":"Aminoacyl-tRNA synthesis","volume":"69","author":"Ibba","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-386497-0.00001-3","article-title":"Quality control in aminoacyl-tRNA synthesis its role in translational fidelity","volume":"86","author":"Yadavalli","year":"2012","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.micro.091208.073210","article-title":"Aminoacyl-tRNA synthesis and translational quality control","volume":"63","author":"Ling","year":"2009","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the Dependency of Cellular Protein Levels on mRNA Abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24676","article-title":"IL-11 is a crucial determinant of cardiovascular fibrosis","volume":"552","author":"Schafer","year":"2017","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1152\/physrev.00007.2019","article-title":"mRNA Metabolism in Cardiac Development and Disease: Life After Transcription","volume":"100","author":"Gao","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41569-023-00958-z","article-title":"RNA-binding proteins in cardiovascular biology and disease: The beat goes on","volume":"21","author":"Volkers","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1038\/s41467-023-41799-1","article-title":"Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy","volume":"14","author":"Hedaya","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cell.2012.02.018","article-title":"Coding Region Polyadenylation Generates a Truncated tRNA Synthetase that Counters Translation Repression","volume":"149","author":"Yao","year":"2012","journal-title":"Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00395-023-00996-1","article-title":"Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo","volume":"118","author":"Varma","year":"2023","journal-title":"Basic. Res. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109100","DOI":"10.1016\/j.celrep.2021.109100","article-title":"Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes","volume":"35","author":"Riechert","year":"2021","journal-title":"Cell Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1093\/nar\/gkad322","article-title":"RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression","volume":"51","author":"Jiang","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1016\/j.molcel.2024.07.025","article-title":"Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role","volume":"84","author":"Anastasakis","year":"2024","journal-title":"Mol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2018.06.004","article-title":"fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: Lessons from DROSHA","volume":"152","author":"Kim","year":"2019","journal-title":"Methods"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Danan, C., Manickavel, S., and Hafner, M. (2016). PAR-CLIP: A Method for Transcriptome-Wide Identification of RNA Binding Protein Interaction Sites, Humana Press. [2nd ed.].","DOI":"10.1007\/978-1-4939-3067-8_10"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Danan, C., Manickavel, S., and Hafner, M. (2022). PAR-CLIP: A Method for Transcriptome-Wide Identification of RNA Binding Protein Interaction Sites, Humana Press. [3rd ed.].","DOI":"10.1007\/978-1-0716-1851-6_9"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Panda, A.C., Martindale, J.L., and Gorospe, M. (2016). Affinity Pulldown of Biotinylated RNA for Detection of Protein-RNA Complexes. Bio-Protoc., 6.","DOI":"10.21769\/BioProtoc.2062"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yao, P., Potdar, A.A., Ray, P.S., Eswarappa, S.M., Flagg, A.C., Willard, B., and Fox, P.L. (2013). The HILDA complex coordinates a conditional switch in the 3\u2032-untranslated region of the VEGFA mRNA. PLoS Biol., 11.","DOI":"10.1371\/journal.pbio.1001635"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gerber, A.P. (2021). RNA-Centric Approaches to Profile the RNA-Protein Interaction Landscape on Selected RNAs. Non-Coding RNA, 7.","DOI":"10.3390\/ncrna7010011"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-1-4939-9546-2_15","article-title":"BioID as a Tool for Protein-Proximity Labeling in Living Cells","volume":"2012","author":"Sears","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1161\/ATVBAHA.123.319925","article-title":"RNA-Binding Proteins Regulate Post-Transcriptional Responses to TGF-beta to Coordinate Function and Mesenchymal Activation of Murine Endothelial Cells","volume":"43","author":"Wardman","year":"2023","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101340","DOI":"10.1016\/j.xpro.2022.101340","article-title":"Optimized proximity ligation assay (PLA) for detection of RNA-protein complex interactions in cell lines","volume":"3","author":"George","year":"2022","journal-title":"STAR Protoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nmeth.2557","article-title":"The CRAPome: A contaminant repository for affinity purification-mass spectrometry data","volume":"10","author":"Mellacheruvu","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1038\/s41467-018-05539-0","article-title":"A widespread alternate form of cap-dependent mRNA translation initiation","volume":"9","author":"Ernlund","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41586-018-0032-3","article-title":"An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1161\/CIRCULATIONAHA.123.067479","article-title":"Transient Inhibition of Translation Improves Cardiac Function After Ischemia\/Reperfusion by Attenuating the Inflammatory Response","volume":"150","author":"Hofmann","year":"2024","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e10018","DOI":"10.15252\/emmm.201810018","article-title":"TIP 30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation","volume":"11","author":"Grund","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_31","first-page":"827","article-title":"EPRS regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis","volume":"127","author":"Wu","year":"2019","journal-title":"bioRxiv"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ymeth.2018.11.015","article-title":"Cell-type specific polysome profiling from mammalian tissues","volume":"155","author":"Seimetz","year":"2019","journal-title":"Methods"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Pereira, I.T., Spangenberg, L., Robert, A.W., Amorin, R., Stimamiglio, M.A., Naya, H., and Dallagiovanna, B. (2019). Cardiomyogenic differentiation is fine-tuned by differential mRNA association with polysomes. BMC Genom., 20.","DOI":"10.1186\/s12864-019-5550-3"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"15395","DOI":"10.1073\/pnas.1304124110","article-title":"Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification","volume":"110","author":"Zhou","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/CIRCRESAHA.119.314817","article-title":"Monitoring Cell-Type-Specific Gene Expression Using Ribosome Profiling in Vivo During Cardiac Hemodynamic Stress","volume":"125","author":"Doroudgar","year":"2019","journal-title":"Circ. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2019.05.010","article-title":"The Translational Landscape of the Human Heart","volume":"178","author":"Witte","year":"2019","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s44161-023-00344-5","article-title":"Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition","volume":"2","author":"Xie","year":"2023","journal-title":"Nat. Cardiovasc. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/cvr\/cvad124","article-title":"FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis","volume":"119","author":"Wu","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.celrep.2019.09.080","article-title":"MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition","volume":"29","author":"Busch","year":"2019","journal-title":"Cell Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/CIRCULATIONAHA.119.039596","article-title":"Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins","volume":"140","author":"Chothani","year":"2019","journal-title":"Circulation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.yjmcc.2018.01.012","article-title":"Localization of transcripts, translation, and degradation for spatiotemporal sarcomere maintenance","volume":"116","author":"Lewis","year":"2018","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/s41467-021-21685-4","article-title":"Microtubules orchestrate local translation to enable cardiac growth","volume":"12","author":"Scarborough","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00395-021-00895-3","article-title":"Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes","volume":"116","author":"Bogdanov","year":"2021","journal-title":"Basic. Res. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e52654","DOI":"10.7554\/eLife.52654","article-title":"A microtranslatome coordinately regulates sodium and potassium currents in the human heart","volume":"8","author":"Eichel","year":"2019","journal-title":"eLife"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41439-019-0067-5","article-title":"Diamond-Blackfan anemia caused by chromosome 1p22 deletion encompassing RPL5","volume":"6","author":"Tominaga","year":"2019","journal-title":"Hum. Genome Var."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ajhg.2018.12.011","article-title":"The Genetic Landscape of Diamond-Blackfan Anemia","volume":"104","author":"Ulirsch","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e002044","DOI":"10.1161\/CIRCGENETICS.117.002044","article-title":"Increased Prevalence of Congenital Heart Disease in Children With Diamond Blackfan Anemia Suggests Unrecognized Diamond Blackfan Anemia as a Cause of Congenital Heart Disease in the General Population: A Report of the Diamond Blackfan Anemia Registry","volume":"11","author":"Vlachos","year":"2018","journal-title":"Circ. Genom. Precis. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3324\/haematol.2022.282042","article-title":"Animal models of Diamond-Blackfan anemia: Updates and challenges","volume":"108","author":"Liu","year":"2023","journal-title":"Haematologica"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Grimes, K.M., Prasad, V., Huo, J., Kuwabara, Y., Vanhoutte, D., Baldwin, T.A., Bowers, S.L.K., Johansen, A.K.Z., Sargent, M.A., and Lin, S.J. (2023). Rpl3l gene deletion in mice reduces heart weight over time. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1054169"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/s41467-023-37838-6","article-title":"RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function","volume":"14","author":"Shiraishi","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1093\/nar\/gkad121","article-title":"Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart","volume":"51","author":"Milenkovic","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Murphy, M.R., Ganapathi, M., Lee, T.M., Fisher, J.M., Patel, M.V., Jayakar, P., Buchanan, A., Rippert, A.L., Ahrens-Nicklas, R.C., and Nair, D. (2025). Recessive but damaging alleles of muscle-specific ribosomal protein gene RPL3L drive neonatal dilated cardiomyopathy. bioRxiv.","DOI":"10.1101\/2025.01.02.630345"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCRESAHA.124.324781","article-title":"Reducing Granules Without Splicing Restoration Alleviates RBM20 Cardiomyopathy","volume":"136","author":"Methawasin","year":"2025","journal-title":"Circ. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hosur, V., Low, B.E., Li, D., Stafford, G.A., Kohar, V., Shultz, L.D., and Wiles, M.V. (2020). Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation. Genome Biol., 21.","DOI":"10.1186\/s13059-020-02086-0"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41592-019-0614-5","article-title":"Biological plasticity rescues target activity in CRISPR knock outs","volume":"16","author":"Smits","year":"2019","journal-title":"Nat. Methods"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jmcb\/mjy003","article-title":"Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development","volume":"10","author":"Han","year":"2018","journal-title":"J. Mol. Cell Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"eadh3892","DOI":"10.1126\/science.adh3892","article-title":"Principles of human pre-60S biogenesis","volume":"381","author":"Klinge","year":"2023","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Witte, F., Ruiz-Orera, J., Mattioli, C.C., Blachut, S., Adami, E., Schulz, J.F., Schneider-Lunitz, V., Hummel, O., Patone, G., and Mucke, M.B. (2021). A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion. Genome Biol., 22.","DOI":"10.1186\/s13059-021-02397-w"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"22915","DOI":"10.1074\/jbc.M101011200","article-title":"Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2\/S1 protein expression in normal and wasted mice","volume":"276","author":"Khalyfa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1093\/hmg\/ddx239","article-title":"Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death","volume":"26","author":"Cao","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e008665","DOI":"10.1161\/CIRCHEARTFAILURE.121.008665","article-title":"Loss of eEF1A2 (Eukaryotic Elongation Factor 1 A2) in Murine Myocardium Results in Dilated Cardiomyopathy","volume":"14","author":"Feng","year":"2021","journal-title":"Circ. Heart Fail."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biocel.2013.12.011","article-title":"Mitochondria: Impaired mitochondrial translation in human disease","volume":"48","author":"Boczonadi","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Euro, L., Konovalova, S., Asin-Cayuela, J., Tulinius, M., Griffin, H., Horvath, R., Taylor, R.W., Chinnery, P.F., Schara, U., and Thorburn, D.R. (2015). Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation. Front. Genet., 6.","DOI":"10.3389\/fgene.2015.00021"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ajhg.2011.04.006","article-title":"Exome Sequencing Identifies Mitochondrial Alanyl-tRNA Synthetase Mutations in Infantile Mitochondrial Cardiomyopathy","volume":"88","author":"Tyynismaa","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"ref_66","first-page":"258","article-title":"Instability of the mitochondrial alanyl-tRNA synthetase underlies fatal infantile-onset cardiomyopathy","volume":"28","author":"Sommerville","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"eaay2118","DOI":"10.1126\/sciadv.aay2118","article-title":"Fidelity of translation initiation is required for coordinated respiratory complex assembly","volume":"5","author":"Rudler","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41576-020-00302-y","article-title":"RNA-binding proteins in human genetic disease","volume":"22","author":"Gebauer","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCRESAHA.123.322929","article-title":"CCND2 Modified mRNA Activates Cell Cycle of Cardiomyocytes in Hearts With Myocardial Infarction in Mice and Pigs","volume":"133","author":"Sun","year":"2023","journal-title":"Circ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1093\/nar\/gkad135","article-title":"PRRC2 proteins impact translation initiation by promoting leaky scanning","volume":"51","author":"Bohlen","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11083","article-title":"A unifying model for mTORC1-mediated regulation of mRNA translation","volume":"485","author":"Thoreen","year":"2012","journal-title":"Nature"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1073\/pnas.1617234114","article-title":"Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells","volume":"114","author":"Sugiyama","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nature18954","article-title":"eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation","volume":"536","author":"Lee","year":"2016","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature14267","article-title":"eIF3 targets cell-proliferation messenger RNAs for translational activation or repression","volume":"522","author":"Lee","year":"2015","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.abb0993","article-title":"A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress","volume":"370","author":"Lamper","year":"2020","journal-title":"Science"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1038\/s41467-021-27087-w","article-title":"A DAP5\/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells","volume":"12","author":"Volta","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"112646","DOI":"10.1016\/j.celrep.2023.112646","article-title":"Breast cancer cell mesenchymal transition and metastasis directed by DAP5\/eIF3d-mediated selective mRNA translation","volume":"42","author":"Alard","year":"2023","journal-title":"Cell Rep."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Das, D., Khor, E.S., Jiang, F., He, J., Kawakami, Y., Wainwright, L., Hollinger, J., Geiger, J., Liu, H., and Meng, F. (2024). Loss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital cardiovascular malformation. medRxiv.","DOI":"10.1101\/2024.09.26.24313895"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Goldberg, N., Bril, D., Eisenstein, M., Olender, T., Savidor, A., Bialik, S., Pietrokovski, S., and Kimchi, A. (2024). The RNA-binding protein PRRC2B preserves 5\u2032 TOP mRNA during starvation to maintain ribosome biogenesis during nutrient recovery. bioRxiv.","DOI":"10.1101\/2024.12.04.626744"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e2300892","DOI":"10.1002\/advs.202300892","article-title":"The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"dev201376","DOI":"10.1242\/dev.201376","article-title":"The translation initiation factor homolog eif4e1c regulates cardiomyocyte metabolism and proliferation during heart regeneration","volume":"150","author":"Rao","year":"2023","journal-title":"Development"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1016\/j.molcel.2021.09.029","article-title":"Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress","volume":"81","author":"Jobava","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.drudis.2018.02.008","article-title":"The integrated stress response system in cardiovascular disease","volume":"23","author":"Godinas","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"E3759","DOI":"10.1073\/pnas.1719089115","article-title":"FAM210A is a novel determinant of bone and muscle structure and strength","volume":"115","author":"Tanaka","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"Sutherland","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e12710","DOI":"10.15252\/emmm.202012710","article-title":"MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling","volume":"13","author":"Wu","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"106322","DOI":"10.1016\/j.pep.2023.106322","article-title":"Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli","volume":"210","author":"Hollinger","year":"2023","journal-title":"Protein Expr. Purif."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","article-title":"Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration","volume":"173","author":"Mohamed","year":"2018","journal-title":"Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yjmcc.2023.01.004","article-title":"Integrated proteomics reveals alterations in sarcomere composition and developmental processes during postnatal swine heart development","volume":"176","author":"Aballo","year":"2023","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/CIRCULATIONAHA.120.049497","article-title":"Cyclin D2 Overexpression Enhances the Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair in a Swine Model of Myocardial Infarction","volume":"144","author":"Zhao","year":"2021","journal-title":"Circulation"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"eade1792","DOI":"10.1126\/sciadv.ade1792","article-title":"mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs","volume":"9","author":"Bartsch","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1161\/CIRCULATIONAHA.122.061192","article-title":"Reduced Mitochondrial Protein Translation Promotes Cardiomyocyte Proliferation and Heart Regeneration","volume":"148","author":"Gao","year":"2023","journal-title":"Circulation"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"e128496","DOI":"10.1172\/jci.insight.128496","article-title":"The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing","volume":"5","author":"Stoehr","year":"2019","journal-title":"JCI Insight"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"18455","DOI":"10.1073\/pnas.1905824116","article-title":"Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling","volume":"116","author":"Wang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI72181","article-title":"Macrophages are required for neonatal heart regeneration","volume":"124","author":"Aurora","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41420-023-01457-3","article-title":"IGF2BP3 promotes adult myocardial regeneration by stabilizing MMP3 mRNA through interaction with m6A modification","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"D425","DOI":"10.1093\/nar\/gkaa1040","article-title":"RBP2GO: A comprehensive pan-species database on RNA-binding proteins, their interactions and functions","volume":"49","author":"Jansen","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.stemcr.2024.08.002","article-title":"Development of adeno-associated viral vectors targeting cardiac fibroblasts for efficient in vivo cardiac reprogramming","volume":"19","author":"Nakano","year":"2024","journal-title":"Stem Cell Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/CIRCULATIONAHA.121.058655","article-title":"Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction","volume":"147","author":"Tani","year":"2023","journal-title":"Circulation"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/CIRCRESAHA.116.305547","article-title":"Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming","volume":"116","author":"Wang","year":"2015","journal-title":"Circ. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrm2818","article-title":"Emerging role for the cytoskeleton as an organizer and regulator of translation","volume":"11","author":"Kim","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1440-1681.2003.03873.x","article-title":"Cardiac hypertrophy: A matter of translation","volume":"30","author":"Hannan","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e24139","DOI":"10.7554\/eLife.24139","article-title":"Poly(A) tail length regulates PABPC1 expression to tune translation in the heart","volume":"6","author":"Chorghade","year":"2017","journal-title":"eLife"},{"key":"ref_108","first-page":"244","article-title":"Myocardial Protein Synthesis in Cardiac Hypertrophy","volume":"63","author":"Gudbjarnason","year":"1964","journal-title":"J. Lab. Clin. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"10477","DOI":"10.1038\/ncomms10477","article-title":"p38gamma and delta promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation","volume":"7","author":"Lopez","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","author":"Dorn","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","article-title":"Mammalian target of rapamycin signaling in cardiac physiology and disease","volume":"114","author":"Sciarretta","year":"2014","journal-title":"Circ. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0014-5793(03)00744-0","article-title":"Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF","volume":"548","author":"Brandenburger","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/01.RES.78.3.354","article-title":"Regulation of rDNA Transcription During Endothelin-1Induced Hypertrophy of Neonatal Cardiomyocytes","volume":"78","author":"Luyken","year":"1996","journal-title":"Circ. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1074\/jbc.271.6.3213","article-title":"Regulation of ribosomal DNA transcription during contraction-induced hypertrophy of neonatal cardiomyocytes","volume":"271","author":"Hannan","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1073\/pnas.111145798","article-title":"Molecular mechanisms of translation initiation in eukaryotes","volume":"98","author":"Pestova","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrm1488","article-title":"Molecular mechanisms of translational control","volume":"5","author":"Gebauer","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/345544a0","article-title":"Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5\u2032 cap","volume":"345","author":"Montine","year":"1990","journal-title":"Nature"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"12966","DOI":"10.1073\/pnas.231343498","article-title":"HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation","volume":"98","author":"Ventoso","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1074\/jbc.271.14.8359","article-title":"Translational Initiation Factor eIF-4E: A LINK BETWEEN CARDIAC LOAD AND PROTEIN SYNTHESIS","volume":"271","author":"Wada","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"H1273","DOI":"10.1152\/ajpheart.1999.277.4.H1273","article-title":"Role of load in regulating eIF-4F complex formation in adult feline cardiocytes","volume":"277","author":"Tuxworth","year":"1999","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(01)00399-7","article-title":"Transcriptional regulation of the rat eIF4E gene in cardiac muscle cells: The role of specific elements in the promoter region","volume":"267","author":"Makhlouf","year":"2001","journal-title":"Gene"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"H2176","DOI":"10.1152\/ajpheart.1999.277.6.H2176","article-title":"Translational mechanisms accelerate the rate of protein synthesis during canine pressure-overload hypertrophy","volume":"277","author":"Nagatomo","year":"1999","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"H2133","DOI":"10.1152\/ajpheart.1998.274.6.H2133","article-title":"Increased expression of eukaryotic initiation factor 4E during growth of neonatal rat cardiocytes in vitro","volume":"274","author":"Makhlouf","year":"1998","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","article-title":"eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation","volume":"68","author":"Gingras","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/bj3560557","article-title":"Modifications of eukaryotic initiation factor 4F (eIF4F) in adult cardiocytes by adenoviral gene transfer: Differential effects on eIF4F activity and total protein synthesis rates","volume":"356","author":"Saghir","year":"2001","journal-title":"Biochem. J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/01.RES.0000124977.59827.80","article-title":"Phosphorylation of Eukaryotic Translation Initiation Factor 2B\u03b5 by Glycogen Synthase Kinase-3\u03b2 Regulates \u03b2-Adrenergic Cardiac Myocyte Hypertrophy","volume":"94","author":"Hardt","year":"2004","journal-title":"Circ. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/HYPERTENSIONAHA.113.02313","article-title":"Loss of the Eukaryotic Initiation Factor 2\u03b1 Kinase General Control Nonderepressible 2 Kinase Protects Mice From Pressure Overload-Induced Congestive Heart Failure Without Affecting Ventricular Hypertrophy","volume":"63","author":"Lu","year":"2013","journal-title":"Hypertension"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1357-2725(98)00128-9","article-title":"Eukaryotic initiation factor eIF2","volume":"31","author":"Kimball","year":"1999","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"66","DOI":"10.14348\/molcells.2017.2259","article-title":"Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway","volume":"40","author":"Rani","year":"2017","journal-title":"Mol. Cells"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.lfs.2018.09.054","article-title":"Alternative mechanisms of translation initiation: An emerging dynamic regulator of the proteome in health and disease","volume":"212","author":"James","year":"2018","journal-title":"Life Sci."},{"key":"ref_132","first-page":"391546","article-title":"Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs","volume":"2012","year":"2012","journal-title":"Comp. Funct. Genom."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311955","article-title":"GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs","volume":"121","author":"Basheer","year":"2017","journal-title":"Circ. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.CIR.95.4.988","article-title":"Disturbed Connexin43 Gap Junction Distribution Correlates with the Location of Reentrant Circuits in the Epicardial Border Zone of Healing Canine Infarcts That Cause Ventricular Tachycardia","volume":"95","author":"Coromilas","year":"1997","journal-title":"Circulation"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.celrep.2013.10.009","article-title":"Autoregulation of connexin43 gap junction formation by internally translated isoforms","volume":"5","author":"Smyth","year":"2013","journal-title":"Cell Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"20979","DOI":"10.1074\/jbc.M113.540187","article-title":"Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-terminal domains of Cx43 and is responsive to hypoxic conditions","volume":"289","author":"Olk","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0014-5793(99)01699-3","article-title":"Connexin43 mRNA contains a functional internal ribosome entry site","volume":"464","author":"Schiavi","year":"1999","journal-title":"FEBS Lett."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1478-811X-12-31","article-title":"Internal translation of the connexin 43 transcript","volume":"12","author":"Peula","year":"2014","journal-title":"Cell Commun. Signal."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"dmm043208","DOI":"10.1242\/dmm.043208","article-title":"Control of translation elongation in health and disease","volume":"13","author":"Knight","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1146\/annurev-biochem-113009-092313","article-title":"Structural Basis of the Translational Elongation Cycle","volume":"82","author":"Voorhees","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature13896","article-title":"mTORC1-mediated translational elongation limits intestinal tumour initiation and growth","volume":"517","author":"Faller","year":"2015","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-019-01971-8","article-title":"Translational control in brain pathologies: Biological significance and therapeutic opportunities","volume":"137","author":"Delaidelli","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_143","first-page":"218","article-title":"Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes","volume":"7","author":"Kameshima","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"H161","DOI":"10.1152\/ajpheart.2001.281.1.H161","article-title":"Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes","volume":"281","author":"Everett","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0014-5793(02)03536-6","article-title":"Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes","volume":"531","author":"Wang","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0014-5793(01)02100-7","article-title":"beta-Adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity","volume":"489","author":"McLeod","year":"2001","journal-title":"FEBS Lett."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cbf.1740","article-title":"Eukaryotic elongation factor-2 (eEF2): Its regulation and peptide chain elongation","volume":"29","author":"Kaul","year":"2011","journal-title":"Cell Biochem. Funct."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1074\/jbc.M807945200","article-title":"Coordination of Eukaryotic Translation Elongation Factor 1A (eEF1A) Function in Actin Organization and Translation Elongation by the Guanine Nucleotide Exchange Factor eEF1B","volume":"284","author":"Pittman","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/hh1701.096038","article-title":"Phosphorylation of Mitochondrial Elongation Factor Tu in Ischemic Myocardium","volume":"89","author":"He","year":"2001","journal-title":"Circ. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0925-4439(95)00080-1","article-title":"Control and kinetic analysis of ischemia-damaged heart mitochondria: Which parts of the oxidative phosphorylation system are affected by ischemia?","volume":"1272","author":"Borutaite","year":"1995","journal-title":"Biochim. Et Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"20308","DOI":"10.1074\/jbc.M001899200","article-title":"Interaction of Mitochondrial Elongation Factor Tu with Aminoacyl-tRNA and Elongation Factor Ts","volume":"275","author":"Cai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Heilmeyer, L.M.G. (1991). Phosphorylation of Elongation Factor Tu in Vitro and in Vivo. Cellular Regulation by Protein Phosphorylation, Springer.","DOI":"10.1007\/978-3-642-75142-4"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1096\/fj.00-0853fje","article-title":"Increased expression of UBF is a critical determinant for rRNA synthesis and hypertrophic growth of cardiac myocytes","volume":"15","author":"Brandenburger","year":"2001","journal-title":"FASEB J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"8290","DOI":"10.1074\/jbc.270.14.8290","article-title":"Regulation of rDNA Transcription Factors during Cardiomyocyte Hypertrophy Induced by Adrenergic Agents","volume":"270","author":"Hannan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1161\/01.RES.77.6.1040","article-title":"Rapamycin Selectively Inhibits Angiotensin II\u2013Induced Increase in Protein Synthesis in Cardiac Myocytes In Vitro","volume":"77","author":"Sadoshima","year":"1995","journal-title":"Circ. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"9703","DOI":"10.1074\/jbc.273.16.9703","article-title":"Activation of Phosphatidylinositol 3-Kinase through Glycoprotein 130 Induces Protein Kinase B and p70 S6 Kinase Phosphorylation in Cardiac Myocytes","volume":"273","author":"Oh","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"12661","DOI":"10.1073\/pnas.1301455110","article-title":"Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1","volume":"110","author":"Volkers","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrm2672","article-title":"Molecular mechanisms of mTOR-mediated translational control","volume":"10","author":"Ma","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1228792","article-title":"Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1","volume":"339","author":"Howell","year":"2013","journal-title":"Science"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.1228771","article-title":"Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis","volume":"339","author":"Robitaille","year":"2013","journal-title":"Science"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"8862","DOI":"10.1128\/MCB.23.23.8862-8877.2003","article-title":"mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF","volume":"23","author":"Hannan","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Pires, K.M., Whitehead, K.J., Olsen, C.D., Wayment, B., Zhang, Y.C., Bugger, H., Ilkun, O., Litwin, S.E., and Thomas, G. (2013). Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054221"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.yjmcc.2016.04.011","article-title":"mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53\/JNK-mediated apoptosis","volume":"97","author":"Mazelin","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/CIRCULATIONAHA.110.977066","article-title":"Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice","volume":"123","author":"Shende","year":"2011","journal-title":"Circulation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1172\/JCI43008","article-title":"MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice","volume":"120","author":"Zhang","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","article-title":"Rapamycin attenuates load-induced cardiac hypertrophy in mice","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.ajpath.2013.02.012","article-title":"Genetic and pharmacological inhibition of Rheb1-mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice","volume":"182","author":"Wu","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yjmcc.2023.06.001","article-title":"Ythdf2 regulates cardiac remodeling through its mRNA target transcripts","volume":"181","author":"Kmietczyk","year":"2023","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ejhf.1672","article-title":"Changes in m6A RNA methylation contribute to heart failure progression by modulating translation","volume":"22","author":"Berulava","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis--a common pathway to organ injury and failure","volume":"372","author":"Rockey","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yjmcc.2013.10.019","article-title":"Myofibroblasts: Trust your heart and let fate decide","volume":"70","author":"Davis","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGF\u03b2 signalling pathway in disease","volume":"11","author":"Akhurst","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.109.893677","article-title":"Therapeutic Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-11 Ameliorates Cardiac Fibrosis After Myocardial Infarction","volume":"121","author":"Obana","year":"2010","journal-title":"Circulation"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41586-024-07701-9","article-title":"Inhibition of IL-11 signalling extends mammalian healthspan and lifespan","volume":"632","author":"Widjaja","year":"2024","journal-title":"Nature"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Schneider-Lunitz, V., Ruiz-Orera, J., Hubner, N., and van Heesch, S. (2021). Multifunctional RNA-binding proteins influence mRNA abundance and translational efficiency of distinct sets of target genes. PLoS Comput. Biol., 17.","DOI":"10.1101\/2021.04.13.439465"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/emmm.201100626","article-title":"Aminoacyl-tRNA synthetases in medicine and disease","volume":"5","author":"Yao","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cell.2004.09.030","article-title":"Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation","volume":"119","author":"Sampath","year":"2004","journal-title":"Cell"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nature07598","article-title":"A stress-responsive RNA switch regulates VEGFA expression","volume":"457","author":"Ray","year":"2009","journal-title":"Nature"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajhg.2018.02.011","article-title":"Bi-allelic Mutations in EPRS, Encoding the Glutamyl-Prolyl-Aminoacyl-tRNA Synthetase, Cause a Hypomyelinating Leukodystrophy","volume":"102","author":"Mendes","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-024-48549-x","article-title":"Homozygous EPRS1 missense variant causing hypomyelinating leukodystrophy-15 alters variant-distal mRNA m6A site accessibility","volume":"15","author":"Khan","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Da, M., Feng, Y., Xu, J., Hu, Y., Lin, Y., Ni, B., Qian, B., Hu, Z., and Mo, X. (2014). Association of aminoacyl-tRNA synthetases gene polymorphisms with the risk of congenital heart disease in the Chinese Han population. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110072"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cels.2016.10.016","article-title":"Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice","volume":"4","author":"Rau","year":"2017","journal-title":"Cell Syst."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Galindo, C.L., Skinner, M.A., Errami, M., Olson, L.D., Watson, D.A., Li, J., McCormick, J.F., McIver, L.J., Kumar, N.M., and Pham, T.Q. (2009). Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy and human cardiac failure. BMC Physiol., 9.","DOI":"10.1186\/1472-6793-9-23"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Widjaja, A.A., Viswanathan, S., Jinrui, D., Singh, B.K., Tan, J., Ting, J.G.W., Lamb, D., Shekeran, S.G., George, B.L., and Schafer, S. (2021). Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.740650"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/wrna.17","article-title":"No-go decay: A quality control mechanism for RNA in translation","volume":"1","author":"Harigaya","year":"2010","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Wu, J., Hollinger, J., Bonanno, E., Jiang, F., and Yao, P. (2023). Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy. Cells, 13.","DOI":"10.1101\/2023.09.19.558539"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.1229017","article-title":"EF-P is essential for rapid synthesis of proteins containing consecutive proline residues","volume":"339","author":"Doerfel","year":"2013","journal-title":"Science"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molcel.2017.03.003","article-title":"eIF5A Functions Globally in Translation Elongation and Termination","volume":"66","author":"Schuller","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/mmi.13233","article-title":"Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A","volume":"99","author":"Lassak","year":"2016","journal-title":"Mol. Microbiol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/s00726-016-2275-3","article-title":"Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer","volume":"48","author":"Nakanishi","year":"2016","journal-title":"Amino Acids"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1152\/ajpendo.00537.2013","article-title":"Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a \u201chumanized\u201d transgenic mouse model of type 1 diabetes","volume":"306","author":"Imam","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Subbaiah, K.C.V., Wu, J., Tang, W.H.W., and Yao, P. (2023). Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10020052"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e038945","DOI":"10.1161\/JAHA.124.038945","article-title":"Myocardial Proteome in Human Heart Failure with Preserved Ejection Fraction","volume":"14","author":"Jani","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1172\/JCI38027","article-title":"Tragedy in a heartbeat: Malfunctioning desmin causes skeletal and cardiac muscle disease","volume":"119","author":"Goldfarb","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"H1220","DOI":"10.1152\/ajpheart.00601.2011","article-title":"Desmin-related cardiomyopathy: An unfolding story","volume":"301","author":"McLendon","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"11043","DOI":"10.1073\/pnas.0802862105","article-title":"Aminoacyl tRNA synthetases and their connections to disease","volume":"105","author":"Park","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"17570","DOI":"10.1073\/pnas.1420196111","article-title":"Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy","volume":"111","author":"Liu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1093\/nar\/gkn028","article-title":"Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps","volume":"36","author":"Yao","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/emboj\/cdg065","article-title":"Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability","volume":"22","author":"Beebe","year":"2003","journal-title":"EMBO J."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature05096","article-title":"Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration","volume":"443","author":"Lee","year":"2006","journal-title":"Nature"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.chembiol.2006.08.011","article-title":"Global Effects of Mistranslation from an Editing Defect in Mammalian Cells","volume":"13","author":"Nangle","year":"2006","journal-title":"Chem. Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"10463","DOI":"10.1093\/nar\/gks783","article-title":"In vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain","volume":"40","author":"Huang","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.RES.18.5.558","article-title":"Inhibition of protein synthesis in cardiac hypertrophy and its relation to myocardial failure","volume":"18","author":"Zuhlke","year":"1966","journal-title":"Circ. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nchembio.790","article-title":"Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase","volume":"8","author":"Keller","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature11774","article-title":"ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase","volume":"494","author":"Zhou","year":"2013","journal-title":"Nature"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"e004453","DOI":"10.1161\/JAHA.116.004453","article-title":"Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress","volume":"6","author":"Qin","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1126\/science.1172638","article-title":"Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response","volume":"324","author":"Sundrud","year":"2009","journal-title":"Science"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/jpet.121.000491","article-title":"Small-Molecule Integrated Stress Response Inhibitor Reduces Susceptibility to Postinfarct Atrial Fibrillation in Rats via the Inhibition of Integrated Stress Responses","volume":"378","author":"Zhang","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2018.12.055","article-title":"Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis","volume":"73","author":"Onat","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Hedaya, O.M., Jiang, F., Baliga, U., Ivanov, A., Chen, S., Schwartz, J.L., Kawakami, Y., Yan, C., and Yao, P. (2025). Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice. bioRxiv.","DOI":"10.1101\/2025.05.18.654700"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1073\/pnas.76.10.5134","article-title":"Interference of nonsense mutations with eukaryotic messenger RNA stability","volume":"76","author":"Losson","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/nar\/gkw010","article-title":"Mechanism and regulation of the nonsense-mediated decay pathway","volume":"44","author":"Hug","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1101\/gad.9.4.437","article-title":"Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen","volume":"9","author":"He","year":"1995","journal-title":"Genes. Dev."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"gkaf395","DOI":"10.1093\/nar\/gkaf395","article-title":"Cell type- and factor-specific nonsense-mediated RNA decay","volume":"53","author":"Tan","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0092-8674(01)00475-5","article-title":"Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20","volume":"106","author":"Ishigaki","year":"2001","journal-title":"Cell"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1093\/emboj\/20.17.4987","article-title":"The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay","volume":"20","author":"Gatfield","year":"2001","journal-title":"EMBO J."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1093\/nar\/gkt1197","article-title":"Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2","volume":"42","author":"Clerici","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0092-8674(81)90396-2","article-title":"Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia","volume":"27","author":"Maquat","year":"1981","journal-title":"Cell"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.molcel.2022.03.032","article-title":"Codon optimality-mediated mRNA degradation: Linking translational elongation to mRNA stability","volume":"82","author":"Bae","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.cell.2015.05.008","article-title":"Widespread Co-translational RNA Decay Reveals Ribosome Dynamics","volume":"161","author":"Pelechano","year":"2015","journal-title":"Cell"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/cr.2016.127","article-title":"Codon optimality and mRNA decay","volume":"26","author":"Harigaya","year":"2016","journal-title":"Cell Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-023-06500-y","article-title":"Pervasive downstream RNA hairpins dynamically dictate start-codon selection","volume":"621","author":"Xiang","year":"2023","journal-title":"Nature"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-018-0258-0","article-title":"The helicase Ded1p controls use of near-cognate translation initiation codons in 5\u2032 UTRs","volume":"559","author":"Guenther","year":"2018","journal-title":"Nature"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuron.2019.09.003","article-title":"CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation","volume":"104","author":"Cheng","year":"2019","journal-title":"Neuron"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-019-1546-z","article-title":"Targeting cardiac fibrosis with engineered T cells","volume":"573","author":"Aghajanian","year":"2019","journal-title":"Nature"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in vivo to treat cardiac injury","volume":"375","author":"Rurik","year":"2022","journal-title":"Science"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41587-024-02393-y","article-title":"Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation","volume":"43","author":"Chen","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ymthe.2022.11.017","article-title":"Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting","volume":"31","author":"Anttila","year":"2023","journal-title":"Mol. Ther."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1702752","article-title":"Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy","volume":"377","author":"Finkel","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nbt.3589","article-title":"Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames","volume":"34","author":"Liang","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Chen, Q., Yu, T., Gong, J., and Shan, H. (2025). Advanced Nanomedicine Delivery Systems for Cardiovascular Diseases: Viral and Non-Viral Strategies in Targeted Therapy. Molecules, 30.","DOI":"10.3390\/molecules30040962"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Philippou, S., Mastroyiannopoulos, N.P., Tomazou, M., Oulas, A., Ackers-Johnson, M., Foo, R.S., Spyrou, G.M., and Phylactou, L.A. (2023). Selective Delivery to Cardiac Muscle Cells Using Cell-Specific Aptamers. Pharm, 16.","DOI":"10.3390\/ph16091264"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Narayan, C., Lin, L.H., Barros, M.N., Gilbert, T.C., Brown, C.R., Reddin, D., London, B., Chen, Y., Wilson, M.E., and Streeter, J. (2024). Identification of In Vivo Internalizing Cardiac-Specific RNA Aptamers. bioRxiv.","DOI":"10.1101\/2024.08.13.607054"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41586-023-06133-1","article-title":"Engineered tRNAs suppress nonsense mutations in cells and in vivo","volume":"618","author":"Albers","year":"2023","journal-title":"Nature"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41587-022-01393-0","article-title":"Engineering circular RNA for enhanced protein production","volume":"41","author":"Chen","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature11508","article-title":"Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat","volume":"491","author":"Carrieri","year":"2012","journal-title":"Nature"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-0716-2010-6_4","article-title":"Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation","volume":"2434","author":"Arnoldi","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"115050","DOI":"10.1016\/j.celrep.2024.115050","article-title":"Ubiquitin-dependent translation control mechanisms: Degradation and beyond","volume":"43","author":"Ford","year":"2024","journal-title":"Cell Rep."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","article-title":"New Insights Into the Role of mTOR Signaling in the Cardiovascular System","volume":"122","author":"Sciarretta","year":"2018","journal-title":"Circ. Res."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/febs.17217","article-title":"Dysregulated ribosome quality control in human diseases","volume":"292","author":"McGirr","year":"2025","journal-title":"FEBS J."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"115371","DOI":"10.1016\/j.celrep.2025.115371","article-title":"RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation","volume":"44","author":"Ford","year":"2025","journal-title":"Cell Rep."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"109468","DOI":"10.1016\/j.celrep.2021.109468","article-title":"The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation","volume":"36","author":"Garzia","year":"2021","journal-title":"Cell Rep."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-662-09889-9_3","article-title":"Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis","volume":"27","author":"Clemens","year":"2001","journal-title":"Prog. Mol. Subcell. Biol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1038\/s41467-021-24215-4","article-title":"Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy","volume":"12","author":"Vanhoutte","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12933-023-02078-x","article-title":"Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B\/GRP78\/PERK signaling pathway","volume":"23","author":"Zhang","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3892\/mmr.2015.3508","article-title":"Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2alpha","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.abb.2014.06.023","article-title":"AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1","volume":"558","author":"Li","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/db12-0533","article-title":"Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes","volume":"62","author":"He","year":"2013","journal-title":"Diabetes"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1463-1326.2010.01336.x","article-title":"Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines","volume":"13","author":"Xie","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"e005418","DOI":"10.1161\/CIRCHEARTFAILURE.118.005418","article-title":"Metformin Enhances Autophagy and Provides Cardioprotection in delta-Sarcoglycan Deficiency-Induced Dilated Cardiomyopathy","volume":"12","author":"Kanamori","year":"2019","journal-title":"Circ. Heart Fail."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/CIRCULATIONAHA.123.067606","article-title":"IRE1alpha Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts","volume":"150","author":"Li","year":"2024","journal-title":"Circulation"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/7863\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:38Z","timestamp":1760034458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/7863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,14]]},"references-count":260,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ijms26167863"],"URL":"https:\/\/doi.org\/10.3390\/ijms26167863","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,14]]}}}