{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:33:40Z","timestamp":1790037220872,"version":"4.0.1"},"reference-count":87,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Foundation","award":["24\u201345-00071"],"award-info":[{"award-number":["24\u201345-00071"]}]},{"name":"Russian Science Foundation","award":["82361138563"],"award-info":[{"award-number":["82361138563"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24\u201345-00071"],"award-info":[{"award-number":["24\u201345-00071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82361138563"],"award-info":[{"award-number":["82361138563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A wide range of water-soluble quaternary ammonium acylhydrazones based on catecholaldehyde were synthesized and characterized using NMR, IR spectroscopy, and elemental analysis. The total antioxidant capacity of the acylhydrazones discussed herein was estimated via coulometric titration with electrogenerated bromine. Pyridinium derivatives 11a\u2013e exhibited the highest antioxidant capacity. Quaternary ammonium acylhydrazones demonstrated high antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus strains. Furthermore, low hemo- and cytotoxicity and the absence of a negative effect on the hemostatic system were confirmed for the studied compounds. According to the results of a CV test, the antimicrobial effect of the most active acylhydrazones, namely, 9a, 10b, 10c, and 11a, is associated with the destruction of the bacterial cell wall. High or moderate activity against phytopathogens of bacterial origin was observed for all the acylhydrazones evaluated. Anti-aggregation activity was observed for compound 10b; the extent was 1.6-fold greater than that exhibited by acetylsalicylic acid. On the contrary, compound 9d exhibited a pro-aggregant effect (with a 6.3% increase in platelet aggregation and a &gt;15% decrease in the latent period compared to the control). Thus, the data obtained can be considered the basis for further pharmaceutical development of these effective drugs with antithrombotic and hemostatic potential.<\/jats:p>","DOI":"10.3390\/ijms26167866","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T15:44:21Z","timestamp":1755186261000},"page":"7866","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ammonium Catecholaldehydes as Multifunctional Bioactive Agents: Evaluating Antimicrobial, Antioxidant, and Antiplatelet Activity"],"prefix":"10.3390","volume":"26","author":[{"given":"Andrei V.","family":"Bogdanov","sequence":"first","affiliation":[{"name":"Department of High Molecular and Organoelement Compounds, Analytical Chemistry Department, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza G.","family":"Tagasheva","sequence":"additional","affiliation":[{"name":"Department of Technology of Basic Organic and Petrochemical Synthesis, Kazan National Research Technological University, K. Marx Str. 68, Kazan 420015, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Voloshina","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2816-8142","authenticated-orcid":false,"given":"Anna","family":"Lyubina","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. 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Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Petrovka St. 25\/2, Moscow 107031, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hangzhou Normal University, Yuhangtan, 2318, Hangzhou 310030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-499X","authenticated-orcid":false,"given":"Aleksandr V.","family":"Samorodov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Bashkir State Medical University, Lenin St. 3, Ufa 450008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-2813","authenticated-orcid":false,"given":"Guzel K.","family":"Ziyatdinova","sequence":"additional","affiliation":[{"name":"Department of High Molecular and Organoelement Compounds, Analytical Chemistry Department, Kazan Federal University, Kremlevskaya Str. 18, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnara R.","family":"Zhiganshina","sequence":"additional","affiliation":[{"name":"G. 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