{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:51:29Z","timestamp":1790826689649,"version":"4.1.0"},"reference-count":91,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Spinal cord injuries are often devastating and result in severe functional limitations. Our review breaks down the pathophysiology, molecular mechanisms, and omics approaches regarding spinal cord injuries. The pathophysiology can be divided into two main phases, with the secondary phase being of greater interest. Understanding the underlying mechanisms behind these phases allows for targeted approaches to be developed. Advancements in omics technologies (genomics, epigenomics, transcriptomics, proteomics, and metabolomics) are excellent tools in creating tailored spinal cord injury treatment plans. Emerging therapeutic solutions involving ion imbalance, oxidative stress, and mitochondrial dysfunction also show promising results. Mitochondrial transplantation has shown promising initial results in maintaining cellular homeostasis and reducing inflammation. However, significant challenges remain in translating the omics and therapeutic approaches from animal models to clinical trials.<\/jats:p>","DOI":"10.3390\/ijms26167895","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T16:09:55Z","timestamp":1755274195000},"page":"7895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Review of Pathophysiology, Molecular Mechanisms, and Omics Approaches of Spinal Cord Injury"],"prefix":"10.3390","volume":"26","author":[{"given":"Milan","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1477-2072","authenticated-orcid":false,"given":"Alison J.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Hasoon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed","family":"Wahezi","sequence":"additional","affiliation":[{"name":"Departments of Rehabilitation Medicine, Anesthesiology, and Orthopedic Surgery, Montefiore Medical Center, Bronx, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Abd-Elsayed","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref_1","unstructured":"National Institute of Neurological Disorders and Stroke (2025, June 16). Spinal Cord Injury, Available online: https:\/\/www.ninds.nih.gov\/health-information\/disorders\/spinal-cord-injury."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3171\/2018.10.SPINE18802","article-title":"Neurological recovery following traumatic spinal cord injury: A systematic review and meta-analysis","volume":"30","author":"Khorasanizadeh","year":"2019","journal-title":"J. Neurosurg. Spine"},{"key":"ref_3","unstructured":"World Health Organization (2024). Spinal Cord Injury, World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/spinal-cord-injury#:~:text=Scope%20of%20the%20problem,YLDs%20attributed%20to%20this%20demographic."},{"key":"ref_4","unstructured":"GBD Spinal Cord Injuries Collaborators (2023). Global, regional, and national burden of spinal cord injury, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol., 22, 1026\u20131047."},{"key":"ref_5","unstructured":"(2017). pinal Cord Injury Facts and Figures at a Glance, National Spinal Cord Injury Statistical Center. Available online: http:\/\/msktc.org\/sites\/default\/files\/lib\/docs\/Data_Sheets_\/SCIMS_Facts_and_Figures_2017_August_FINAL.pdf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/13669877.2012.713388","article-title":"Romantic motives and risk-taking: An evolutionary approach","volume":"16","author":"Greitemeyer","year":"2012","journal-title":"J. Risk Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/1363849031000095279","article-title":"Estrogen and progesterone as neuroprotective agents in the treatment of acute brain injuries","volume":"6","author":"Stein","year":"2003","journal-title":"Pediatr. Rehabil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/089771501750451811","article-title":"Neuropathological Protection after Traumatic Brain Injury in Intact Female Rats Versus Males or Ovariectomized Females","volume":"18","author":"Bramlett","year":"2004","journal-title":"J. Neurotrauma"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lima, R., Monteiro, A., Salgado, A.J., Monteiro, S., and Silva, N.A. (2022). Pathophysiology and Therapeutic Approaches for Spinal Cord Injury. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232213833"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/FOC.2008.25.11.E2","article-title":"Current status of acute spinal cord injury pathophysiology and emerging therapies: Promise on the horizon","volume":"25","author":"Rowland","year":"2008","journal-title":"Neurosurg. Focus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101742","DOI":"10.1016\/j.xcrm.2024.101742","article-title":"The impact of multi-omics in medicine","volume":"5","author":"Wang","year":"2024","journal-title":"Cell Rep. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Peng, R., Zhang, L., Xie, Y., Guo, S., Cao, X., and Yang, M. (2024). Spatial multi-omics analysis of the microenvironment in traumatic spinal cord injury: A narrative review. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1432841"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/10790268.2016.1210925","article-title":"Spinal Cord Injury (SCI) 2016 Facts and Figures at a Glance","volume":"39","author":"Newland","year":"2016","journal-title":"J. Spinal Cord. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Anjum, A., Yazid, M.D., Daud, M.F., Idris, J., Ng, A.M.H., Naicker, A.S., Ismail, O.H.R., Kumar, R.K.A., and Lokanathan, Y. (2020). Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207533"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Weidner, N., Rupp, R., and Tansey, K. (2017). Pathophysiology of Traumatic Spinal Cord Injury. Neurological Aspects of Spinal Cord Injury, Springer.","DOI":"10.1007\/978-3-319-46293-6"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1089\/0897715041269641","article-title":"The role of excitotoxicity in secondary mechanisms of spinal cord injury: A review with an emphasis on the implications for white matter degeneration","volume":"21","author":"Park","year":"2004","journal-title":"J. Neurotrauma"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10863-015-9600-5","article-title":"Lipid peroxidation in brain or spinal cord mitochondria after injury","volume":"48","author":"Hall","year":"2016","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: A review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e70184","DOI":"10.1002\/mco2.70184","article-title":"Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets","volume":"6","author":"Yang","year":"2025","journal-title":"MedComm"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2856213","DOI":"10.1155\/2016\/2856213","article-title":"The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is \u201cInflammation\u201d Always Inflammation?","volume":"2016","author":"Kulkarni","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuropharm.2007.10.003","article-title":"Dendritic and Mitochondrial Changes During Glutamate Excitotoxicity","volume":"53","author":"Greenwood","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kritis, A., Stamoula, E.G., Paniskaki, K.A., and Vavilis, T.D. (2015). Researching Glutamate\u2014Induced Cytotoxicity in Different Cell Lines: A Comparative\/Collective Analysis\/Study. Front. Cell. Neurosci., 9, Available online: https:\/\/www.frontiersin.org\/journals\/cellular-neuroscience\/articles\/10.3389\/fncel.2015.00091\/full.","DOI":"10.3389\/fncel.2015.00091"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"360438","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s10522-017-9710-z","article-title":"Lipid (per) oxidation in mitochondria: An emerging target in the ageing process?","volume":"18","author":"Ademowo","year":"2017","journal-title":"Biogerontology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.bbabio.2012.02.028","article-title":"Effect of mtDNA Point Mutations on Cellular Bioenergetics","volume":"1817","author":"Szczepanowska","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA) Bioenerg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbrc.2016.11.088","article-title":"The Role of Mitochondria in Metabolism and Cell Death","volume":"482","author":"Ouchida","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cant\u00f3-Santos, J., Grau-Junyent, J.M., and Garrabou, G. (2020). The Impact of Mitochondrial Deficiencies in Neuromuscular Diseases. Antioxidants, 9.","DOI":"10.3390\/antiox9100964"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e12992","DOI":"10.1111\/cpr.12992","article-title":"Programmed cell death in spinal cord injury pathogenesis and therapy","volume":"54","author":"Shi","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/sj.sc.3101483","article-title":"Post-traumatic inflammation following spinal cord injury","volume":"41","author":"Hausmann","year":"2003","journal-title":"Spinal Cord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<798::AID-JNR16>3.0.CO;2-Y","article-title":"Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats","volume":"50","author":"Shuman","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1523\/JNEUROSCI.17-14-05395.1997","article-title":"Neuronal and glial apoptosis after traumatic spinal cord injury","volume":"17","author":"Liu","year":"1997","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"MMoura, M.M., Monteiro, A., Salgado, A.J., Silva, N.A., and Monteiro, S. (2024). Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation. Neurobiol. Dis., 195.","DOI":"10.1016\/j.nbd.2024.106500"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Elmalky, M.I., Alvarez-Bolado, G., Younsi, A., and Skutella, T. (2024). Axonal Regeneration after Spinal Cord Injury: Molecular Mechanisms, Regulatory Pathways, and Novel Strategies. Biology, 13.","DOI":"10.3390\/biology13090703"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1385\/CRIAI:28:3:197","article-title":"Role of IL-6 in spinal cord injury in a mouse model","volume":"28","author":"Nakamura","year":"2005","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Patel, M., Wahezi, S., Mavrocordatos, P., and Abd-Elsayed, A. (2025). The Effects and Mechanisms of Phytochemicals on Pain Management and Analgesic. Nutrients, 17.","DOI":"10.3390\/nu17040633"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and Central Sensitization in Chronic and Widespread Pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Patilas, C., Varsamos, I., Galanis, A., Vavourakis, M., Zachariou, D., Marougklianis, V., Kolovos, I., Tsalimas, G., Karampinas, P., and Kaspiris, A. (2024). The Role of Interleukin-10 in the Pathogenesis and Treatment of a Spinal Cord Injury. Diagnostics, 14.","DOI":"10.3390\/diagnostics14020151"},{"key":"ref_38","unstructured":"Jewett, B.E., and Thapa, B. (2025, July 12). Physiology, NMDA Receptor, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519495\/."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/s13287-024-04077-5","article-title":"Mechanism and prospects of mitochondrial transplantation for spinal cord injury treatment","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref_40","first-page":"804","article-title":"Ketamine for acute neuropathic pain in patients with spinal cord injury","volume":"20","author":"Kim","year":"2013","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.4238\/2015.April.17.4","article-title":"Neuroprotective effect of ketamine on acute spinal cord injury in rats","volume":"14","author":"Tang","year":"2015","journal-title":"Genet. Mol. Res. GMR"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/jnr.25221","article-title":"Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets","volume":"101","author":"Yu","year":"2023","journal-title":"J. Neurosci. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Juan, C.A., de la Lastra, J.M.P., Plou, F.J., and P\u00e9rez-Lebe\u00f1a, E. (2021). The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094642"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1038\/s41467-019-11707-7","article-title":"Moving beyond the glial scar for spinal cord repair","volume":"10","author":"Bradbury","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4103\/1673-5374.187022","article-title":"Reactive astrocyte scar and axon regeneration: Suppressor or facilitator?","volume":"11","author":"Li","year":"2016","journal-title":"Neural Regen. Res."},{"key":"ref_46","unstructured":"Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, Board on Health Care Services, Board on Health Sciences Policy, Institute of Medicine, Micheel, C.M., Nass, S.J., and Omenn, G.S. (2025, July 12). 2. Omics-Based Clinical Discovery: Science, Technology, and Applications, Evolution of Translational Omics: Lessons Learned and the Path Forward, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK202165\/."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6001\/actamedica.v24i1.3457","article-title":"The most common technologies and tools for functional genome analysis","volume":"24","author":"Gasperskaja","year":"2017","journal-title":"Acta Medica Litu."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hasin, Y., Seldin, M., and Lusis, A. (2017). Multi-omics approaches to disease. Genome Biol., 18.","DOI":"10.1186\/s13059-017-1215-1"},{"key":"ref_49","unstructured":"Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P. (2025, June 20). From DNA to RNA, Molecular Biology of the Cell, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK26887\/."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.15698\/cst2018.07.145","article-title":"Epigenetic mechanisms behind cellular sensitivity to DNA damage","volume":"2","author":"Williamson","year":"2018","journal-title":"Cell Stress"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human Transcription Factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.4103\/1673-5374.276323","article-title":"Decoding epigenetic codes: New frontiers in exploring recovery from spinal cord injury","volume":"15","author":"Chang","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Mun, S., Han, K., and Hyun, J.K. (2022). The Time Sequence of Gene Expression Changes after Spinal Cord Injury. Cells, 11.","DOI":"10.3390\/cells11142236"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s12035-014-8681-1","article-title":"Endoplasmic reticulum protein 29 protects cortical neurons from apoptosis and promoting corticospinal tract regeneration to improve neural behavior via caspase and Erk signal in rats with spinal cord transection","volume":"50","author":"Liu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_55","unstructured":"(2025, June 23). Available online: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11811828\/."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100096","DOI":"10.1016\/j.mcpro.2021.100096","article-title":"Proteomic Portraits Reveal Evolutionarily Conserved and Divergent Responses to Spinal Cord Injury","volume":"20","author":"Skinnider","year":"2021","journal-title":"Mol. Cell. Proteom. MCP"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12031-021-01903-w","article-title":"Parallel Metabolomic Profiling of Cerebrospinal Fluid, Plasma, and Spinal Cord to Identify Biomarkers for Spinal Cord Injury","volume":"72","author":"Yang","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zeng, Z., Li, M., Jiang, Z., Lan, Y., Chen, L., Chen, Y., Li, H., Hui, J., Zhang, L., and Hu, X. (2022). Integrated transcriptomic and metabolomic profiling reveals dysregulation of purine metabolism during the acute phase of spinal cord injury in rats. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.1066528"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1073\/pnas.0500307102","article-title":"Uric acid protects against secondary damage after spinal cord injury","volume":"102","author":"Scott","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","first-page":"245","article-title":"Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: Improved behavioral and neuroanatomical recovery with riluzole","volume":"94","author":"Schwartz","year":"2001","journal-title":"J. Neurosurg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11916-013-0359-2","article-title":"Update on Neuropathic Pain Treatment: Ion Channel Blockers and Gabapentinoids","volume":"17","author":"Chen","year":"2013","journal-title":"Curr. Pain. Headache Rep."},{"key":"ref_62","unstructured":"Dokken, K., Chen, R.J., and Fairley, P. (2025, July 24). Sodium Channel Blocker Toxicity, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534844\/."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1089\/neu.2015.3963","article-title":"Methylprednisolone for the Treatment of Patients with Acute Spinal Cord Injuries: A Propensity Score-Matched Cohort Study from a Canadian Multi-Center Spinal Cord Injury Registry","volume":"32","author":"Evaniew","year":"2015","journal-title":"J. Neurotrauma"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.wneu.2021.02.116","article-title":"Updated Review: The Steroid Controversy for Management of Spinal Cord Injury","volume":"150","author":"Canseco","year":"2021","journal-title":"World Neurosurg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e467","DOI":"10.1016\/j.wneu.2018.09.239","article-title":"Steroids in Acute Spinal Cord Injury: All But Gone Within 5 Years","volume":"122","author":"Janusz","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e004587","DOI":"10.1136\/bmjopen-2013-004587","article-title":"Corticosteroids and risk of gastrointestinal bleeding: A systematic review and meta-analysis","volume":"4","author":"Narum","year":"2014","journal-title":"BMJ Open"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.rdc.2015.08.004","article-title":"Infection Risk and Safety of Corticosteroid Use","volume":"42","author":"Youssef","year":"2016","journal-title":"Rheum. Dis. Clin. N. Am."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1471-4159.2010.06749.x","article-title":"Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals","volume":"114","author":"Mustafa","year":"2010","journal-title":"J. Neurochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/exnr.1996.0154","article-title":"Glucocorticoids increase the accumulation of reactive oxygen species and enhance adriamycin-induced toxicity in neuronal culture","volume":"141","author":"McIntosh","year":"1996","journal-title":"Exp. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/01.RES.0000050588.35034.3C","article-title":"Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction","volume":"92","author":"Iuchi","year":"2003","journal-title":"Circ. Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3164\/jcbn.10-58","article-title":"Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats","volume":"47","author":"Sato","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1089\/neu.2009.1172","article-title":"Lipid peroxidation-derived reactive aldehydes directly and differentially impair spinal cord and brain mitochondrial function","volume":"27","author":"Vaishnav","year":"2010","journal-title":"J. Neurotrauma"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-079X.2009.00703.x","article-title":"Therapeutic potential of melatonin in traumatic central nervous system injury","volume":"47","author":"Samantaray","year":"2009","journal-title":"J. Pineal Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"H94","DOI":"10.1152\/ajpheart.00567.2008","article-title":"Injection of isolated mitochondria during early reperfusion for cardioprotection","volume":"296","author":"McCully","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_75","first-page":"e00355","article-title":"Mitochondrial transplantation exhibits neuroprotective effects and improves behavioral deficits in an animal model of Parkinson\u2019s disease","volume":"21","author":"Eo","year":"2024","journal-title":"Neurother. J. Am. Soc. Exp. Neurother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mito.2017.05.007","article-title":"Prospects for therapeutic mitochondrial transplantation","volume":"35","author":"Gollihue","year":"2017","journal-title":"Mitochondrion"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1089\/neu.2017.5605","article-title":"Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury","volume":"35","author":"Gollihue","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_78","unstructured":"Donnally, C.J., Hanna, A., and Odom, C.K. (2025, June 13). Cervical Myelopathy, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482312\/."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5144\/0256-4947.2017.130","article-title":"Myelopathy associated with age-related cervical disc herniation: A retrospective review of magnetic resonance images","volume":"37","author":"AlRyalat","year":"2017","journal-title":"Ann. Saudi Med."},{"key":"ref_80","first-page":"619","article-title":"Degenerative cervical myelopathy: Diagnosis and management in primary care","volume":"65","author":"Milligan","year":"2019","journal-title":"Can. Fam. Physician"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"bcr2013202793","DOI":"10.1136\/bcr-2013-202793","article-title":"Spinal cord infarction: A rare cause of paraplegia","volume":"2014","author":"Patel","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3340\/jkns.2008.43.2.114","article-title":"Paraplegia due to Spinal Cord Infarction After Lifting Heavy Objects","volume":"434","author":"Lee","year":"2008","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1007\/s00586-010-1427-5","article-title":"C5 palsy following anterior decompression and spinal fusion for cervical degenerative diseases","volume":"19","author":"Hashimoto","year":"2010","journal-title":"Eur. Spine J. Off. Publ. Eur. Spine Soc. Eur. Spinal Deform. Soc. Eur. Sect. Cerv. Spine Res. Soc."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Fang, M., Zhou, J., Zeng, Y., Huang, S., and Song, Y. (2022). Conversion Paralysis After Cervical Surgery: A Case Report and Literature Review. Front. Surg., 9, Available online: https:\/\/www.frontiersin.org\/journals\/surgery\/articles\/10.3389\/fsurg.2022.814498\/full.","DOI":"10.3389\/fsurg.2022.814498"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"23","DOI":"10.46292\/sci23-00044S","article-title":"Challenges in Translating Regenerative Therapies for Spinal Cord Injury","volume":"29","author":"Stewart","year":"2023","journal-title":"Top. Spinal Cord. Inj. Rehabil."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.gpb.2023.01.002","article-title":"Artificial Intelligence in Omics","volume":"20","author":"Gao","year":"2022","journal-title":"Genom. Proteom. Bioinform."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/procel\/pwad003","article-title":"Recent progress and challenges in the treatment of spinal cord injury","volume":"14","author":"Tian","year":"2023","journal-title":"Protein Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1515\/REVNEURO.2008.19.1.47","article-title":"Animal models in spinal cord injury: A review","volume":"19","author":"Akhtar","year":"2008","journal-title":"Rev. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/s41393-020-0477-8","article-title":"\u201cTime is spine\u201d: The importance of early intervention for traumatic spinal cord injury","volume":"58","author":"Ahuja","year":"2020","journal-title":"Spinal Cord."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Li, M.-Q., Wang, Q.H., Dong, C.M., and Qi, L.J. (2025). Spinal Cord Injury Models: Advantages and Disadvantages in the View of Pathophysiology and Clinical Significance. Biochem. Biophys. Rep., 42, Available online: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2405580825001505.","DOI":"10.1016\/j.bbrep.2025.102063"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jpain.2013.06.008","article-title":"An overview of animal models of pain: Disease models and outcome measures","volume":"14","author":"Gregory","year":"2013","journal-title":"J. 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