{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:32:25Z","timestamp":1788492745490,"version":"build-2803163510"},"reference-count":55,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Funda\u00e7\u00e3o Arauc\u00e1ria\u2014NAPI"},{"name":"State University of Maring\u00e1 (UEM)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Evidence supporting the clinical use of neuroprotective drugs for cerebral ischemia remains limited. Spatial and temporal disorientation, along with cognitive dysfunction, are among the most prominent long-term consequences of hippocampal neurodegeneration following cerebral ischemia. Cannabigerol (CBG), a non-psychotomimetic constituent of Cannabis sativa, has demonstrated neuroprotective effects in experimental models of cerebral injury. This study investigated the neuroprotective mechanisms of CBG in mitigating memory impairments caused by transient global cerebral ischemia in C57BL\/6 mice using the bilateral common carotid artery occlusion (BCCAO) model. Mice underwent sham or BCCAO surgeries and received intraperitoneal (i.p.) injections of either a vehicle or CBG (1, 5, or 10 mg\/Kg), starting 1 h post-surgery and continuing daily for 7 days. Spatial memory performance and depression-like behaviors were assessed using the object location test (OLT) and tail suspension test (TST), respectively. Additional analyses examined neuronal degeneration, neuroinflammation, and neuronal plasticity markers in the hippocampus. CBG attenuated ischemia-induced memory deficits, reduced neuronal loss in the hippocampus, and enhanced neuronal plasticity. These findings suggest that CBG\u2019s neuroprotective effects against BCCAO-induced memory impairments may be mediated by reductions in neuroinflammation and modifications in neuroplasticity within the hippocampus.<\/jats:p>","DOI":"10.3390\/ijms26168056","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T08:02:44Z","timestamp":1755763364000},"page":"8056","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cannabigerol Attenuates Memory Impairments, Neurodegeneration, and Neuroinflammation Caused by Transient Global Cerebral Ischemia in Mice"],"prefix":"10.3390","volume":"26","author":[{"given":"Nathalia Akemi Neves","family":"Kohara","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Av. Colombo, 5790, Maring\u00e1 87020-900, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Guilherme Pinhatti","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Av. Colombo, 5790, Maring\u00e1 87020-900, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Fernando Fernandes","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Av. Colombo, 5790, Maring\u00e1 87020-900, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Pompeu","family":"Quini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Av. Colombo, 5790, Maring\u00e1 87020-900, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Del Bel","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Basic and Oral Biology, School of Medicine, University of S\u00e3o Paulo, Av. Bandeirantes, Ribeir\u00e3o Preto 14015-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-8317","authenticated-orcid":false,"given":"Humberto","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, State University of Maring\u00e1, Av. 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