{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:12:41Z","timestamp":1789240361714,"version":"build-2803163510"},"reference-count":205,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SIMDO (Societa\u2019 Italiana Metabolismo Diabete E Obesita\u2019)","award":["Tonolo24"],"award-info":[{"award-number":["Tonolo24"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In humans, taurine (TAU) is a conditionally essential nutrient that exhibits pleiotropic activity in several and different biological processes suggesting its use in the prevention and therapy for a long time. However, its actual role in prevention and treatment is still incomplete and unclear. This review focuses on the potential therapeutic effect of TAU in genetic diseases, cardiovascular diseases (heart failure, hypertension), metabolic syndrome, and on the first pandemic of the third millennium, namely, diabetes mellitus and some gestational diseases such as gestational diabetes, intrauterine growth restriction, and pre-eclampsia, discussing the role of TAU in developmental trajectory. Previous preclinical and clinical TAU investigations predominately enrolled male animals, including humans, even though sex and gender differences play a critical role both in numerous physiological and pathological conditions. This review aims to outline some biological actions of TAU and evidences the sex and gender gap must be reduced in order to establish the role of TAU in prevention and therapy for all individuals.<\/jats:p>","DOI":"10.3390\/ijms26168097","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:41:45Z","timestamp":1755848505000},"page":"8097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Do Sex and Gender Interact with the Biological Actions of Taurine? A Critical Rereading of the Literature"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-4455","authenticated-orcid":false,"given":"Giuseppe","family":"Seghieri","sequence":"first","affiliation":[{"name":"Scienze Biomediche, Sperimentali e Cliniche, Universit\u00e0 di Firenze, 50121 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1681-6448","authenticated-orcid":false,"given":"Ilaria","family":"Campesi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Universit\u00e0 degli Studi di Sassari, 07100 Sassari, Italy"},{"name":"Laboratorio Nazionale di Farmacologia e Medicina di Genere, Instituto Nazionale Biostrutture Biosistemi, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Tonolo","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Diabetologia della Asl Gallura, 07026 Olbia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bennardini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Farmacia, Universit\u00e0 degli Studi di Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Stendardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Universit\u00e0 di Firenze, 50121 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Matucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Universit\u00e0 di Firenze, 50121 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-0273","authenticated-orcid":false,"given":"Flavia","family":"Franconi","sequence":"additional","affiliation":[{"name":"Laboratorio Nazionale di Farmacologia e Medicina di Genere, Instituto Nazionale Biostrutture Biosistemi, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Santulli, G., Kansakar, U., Varzideh, F., Mone, P., Jankauskas, S.S., and Lombardi, A. (2023). Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview. Nutrients, 15.","DOI":"10.3390\/nu15194236"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/978-94-024-1079-2_88","article-title":"The Taurine Content of Japanese Seaweed","volume":"975","author":"Kawasaki","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","unstructured":"(2024, October 22). Taurine Uses, Benefits & Dosage\u2014Drugs.Com Herbal Database. Available online: https:\/\/www.drugs.com\/npp\/taurine.html."},{"key":"ref_4","unstructured":"Grand View Research (2023). Taurine Supplements Market Size and Share Report, 2030, Grand View Research."},{"key":"ref_5","unstructured":"Statista (2024). Adults in the U.S. Taking Dietary Supplements by Gender 2020, Statista."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/dmrr.229","article-title":"The Role of Taurine in Diabetes and the Development of Diabetic Complications","volume":"17","author":"Hansen","year":"2001","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jphs.2023.12.006","article-title":"Taurine Deficiency Associated with Dilated Cardiomyopathy and Aging","volume":"154","author":"Ito","year":"2024","journal-title":"J. Pharmacol. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Qaradakhi, T., Gadanec, L.K., McSweeney, K.R., Abraham, J.R., Apostolopoulos, V., and Zulli, A. (2020). The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease. Nutrients, 12.","DOI":"10.3390\/nu12092847"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"173533","DOI":"10.1016\/j.ejphar.2020.173533","article-title":"The Effects of Taurine Supplementation on Obesity, Blood Pressure and Lipid Profile: A Meta-Analysis of Randomized Controlled Trials","volume":"885","author":"Guan","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/ajcn\/61.5.1115","article-title":"Plasma and Platelet Taurine Are Reduced in Subjects with Insulin-Dependent Diabetes Mellitus: Effects of Taurine Supplementation","volume":"61","author":"Franconi","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1440-2440(00)80038-9","article-title":"Gender Differences in Metabolism; Nutrition and Supplements","volume":"3","author":"Tarnopolsky","year":"2000","journal-title":"J. Sci. Med. Sport"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2011.02.001","article-title":"Nutrition and Human Health from a Sex-Gender Perspective","volume":"32","author":"Marino","year":"2011","journal-title":"Mol. Asp. Med."},{"key":"ref_13","first-page":"91","article-title":"Lifelong Gender Health Programming in Fetal Life","volume":"4","author":"Minucci","year":"2018","journal-title":"Ital. J. Gend. Specif. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.genm.2008.03.012","article-title":"Sex Differences in the Fetal Programming of Hypertension","volume":"5","author":"Grigore","year":"2008","journal-title":"Gend. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2459\/JCM.0000000000000315","article-title":"Arterial Hypertension in the Female World: Pathophysiology and Therapy","volume":"17","author":"Cadeddu","year":"2016","journal-title":"J. Cardiovasc. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/eurheartj\/ehv598","article-title":"Gender in Cardiovascular Diseases: Impact on Clinical Manifestations, Management, and Outcomes","volume":"37","author":"Prescott","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2174\/1573399812666160517115756","article-title":"The Effect of Sex and Gender on Diabetic Complications","volume":"13","author":"Seghieri","year":"2017","journal-title":"Curr. Diabetes Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/cvr\/cvx066","article-title":"Sex in Basic Research: Concepts in the Cardiovascular Field","volume":"113","author":"Dworatzek","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jphs.2023.11.003","article-title":"Identification of a Novel Enzyme and the Regulation of Key Enzymes in Mammalian Taurine Synthesis","volume":"154","author":"Miyazaki","year":"2024","journal-title":"J. Pharmacol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"G295","DOI":"10.1152\/ajpgi.00076.2022","article-title":"Testosterone Enhances Taurine Synthesis by Upregulating Androgen Receptor and Cysteine Sulfinic Acid Decarboxylase Expressions in Male Mouse Liver","volume":"324","author":"Zhang","year":"2023","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"G277","DOI":"10.1152\/ajpgi.00107.2014","article-title":"Estradiol Decreases Taurine Level by Reducing Cysteine Sulfinic Acid Decarboxylase via the Estrogen Receptor-\u03b1 in Female Mice Liver","volume":"308","author":"Ma","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2538S","DOI":"10.1093\/jn\/nxaa254","article-title":"Metabolic Consequences of Supplemented Methionine in a Clinical Context","volume":"150","author":"Engelen","year":"2020","journal-title":"J. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.etp.2012.05.004","article-title":"Glutamyl Cycle in the Rat Liver Appears to Be Sex-Gender Specific","volume":"65","author":"Campesi","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"eabn9257","DOI":"10.1126\/science.abn9257","article-title":"Taurine Deficiency as a Driver of Aging","volume":"380","author":"Singh","year":"2023","journal-title":"Science"},{"key":"ref_25","first-page":"246","article-title":"Taurine in Congestive Heart Failure","volume":"8","author":"Ahmad","year":"2021","journal-title":"Int. J. Clin. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00726-020-02823-6","article-title":"Important Roles of Dietary Taurine, Creatine, Carnosine, Anserine and 4-Hydroxyproline in Human Nutrition and Health","volume":"52","author":"Wu","year":"2020","journal-title":"Amino Acids"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.3892\/mmr.2020.11321","article-title":"Significance of Taurine Transporter (TauT) in Homeostasis and Its Layers of Regulation","volume":"22","author":"Baliou","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1021\/acs.jproteome.8b00915","article-title":"Metabolomic Profiling of Aqueous Humor in Glaucoma Points to Taurine and Spermine Deficiency: Findings from the Eye-D Study","volume":"18","author":"Buisset","year":"2019","journal-title":"J. Proteome Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Liu, F.C., Cheng, M.L., Lo, C.J., Hsu, W.C., Lin, G., and Lin, H.T. (2023). Exploring the Aging Process of Cognitively Healthy Adults by Analyzing Cerebrospinal Fluid Metabolomics Using Liquid Chromatography-Tandem Mass Spectrometry. BMC Geriatr., 23.","DOI":"10.1186\/s12877-023-03939-6"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.aca.2018.04.002","article-title":"A Global HILIC-MS Approach to Measure Polar Human Cerebrospinal Fluid Metabolome: Exploring Gender-Associated Variation in a Cohort of Elderly Cognitively Healthy Subjects","volume":"1037","author":"Konz","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1046\/j.1471-4159.1995.65062652.x","article-title":"Gamma-Glutamylglutamine and Taurine Concentrations Are Decreased in the Cerebrospinal Fluid of Drug-Naive Patients with Schizophrenic Disorders","volume":"65","author":"Do","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_32","first-page":"497","article-title":"Regular Cigarette Smoking Influences the Transsulfuration Pathway, Endothelial Function, and Inflammation Biomarkers in a Sex-Gender Specific Manner in Healthy Young Humans","volume":"5","author":"Campesi","year":"2013","journal-title":"Am. J. Transl. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.2337\/dc07-0872","article-title":"Taurine Intestinal Absorption and Renal Excretion Test in Diabetic Patients: A Pilot Study","volume":"30","author":"Merheb","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1007\/s00726-011-0968-1","article-title":"Taurine Transporter Gene Expression in Peripheral Mononuclear Blood Cells of Type 2 Diabetic Patients","volume":"42","author":"Bianchi","year":"2012","journal-title":"Amino Acids"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7313162","DOI":"10.1155\/2016\/7313162","article-title":"Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients","volume":"2016","author":"Napoli","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sak, D., Erdenen, F., M\u00fcderrisoglu, C., Altunoglu, E., Sozer, V., Gungel, H., Guler, P.A., Sak, T., and Uzun, H. (2019). The Relationship between Plasma Taurine Levels and Diabetic Complications in Patients with Type 2 Diabetes Mellitus. Biomolecules, 9.","DOI":"10.3390\/biom9030096"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Khoramjoo, M., Wang, K., Srinivasan, K., Gheblawi, M., Mandal, R., Rousseau, S., Wishart, D., Prasad, V., Richer, L., and Cheung, A.M. (2024). Plasma Taurine Level Is Linked to Symptom Burden and Clinical Outcomes in Post-COVID Condition. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0304522"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e15159","DOI":"10.1111\/exd.15159","article-title":"Metabolic Profiling of Psoriasis Vulgaris and Palmoplantar Pustulosis","volume":"33","author":"Lee","year":"2024","journal-title":"Exp. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1515\/cclm-2011-0846","article-title":"Age-Related Changes in Serum Amino Acids Concentrations in Healthy Individuals","volume":"50","author":"Kouchiwa","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Li, N., Li, J., Wang, H., Qiao, Y., Li, W., Gao, M., Liu, E., Yu, Z., Hu, G., and Fang, Z. (2023). Serum Sulfur-Containing Amino Acids and Risk of Maternal Gestational Diabetes and Adverse Growth Patterns in Offspring. Nutrients, 15.","DOI":"10.3390\/nu15184089"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, J., Wang, Y., Zheng, W., Yuan, X., Liu, C., Zhang, Y., Song, W., Wang, X., Liang, S., and Ma, X. (2023). Dynamic Changes of Serum Taurine and the Association with Gestational Diabetes Mellitus: A Nested Case-Control Study. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1116044"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.diabres.2006.08.008","article-title":"Taurine in Women with a History of Gestational Diabetes","volume":"76","author":"Seghieri","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Sun, S., He, D., Luo, C., Lin, X., Wu, J., Yin, X., Jia, C., Pan, Q., Dong, X., and Zheng, F. (2022). Metabolic Syndrome and Its Components Are Associated with Altered Amino Acid Profile in Chinese Han Population. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.795044"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Spanou, L., Dimou, A., Kostara, C.E., Bairaktari, E., Anastasiou, E., and Tsimihodimos, V. (2022). A Study of the Metabolic Pathways Affected by Gestational Diabetes Mellitus: Comparison with Type 2 Diabetes. Diagnostics, 12.","DOI":"10.3390\/diagnostics12112881"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"606","DOI":"10.4103\/1673-5374.380820","article-title":"Taurine: A Promising Nutraceutic in the Prevention of Retinal Degeneration","volume":"19","author":"Picaud","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-1097(03)00611-6","article-title":"Taurine: New Implications for an Old Amino Acid","volume":"226","author":"Park","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Jong, C.J., Sandal, P., and Schaffer, S.W. (2021). The Role of Taurine in Mitochondria Health: More than Just an Antioxidant. Molecules, 26.","DOI":"10.3390\/molecules26164913"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhao, P., Qi, Y., Zhao, P., and Qi, Y. (2025). Taurine: A Comprehensive Review of Its Origin, Pharmacological Properties, Potential Health Benefits, Therapeutic Applications, and Safety Profile. Food Sci. Hum. Wellness, 15.","DOI":"10.26599\/FSHW.2024.9250433"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wang, L., Xie, Z., Wu, M., Chen, Y., Wang, X., Li, X., and Liu, F. (2024). The Role of Taurine through Endoplasmic Reticulum in Physiology and Pathology. Biochem. Pharmacol., 226.","DOI":"10.1016\/j.bcp.2024.116386"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101040","DOI":"10.1016\/j.dmpk.2024.101040","article-title":"In Vitro Characterization of Taurine Transport Using the Human Brain Microvascular Endothelial Cell Line as a Human Blood-Brain Barrier Model","volume":"61","author":"Tega","year":"2024","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1124\/dmd.120.000181","article-title":"Sex-, Age-, and Race\/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers","volume":"49","author":"Liu","year":"2021","journal-title":"Drug Metab. Dispos."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jphs.2015.08.007","article-title":"Impact of Taurine Depletion on Glucose Control and Insulin Secretion in Mice","volume":"129","author":"Ito","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Tochitani, S. (2022). Taurine: A Maternally Derived Nutrient Linking Mother and Offspring. Metabolites, 12.","DOI":"10.3390\/metabo12030228"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2478\/s11658-007-0011-4","article-title":"Estrogen Regulation and Ion Dependence of Taurine Uptake by MCF-7 Human Breast Cancer Cells","volume":"12","author":"Shennan","year":"2007","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/09687860500421779","article-title":"Isolation and Function of the Amino Acid Transporter PAT1 (Slc36a1) from Rabbit and Discrimination between Transport via PAT1 and System IMINO in Renal Brush-Border Membrane Vesicles","volume":"22","author":"Miyauchi","year":"2005","journal-title":"Mol. Membr. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.xphs.2020.08.010","article-title":"Inhibitory Effects of 17-\u03b1-Ethinyl-Estradiol and 17-\u03b2-Estradiol on Transport via the Intestinal Proton-Coupled Amino Acid Transporter (PAT1) Investigated in Vitro and in Vivo","volume":"110","author":"Nielsen","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3892\/mmr.2021.12242","article-title":"Protective Role of Taurine against Oxidative Stress","volume":"24","author":"Baliou","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00726-022-03198-6","article-title":"Effects of Taurine on Vascular Tone","volume":"54","author":"Yildiz","year":"2022","journal-title":"Amino Acids"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/nass\/1.1.257","article-title":"Novel Taurine-Containing Uridine Derivatives and Mitochondrial Human Diseases","volume":"1","author":"Suzuki","year":"2001","journal-title":"Nucleic Acids Symp. Ser."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jong, C.J., Ito, T., Prentice, H., Wu, J.Y., and Schaffer, S.W. (2017). Role of Mitochondria and Endoplasmic Reticulum in Taurine-Deficiency-Mediated Apoptosis. Nutrients, 9.","DOI":"10.3390\/nu9080795"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/med.22034","article-title":"Enhancing Healthy Aging with Small Molecules: A Mitochondrial Perspective","volume":"44","author":"Qin","year":"2024","journal-title":"Med. Res. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.freeradbiomed.2024.03.017","article-title":"Mitochondria-Tau Association Promotes Cognitive Decline and Hippocampal Bioenergetic Deficits during the Aging","volume":"217","author":"Olesen","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jakovljevic, N.K., Pavlovic, K., Jotic, A., Lalic, K., Stoiljkovic, M., Lukic, L., Milicic, T., Macesic, M., Gajovic, J.S., and Lalic, N.M. (2021). Targeting Mitochondria in Diabetes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126642"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"C949","DOI":"10.1152\/ajpcell.00042.2004","article-title":"Taurine Inhibits Apoptosis by Preventing Formation of the Apaf-1\/Caspase-9 Apoptosome","volume":"287","author":"Takatani","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.toxicon.2020.04.097","article-title":"Regulation of Taurine in OTA-Induced Apoptosis and Autophagy","volume":"181","author":"Liu","year":"2020","journal-title":"Toxicon"},{"key":"ref_66","first-page":"287","article-title":"Modulation of Ionizing Radiation-Induced Apoptosis by Taurine in Human Peripheral Blood Lymphocytes: Flow Cytometry-Based Quantification","volume":"14","author":"Faraji","year":"2024","journal-title":"J. Biomed. Phys. Eng."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2020.1797280","article-title":"Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)","volume":"17","author":"Klionsky","year":"2021","journal-title":"Autophagy"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.3748\/wjg.v30.i15.2143","article-title":"Taurine Attenuates Activation of Hepatic Stellate Cells by Inhibiting Autophagy and Inducing Ferroptosis","volume":"30","author":"Li","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00726-018-2550-6","article-title":"Taurine Is an Amino Acid with the Ability to Activate Autophagy in Adipocytes","volume":"50","author":"Kaneko","year":"2018","journal-title":"Amino Acids"},{"key":"ref_70","first-page":"250","article-title":"Taurine Induces Autophagy and Inhibits Oxidative Stress in Mice Leydig Cells","volume":"24","author":"Yahyavy","year":"2020","journal-title":"JBRA Assist. Reprod."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"17353","DOI":"10.18632\/aging.103730","article-title":"Taurine Suppresses ROS-Dependent Autophagy via Activating Akt\/MTOR Signaling Pathway in Calcium Oxalate Crystals-Induced Renal Tubular Epithelial Cell Injury","volume":"12","author":"Sun","year":"2020","journal-title":"Aging"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Campesi, I., Brunetti, A., Capobianco, G., Galistu, A., Montella, A., Ieri, F., and Franconi, F. (2022). Sex Differences in X-Ray-Induced Endothelial Damage: Effect of Taurine and N-Acetylcysteine. Antioxidants, 12.","DOI":"10.3390\/antiox12010077"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrm.2016.29","article-title":"VRACs and Other Ion Channels and Transporters in the Regulation of Cell Volume and Beyond","volume":"17","author":"Jentsch","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Schaffer, S.W., Ju Jong, C., Kc, R., and Azuma, J. (2010). Physiological Roles of Taurine in Heart and Muscle. J. Biomed. Sci., 17.","DOI":"10.1186\/1423-0127-17-S1-S2"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/978-981-13-8023-5_87","article-title":"Ribose-Taurine Suppresses Inflammation through NF-\u039aB Regulation in Activated RAW 264.7 Macrophages","volume":"1155","author":"Lee","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.4049\/jimmunol.167.4.2275","article-title":"Taurine Chloramine Inhibits Inducible Nitric Oxide Synthase and TNF-Alpha Gene Expression in Activated Alveolar Macrophages: Decreased NF-KappaB Activation and IkappaB Kinase Activity","volume":"167","author":"Barua","year":"2001","journal-title":"J. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00726-012-1434-4","article-title":"Potential Role of Taurine in the Prevention of Diabetes and Metabolic Syndrome","volume":"46","author":"Imae","year":"2014","journal-title":"Amino Acids"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Seol, S.I., Kang, I.S., Lee, J.S., Lee, J.K., and Kim, C. (2024). Taurine Chloramine-Mediated Nrf2 Activation and HO-1 Induction Confer Protective Effects in Astrocytes. Antioxidants, 13.","DOI":"10.3390\/antiox13020169"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41430-021-01010-4","article-title":"Profiling Inflammatory and Oxidative Stress Biomarkers Following Taurine Supplementation: A Systematic Review and Dose-Response Meta-Analysis of Controlled Trials","volume":"76","author":"Faghfouri","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Barbiera, A., Sorrentino, S., Fard, D., Lepore, E., Sica, G., Dobrowolny, G., Tamagnone, L., and Scicchitano, B.M. (2022). Taurine Administration Counteracts Aging-Associated Impingement of Skeletal Muscle Regeneration by Reducing Inflammation and Oxidative Stress. Antioxidants, 11.","DOI":"10.3390\/antiox11051016"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Flori, L., Veneziano, S., Martelli, A., Piragine, E., and Calderone, V. (2025). Transsulfuration Pathway Products and H2S-Donors in Hyperhomocysteinemia: Potential Strategies Beyond Folic Acid. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136430"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"108238","DOI":"10.1016\/j.pharmthera.2022.108238","article-title":"Bile Acid Metabolism and Signaling, the Microbiota, and Metabolic Disease","volume":"237","author":"Cai","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Tagawa, R., Kobayashi, M., Sakurai, M., Yoshida, M., Kaneko, H., Mizunoe, Y., Nozaki, Y., Okita, N., Sudo, Y., and Higami, Y. (2022). Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031793"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jcmgh.2024.01.011","article-title":"Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer in Mice","volume":"17","author":"Golonka","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Song, Q., Kobayashi, S., Kataoka, Y., and Oda, H. (2024). Direct Molecular Action of Taurine on Hepatic Gene Expression Associated with the Amelioration of Hypercholesterolemia in Rats. Antioxidants, 13.","DOI":"10.3390\/antiox13080990"},{"key":"ref_86","first-page":"G556","article-title":"Characterization of the Mechanisms Involved in the Gender Differences in Hepatic Taurocholate Uptake","volume":"276","author":"Simon","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"G782","DOI":"10.1152\/ajpgi.00379.2003","article-title":"Multihormonal Regulation of Hepatic Sinusoidal Ntcp Gene Expression","volume":"287","author":"Simon","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Fu, Z.D., Csanaky, I.L., and Klaassen, C.D. (2012). Gender-Divergent Profile of Bile Acid Homeostasis during Aging of Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032551"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/hep.29251","article-title":"Hepatic Uptake of Conjugated Bile Acids Is Mediated by Both Sodium Taurocholate Cotransporting Polypeptide and Organic Anion Transporting Polypeptides and Modulated by Intestinal Sensing of Plasma Bile Acid Levels in Mice","volume":"66","author":"Slijepcevic","year":"2017","journal-title":"Hepatology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.coph.2021.06.007","article-title":"Type 2 Diabetic Women Are Not Small Type 2 Diabetic Men: Sex-and-Gender Differences in Antidiabetic Drugs","volume":"60","author":"Campesi","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Campesi, I., Montella, A., Seghieri, G., and Franconi, F. (2021). The Person\u2019s Care Requires a Sex and Gender Approach. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204770"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)31561-0","article-title":"Sex and Gender: Modifiers of Health, Disease, and Medicine","volume":"396","author":"Barnes","year":"2020","journal-title":"Lancet"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/hmg\/ddz303","article-title":"Taurine Treatment of Retinal Degeneration and Cardiomyopathy in a Consanguineous Family with SLC6A6 Taurine Transporter Deficiency","volume":"29","author":"Ansar","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"7480","DOI":"10.1093\/nar\/gkad591","article-title":"Mitochondrial Haplotype Mutation Alleviates Respiratory Defect of MELAS by Restoring Taurine Modification in TRNA with 3243A > G Mutation","volume":"51","author":"Ueda","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/jnnp-2018-317964","article-title":"Taurine Supplementation for Prevention of Stroke-like Episodes in MELAS: A Multicentre, Open-Label, 52-Week Phase III Trial","volume":"90","author":"Ohsawa","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jimd.12085","article-title":"Biomarkers of Oxidative Stress, Inflammation, and Vascular Dysfunction in Inherited Cystathionine \u03b2-Synthase Deficient Homocystinuria and the Impact of Taurine Treatment in a Phase 1\/2 Human Clinical Trial","volume":"42","author":"Freehauf","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12937-024-00995-5","article-title":"Insights into the Cardiovascular Benefits of Taurine: A Systematic Review and Meta-Analysis","volume":"23","author":"Tzang","year":"2024","journal-title":"Nutr. J."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Swiderski, J., Sakkal, S., Apostolopoulos, V., Zulli, A., and Gadanec, L.K. (2023). Combination of Taurine and Black Pepper Extract as a Treatment for Cardiovascular and Coronary Artery Diseases. Nutrients, 15.","DOI":"10.3390\/nu15112562"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.niox.2019.10.008","article-title":"Modulation of Endothelium-Derived Nitric Oxide Production and Activity by Taurine and Taurine-Conjugated Bile Acids","volume":"94","author":"Guizoni","year":"2020","journal-title":"Nitric Oxide"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/978-0-387-75681-3_43","article-title":"Effect of Taurine Supplementation on Plasma Homocysteine Levels of the Middle-Aged Korean Women","volume":"643","author":"Ahn","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1291\/hypres.24.453","article-title":"Distribution of Twenty-Four Hour Urinary Taurine Excretion and Association with Ischemic Heart Disease Mortality in 24 Populations of 16 Countries: Results from the WHO-CARDIAC Study","volume":"24","author":"Yamori","year":"2001","journal-title":"Hypertens. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00394-011-0300-6","article-title":"Serum Taurine and Risk of Coronary Heart Disease: A Prospective, Nested Case-Control Study","volume":"52","author":"Koenig","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/1570163820666230525101353","article-title":"Biological Effects and Mechanisms of Taurine in Various Therapeutics","volume":"20","author":"Sharma","year":"2023","journal-title":"Curr. Drug Discov. Technol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9","DOI":"10.12688\/wellcomeopenres.17505.2","article-title":"Effect of Taurine Administration on Symptoms, Severity, or Clinical Outcome of Dilated Cardiomyopathy and Heart Failure in Humans: A Systematic Review","volume":"7","author":"McGurk","year":"2022","journal-title":"Wellcome Open Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1161\/HYPERTENSIONAHA.115.06624","article-title":"Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study","volume":"67","author":"Sun","year":"2016","journal-title":"Hypertension"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11906-018-0881-z","article-title":"The Effects of Oral Taurine on Resting Blood Pressure in Humans: A Meta-Analysis","volume":"20","author":"Waldron","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cardfail.2021.10.006","article-title":"Sex Differences in Heart Failure","volume":"28","author":"Lala","year":"2022","journal-title":"J. Card. Fail."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1139\/apnm-2015-0560","article-title":"Taurine Supplementation Attenuates Delayed Increase in Exercise-Induced Arterial Stiffness","volume":"41","author":"Ra","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_109","first-page":"543","article-title":"Double-Blind Randomized Crossover Trial of Taurine in Congestive Heart-Failure","volume":"34","author":"Azuma","year":"1983","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/clc.4960080507","article-title":"Therapeutic Effect of Taurine in Congestive Heart Failure: A Double-Blind Crossover Trial","volume":"8","author":"Azuma","year":"1985","journal-title":"Clin. Cardiol."},{"key":"ref_111","first-page":"62","article-title":"A Clinical Experience of Taurine and Trimetazidine Use in Premenopausal Women with Chronic Heart Failure","volume":"50","author":"Sedova","year":"2010","journal-title":"Kardiologiia"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jjcc.2011.01.007","article-title":"Effect of Taurine Supplementation on Exercise Capacity of Patients with Heart Failure","volume":"57","author":"Beyranvand","year":"2011","journal-title":"J. Cardiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"63","DOI":"10.15829\/1728-8800-2012-1-63-68","article-title":"Taurine Effects on the Occurrence of Cardiac Arrhythmias and QT Interval Dispersion in Patients with Postinfarction Cardiosclerosis and Chronic Heart Failure: A Comparative Randomised Study","volume":"11","author":"Gordeev","year":"2012","journal-title":"Cardiovasc. Ther. Prev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1253\/jcj.56.95","article-title":"Usefulness of Taurine in Chronic Congestive Heart Failure and Its Prospective Application","volume":"56","author":"Azuma","year":"1992","journal-title":"Jpn. Circ. J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/01.CIR.75.3.525","article-title":"Effects of Increased Adrenomedullary Activity and Taurine in Young Patients with Borderline Hypertension","volume":"75","author":"Fujita","year":"1987","journal-title":"Circulation"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1067\/mhj.2002.121927","article-title":"Nutritional Supplementation with MyoVive Repletes Essential Cardiac Myocyte Nutrients and Reduces Left Ventricular Size in Patients with Left Ventricular Dysfunction","volume":"143","author":"Jeejeebhoy","year":"2002","journal-title":"Am. Heart J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/978-3-319-15126-7_51","article-title":"Use of Taurine during Rehabilitation after Cardiac Surgery","volume":"803","author":"Averin","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/19390211.2016.1267059","article-title":"Taurine Supplementation Improves Functional Capacity, Myocardial Oxygen Consumption, and Electrical Activity in Heart Failure","volume":"14","author":"Ahmadian","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"ref_119","unstructured":"Adamchik, A.S., Kryuchkova, I.V., Ruban, G.M., and Blagodyreva, Y.A. (2024, October 23). New Potential of Pharmaceutical Therapy in Diastolic Chronic Heart Failure Treatment. Available online: https:\/\/www.researchgate.net\/publication\/292322246_New_potential_of_pharmaceutical_therapy_in_diastolic_chronic_heart_failure_treatment."},{"key":"ref_120","first-page":"41","article-title":"Effects of taurine supplementation on response of the cardiac injury biomarkers to Bruce diagnostic protocol in patients with heart failure","volume":"13","year":"2011","journal-title":"Koomesh"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jcjd.2020.05.004","article-title":"The Effects of Taurine Supplementation on Metabolic Profiles, Pentosidine, Soluble Receptor of Advanced Glycation End Products and Methylglyoxal in Adults with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"45","author":"Esmaeili","year":"2021","journal-title":"Can. J. Diabetes"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12986-022-00684-2","article-title":"Protective and Therapeutic Effectiveness of Taurine Supplementation plus Low Calorie Diet on Metabolic Parameters and Endothelial Markers in Patients with Diabetes Mellitus: A Randomized, Clinical Trial","volume":"19","author":"Moludi","year":"2022","journal-title":"Nutr. Metab."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1080\/09537100400020575","article-title":"No Effect of Taurine on Platelet Aggregation in Men with a Predisposition to Type 2 Diabetes Mellitus","volume":"16","author":"Spohr","year":"2005","journal-title":"Platelets"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/1479164110375971","article-title":"Two Weeks Taurine Supplementation Reverses Endothelial Dysfunction in Young Male Type 1 Diabetics","volume":"7","author":"Moloney","year":"2010","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/apt.14377","article-title":"Randomised Clinical Study: The Effects of Oral Taurine 6g\/Day vs Placebo on Portal Hypertension","volume":"47","author":"Schwarzer","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3803\/EnM.2023.1776","article-title":"The Impact of Taurine on Obesity-Induced Diabetes Mellitus: Mechanisms Underlying Its Effect","volume":"38","author":"Ahmed","year":"2023","journal-title":"Endocrinol. Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"100106","DOI":"10.1016\/j.fochms.2022.100106","article-title":"The Effects of Taurine Supplementation on Diabetes Mellitus in Humans: A Systematic Review and Meta-Analysis","volume":"4","author":"Tao","year":"2022","journal-title":"Food Chem. Mol. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13098-020-0518-7","article-title":"The Effects of Taurine Supplementation on Oxidative Stress Indices and Inflammation Biomarkers in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"12","author":"Maleki","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/ijhas.IJHAS_27_19","article-title":"Can N Acetyl Cysteine\u2014Taurine Provide Additional Reduction in Microalbuminuria in Type 2 Diabetic Patients Already on Optimum Doses of Angiotensin Converting Enzyme Inhibitors?","volume":"8","author":"Premanath","year":"2019","journal-title":"Int. J. Health Allied Sci."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Masouleh, S.S., Bagheri, R., Ashtary-Larky, D., Cheraghloo, N., Wong, A., Bilesvar, O.Y., Suzuki, K., and Siahkouhian, M. (2021). The Effects of TRX Suspension Training Combined with Taurine Supplementation on Body Composition, Glycemic and Lipid Markers in Women with Type 2 Diabetes. Nutrients, 13.","DOI":"10.3390\/nu13113958"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Li, C., Gao, L., Lv, C., Li, Z., Fan, S., Liu, X., Rong, X., Huang, Y., and Liu, J. (2023). Active Role of Amino Acid Metabolism in Early Diagnosis and Treatment of Diabetic Kidney Disease. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1239838"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/biof.1938","article-title":"Taurine Rescues Pancreatic \u03b2-Cell Stress by Stimulating \u03b1-Cell Transdifferentiation","volume":"49","author":"Sarnobat","year":"2023","journal-title":"BioFactors"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5.47.1","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-Induced Diabetic Models in Mice and Rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fct.2017.10.022","article-title":"Prophylactic Role of Taurine and Its Derivatives against Diabetes Mellitus and Its Related Complications","volume":"110","author":"Sarkar","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Nisoli, E., Aquilani, R., and D\u2019Antona, G. (2013). Amino Acid Supplements and Diabetes. Bioactive Food as Dietary Interventions for Diabetes, Academic Press.","DOI":"10.1016\/B978-0-12-397153-1.00009-3"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Murakami, S., Funahashi, K., Tamagawa, N., Ning, M., and Ito, T. (2022). Taurine Ameliorates Streptozotocin-Induced Diabetes by Modulating Hepatic Glucose Metabolism and Oxidative Stress in Mice. Metabolites, 12.","DOI":"10.3390\/metabo12060524"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1080\/15376516.2021.2021579","article-title":"A Systematic Review of Preclinical Studies on the Taurine Role during Diabetic Nephropathy: Focused on Anti-Oxidative, Anti-Inflammation, and Anti-Apoptotic Effects","volume":"32","author":"Ma","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"43603","DOI":"10.1155\/2007\/43603","article-title":"Oxidative Stress and Diabetic Retinopathy","volume":"2007","author":"Kowluru","year":"2007","journal-title":"Exp. Diabetes Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"113700","DOI":"10.1016\/j.fct.2023.113700","article-title":"Taurine Reduces Apoptosis Mediated by Endoplasmic Reticulum Stress in Islet \u03b2-Cells Induced by High-Fat and -Glucose Diets","volume":"175","author":"Zhao","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1053\/meta.2001.19432","article-title":"Taurine and Osmoregulation: Platelet Taurine Content, Uptake, and Release in Type 2 Diabetic Patients","volume":"50","author":"Calpona","year":"2001","journal-title":"Metabolism"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/hmg\/ddab013","article-title":"A Plasma Metabolomic Signature of Leber Hereditary Optic Neuropathy Showing Taurine and Nicotinamide Deficiencies","volume":"30","author":"Bocca","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00726-018-2544-4","article-title":"Ameliorative Effects of Taurine against Diabetes: A Review","volume":"50","author":"Piao","year":"2018","journal-title":"Amino Acids"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/02713683.2020.1836228","article-title":"New Insights into Diabetic and Vision-Threatening Retinopathy: Importance of Plasma Long Pentraxine 3 and Taurine Levels","volume":"46","author":"Erdenen","year":"2021","journal-title":"Curr. Eye Res."},{"key":"ref_144","first-page":"231","article-title":"Disruption of the Taurine Transporter Gene (Taut) Leads to Retinal Degeneration in Mice","volume":"16","author":"Rascher","year":"2002","journal-title":"FASEB J."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Lee, D., and Smith, L.E.H. (2024). Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases. Life, 14.","DOI":"10.3390\/life14121566"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s11064-010-0216-1","article-title":"Effects of Taurine on Glial Cells Apoptosis and Taurine Transporter Expression in Retina under Diabetic Conditions","volume":"35","author":"Zeng","year":"2010","journal-title":"Neurochem. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00726-002-0202-2","article-title":"Chronic Taurine Supplementation Ameliorates Oxidative Stress and Na+ K+ ATPase Impairment in the Retina of Diabetic Rats","volume":"23","author":"Santini","year":"2002","journal-title":"Amino Acids"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/1071576021000055271","article-title":"Potential Therapeutic Effect of Antioxidants in Experimental Diabetic Retina: A Comparison between Chronic Taurine and Vitamin E plus Selenium Supplementations","volume":"37","author":"Ghirlanda","year":"2003","journal-title":"Free Radic. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/02713683.2019.1653927","article-title":"Taurine Protects Retinal Cells and Improves Synaptic Connections in Early Diabetic Rats","volume":"45","author":"Fan","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1464-5491.2006.01918.x","article-title":"IDF Clinical Guidelines Task Force Global Guideline for Type 2 Diabetes: Recommendations for Standard, Comprehensive, and Minimal Care","volume":"23","author":"Home","year":"2006","journal-title":"Diabet. Med."},{"key":"ref_151","unstructured":"(2021). IDF Diabetes Atlas 2021, International Diabetes Federation."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1222395","DOI":"10.1155\/2024\/1222395","article-title":"Inulin Reduces Kidney Damage in Type 2 Diabetic Mice by Decreasing Inflammation and Serum Metabolomics","volume":"2024","author":"He","year":"2024","journal-title":"J. Diabetes Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Zou, J., Song, Q., Shaw, P.C., and Zuo, Z. (2024). Dendrobium Officinale Regulate Lipid Metabolism in Diabetic Mouse Liver via PPAR-RXR Signaling Pathway: Evidence from an Integrated Multi-Omics Analysis. Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116395"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Norman, J.E., Nuthikattu, S., Milenkovic, D., and Villablanca, A.C. (2023). Sex Modifies the Impact of Type 2 Diabetes Mellitus on the Murine Whole Brain Metabolome. Metabolites, 13.","DOI":"10.3390\/metabo13091012"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Tk\u00e1\u010d, I., Xie, T., Shah, N., Larson, S., Dubinsky, J.M., Gomez-Pastor, R., McLoughlin, H.S., Orr, H.T., Eberly, L.E., and \u00d6z, G. (2023). Regional Sex Differences in Neurochemical Profiles of Healthy Mice Measured by Magnetic Resonance Spectroscopy at 9.4 Tesla. Front. Neurosci., 17.","DOI":"10.3389\/fnins.2023.1278828"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Zheng, S.J., Luo, Y., Wang, J.B., Chen, X.M., Xu, Y., and Xiao, J.H. (2024). Regulated Intestinal Microbiota and Gut Immunity to Ameliorate Type 1 Diabetes Mellitus: A Novel Mechanism for Stem Cell-Based Therapy. Biomed. Pharmacother., 170.","DOI":"10.1016\/j.biopha.2023.116033"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bcp.2015.05.014","article-title":"Sulfur Amino Acid Metabolism in Zucker Diabetic Fatty Rats","volume":"96","author":"Kwak","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Merlin, E., Salio, C., and Ferrini, F. (2024). Painful Diabetic Neuropathy: Sex-Specific Mechanisms and Differences from Animal Models to Clinical Outcomes. Cells, 13.","DOI":"10.3390\/cells13232024"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e28400","DOI":"10.1016\/j.heliyon.2024.e28400","article-title":"Alleviation of Taurine on Liver Injury of Type 2 Diabetic Rats by Improving Antioxidant and Anti-Inflammatory Capacity","volume":"10","author":"Ouyang","year":"2024","journal-title":"Heliyon"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Bkaily, G., Simon, Y., Normand, A., Jazzar, A., Najibeddine, H., Khalil, A., and Jacques, D. (2022). Short-Communication: Short-Term Treatment with Taurine Prevents the Development of Cardiac Hypertrophy and Early Death in Hereditary Cardiomyopathy of the Hamster and Is Sex-Dependent. Nutrients, 14.","DOI":"10.3390\/nu14163287"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Bkaily, G., Simon, Y., Abou Abdallah, J., Ouertane, C., Essalhi, A., Khalil, A., and Jacques, D. (2024). Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent. Nutrients, 16.","DOI":"10.3390\/nu16070946"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00018-024-05124-3","article-title":"Decreased Expression of the NLRP6 Inflammasome Is Associated with Increased Intestinal Permeability and Inflammation in Obesity with Type 2 Diabetes","volume":"81","author":"Becerril","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-981-13-8023-5_27","article-title":"Relation of Taurine Intake during Pregnancy and Newborns\u2019 Growth","volume":"1155","author":"Jung","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40348-018-0082-5","article-title":"Intrauterine Growth Restriction\u2014Impact on Cardiovascular Diseases Later in Life","volume":"5","author":"Rascher","year":"2018","journal-title":"Mol. Cell. Pediatr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e002833","DOI":"10.1136\/openhrt-2024-002833","article-title":"Pregnancy Complications and Long-Term Risk of Cardiovascular Events in Women with Structural Heart Disease","volume":"11","author":"Lindhagen","year":"2024","journal-title":"Open Heart"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Troisi, J., Symes, S.J.K., Lombardi, M., Cavallo, P., Colucci, A., Scala, G., Adair, D.C., Guida, M., and Richards, S.M. (2023). Placental Metabolomics of Fetal Growth Restriction. Metabolites, 13.","DOI":"10.3390\/metabo13020235"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuro.2023.08.004","article-title":"Associations between Serum Taurine Concentrations in Mothers and Neonates and the Children\u2019s Anthropometrics and Early Neurodevelopment: Results from the Seychelles Child Development Study, Nutrition Cohort 2","volume":"99","author":"Beggan","year":"2023","journal-title":"Neurotoxicology"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Bakshi, S., Paswan, V.K., Yadav, S.P., Bhinchhar, B.K., Kharkwal, S., Rose, H., Kanetkar, P., Kumar, V., Al-Zamani, Z.A.S., and Bunkar, D.S. (2023). A Comprehensive Review on Infant Formula: Nutritional and Functional Constituents, Recent Trends in Processing and Its Impact on Infants\u2019 Gut Microbiota. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1194679"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Goulet, O. (2024). An Overview of Parenteral Nutrition from Birth to Adolescence Based on a Composite Fish Oil Containing Lipid Emulsion and a Pediatric Amino Acid Solution. Nutrients, 16.","DOI":"10.3390\/nu16030440"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"482","DOI":"10.4239\/wjd.v13.i7.482","article-title":"Fetal Programming of Obesity and Type 2 Diabetes","volume":"13","author":"Seneviratne","year":"2022","journal-title":"World J. Diabetes"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1056\/NEJMe058187","article-title":"Developmental Origins of Health and Disease","volume":"353","author":"Gillman","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/bmb\/60.1.5","article-title":"The Thrifty Phenotype Hypothesis","volume":"60","author":"Hales","year":"2001","journal-title":"Br. Med. Bull."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4103\/1673-5374.353491","article-title":"Taurine: An Essential Amino Sulfonic Acid for Retinal Health","volume":"18","author":"Picaud","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Jakaria, M., Azam, S., Haque, M.E., Jo, S.H., Uddin, M.S., Kim, I.S., and Choi, D.K. (2019). Taurine and Its Analogs in Neurological Disorders: Focus on Therapeutic Potential and Molecular Mechanisms. Redox Biol., 24.","DOI":"10.1016\/j.redox.2019.101223"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-94-024-1079-2_26","article-title":"Perinatal Taurine Supplementation Prevents Metabolic and Cardiovascular Effects of Maternal Diabetes in Adult Rat Offspring","volume":"975","author":"Thaeomor","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Roysommuti, S., Malila, P., Jirakulsomchok, D., and Wyss, J.M. (2010). Adult Renal Function Is Modified by Perinatal Taurine Status in Conscious Male Rats. J. Biomed. Sci., 17.","DOI":"10.1186\/1423-0127-17-S1-S31"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00726-012-1417-5","article-title":"Perinatal Taurine Exposure Affects Adult Arterial Pressure Control","volume":"46","author":"Roysommuti","year":"2014","journal-title":"Amino Acids"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/1440-1681.13260","article-title":"Perinatal Taurine Exerts a Hypotensive Effect in Male Spontaneously Hypertensive Rats and Down-Regulates Endothelial Oxide Nitric Synthase in the Aortic Arch","volume":"47","author":"Mensegue","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-4899-0117-0_8","article-title":"Taurine Levels and Localization in Pancreatic Islets","volume":"442","author":"Bustamante","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"118813","DOI":"10.1016\/j.lfs.2020.118813","article-title":"The Role of Taurine on Chemotherapy-Induced Cardiotoxicity: A Systematic Review of Non-Clinical Study","volume":"265","author":"Samadi","year":"2021","journal-title":"Life Sci."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"117889","DOI":"10.1016\/j.lfs.2020.117889","article-title":"Taurine Attenuates Liver Autophagy and Injury of Offspring in Gestational Diabetic Mellitus Rats","volume":"257","author":"Luo","year":"2020","journal-title":"Life Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.earlhumdev.2007.03.011","article-title":"Neonatal Taurine Administration Modifies Metabolic Programming in Male Mice","volume":"83","author":"Loizzo","year":"2007","journal-title":"Early Hum. Dev."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Tain, Y.L., and Hsu, C.N. (2024). Amino Acids during Pregnancy and Offspring Cardiovascular-Kidney-Metabolic Health. Nutrients, 16.","DOI":"10.3390\/nu16091263"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.brainresbull.2004.04.004","article-title":"Taurine Administration during Lactation Modifies Hippocampal CA1 Neurotransmission and Behavioural Programming in Adult Male Mice","volume":"63","author":"Franconi","year":"2004","journal-title":"Brain Res. Bull."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Furukawa, T., and Fukuda, A. (2023). Maternal Taurine as a Modulator of Cl- Homeostasis as Well as of Glycine\/GABAA Receptors for Neocortical Development. Front. Cell. Neurophysiol., 17.","DOI":"10.3389\/fncel.2023.1221441"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"49","DOI":"10.17816\/RCF21149-56","article-title":"The Effect of Taurine on State of Experimental Gestosis in Rats","volume":"21","author":"Sivak","year":"2023","journal-title":"Rev. Clin. Pharmacol. Drug Ther."},{"key":"ref_187","unstructured":"Hirst, C. (2015). Placental Taurine Transport in Pre-Eclampsia\u2014Research Explorer. [Ph.D. Thesis, The University of Manchester]."},{"key":"ref_188","first-page":"386","article-title":"Correction of the Endothelial Function and the Hemostasis System Disorders with Ademethionin and Taurine in Model Associated with ADMA-like Preeclampsia","volume":"9","author":"Pokrovskaya","year":"2021","journal-title":"J. Res. Med. Dent. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Kuc, S., Koster, M.P.H., Pennings, J.L.A., Hankemeier, T., Berger, R., Harms, A.C., Dane, A.D., Schielen, P.C.J.I., Visser, G.H.A., and Vreeken, R.J. (2014). Metabolomics Profiling for Identification of Novel Potential Markers in Early Prediction of Preeclampsia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098540"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and Adverse Pregnancy Outcomes","volume":"358","author":"Metzger","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Liu, P.J., Liu, Y., Ma, L., Liu, L., Hu, T., An, Z., Yao, A.M., and Xia, L.Y. (2021). The Relationship between Plasma Taurine Levels in Early Pregnancy and Later Gestational Diabetes Mellitus Risk in Chinese Pregnant Women. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-87178-y"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"8850080","DOI":"10.1155\/2021\/8850080","article-title":"Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review","volume":"2021","author":"Almeida","year":"2021","journal-title":"Int. J. Food Sci."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Jagim, A.R., Fields, J., Magee, M.K., Kerksick, C.M., and Jones, M.T. (2022). Contributing Factors to Low Energy Availability in Female Athletes: A Narrative Review of Energy Availability, Training Demands, Nutrition Barriers, Body Image, and Disordered Eating. Nutrients, 14.","DOI":"10.3390\/nu14050986"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/apt.14950","article-title":"Randomised Clinical Trial: Oral Taurine Supplementation versus Placebo Reduces Muscle Cramps in Patients with Chronic Liver Disease","volume":"48","author":"Vidot","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Rubio, C., C\u00e1mara, M., Giner, R.M., Gonz\u00e1lez-Mu\u00f1oz, M.J., L\u00f3pez-Garc\u00eda, E., Morales, F.J., Moreno-Arribas, M.V., Portillo, M.P., and Bethencourt, E. (2022). Caffeine, D-Glucuronolactone and Taurine Content in Energy Drinks: Exposure and Risk Assessment. Nutrients, 14.","DOI":"10.3390\/nu14235103"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.yrtph.2008.01.004","article-title":"Risk Assessment for the Amino Acids Taurine, L-Glutamine and L-Arginine","volume":"50","author":"Shao","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"EFSA (2012). Scientific Opinion on the Safety and Efficacy of Taurine as a Feed Additive for All Animal Species. EFSA J., 10, 2736.","DOI":"10.2903\/j.efsa.2012.2736"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-025-09018-7","article-title":"Taurine from Tumour Niche Drives Glycolysis to Promote Leukaemogenesis","volume":"644","author":"Sharma","year":"2025","journal-title":"Nature"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.fct.2009.04.030","article-title":"Effect of Taurine Supplementation on Cytochrome P450 2E1 and Oxidative Stress in the Liver and Kidneys of Rats with Streptozotocin-Induced Diabetes","volume":"47","author":"Yao","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/978-3-030-93337-1_44","article-title":"In Vivo Sex-Dependent Effects of Perinatal Pb2+ Exposure on Pilocarpine-Induced Seizure Susceptibility and Taurine Neuropharmacology","volume":"1370","author":"Vasquez","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Sedlmeier, E.M., Meyer, D.M., Stecher, L., Sailer, M., Daniel, H., Hauner, H., and Bader, B.L. (2021). Fetal Sex Modulates Placental MicroRNA Expression, Potential MicroRNA-MRNA Interactions, and Levels of Amino Acid Transporter Expression and Substrates: INFAT Study Subpopulation Analysis of n-3 LCPUFA Intervention during Pregnancy and Associations with Offspring Body Composition. BMC Mol. Cell Biol., 22.","DOI":"10.1186\/s12860-021-00345-x"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"100097","DOI":"10.1016\/j.arres.2024.100097","article-title":"Sex-Specific Antioxidant Biomarker Depletion in Patients with a History of Mild Traumatic Brain Injury","volume":"10","author":"Koza","year":"2024","journal-title":"Adv. Redox Res."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"111706","DOI":"10.1016\/j.nut.2022.111706","article-title":"Taurine as a Possible Antiaging Therapy: A Controlled Clinical Trial on Taurine Antioxidant Activity in Women Ages 55 to 70","volume":"101","author":"Abud","year":"2022","journal-title":"Nutrition"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Legato, M. (2017). Principles of Gender-Specific Medicine, Academic Press. [3rd ed.].","DOI":"10.1016\/B978-0-12-811850-4.00001-6"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Greaves, L., Brabete, A.C., Maximos, M., Huber, E., Li, A., L\u00ea, M.L., Eltonsy, S., and Boscoe, M. (2023). Sex, Gender, and the Regulation of Prescription Drugs: Omissions and Opportunities. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20042962"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/8097\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:33:01Z","timestamp":1760034781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/16\/8097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":205,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["ijms26168097"],"URL":"https:\/\/doi.org\/10.3390\/ijms26168097","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]}}}