{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:17:01Z","timestamp":1790957821859,"version":"4.1.0"},"reference-count":123,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YQ2024H028"],"award-info":[{"award-number":["YQ2024H028"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ischemia-reperfusion (I\/R) injury refers to the exacerbation of tissue or organ damage upon the restoration of blood flow after an ischemic event. Despite its widespread clinical occurrence, therapeutic interventions for I\/R injury remain limited in efficacy, presenting a significant challenge in modern medicine. Garlic, traditionally consumed as a food, has gained considerable attention for its medicinal properties. Numerous animal studies have shown that garlic-derived organic polysulfides significantly improve nerve function scores post-I\/R, reduce infarct size, mitigate inflammatory responses, and inhibit cellular apoptosis. Thus, understanding the role of garlic-derived organic polysulfides in I\/R injury may unveil novel therapeutic targets. This review explores the protective effects and mechanisms of garlic-derived organic polysulfides on I\/R injury in various organs, including the brain, spinal cord, myocardium, lungs, liver, kidneys, and testes, highlighting their potential in advancing treatment strategies for affected patients.<\/jats:p>","DOI":"10.3390\/ijms26178257","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:43:18Z","timestamp":1756219398000},"page":"8257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Therapeutic Potential of Garlic-Derived Organic Polysulfides for Ischemia-Reperfusion Injury"],"prefix":"10.3390","volume":"26","author":[{"given":"Chunlei","family":"Wang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Han","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2373-4341","authenticated-orcid":false,"given":"Caiyun","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyou","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Song","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutao","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1134\/S0026893323060067","article-title":"Ischemia-Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction","volume":"57","author":"Goncharov","year":"2023","journal-title":"Mol. 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