{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:59:03Z","timestamp":1788667143849,"version":"build-2803163510"},"reference-count":67,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","doi-asserted-by":"publisher","award":["PID2021-124983OB-I00"],"award-info":[{"award-number":["PID2021-124983OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades, Spain","doi-asserted-by":"publisher","award":["PID2024-157360OB-I00"],"award-info":[{"award-number":["PID2024-157360OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The design and synthesis of a small library of 2-styrylquinoline derivatives containing a push-pull system, aimed at displacing their fluorescence emission towards the NIR region, is described. We describe here their synthesis, fluorescent characterization and pharmacological evaluation against different amyloid proteins. Their study showed that these compounds are capable to change their spectroscopic properties upon protein interaction, resulting in changes in the absorption and emission wavelengths, together with increased fluorescence intensity. They also showed sensitivity to pH and environment polarity, exhibiting red shifts in lower polarity environments with regard to aqueous media. Inner charge transfer is observed and employed for detecting the interaction of these compounds with protein aggregates. The study of the alterations in the fluorescence intensity allows to calculate the dissociation constant values for the protein-sensor interaction. These spectroscopic results were the basis for the use of these compounds to visualize \u03b2-amyloid plates with selectivity over phosphorylated tau in samples of cerebral tissue from deceased Alzheimer patients under fluorescence microscopy, using immunofluorescence techniques. Pharmacological assays showed that the compounds inhibit the aggregation of the A\u03b21\u201342 and AcPHF6 peptides, representing tau protein. They also showed neuroprotective activity following okadaic acid insult.<\/jats:p>","DOI":"10.3390\/ijms26178270","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:43:18Z","timestamp":1756219398000},"page":"8270","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["2-Styrylquinolines with Push-Pull Architectures as Sensors for \u03b2-Amyloid Aggregation with Theranostic Properties"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-8073","authenticated-orcid":false,"given":"Marta","family":"Piquero","sequence":"first","affiliation":[{"name":"Unidad de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-3845","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Sarabia-Vallejo","sequence":"additional","affiliation":[{"name":"Unidad de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latoya","family":"Bote-Mat\u00edas","sequence":"additional","affiliation":[{"name":"Unidad de Qu\u00edmica Anal\u00edtica, Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-2614","authenticated-orcid":false,"given":"Gonzalo","family":"Le\u00f3n-Espinosa","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica y Bioqu\u00edmica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, Boadilla del Monte, 28660 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Hern\u00e1ndez-Arasti","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Farmacognosia y Bot\u00e1nica, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1612-2726","authenticated-orcid":false,"given":"Sagrario","family":"Mart\u00edn-Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Farmacognosia y Bot\u00e1nica, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-7852","authenticated-orcid":false,"given":"Paloma","family":"Bermejo-Besc\u00f3s","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Farmacognosia y Bot\u00e1nica, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-1700","authenticated-orcid":false,"given":"Ana I.","family":"Olives","sequence":"additional","affiliation":[{"name":"Unidad de Qu\u00edmica Anal\u00edtica, Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"L\u00f3pez-Alvarado","sequence":"additional","affiliation":[{"name":"Unidad de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense, Plaza de Ram\u00f3n y Cajal s\/n, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-8621","authenticated-orcid":false,"given":"M. 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