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This study aimed to optimize the extraction of bioactive compounds and assess their antioxidant and antidiabetic properties. Fresh and freeze-dried samples were compared in terms of proximate composition, dietary fiber, reducing sugars, and fatty acid profiles. Proximate and fiber contents were determined using AOAC methods, while fatty acids were analyzed by gas chromatography, and \u03b1-tocopherol levels were measured via HPLC. Extraction optimization was conducted using a Box\u2013Behnken design within a response surface methodology framework, employing freeze-dried samples. Total phenolic (TPC), flavonoid (TFC), and anthocyanin (TAC) contents were quantified spectrophotometrically. Antioxidant potential was assessed by DPPH and ORAC assays, while \u03b1-glucosidase inhibition determined antidiabetic activity. Phenolic profiles were characterized by HPLC. Optimal extraction conditions (58% ethanol, 60% ultrasound power, 30 min) enhanced antioxidant response. Results showed high fiber content (~39%), linoleic acid as the predominant fatty acid, and an \u03b1-tocopherol concentration of ~95 \u00b5g\/g. TPC, TFC, and TAC values reached 25.43 \u00b1 0.85, 46.51 \u00b1 1.38, and 5.91 \u00b1 0.40 mg\/g d.m., respectively. Antioxidant capacity was 289.54 \u00b1 9.05 \u03bcmol TE\/g (DPPH) and 451.09 \u00b1 6.04 \u03bcmol TE\/g (ORAC). The IC50 for \u03b1-glucosidase inhibition was 0.558 \u00b1 0.015 mg\/mL. Phenolic compounds were identified. These findings position the Cauchao berry as a promising source of bioactive compounds with potential health benefits.<\/jats:p>","DOI":"10.3390\/ijms26178391","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:08:52Z","timestamp":1756458532000},"page":"8391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cauchao Berry (Amomyrtus luma) as a Promising Source of Bioactive Compounds: Optimized Extraction, Phytochemical Characterization, and Assessment of Antioxidant and Antidiabetic Potential"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1029-7402","authenticated-orcid":false,"given":"Luis S.","family":"Gomez-Perez","sequence":"first","affiliation":[{"name":"Centro de Biolog\u00eda Integrativa, Facultad de Ciencias, Universidad Mayor, Santiago 8380000, Chile"},{"name":"Escuela Nutrici\u00f3n y Diet\u00e9tica, Facultad de Medicina y Ciencias de la Salud, Universidad Mayor, Santiago 8580745, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9789-0323","authenticated-orcid":false,"given":"Jacqueline","family":"Poblete","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda en Alimentos, Universidad de La Serena, La Serena 1700000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda en Alimentos, Universidad de La Serena, La Serena 1700000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4305-7387","authenticated-orcid":false,"given":"Ren\u00e9 L.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Integrativa, Facultad de Ciencias, Universidad Mayor, Santiago 8380000, Chile"},{"name":"Centro FONDAP de Gerociencia, Salud Mental y Metabolismo (GERO), Santiago 8380000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jsfa.10621","article-title":"Antioxidant, Functional Properties and Health-promoting Potential of Native South American Berries: A Review","volume":"101","author":"Stucken","year":"2021","journal-title":"J. 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