{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:43:44Z","timestamp":1790624624962,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The gastrointestinal tract is affected by multiple ailments that manifest with similar chemical, subcellular, and cellular changes, such as those in intestinal ischemia\u2013reperfusion injury (IRI). The main chemical changes that are described under IRI conditions include the depletion of oxygen available for normal metabolism and the abundant production and increase in intracellular and extracellular concentrations of hydrogen peroxide and other reactive oxygen species (ROS). The enzymes causing this accumulation are xanthine dehydrogenase turning into xanthine oxidase, nicotinamide adenine dinucleotide phosphate oxidase, and nitric oxide synthase. The cellular changes revolve around an oxygen-sensing system that is responsive to varying oxygen levels, which has Hypoxia-Inducible Factors (HIFs) at its base. HIFs are transcription factors, the intracellular concentrations of which significantly increase under hypoxic conditions. Upon activation, they alter the expression of gene sets to ensure appropriate cellular adjustment to the hypoxic and IRI environment. Despite the primary regulation of the system involving oxygen, it is interconnected with multiple other subcellular and cellular functions. Thus, it represents a linchpin control mechanism of cellular adaptation. The effect of HIF activation in intestinal cells aims at preserving the structural integrity of the intestinal lining. The effect in different subtypes of leucocytes aims at immune system activation to protect against previously luminally located and subsequently invading pathogens and toxins. All in all, the HIF system is an integral part of cellular and tissue compensation against intestinal IRI.<\/jats:p>","DOI":"10.3390\/ijms26178398","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T16:42:21Z","timestamp":1756485741000},"page":"8398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oxygen-Mediated Molecular Mechanisms Involved in Intestinal Ischemia and Reperfusion Injury"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-6916","authenticated-orcid":false,"given":"Paraschos","family":"Archontakis-Barakakis","sequence":"first","affiliation":[{"name":"Department of Medicine, Redington-Fairview General Hospital, Skowhegan, ME 04976, USA"},{"name":"Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-5106","authenticated-orcid":false,"given":"Theodoros","family":"Mavridis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tallaght University Hospital (TUH), The Adelaide and Meath Hospital Incorporating the National Children\u2019s Hospital (AMNCH), D24NR0A Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-4665","authenticated-orcid":false,"given":"Athanasios","family":"Chalkias","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Outcomes Research Consortium<sup>\u00ae<\/sup>, Houston, TX 77030, USA"},{"name":"Department of Critical Care Medicine, General Hospital of Piraeus \u201cTzaneio\u201d, 18536 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.2040-4603.2017.tb00741.x","article-title":"Ischemia\/Reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jss.2013.10.033","article-title":"The interaction between oxidative stress and mast cell activation plays a role in acute lung injuries induced by intestinal ischemia-reperfusion","volume":"187","author":"Zhao","year":"2014","journal-title":"J. Surg. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2741\/1816","article-title":"Role of the gut in the development of injury- and shock induced SIRS and MODS: The gut-lymph hypothesis, a review","volume":"11","author":"Deitch","year":"2006","journal-title":"Front. Biosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/labinvest.2010.177","article-title":"Anti-apoptotic PI3K\/Akt signaling by sodium\/glucose transporter 1 reduces epithelial barrier damage and bacterial translocation in intestinal ischemia","volume":"91","author":"Huang","year":"2011","journal-title":"Lab. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1055\/s-0031-1287871","article-title":"Gut failure in the ICU","volume":"32","author":"Puleo","year":"2011","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s002689900065","article-title":"Role of the gut in multiple organ failure: Bacterial translocation and permeability changes","volume":"20","author":"Swank","year":"1996","journal-title":"World J. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00595-004-2924-0","article-title":"Acute mesenteric ischemia: The challenge of gastroenterology","volume":"35","author":"Yasuhara","year":"2005","journal-title":"Surg. Today"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e70136","DOI":"10.1002\/ctm2.70136","article-title":"Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia-reperfusion injury","volume":"15","author":"Mavridis","year":"2025","journal-title":"Clin. Transl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1023\/B:DDAS.0000042232.98927.91","article-title":"Ischemia-reperfusion injury of the intestine and protective strategies against injury","volume":"49","author":"Mallick","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/icvts\/ivu139","article-title":"Mesenteric ischaemia following cardiac surgery: The influence of intraoperative perfusion parameters","volume":"19","author":"Sastry","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bpg.2013.08.006","article-title":"Gastro-intestinal vascular emergencies","volume":"27","author":"Corcos","year":"2013","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/SLA.0000000000000631","article-title":"Intraluminal nonbacterial intestinal components control gut and lung injury after trauma hemorrhagic shock","volume":"260","author":"Fishman","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ajg.2014.395","article-title":"ACG clinical guideline: Epidemiology, risk factors, patterns of presentation, diagnosis, and management of colon ischemia (CI)","volume":"110","author":"Brandt","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/j.semvascsurg.2009.12.001","article-title":"Epidemiology of mesenteric vascular disease: Clinical implications","volume":"23","author":"Acosta","year":"2010","journal-title":"Semin. Vasc. Surg."},{"key":"ref_15","first-page":"1311","article-title":"Ischemia\/reperfusion injury of the ascending colon in ponies: A correlative study utilizing microvascular histopathology and corrosion casting","volume":"7","author":"Darien","year":"1993","journal-title":"Scanning Microsc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.ph.57.030195.001523","article-title":"Physiologic mechanisms of postischemic tissue injury","volume":"57","author":"Granger","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1053\/j.gastro.2007.11.049","article-title":"Life in the gut without oxygen: Adaptive mechanisms and inflammatory bowel disease","volume":"134","author":"Blikslager","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Derikx, J.P., Matthijsen, R.A., de Bruine, A.P., van Bijnen, A.A., Heineman, E., van Dam, R.M., Dejong, C.H., and Buurman, W.A. (2008). Rapid reversal of human intestinal ischemia-reperfusion induced damage by shedding of injured enterocytes and reepithelialisation. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003428"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00134-013-2982-0","article-title":"Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: A randomized, placebo-controlled, double-blind, crossover study","volume":"39","author":"Hernandez","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1469-7793.1999.245af.x","article-title":"Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation","volume":"514","author":"Sinaasappel","year":"1999","journal-title":"J. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/jsre.1995.1170","article-title":"Ischemic time-dependent microvascular changes and reperfusion injury in the rat small intestine","volume":"59","author":"Boros","year":"1995","journal-title":"J. Surg. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"C1130","DOI":"10.1152\/ajpcell.1997.273.4.C1130","article-title":"Intestinal ischemia and reperfusion injury in transgenic mice overexpressing copper-zinc superoxide dismutase","volume":"273","author":"Deshmukh","year":"1997","journal-title":"Am. J. Physiol."},{"key":"ref_24","first-page":"G683","article-title":"Leukocyte adherence to venular endothelium during ischemia-reperfusion","volume":"257","author":"Granger","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_25","first-page":"47","article-title":"Ischemia-reperfusion injury: Role of oxygen-derived free radicals","volume":"548","author":"Granger","year":"1986","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0016-5085(81)90648-X","article-title":"Superoxide radicals in feline intestinal ischemia","volume":"81","author":"Granger","year":"1981","journal-title":"Gastroenterology"},{"key":"ref_27","first-page":"G567","article-title":"Xanthine oxidase and neutrophil infiltration in intestinal ischemia","volume":"251","author":"Grisham","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_28","first-page":"211","article-title":"Expression of xanthine oxidase activity by murine leukocytes","volume":"116","author":"Grum","year":"1990","journal-title":"J. Lab. Clin. Med."},{"key":"ref_29","first-page":"147","article-title":"Mucosal lesions of the small intestine after intestinal vascular obstruction in the rat","volume":"151","author":"Haglind","year":"1985","journal-title":"Acta Chir. Scand."},{"key":"ref_30","first-page":"G49","article-title":"A role for iron in oxidant-mediated ischemic injury to intestinal microvasculature","volume":"253","author":"Hernandez","year":"1987","journal-title":"Am. J. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0016-5085(92)90010-V","article-title":"Ischemia\/reperfusion-induced feline intestinal dysfunction: Importance of granulocyte recruitment","volume":"103","author":"Kubes","year":"1992","journal-title":"Gastroenterology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/BF01296817","article-title":"Effects of cyclosporin A and FK506 on ischemia\/reperfusion-induced neutrophil infiltration in the cat","volume":"36","author":"Kubes","year":"1991","journal-title":"Dig. Dis. Sci."},{"key":"ref_33","first-page":"G878","article-title":"Granulocyte accumulation in postischemic intestine: Role of leukocyte adhesion glycoprotein CD11\/CD18","volume":"262","author":"Kurtel","year":"1992","journal-title":"Am. J. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000129253","article-title":"Feline intestinal ischemia and reperfusion: Relation between radical formation and tissue damage","volume":"25","author":"Nilsson","year":"1993","journal-title":"Eur. Surg. Res."},{"key":"ref_35","first-page":"G409","article-title":"Radical production during in vivo intestinal ischemia and reperfusion in the cat","volume":"257","author":"Nilsson","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0016-5085(94)90695-5","article-title":"Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine","volume":"106","author":"Nilsson","year":"1994","journal-title":"Gastroenterology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0016-5085(82)90115-9","article-title":"Ischemic injury in the cat small intestine: Role of superoxide radicals","volume":"82","author":"Parks","year":"1982","journal-title":"Gastroenterology"},{"key":"ref_38","first-page":"G749","article-title":"Contributions of ischemia and reperfusion to mucosal lesion formation","volume":"250","author":"Parks","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_39","first-page":"G285","article-title":"Ischemia-induced vascular changes: Role of xanthine oxidase and hydroxyl radicals","volume":"245","author":"Parks","year":"1983","journal-title":"Am. J. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1136\/gut.32.8.905","article-title":"Involvement of neutrophils in postischaemic damage to the small intestine","volume":"32","author":"Schoenberg","year":"1991","journal-title":"Gut"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jlb.50.5.488","article-title":"Leukocyte-endothelial cell adhesive interactions: Role of xanthine oxidase-derived oxidants","volume":"50","author":"Suzuki","year":"1991","journal-title":"J. Leukoc. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1749-6632.1990.tb37667.x","article-title":"Use of ATP following shock and ischemia","volume":"603","author":"Chaudry","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11357-997-0012-2","article-title":"Xanthine dehydrogenase\/xanthine oxidase and oxidative stress","volume":"20","author":"Chung","year":"1997","journal-title":"Age"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0016-5085(86)90078-8","article-title":"Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine","volume":"90","author":"Granger","year":"1986","journal-title":"Gastroenterology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev.pharmtox.45.120403.095857","article-title":"Glutathione transferases","volume":"45","author":"Hayes","year":"2005","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/abbi.1999.1650","article-title":"Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases","volume":"375","author":"Jaiswal","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.resuscitation.2012.06.030","article-title":"Mild hypothermia reduces per-ischemic reactive oxygen species production and preserves mitochondrial respiratory complexes","volume":"84","author":"Tissier","year":"2013","journal-title":"Resuscitation"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.lfs.2007.08.019","article-title":"Mitochondrial DNA fragments released through the permeability transition pore correspond to specific gene size","volume":"81","author":"Garcia","year":"2007","journal-title":"Life Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.freeradbiomed.2008.08.033","article-title":"Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells","volume":"45","author":"Kuwano","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"G933","DOI":"10.1152\/ajpgi.00198.2004","article-title":"Dual oxidase2 is expressed all along the digestive tract","volume":"288","author":"Benfares","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1117311","article-title":"A direct role for dual oxidase in Drosophila gut immunity","volume":"310","author":"Ha","year":"2005","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0002-9343(00)00480-0","article-title":"Nitric oxide and intestinal inflammation","volume":"109","author":"Kubes","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nchembio.607","article-title":"Chemistry and biology of reactive oxygen species in signaling or stress responses","volume":"7","author":"Dickinson","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrmicro3032","article-title":"The molecular mechanisms and physiological consequences of oxidative stress: Lessons from a model bacterium","volume":"11","author":"Imlay","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"806","DOI":"10.21037\/apm-21-3286","article-title":"Role of the PI3K\/Akt signaling pathway in liver ischemia reperfusion injury: A narrative review","volume":"11","author":"Wang","year":"2022","journal-title":"Ann. Palliat. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"10331","DOI":"10.1074\/jbc.M308013200","article-title":"Ras induction of superoxide activates ERK-dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave-stimulated osteoblasts","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Fiorini, G., and Schofield, C.J. (2024). Biochemistry of the hypoxia-inducible factor hydroxylases. Curr. Opin. Chem. Biol., 79.","DOI":"10.1016\/j.cbpa.2024.102428"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1074\/jbc.REV120.011188","article-title":"Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine","volume":"295","author":"Singhal","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-4939-3801-8_7","article-title":"Hydroxylation-Dependent Interaction of Substrates to the Von Hippel-Lindau Tumor Suppressor Protein (VHL)","volume":"1458","author":"Heir","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/35017054","article-title":"Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein","volume":"2","author":"Ohh","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1096\/fj.00-0732fje","article-title":"Induction of HIF-1alpha in response to hypoxia is instantaneous","volume":"15","author":"Jewell","year":"2001","journal-title":"FASEB J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.molmed.2018.10.006","article-title":"Inflammation and Hypoxia: HIF and PHD Isoform Selectivity","volume":"25","author":"Watts","year":"2019","journal-title":"Trends Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.1068592","article-title":"Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch","volume":"295","author":"Lando","year":"2002","journal-title":"Science"},{"key":"ref_66","first-page":"re12","article-title":"Integration of oxygen signaling at the consensus HRE","volume":"2005","author":"Wenger","year":"2005","journal-title":"Sci. STKE Signal Transduct. Knowl. Environ."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e46401","DOI":"10.15252\/embr.201846401","article-title":"Inherent DNA-binding specificities of the HIF-1alpha and HIF-2alpha transcription factors in chromatin","volume":"20","author":"Smythies","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","article-title":"The effect of HIF on metabolism and immunity","volume":"18","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-physiol-021115-105202","article-title":"Role of Intestinal HIF-2alpha in Health and Disease","volume":"78","author":"Ramakrishnan","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Sun, L., Li, T., Tang, H., Yu, K., Ma, Y., Yu, M., Qiu, Y., Xu, P., Xiao, W., and Yang, H. (2019). Intestinal Epithelial Cells-Derived Hypoxia-Inducible Factor-1alpha Is Essential for the Homeostasis of Intestinal Intraepithelial Lymphocytes. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00806"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/ars.2022.0003","article-title":"The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor","volume":"37","author":"Volkova","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"G833","DOI":"10.1152\/ajpgi.00065.2010","article-title":"HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury","volume":"299","author":"Feinman","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molcel.2015.12.002","article-title":"TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions","volume":"61","author":"Diebold","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41575-019-0193-z","article-title":"Intestinal gases: Influence on gut disorders and the role of dietary manipulations","volume":"16","author":"Berean","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nri2607","article-title":"Interdependence of hypoxic and innate immune responses","volume":"9","author":"Nizet","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.V94.5.1561","article-title":"Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1","volume":"94","author":"Rutkowski","year":"1999","journal-title":"Blood"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"G373","DOI":"10.1152\/ajpgi.00076.2002","article-title":"Cytokines induce HIF-1 DNA binding and the expression of HIF-1-dependent genes in cultured rat enterocytes","volume":"284","author":"Scharte","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/01.shk.0000135256.67441.3f","article-title":"Persistent HIF-1alpha activation in gut ischemia\/reperfusion injury: Potential role of bacteria and lipopolysaccharide","volume":"22","author":"Koury","year":"2004","journal-title":"Shock"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","article-title":"Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway","volume":"95","author":"Huang","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jss.2006.05.027","article-title":"LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats","volume":"135","author":"Scharte","year":"2006","journal-title":"J. Surg. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1158\/1541-7786.MCR-07-2177","article-title":"Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells","volume":"6","author":"Niu","year":"2008","journal-title":"Mol. Cancer Res. MCR"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41467-019-13889-6","article-title":"PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase","volume":"11","author":"Masschelein","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1alpha pathway: Role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cmet.2020.08.002","article-title":"The Role of HIF in Immunity and Inflammation","volume":"32","author":"McGettrick","year":"2020","journal-title":"Cell Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/01.mog.0000203864.48255.4f","article-title":"Regulation of the intestinal epithelial barrier by the apical junctional complex","volume":"22","author":"Laukoetter","year":"2006","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1091\/mbc.E14-07-1194","article-title":"HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity","volume":"26","author":"Saeedi","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Bin Hafeez, A., Jiang, X., Bergen, P.J., and Zhu, Y. (2021). Antimicrobial Peptides: An Update on Classifications and Databases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111691"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/jcb.20947","article-title":"Selective induction of mucin-3 by hypoxia in intestinal epithelia","volume":"99","author":"Louis","year":"2006","journal-title":"J. Cell. Biochem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Krzywinska, E., and Stockmann, C. (2018). Hypoxia, Metabolism and Immune Cell Function. Biomedicines, 6.","DOI":"10.3390\/biomedicines6020056"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/SHK.0b013e31825b1717","article-title":"Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shock","volume":"38","author":"Kistler","year":"2012","journal-title":"Shock"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Chang, M., Alsaigh, T., Kistler, E.B., and Schmid-Schonbein, G.W. (2012). Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040087"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"287","DOI":"10.5492\/wjccm.v4.i4.287","article-title":"In vivo analysis of intestinal permeability following hemorrhagic shock","volume":"4","author":"Alsaigh","year":"2015","journal-title":"World J. Crit. Care Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0039-6060(97)90107-0","article-title":"Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?","volume":"121","author":"Blikslager","year":"1997","journal-title":"Surgery"},{"key":"ref_96","first-page":"574","article-title":"The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion","volume":"107","author":"Park","year":"1990","journal-title":"Surgery"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"169ra111","DOI":"10.1126\/scitranslmed.3005046","article-title":"Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock","volume":"5","author":"DeLano","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41423-019-0208-2","article-title":"T lymphocytes in the intestinal mucosa: Defense and tolerance","volume":"16","author":"Ma","year":"2019","journal-title":"Cell Mol. Immunol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00024382-199702000-00010","article-title":"Interleukin-6 and tumor necrosis factor production in an enterocyte cell model (Caco-2) during exposure to Escherichia coli","volume":"7","author":"Michalsky","year":"1997","journal-title":"Shock"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0016-5085(00)70258-7","article-title":"Rapid activation of NF-kappaB and AP-1 and target gene expression in postischemic rat intestine","volume":"118","author":"Yeh","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s004020000211","article-title":"Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock","volume":"121","author":"Hierholzer","year":"2001","journal-title":"Arch. Orthop. Trauma. Surg."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00024382-200014020-00010","article-title":"Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia","volume":"14","author":"Liaudet","year":"2000","journal-title":"Shock"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2353\/ajpath.2010.091069","article-title":"Human intestinal ischemia-reperfusion-induced inflammation characterized: Experiences from a new translational model","volume":"176","author":"Grootjans","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jss.2013.01.064","article-title":"Bacterial translocation in an experimental model of multiple organ dysfunctions","volume":"183","author":"Louis","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_105","first-page":"G495","article-title":"Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: The best offense is a good defense","volume":"277","author":"Podolsky","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e49799","DOI":"10.15252\/embr.201949799","article-title":"Mitochondrial DNA in inflammation and immunity","volume":"21","author":"Riley","year":"2020","journal-title":"EMBO Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Rose, W.A., Sakamoto, K., and Leifer, C.A. (2012). TLR9 is important for protection against intestinal damage and for intestinal repair. Sci. Rep., 2.","DOI":"10.1038\/srep00574"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.trsl.2021.06.001","article-title":"Epithelial wound healing in inflammatory bowel diseases: The next therapeutic frontier","volume":"236","author":"Liu","year":"2021","journal-title":"Transl. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cmet.2017.06.018","article-title":"Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control","volume":"26","author":"Prochnicki","year":"2017","journal-title":"Cell Metab."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zhen, Y., and Zhang, H. (2019). NLRP3 Inflammasome and Inflammatory Bowel Disease. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00276"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ni.2714","article-title":"Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen","volume":"14","author":"Doedens","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"C580","DOI":"10.1152\/ajpcell.00204.2015","article-title":"Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia","volume":"309","author":"Tao","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ccell.2017.10.003","article-title":"An HIF-1alpha\/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression","volume":"32","author":"Palazon","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1182\/blood-2002-02-0454","article-title":"Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis","volume":"100","author":"Mecklenburgh","year":"2002","journal-title":"Blood"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"10440","DOI":"10.1073\/pnas.0401339101","article-title":"Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression","volume":"101","author":"Kong","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_117","first-page":"H1740","article-title":"Superoxide mediates reperfusion-induced leukocyte-endothelial cell interactions","volume":"257","author":"Suzuki","year":"1989","journal-title":"Am. J. Physiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1172\/JCI43273","article-title":"Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice","volume":"121","author":"Walmsley","year":"2011","journal-title":"J. Clin. Investig."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trre.2008.08.003","article-title":"Lymphocytes and ischemia-reperfusion injury","volume":"23","author":"Linfert","year":"2009","journal-title":"Transplant. Rev."},{"key":"ref_120","first-page":"H390","article-title":"Reperfusion-induced leukocyte infiltration: Role of elastase","volume":"259","author":"Zimmerman","year":"1990","journal-title":"Am. J. Physiol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nri2532","article-title":"Intravascular immunity: The host-pathogen encounter in blood vessels","volume":"9","author":"Hickey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/mi.2015.67","article-title":"Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis","volume":"9","author":"Fluck","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/eji.201142053","article-title":"Influence of hypoxia-inducible factor 1alpha on dendritic cell differentiation and migration","volume":"42","author":"Kohler","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Kuhlicke, J., Frick, J.S., Morote-Garcia, J.C., Rosenberger, P., and Eltzschig, H.K. (2007). Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0001364"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1515\/hsz-2012-0320","article-title":"Role of hypoxia inducible factor-1alpha for interferon synthesis in mouse dendritic cells","volume":"394","author":"Wobben","year":"2013","journal-title":"Biol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/eji.201445427","article-title":"Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal","volume":"46","author":"Mills","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Barrero, C.A., Datta, P.K., Sen, S., Deshmane, S., Amini, S., Khalili, K., and Merali, S. (2013). HIV-1 Vpr modulates macrophage metabolic pathways: A SILAC-based quantitative analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068376"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1038\/emi.2017.21","article-title":"Nuclear translocation of HIF-1alpha induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines","volume":"6","author":"Guo","year":"2017","journal-title":"Emerg. Microbes Infect."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.imbio.2010.12.005","article-title":"Monocyte-derived macrophages matured under prolonged hypoxia transcriptionally up-regulate HIF-1alpha mRNA","volume":"216","author":"Staples","year":"2011","journal-title":"Immunobiology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1182\/blood-2018-12-844605","article-title":"Neutrophil transendothelial migration: Updates and new perspectives","volume":"133","author":"Filippi","year":"2019","journal-title":"Blood"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1067\/msy.2002.125320","article-title":"Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum","volume":"132","author":"Gayle","year":"2002","journal-title":"Surgery"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2013.11.020","article-title":"Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation","volume":"40","author":"Campbell","year":"2014","journal-title":"Immunity"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e376","DOI":"10.1097\/CCM.0b013e318292388d","article-title":"Synergistic deleterious effect of hypoxemia and hypovolemia on microcirculation in intestinal villi*","volume":"41","author":"Harrois","year":"2013","journal-title":"Crit. Care Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.yjmcc.2011.06.009","article-title":"Coronary no reflow","volume":"52","author":"Schwartz","year":"2012","journal-title":"J. Mol. Cell Cardiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/01.STR.22.10.1276","article-title":"Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons","volume":"22","author":"Mori","year":"1991","journal-title":"Stroke"},{"key":"ref_137","first-page":"H699","article-title":"Role of neutrophils in ischemia-reperfusion-induced microvascular injury","volume":"253","author":"Hernandez","year":"1987","journal-title":"Am. J. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-012-1390-z","article-title":"Proteases and the gut barrier","volume":"351","author":"Biancheri","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2147\/JIR.S288280","article-title":"Metalloproteinases in Inflammatory Bowel Diseases","volume":"14","author":"Maronek","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","article-title":"Biochemical and Biological Attributes of Matrix Metalloproteinases","volume":"147","author":"Cui","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_141","first-page":"762","article-title":"Matrix metalloproteinases as drug targets in ischemia\/reperfusion injury","volume":"16","author":"Dejonckheere","year":"2011","journal-title":"Drug Discov. Today"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3892\/ijo.2021.5282","article-title":"Matrix metalloproteinase-1 expression is regulated by HIF-1-dependent and epigenetic mechanisms and serves a tumor-suppressive role in gastric cancer progression","volume":"59","author":"Ito","year":"2021","journal-title":"Int. J. Oncol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/mc.20678","article-title":"Transcriptional upregulation of MT2-MMP in response to hypoxia is promoted by HIF-1alpha in cancer cells","volume":"50","author":"Zhu","year":"2011","journal-title":"Mol. Carcinog."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1593\/neo.91326","article-title":"Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis","volume":"11","author":"Huang","year":"2009","journal-title":"Neoplasia"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1172\/JCI119076","article-title":"Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability","volume":"98","author":"Rajagopalan","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI112790","article-title":"Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites","volume":"79","author":"Shah","year":"1987","journal-title":"J. Clin. Investig."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.2982211","article-title":"Oxidative autoactivation of latent collagenase by human neutrophils","volume":"227","author":"Weiss","year":"1985","journal-title":"Science"},{"key":"ref_148","first-page":"321","article-title":"On the pathophysiology of intestinal ischemic injury. Clinical review","volume":"153","author":"Haglund","year":"1987","journal-title":"Acta Chir. Scand."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1007\/s00134-005-2790-2","article-title":"Noninvasive monitoring of peripheral perfusion","volume":"31","author":"Lima","year":"2005","journal-title":"Intensive Care Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1255\/jnirs.580","article-title":"Detecting Intestinal Ischemia Using near Infrared Spectroscopy","volume":"14","author":"Sowa","year":"2006","journal-title":"J. Near Infrared Spectrosc."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00003246-198702000-00015","article-title":"Predictive value of the stomach wall pH for complications after cardiac operations: Comparison with other monitoring","volume":"15","author":"Baker","year":"1987","journal-title":"Crit. Care Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/17\/8398\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:35:09Z","timestamp":1760034909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/17\/8398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":151,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ijms26178398"],"URL":"https:\/\/doi.org\/10.3390\/ijms26178398","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}