{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:06:47Z","timestamp":1792001207092,"version":"4.4.0"},"reference-count":158,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Agriculture and Forestry University Special Fund Project for Scientific and Technological Innovation, \u201cStructure-Activity Relationship of Ganoderma lucidum Polysaccharide Peptide GL-PPQ3 and Its Protective Effect on Gastric Ulcer Injury\u201d","award":["KFB24058"],"award-info":[{"award-number":["KFB24058"]}]},{"name":"Fujian Agriculture and Forestry University Special Fund Project for Scientific and Technological Innovation, \u201cStructure-Activity Relationship of Ganoderma lucidum Polysaccharide Peptide GL-PPQ3 and Its Protective Effect on Gastric Ulcer Injury\u201d","award":["2019GBJ003216"],"award-info":[{"award-number":["2019GBJ003216"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["KFB24058"],"award-info":[{"award-number":["KFB24058"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2019GBJ003216"],"award-info":[{"award-number":["2019GBJ003216"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Mushrooms, renowned for their nutritional value and bioactive compounds, offer potential health benefits, including antioxidants and anti-aging properties. Aging, characterized by cellular and tissue decline, is often associated with autophagy dysfunction, a crucial cellular cleaning process. This study aimed to investigate the neuroprotective, hepatoprotective, and antimicrobial properties of extracts from four medicinal and edible mushrooms: Ganoderma lucidum, Hericium erinaceus, Pleurotus ostreatus, and Agaricus bisporus. The protein, total phenol, and flavonoid content of mushroom extracts were determined. Aging was induced with 120 mg\/kg D-galactose and treated with 500 mg\/kg mushroom extracts. The study evaluated liver enzyme levels, histopathological changes in liver and brain tissues, gene expression correlated to neurodegeneration (SEPT5-SV2B-ATXN2-PARK2), telomere length, and immunomodulatory and pro-inflammatory (IL-2-IL-4-IL-6) gene expression pathways. Additionally, the antimicrobial potential of mushroom extracts was assessed against several bacteria (Lysinibacillus odyssey, Lysinibacillus fusiformis, Klebsiella oxytoca, and Escherichia coli) using agar well diffusion and lowest minimum inhibitory concentration (MIC) methods. By exploring these diverse aspects, this study aimed to provide a foundation for a better understanding of the potential of mushrooms as natural neuroprotective, hepatoprotective, and antimicrobial agents and their potential applications in human health. Results indicated that all mushroom extracts effectively mitigated oxidative stress. Agaricus bisporus exhibited the highest protein and flavonoid content, and Pleurotus ostreatus displayed the highest phenolic content. Notably, Hericium erinaceus and Ganoderma lucidum extracts demonstrated significant neuroprotective and hepatoprotective properties against D-galactose-induced aging, as evidenced by histopathological examination. All extracts exhibited a significant decrease (p &lt; 0.001) in liver function (serum levels of aspartate aminotransferase (GOT) and alanine aminotransferase (GPT)) and showed immunomodulatory and anti-inflammatory effects, characterized by upregulated IL-2 and IL-4 gene expression and downregulated IL-6 gene expression. Hericium erinaceus demonstrated the most pronounced upregulation (p &lt; 0.001) of SEPT5, SV2B, and telomere length gene expression, suggesting potential anti-aging effects. Furthermore, all mushroom extracts displayed antimicrobial activity against the tested bacterial strains, except Hericium erinaceus, which exhibited antibacterial activity solely against E. coli. Agaricus bisporus exhibited the largest inhibition zones (22 \u00b1 0.06 mm) against Lysinibacillus odyssey, while Hericium erinaceus displayed the largest inhibition zone against E. coli. The MIC value was observed with Agaricus bisporus extract against Lysinibacillus odyssey (1.95 \u00b1 0.16 mg\/mL). Lysinibacillus fusiformis exhibited the highest resistance to the tested mushroom extracts. These findings suggest that these edible and medicinal mushrooms possess a wide range of health-promoting properties, including neuroprotective, hepatoprotective, and antimicrobial activities. Further research is needed to fully understand the underlying mechanisms and optimize applications. However, our results provide a strong foundation for exploring these mushrooms as potential natural agents that promote overall health and combat age-related decline.<\/jats:p>","DOI":"10.3390\/ijms26178440","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:02:57Z","timestamp":1756825377000},"page":"8440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Investigating the Neuroprotective, Hepatoprotective, and Antimicrobial Effects of Mushroom Extracts"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5253-9202","authenticated-orcid":false,"given":"Menna-Allah E.","family":"Abdelkader","sequence":"first","affiliation":[{"name":"China National Engineering Research Center of Juncao Technology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"Department of Genetics, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6598-9664","authenticated-orcid":false,"given":"Hatungimana","family":"Mediatrice","sequence":"additional","affiliation":[{"name":"China National Engineering Research Center of Juncao Technology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"Rwanda Agriculture and Animal Resources Development Board, Kigali 5016, Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanxi","family":"Lin","sequence":"additional","affiliation":[{"name":"China National Engineering Research Center of Juncao Technology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-7953","authenticated-orcid":false,"given":"Christopher","family":"Rensing","sequence":"additional","affiliation":[{"name":"Institute of Environmental Microbiology, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2403-6089","authenticated-orcid":false,"given":"Mohamed M.","family":"Yacout","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Lin","sequence":"additional","affiliation":[{"name":"China National Engineering Research Center of Juncao Technology, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5679-8857","authenticated-orcid":false,"given":"Sarah A.","family":"Aggag","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Agriculture, Alexandria University, Alexandria 21545, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Agrawal, D., Chen, E., Chang, H., Tsay, H., Chandra Agrawal, D., Chin-Fun Chen, E., Chang, H.-C., Chen, C.-C., Kuo, C.-L., and Tsay, H.-S. (2017). Biotechnology of Medicinal Plants and Fungi in Taiwan: Production of Bioactive Secondary Metabolites in In Vitro Culture Systems. Medicinal Plants and Fungi: Recent Advances in Research and Development, Springer. Medicinal and Aromatic Plants of the World.","DOI":"10.1007\/978-981-10-5978-0_14"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5620484","DOI":"10.1155\/2020\/5620484","article-title":"Antioxidant and Antigenotoxic Potential of Infundibulicybe geotropa Mushroom Collected from Northwestern Turkey","volume":"2020","author":"Sevindik","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijbiomac.2016.07.016","article-title":"Characterization and Immunomodulatory Activities of Polysaccharide Isolated from Pleurotus eryngii","volume":"92","author":"Xu","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Venturella, G., Ferraro, V., Cirlincione, F., and Gargano, M.L. (2021). Medicinal mushrooms: Bioactive compounds, use, and clinical trials. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020634"},{"key":"ref_5","unstructured":"Chattopadhyay, A., Kadappa, H.S., and Meena, S.C. (2014). Recent molecular genetics and biotechnological approaches in mushroom research. Microbial Biodiversity in Sustainable Agriculture, Daya Publishing House, Astral International (P) Ltd."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Assemie, A., and Abaya, G. (2022). The Effect of Edible Mushroom on Health and Their Biochemistry. Int. J. Microbiol., 2022.","DOI":"10.1155\/2022\/8744788"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"127933","DOI":"10.1016\/j.foodchem.2020.127933","article-title":"Immunomodulatory Activities of Polysaccharides from Ganoderma on Immune Effector Cells","volume":"340","author":"Ren","year":"2021","journal-title":"Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.59411\/x0s16496","article-title":"Pharmacological Activities of Reishi (Ganoderma lucidum): Potent Medicinal Mushroom","volume":"3","author":"Meshesha","year":"2023","journal-title":"Microb. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41401-018-0077-8","article-title":"Ganoderma lucidum Extract Ameliorates MPTP-Induced Parkinsonism and Protects Dopaminergic Neurons from Oxidative Stress via Regulating Mitochondrial Function, Autophagy, and Apoptosis","volume":"40","author":"Ren","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yuan, S., Yang, Y., Li, J., Tan, X., Cao, Y., Li, S., Hong, H.D., Liu, L., and Zhang, Q. (2020). Ganoderma lucidum Rhodiola Compound Preparation Prevent D-Galactose-Induced Immune Impairment and Oxidative Stress in Aging Rat Model. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-76249-1"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.stemcr.2016.12.007","article-title":"Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer\u2019s Disease","volume":"8","author":"Huang","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.18632\/oncoscience.316","article-title":"The Anti-Cancer Components of Ganoderma lucidum Possesses Cardiovascular Protective Effect by Regulating Circular RNA Expression","volume":"3","author":"Xie","year":"2016","journal-title":"Oncoscience"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"He, J., Sun, Y., Jia, Y., Geng, X., Chen, R., Zhou, H., and Yang, B. (2019). Ganoderma triterpenes Protect against Hyperhomocysteinemia Induced Endothelial-Mesenchymal Transition via TGF-\u03b2 Signaling Inhibition. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00192"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4314\/tjpr.v17i2.10","article-title":"Effect of JUNCAO-Cultivated Ganoderma lucidum Spent Mushroom Substrate-Hot Water Extract on Immune Function in Mice","volume":"17","author":"Liu","year":"2018","journal-title":"Trop. J. Pharm. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.foodchem.2018.04.097","article-title":"Two New Farnesyl Phenolic Compounds with Anti-Inflammatory Activities from Ganoderma duripora","volume":"263","author":"Liu","year":"2018","journal-title":"Food Chem."},{"key":"ref_16","first-page":"5","article-title":"Antioxidant and Antimicrobial Capacities of Ganoderma lucidum","volume":"7","author":"Celal","year":"2019","journal-title":"MedCrave"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Savin, S., Craciunescu, O., Oancea, A., Ilie, D., Ciucan, T., Antohi, L.S., Toma, A., Nicolescu, A., Deleanu, C., and Oancea, F. (2020). Antioxidant, Cytotoxic and Antimicrobial Activity of Chitosan Preparations Extracted from Ganoderma lucidum Mushroom. Chem. Biodivers., 17.","DOI":"10.1002\/cbdv.202000175"},{"key":"ref_18","first-page":"8","article-title":"Evaluation of Antibacterial and Antifungal Activity of Ganoderma lucidum (Curtis) P. Karst Fruit Bodies Extracts","volume":"1","author":"Sridhar","year":"2011","journal-title":"World J. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1016\/j.bmcl.2015.10.016","article-title":"Chemical Constituents from Hericium erinaceus and Their Ability to Stimulate NGF-Mediated Neurite Out-growth on PC12 Cells","volume":"25","author":"Zhang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5802634","DOI":"10.1155\/2018\/5802634","article-title":"Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines","volume":"2018","author":"Li","year":"2018","journal-title":"Behav. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Limanaqi, F., Biagioni, F., Busceti, C.L., Polzella, M., Fabrizi, C., and Fornai, F. (2020). Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants, 9.","DOI":"10.3390\/antiox9030234"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/jnc.15767","article-title":"Hericerin Derivatives Activates a Pan-Neurotrophic Pathway in Central Hippocampal Neurons Converging to ERK1\/2 Signaling Enhancing Spatial Memory","volume":"165","author":"Chai","year":"2023","journal-title":"J. Neurochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00284-016-1073-1","article-title":"Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02","volume":"73","author":"Cui","year":"2016","journal-title":"Curr. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1615\/IntJMedMushrooms.v17.i7.10","article-title":"The Anti-Inflammatory Effects of Lion\u2019s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages","volume":"17","author":"Mori","year":"2015","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Tu, J., Liu, H., Wen, Y., Chen, P., and Liu, Z. (2021). A Novel Polysaccharide from Hericium erinaceus: Preparation, Structural Characteristics, Thermal Stabilities, and Antioxidant Activities in Vitro. J. Food Biochem., 45.","DOI":"10.1111\/jfbc.13871"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11557-015-1105-4","article-title":"Hericium erinaceus, an Amazing Medicinal Mushroom","volume":"14","author":"Thongbai","year":"2015","journal-title":"Mycol. Prog."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Suleiman, W.B., Shehata, R.M., and Younis, A.M. (2022). In Vitro Assessment of Multipotential Therapeutic Importance of Hericium erinaceus Mushroom Extracts Using Different Solvents. Bioresour. Bioprocess., 9.","DOI":"10.1186\/s40643-022-00592-6"},{"key":"ref_28","first-page":"691","article-title":"Antibacterial Activity of (Hericium erinaceus) Extract on Some Clinical Pathogenic Isolates","volume":"54","author":"Khalaf","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3839\/jabc.2019.024","article-title":"Inhibitory Activity against Biological Activities and Antimicrobial Activity against Pathogenic Bacteria of Extracts from Hericium erinaceus","volume":"62","author":"Kim","year":"2019","journal-title":"J. Appl. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2298\/BOTSERB2302241L","article-title":"The antibacterial activity of culture filtrates and mycelia of selected strains of macromycetes from the genus Hericium","volume":"47","author":"Lomberg","year":"2023","journal-title":"Bot. Serb."},{"key":"ref_31","first-page":"68","article-title":"Modelling the Effects of Temperature and Light Intensity on the Development and Yield of Different Pleurotus Species","volume":"41","author":"Kibar","year":"2008","journal-title":"Agric. Trop. Subtrop."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.36103\/ijas.v51i5.1150","article-title":"Evaluating the Ability of Pleurotus ostreatus Aqueous Extract to Modulate Genotoxicity Induced by Cyclophosphamide in Mice Bone Marrow Cells","volume":"51","author":"Farhan","year":"2020","journal-title":"Iraqi. J. Agric. Sci."},{"key":"ref_33","first-page":"2694","article-title":"Bioactive Compounds with Special References to Anticancer Property of Oyster Mushroom Pleurotus ostreatus","volume":"7","author":"Sarma","year":"2018","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.fct.2006.06.025","article-title":"Antioxidant Activity of the Oyster Mushroom, Pleurotus ostreatus, on CCl4-Induced Liver Injury in Rats","volume":"44","author":"Jayakumar","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ijbiomac.2015.11.045","article-title":"Antidiabetic Effect of Polysaccharides from Pleurotus ostreatus in Streptozotocin-Induced Diabetic Rats","volume":"83","author":"Zhang","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exger.2006.10.006","article-title":"Protective Effect of an Extract of the Oyster Mushroom, Pleurotus ostreatus, on Antioxidants of Major Organs of Aged Rats","volume":"42","author":"Jayakumar","year":"2007","journal-title":"Exp. Gerontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jfutfo.2023.06.001","article-title":"Extraction and Bioactivities of the Chemical Composition from Pleurotus ostreatus: A Review","volume":"4","author":"Zhao","year":"2024","journal-title":"J. Future Foods"},{"key":"ref_38","first-page":"12","article-title":"Antibacterial and Antioxidant Activity of Mycelial Extracts of Different Pleurotus Species","volume":"5","author":"Algur","year":"2019","journal-title":"Food Health"},{"key":"ref_39","first-page":"1","article-title":"Utilization of Agro-Wastes to Produce Oyster Mushroom (Pleurotus ostreatus) with High Antioxidant and Antimicrobial Activities","volume":"17","author":"Amal","year":"2020","journal-title":"Alex. J. Food Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"180","DOI":"10.31254\/phyto.2021.10306","article-title":"Phytochemical Properties and In-Vitro Antimicrobial Potency of Wild Edible Mushrooms (Pleurotus ostreatus) Obtained from Yenagoa, Nigeria","volume":"10","author":"Ogidi","year":"2021","journal-title":"J. Phytopharm."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Hamad, D., El-Sayed, H., Ahmed, W., Sonbol, H., and Ramadan, M.A.H. (2022). GC-MS Analysis of Potentially Volatile Compounds of Pleurotus ostreatus Polar Extract: In Vitro Antimicrobial, Cytotoxic, Immunomodulatory, and Antioxidant Activities. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.834525"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2478\/fhort-2018-0012","article-title":"Bioactive Compounds and Medicinal Properties of Oyster Mushrooms (Pleurotus sp.)","volume":"30","author":"Spizewski","year":"2018","journal-title":"Folia Hortic."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.foodchem.2019.04.035","article-title":"Agaricus Bisporus and Its By-Products as a Source of Valuable Extracts and Bioactive Compounds","volume":"292","author":"Ramos","year":"2019","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Das, B., De, B., Chetree, R., and Mandal, S.C. (2019). Medicinal Aspect of Mushrooms: A View Point. Herbal Medicine in India: Indigenous Knowledge, Practice, Innovation and its Value, Springer.","DOI":"10.1007\/978-981-13-7248-3_31"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1515\/pjfns-2016-0032","article-title":"Composition and Biological Properties of Agaricus Bisporus Fruiting Bodies\u2014A Review","volume":"67","author":"Rojowski","year":"2017","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Duan, H., Li, J., and Fan, L. (2023). Agaricus bisporus Polysaccharides Ameliorates Behavioral Deficits in D-Galactose-Induced Aging Mice: Mediated by Gut Microbiota. Foods, 12.","DOI":"10.3390\/foods12020424"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Sanmart\u00edn, J., Bobadilla, M., Mirpuri, E., Grifoll, V., P\u00e9rez-Clavijo, M., and Mart\u00ednez, A. (2022). Agaricus Mushroom-Enriched Diets Modulate the Microbiota-Gut-Brain Axis and Reduce Brain Oxidative Stress in Mice. Antioxidants, 11.","DOI":"10.3390\/antiox11040695"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"69","DOI":"10.21608\/eajbsg.2014.16502","article-title":"Evaluation of Antimicrobial and Antioxidant Activities of Some Edible Mushrooms","volume":"6","author":"Ghoneimy","year":"2014","journal-title":"Egypt. Acad. J. Biol. Sci. G Microb."},{"key":"ref_49","first-page":"56","article-title":"Antibacterial Activity of Crude Extracts and Fractions from Iranian Wild-Grown and Cultivated Agaricus spp","volume":"27","author":"Soltanian","year":"2015","journal-title":"Biomed. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuron.2024.09.015","article-title":"Autophagy, Aging, and Age-Related Neurodegeneration","volume":"113","author":"Palmer","year":"2024","journal-title":"Neuron"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Youssef, P., Chami, B., Lim, J., Middleton, T., Sutherland, G.T., and Witting, P.K. (2018). Evidence Supporting Oxidative Stress in a Moderately Affected Area of the Brain in Alzheimer\u2019s Disease. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-29770-3"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Jia, E., Sheng, Y., Shi, H., Wang, Y., Zhou, Y., Liu, Z., Qi, T., Pan, M., Bai, Y., and Zhao, X. (2023). Spatial Transcriptome Profiling of Mouse Hippocampal Single Cell Microzone in Parkinson\u2019s Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031810"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"dmm049177","DOI":"10.1242\/dmm.049177","article-title":"Bisphenol-A Impairs Synaptic Formation and Function by RGS4-Mediated Regulation of BDNF Signaling in the Cerebral Cortex","volume":"15","author":"Hyun","year":"2022","journal-title":"DMM Dis. Models Mech."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative Stress Shortens Telomeres","volume":"27","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1556\/2060.105.2018.4.32","article-title":"Advances and Challenges in Geroscience Research: An Update","volume":"105","author":"Yabluchanskiy","year":"2018","journal-title":"Physiol. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1055\/s-0032-1315370","article-title":"A Review on Antimicrobial Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds","volume":"78","author":"Alves","year":"2012","journal-title":"Planta Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1473-3099(18)30219-6","article-title":"Antimicrobial Resistance among Migrants in Europe: A Systematic Review and Meta-Analysis","volume":"18","author":"Nellums","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fct.2018.05.017","article-title":"Procyanidin B2 Protects against D-Galactose-Induced Mimetic Aging in Mice: Metabolites and Microbiome Analysis","volume":"119","author":"Xiao","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Shibu, M.A., Agrawal, D.C., and Huang, C.-Y. (2017). Mushrooms: A Pandora Box of Cardioprotective Phytochemicals. Medicinal Plants and Fungi: Recent Advances in Research and Development, Springer.","DOI":"10.1007\/978-981-10-5978-0_11"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Usman, M., Murtaza, G., and Ditta, A. (2021). Nutritional, Medicinal, and Cosmetic Value of Bioactive Compounds in Button Mushroom (Agaricus bisporus): A Review. Appl. Sci., 13.","DOI":"10.3390\/app11135943"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Amirullah, N.A., Abdullah, E., Zainal Abidin, N., Abdullah, N., and Manickam, S. (2023). Influence of Extraction Technologies on the Therapeutic Properties of Pleurotus spp. (Oyster mushrooms)\u2014A Critical Review. Food Biosci., 56.","DOI":"10.1016\/j.fbio.2023.103352"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Yang, Y., Zhang, H., Zuo, J., Gong, X., Yi, F., Zhu, W., and Li, L. (2019). Advances in Research on the Active Constituents and Physiological Effects of Ganoderma lucidum. Biomed. Dermatol., 3.","DOI":"10.1186\/s41702-019-0044-0"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.26599\/FSHW.2022.9250152","article-title":"Bioactive Substances in Hericium erinaceus and Their Biological Properties: A Review","volume":"13","author":"Qiu","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0308-8146(01)00229-1","article-title":"Compositional and Nutritional Studies on Two Wild Edible Mushrooms from Northwest Spain","volume":"75","author":"Alvarez","year":"2001","journal-title":"Food Chem."},{"key":"ref_65","unstructured":"World Health Organization (1991). Protein Quality Evaluation: Report of the Joint FAO\/WHO Expert Consultation, Food & Agriculture Organization."},{"key":"ref_66","first-page":"224","article-title":"Cultivated Mushrooms as a Valuable Diet Constituent and a Source of Biologically Active Substances","volume":"55","author":"Kalbarczyk","year":"2009","journal-title":"Herba Pol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0925-5214(95)00034-8","article-title":"Protein Analysis of the Common Mushroom Agaricus bisporus","volume":"7","author":"Braaksma","year":"1996","journal-title":"Postharvest Biol. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.foodchem.2010.10.056","article-title":"Indole Compounds in Fruiting Bodies of Some Edible Basidiomycota Species","volume":"125","author":"Ekiert","year":"2011","journal-title":"Food Chem."},{"key":"ref_69","first-page":"97","article-title":"Nutritive Value of Edible Wild and Cultured Mushrooms","volume":"34","year":"2010","journal-title":"Turk. J. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2454180","DOI":"10.1155\/2022\/2454180","article-title":"Nutritional Value, Medicinal Importance, and Health-Promoting Effects of Dietary Mushroom (Pleurotus ostreatus)","volume":"2022","author":"Lesa","year":"2022","journal-title":"J. Food Qual."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"9493","DOI":"10.3390\/cimb46090563","article-title":"Evaluation of the Influence of Varied Juncao Grass Substrates on Physiological and Enzymatic Reactions of Pleurotus ostreatus","volume":"46","author":"Claude","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0963-9969(01)00067-9","article-title":"Non-Volatile Components of Several Medicinal Mushrooms","volume":"34","author":"Mau","year":"2001","journal-title":"Food Res. Int."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1021\/acs.jafc.5b02914","article-title":"Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion\u2019s Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds","volume":"63","author":"Friedman","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_74","first-page":"927","article-title":"In Vitro Antioxidant Activity of Some Extracts Obtained from Agaricus bisporus Brown, Pleurotus ostreatus and Fomes fomentarius","volume":"63","author":"Mircea","year":"2015","journal-title":"Farmacia"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.3889\/oamjms.2019.741","article-title":"The Phytochemical Screening, Total Phenolic Contents and Antioxidant Activities in Vitro of White Oyster Mushroom (Pleurotus ostreatus) Preparations","volume":"7","author":"Rahimah","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Palma, I., Escalona-Buend\u00eda, H.B., Ponce-Alquicira, E., T\u00e9llez-T\u00e9llez, M., Gupta, V.K., D\u00edaz-God\u00ednez, G., and Soriano-Santos, J. (2016). Evaluation of the Antioxidant Activity of Aqueous and Methanol Extracts of Pleurotus ostreatus in Different Growth Stages. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.01099"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Elhusseiny, S.M., El-Mahdy, T.S., Awad, M.F., Elleboudy, N.S., Farag, M.M.S., Yassein, M.A., and Aboshanab, K.M. (2021). Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms. Molecules, 26.","DOI":"10.3390\/molecules26154623"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.procbio.2022.06.021","article-title":"Dietary Nutrients in Edible Mushroom, Agaricus bisporus and Their Radical Scavenging, Antibacterial, and Antifungal Effects","volume":"121","author":"Krishnamoorthi","year":"2022","journal-title":"Process Biochem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.lwt.2019.03.017","article-title":"Bio Compounds of Edible Mushrooms: In Vitro Antioxidant and Antimicrobial Activities","volume":"107","author":"Bach","year":"2019","journal-title":"LWT Food Sci. Technol."},{"key":"ref_80","first-page":"5","article-title":"Phenolic Content and Antioxidant Activity of Mushroom Extracts from Bosnian Market","volume":"44","author":"Pazalja","year":"2015","journal-title":"Bull. Chem. Technol. Bosnia Herzeg."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Nitthikan, N., Leelapornpisid, P., Naksuriya, O., Intasai, N., and Kiattisin, K. (2022). Potential and Alternative Bioactive Compounds from Brown Agaricus bisporus Mushroom Extracts for Xerosis Treatment. Sci. Pharm., 90.","DOI":"10.3390\/scipharm90040059"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11694-023-02163-5","article-title":"Optimization of Flavonoid Compound Extraction from Ganoderma lucidum and Its Antioxidant Activity on PC12 Cells Exposed to H2O2","volume":"18","author":"Wu","year":"2024","journal-title":"J. Food Meas. Charact."},{"key":"ref_83","first-page":"100130","article-title":"Comparison of Antioxidant Activity and Extraction Techniques for Commercially and Laboratory Prepared Extracts from Six Mushroom Species","volume":"4","author":"Sharpe","year":"2021","journal-title":"J. Agric. Food Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"464238","DOI":"10.1155\/2012\/464238","article-title":"Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities","volume":"2012","author":"Abdullah","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_85","first-page":"47","article-title":"Effects of Cultivation Techniques and Processing on Antimicrobial and Antioxidant Activities of Hericium erinaceus (Bull.:Fr.) Pers. Extracts.","volume":"47","author":"Wong","year":"2009","journal-title":"Food Technol. Biotechnol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1590\/fst.09919","article-title":"Antioxidant-Mediated Protective Role of Hericium Erinaceus (Bull.: Fr.) Pers. against Oxidative Damage in Fibroblasts from Friedreich\u2019s Ataxia Patient","volume":"40","author":"Lew","year":"2019","journal-title":"Food Sci. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Abdelkader, M.A.E., Mediatrice, H., Lin, D., Lin, Z., and Aggag, S.A. (2024). Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts. Foods, 13.","DOI":"10.3390\/foods13244028"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"103724","DOI":"10.1016\/j.jff.2019.103724","article-title":"Anti-Aging Effect of Brown Black Wolfberry on Drosophila Melanogaster and D-Galactose-Induced Aging Mice","volume":"65","author":"Zhang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/01480545.2017.1381110","article-title":"Acute and Developmental Toxicity Assessment of Erincine A-Enriched Hericium erinaceus Mycelia in Sprague\u2013Dawley Rats","volume":"41","author":"Li","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"ref_90","unstructured":"Moukha, S., F\u00e9randon, C., Mobio, T., Creppy, E.E., Ferandon, C., and Mobio, T. (2011, January 4\u20137). Safety Evaluation of Agaricus subrufescens Varieties and Their Products of Therapeutic Interest or for Disease Prevention. Proceedings of the 7th International Conference on Mushroom Biology and Mushroom Products, Arcachon, France."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Sharma, P., Tulsawani, R., and Agrawal, U. (2019). Pharmacological Effects of Ganoderma lucidum Extract against High-Altitude Stressors and Its Subchronic Toxicity Assessment. J. Food Biochem., 43.","DOI":"10.1111\/jfbc.13081"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Rahimah, S.B., Kharisma, Y., Dewi, M.K., Hartati, J., and Maharani, W. (2020). Acute Toxicity Test for the Ethanolic Extract of the White Oyster Mushroom. Medical Technology and Environmental Health, CRC Press.","DOI":"10.1201\/9781003016700-9"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Hu, Y., Xu, J., Sheng, Y., Liu, J., Li, H., Guo, M., Xu, W., Luo, Y., Huang, K., and He, X. (2022). Pleurotus ostreatus Ameliorates Obesity by Modulating the Gut Microbiota in Obese Mice Induced by High-Fat Diet. Nutrients, 14.","DOI":"10.3390\/nu14091868"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Kim, H., Jeon, Y.-E., Kim, S.-M., Jung, J.-I., Ko, D., Kim, E.-J., Kim, H., Jeon, Y.-E., Kim, S.-M., and Jung, J.-I. (2023). Agaricus bisporus Extract Exerts an Anti-Obesity Effect in High-Fat Diet-Induced Obese C57BL\/6N Mice by Inhibiting Pancreatic Lipase-Mediated Fat Absorption. Nutrients, 15.","DOI":"10.3390\/nu15194225"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ijbiomac.2017.08.135","article-title":"Antioxidant and Anti-Aging Effects of Acidic-Extractable Polysaccharides by Agaricus bisporus","volume":"106","author":"Li","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"32","DOI":"10.56499\/jppres19.666_8.1.32","article-title":"Restoration of Liver Function in Malnourished Mice Orally Administered with Pleurotus Ostreatus Fruiting Bodies Extract","volume":"8","author":"Morris","year":"2020","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Dimopoulos, T.T., Lippi, S.L.P., Davila, J.F., Barkey, R.E., Doherty, E.N., and Flinn, J.M. (2022). White Button Mushroom (Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer\u2019s Disease. Brain Sci., 12.","DOI":"10.3390\/brainsci12101364"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sharma, P., and Tulsawani, R. (2020). Ganoderma lucidum Aqueous Extract Prevents Hypobaric Hypoxia Induced Memory Deficit by Modulating Neurotransmission, Neuroplasticity and Maintaining Redox Homeostasis. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-65812-5"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Roda, E., Priori, E.C., Ratto, D., De Luca, F., Di Iorio, C., Angelone, P., Locatelli, C.A., Desiderio, A., Goppa, L., and Savino, E. (2021). Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126379"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.foodchem.2018.07.115","article-title":"Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis","volume":"271","author":"Zhao","year":"2019","journal-title":"Food Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cyto.2016.08.033","article-title":"Role of Interleukin-6 to Differentiate Sepsis from Non-Infectious Systemic Inflammatory Response Syndrome","volume":"88","author":"Ma","year":"2016","journal-title":"Cytokine"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Martinelli, I., Tomassoni, D., Roy, P., Amenta, F., Khosrow Tayebati, S., Jin, K., Su, H., and Yang, G.-Y. (2021). Altered Brain Cholinergic and Synaptic Markers in Obese Zucker Rats. Cells, 10.","DOI":"10.3390\/cells10102528"},{"key":"ref_103","first-page":"1","article-title":"Chronic Overload of SEPT4, a Parkin Substrate That Aggregates in Parkinson\u2019s Disease, Causes Behavioral Alterations but Not Neurodegeneration in Mice","volume":"6","author":"Yamakado","year":"2013","journal-title":"Mol. Brain"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1007\/s00018-020-03468-0","article-title":"Synaptic Mitochondrial Dysfunction and Septin Accumulation Are Linked to Complement-Mediated Synapse Loss in an Alzheimer\u2019s Disease Animal Model","volume":"77","author":"Micsonai","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s10142-019-00690-3","article-title":"A Blueprint of Septin Expression in Human Tissues","volume":"19","author":"Zuvanov","year":"2019","journal-title":"Funct. Integr. Genom."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ferreira, C.B., Marttinen, M., Coelho, J.E., Paldanius, K.M.A., Takalo, M., M\u00e4kinen, P., Lepp\u00e4nen, L., Miranda-Louren\u00e7o, C., Fonseca-Gomes, J., and Tanqueiro, S.R. (2022). S327 Phosphorylation of the Presynaptic Protein SEPTIN5 Increases in the Early Stages of Neurofibrillary Pathology and Alters the Functionality of SEPTIN5. Neurobiol. Dis., 163.","DOI":"10.1016\/j.nbd.2021.105603"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Pallotta, M.M., Ronca, R., Carotenuto, R., Porreca, I., Turano, M., Ambrosino, C., and Capriglione, T. (2017). Specific Effects of Chronic Dietary Exposure to Chlorpyrifos on Brain Gene Expression-A Mouse Study. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18112467"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Toyama, B.H., and Hetzer, M.W. (2013). Protein Homeostasis: Live Long, Won\u2019t Prosper, Nature Publishing Group.","DOI":"10.1038\/nrm3496"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Noda, S., Sato, S., Fukuda, T., Tada, N., Uchiyama, Y., Tanaka, K., and Hattori, N. (2020). Loss of Parkin Contributes to Mitochondrial Turnover and Dopaminergic Neuronal Loss in Aged Mice. Neurobiol. Dis., 136.","DOI":"10.1016\/j.nbd.2019.104717"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1113\/JP277157","article-title":"Parkin Overexpression Protects from Ageing-Related Loss of Muscle Mass and Strength","volume":"597","author":"Reynaud","year":"2019","journal-title":"J. Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5019815","DOI":"10.1155\/2019\/5019815","article-title":"MiR-185 and SEPT5 Genes May Contribute to Parkinson\u2019s Disease Pathophysiology","volume":"2019","author":"Rahimmi","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neurobiolaging.2016.02.007","article-title":"Role of DHA in Aging-Related Changes in Mouse Brain Synaptic Plasma Membrane Proteome","volume":"41","author":"Sidhu","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4103\/1673-5374.338996","article-title":"Are ATXN2 Variants Modifying Our Understanding about Neural Pathogenesis, Phenotypes, and Diagnostic?","volume":"17","author":"Paucar","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_114","first-page":"232","article-title":"Expression of Ataxin-2 in Brains from Normal Individuals and Patients with Alzheimer\u2019s Disease and Spinocerebellar Ataxia 2","volume":"45","author":"Huynh","year":"1999","journal-title":"Ann. Neurol. Off. J. Am. Neurol. Assoc. Child Neurol. Soc."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/hmg\/ddr227","article-title":"Ataxin-2 Repeat-Length Variation and Neurodegeneration","volume":"20","author":"Ross","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature22038","article-title":"Therapeutic Reduction of Ataxin-2 Extends Lifespan and Reduces Pathology in TDP-43 Mice","volume":"544","author":"Becker","year":"2017","journal-title":"Nature"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1515\/cclm-2017-0870","article-title":"Telomere Biology and Age-Related Diseases","volume":"56","author":"Herrmann","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/ptr.6982","article-title":"Evaluation of the Effect of Thymoquinone in D-Galactose-Induced Memory Impairments in Rats: Role of MAPK, Oxidative Stress, and Neuroinflammation Pathways and Telomere Length","volume":"35","author":"Oskouei","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.fmre.2022.02.010","article-title":"Ultrasound Deep Brain Stimulation Decelerates Telomere Shortening in Alzheimer\u2019s Disease and Aging Mice","volume":"3","author":"Zhang","year":"2023","journal-title":"Fundam. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1002\/fsn3.2333","article-title":"Cerebroprotein Hydrolysate-I Protects Senescence-Induced by D-Galactose in PC12 Cells and Mice","volume":"9","author":"Zhu","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Zeng, M., Qi, L., Guo, Y., Zhu, X., Tang, X., Yong, T., Xie, Y., Wu, Q., Zhang, M., and Chen, D. (2021). Long-Term Administration of Triterpenoids from Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.628860"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"El-Far, A.H., Elghaity, M.M., Mohamed, S.A., Noreldin, A.E., Elewa, Y.H.A., Al Jaouni, S.K., and Alsenosy, A.A. (2024). Diosgenin Alleviates D-Galactose-Induced Oxidative Stress in Rats\u2019 Brain and Liver Targeting Aging and Apoptotic Marker Genes. Front. Mol. Biosci., 11.","DOI":"10.3389\/fmolb.2024.1303379"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Boccardi, V., and Marano, L. (2024). Aging, Cancer, and Inflammation: The Telomerase Connection. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25158542"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Luo, J., Ganesan, K., and Xu, B. (2024). Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms. J. Fungi, 10.","DOI":"10.3390\/jof10030215"},{"key":"ref_125","first-page":"654","article-title":"Comparitive Study on the Antioxidant, Anticancer and Antimicrobial Property of Agaricus bisporus (JE Lange) Imbach before and after Boiling","volume":"8","author":"Jagadish","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/jmf.2009.0090","article-title":"Antimicrobial and Antioxidant Activities of Mycelia of 10 Wild Mushroom Species","volume":"13","author":"Kalyoncu","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1081\/FRI-200051893","article-title":"Antimicrobial Activity of the Medicinal Mushroom Ganoderma","volume":"21","author":"Gao","year":"2005","journal-title":"Food Rev. Int."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Poniedzia\u0142ek, B., Siwulski, M., Wiater, A., Komaniecka, I., Komosa, A., Asecka, M.G., Magdziak, Z., Mleczek, M., Niedzielski, P., and Edrzej Proch, J. (2019). The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In Vitro Screening of Eight Edible Species. Nutrients, 11.","DOI":"10.3390\/nu11123040"},{"key":"ref_129","unstructured":"Kumar, H. (2022). Kjeldahl Method. Advanced Techniques of Analytical Chemistry, Bentham Science Publisher."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1021\/jf049571r","article-title":"Antioxidant Activity of a Flavonoid-Rich Extract of Hypericum perforatum L. in Vitro","volume":"52","author":"Zou","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","article-title":"Analysis of Total Phenols and Other Oxidation Substrates and Antioxidants by Means of Folin-Ciocalteu Reagent","volume":"299","author":"Singleton","year":"1999","journal-title":"Methods Enzymol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Roberts, C.E., Raner, G.M., and Isaacs, G.D. (2018). High Performance Liquid Chromatography Separation of Epigenetic Cytosine Variants. Methods Protoc., 1.","DOI":"10.3390\/mps1020010"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"131122","DOI":"10.1016\/j.foodchem.2021.131122","article-title":"Antioxidant capacity of phenolic compounds separated from tea seed oil in vitro and in vivo","volume":"371","author":"Liu","year":"2022","journal-title":"Food Chem."},{"key":"ref_134","unstructured":"Bancroft, J.D., and Gamble, M. (2008). Theory and Practice of Histological Techniques, Elsevier Health Sciences."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"200130","DOI":"10.1016\/j.angen.2022.200130","article-title":"Neomycin\u2019s Immunomodulatory Effect on the Gene Expression, Some Hematologic Parameters, and Intestinal Histology in Two Rabbit Lines","volume":"25","author":"Aggag","year":"2022","journal-title":"Anim. Gene"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.vetpar.2009.12.018","article-title":"Quantitation of Cytokine mRNA by Real-Time RT-PCR during a Vaccination Trial in a Rabbit Model of Fascioliasis","volume":"169","author":"Espino","year":"2010","journal-title":"Vet. Parasitol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere Measurement by Quantitative PCR","volume":"30","author":"Cawthon","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref_139","unstructured":"Ali, R.M., Makhlouf, A.A., Abdelrrassoul, H.A., and Yacuot, M.M. (2017, January 17\u201320). Molecular Genetic Studies on Some Pathogenic Bacteria Isolated from Rabbit Stomach. Proceedings of the 15th International Symposium on Biocontrol and Biotechnology (ISBB 2017), Hurghada, Egypt."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"101176","DOI":"10.1016\/j.eujim.2020.101176","article-title":"Evaluation of the Phytoconstituents of Auricularia Auricula-Judae Mushroom and Antimicrobial Activity of Its Protein Extract","volume":"38","author":"Oli","year":"2020","journal-title":"Eur. J. Integr. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13020-023-00735-7","article-title":"Neurobiological Effects of Gallic Acid: Current Perspectives","volume":"18","author":"Bhuia","year":"2023","journal-title":"Chin. Med."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Hadidi, M., Li\u00f1\u00e1n-Atero, R., Tarahi, M., Christodoulou, M.C., and Aghababaei, F. (2024). The Potential Health Benefits of Gallic Acid: Therapeutic and Food Applications. Antioxidants, 13.","DOI":"10.3390\/antiox13081001"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1007\/s00253-017-8709-3","article-title":"The Specific Effect of Gallic Acid on Escherichia coli Biofilm Formation by Regulating PgaABCD Genes Expression","volume":"102","author":"Kang","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2174\/1389557521666210902162120","article-title":"Pharmacological Actions and Underlying Mechanisms of Catechin: A Review","volume":"22","author":"Baranwal","year":"2021","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Nguyen, V., Taine, E.G., Meng, D., Cui, T., and Tan, W. (2024). Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials. Nutrients, 16.","DOI":"10.3390\/nu16070924"},{"key":"ref_146","first-page":"1560","article-title":"Effect of P-Coumaric Acid against Oxidative Stress Induced by Cisplatin in Brain Tissue of Rats","volume":"27","author":"Alwasel","year":"2017","journal-title":"JAPS J. Anim. Plant Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.foodcont.2011.11.022","article-title":"p-Coumaric Acid Kills Bacteria through Dual Damage Mechanisms","volume":"25","author":"Lou","year":"2012","journal-title":"Food Control."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1002\/jsfa.13931","article-title":"Ferulic Acid: Extraction, Estimation, Bioactivity and Applications for Human Health and Food","volume":"105","author":"Kumar","year":"2025","journal-title":"J. Sci. Food Agric."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zhai, Y., Wang, T., Fu, Y., Yu, T., Ding, Y., and Nie, H. (2023). Ferulic Acid: A Review of Pharmacology, Toxicology, and Therapeutic Effects on Pulmonary Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098011"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1021\/acschemneuro.4c00349","article-title":"Pharmacological Activities and Molecular Mechanisms of Sinapic Acid in Neurological Disorders","volume":"15","author":"Farzan","year":"2024","journal-title":"ACS Chem. Neurosci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1007\/s11033-021-06367-0","article-title":"Pharmacological and Therapeutic Applications of Sinapic Acid\u2014An Updated Review","volume":"48","author":"Pandi","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/jac\/dky079","article-title":"Antimicrobial Activity of Ellagic Acid against Helicobacter pylori Isolates from India and during Infections in Mice","volume":"73","author":"De","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Zhu, H., Yan, Y., Jiang, Y., and Meng, X. (2022). Ellagic Acid and Its Anti-Aging Effects on Central Nervous System. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810937"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e21844","DOI":"10.1016\/j.heliyon.2023.e21844","article-title":"The Effect of Ellagic Acid on the Metabolic Syndrome: A Review Article","volume":"9","author":"Naraki","year":"2023","journal-title":"Heliyon"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1177\/08853282211058099","article-title":"Biomedical Applications of Tannic Acid","volume":"36","author":"Baldwin","year":"2022","journal-title":"J. Biomater. Appl."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"101908","DOI":"10.1016\/j.progpolymsci.2024.101908","article-title":"The Multifaceted Role of Tannic Acid: From Its Extraction and Structure to Antibacterial Properties and Applications","volume":"160","author":"Hosseini","year":"2025","journal-title":"Prog. Polym. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Ruwizhi, N., and Aderibigbe, B.A. (2020). Cinnamic Acid Derivatives and Their Biological Efficacy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165712"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"429320","DOI":"10.1155\/2012\/429320","article-title":"Anti-Inflammatory Activities of Cinnamomum Cassia Constituents In Vitro and In Vivo","volume":"2012","author":"Liao","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/17\/8440\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:35:49Z","timestamp":1760034949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/17\/8440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":158,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ijms26178440"],"URL":"https:\/\/doi.org\/10.3390\/ijms26178440","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}