{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:17:03Z","timestamp":1793121423155,"version":"4.5.0"},"reference-count":202,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The anti-aging protein \u03b1-Klotho has several therapeutic effects on different pathophysiological conditions, mainly its anti-inflammatory and antioxidant effects. Experimental evidence and observational studies suggest that there are several strategies to increase \u03b1-Klotho in the brain and enhance its beneficial effects, thus contributing to improving its neuroprotective and neuroplasticity mechanisms in brain aging, Alzheimer\u2019s, Parkinson\u2019s, and ischemic stroke diseases. In this article, we summarize the relevant information on \u03b1-Klotho, brain aging, Alzheimer\u2019s, Parkinson\u2019s, and ischemic stroke diseases and analyze the role of \u03b1-Klotho in each of these alterations, as well as the effect of physical exercise, exogenous application of \u03b1-klotho, and various drugs approved for different human diseases on \u03b1-Klotho production.<\/jats:p>","DOI":"10.3390\/ijms26178551","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T08:08:46Z","timestamp":1756973326000},"page":"8551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Anti-Inflammatory Actions of Soluble Klotho in Brain Aging and Its Main Associated Diseases"],"prefix":"10.3390","volume":"26","author":[{"given":"H\u00e9ctor E.","family":"L\u00f3pez-Vald\u00e9s","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Hern\u00e1ndez-Lucas","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D. J.","family":"Rodr\u00edguez-Fabi\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2332-1546","authenticated-orcid":false,"given":"Nadia F.","family":"Esteban-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7174-8647","authenticated-orcid":false,"given":"Roger","family":"Guti\u00e9rrez-Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Biom\u00e9dicas, Escuela de Medicina, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Arrieta-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n B\u00e1sica, Divisi\u00f3n de Investigaci\u00f3n, Instituto Nacional de Geriatr\u00eda, Secretar\u00eda de Salud, M\u00e9xico City 10200, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Mart\u00ednez-Coria","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico City 04360, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Coria, H., Arrieta-Cruz, I., Guti\u00e9rrez-Ju\u00e1rez, R., and L\u00f3pez-Vald\u00e9s, H.E. 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