{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:27:34Z","timestamp":1787495254400,"version":"build-2736575974"},"reference-count":212,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008050","name":"Fundaci\u00f3 Privada Cellex","doi-asserted-by":"publisher","award":["CP042187"],"award-info":[{"award-number":["CP042187"]}],"id":[{"id":"10.13039\/100008050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Schizophrenia (SCZ) is a complex psychiatric disorder with positive, negative, and cognitive symptoms that cause long-term functional impairment. Despite available treatments, limitations in addressing cognitive and negative symptoms, medication side effects, and poor adherence highlight the need for novel biomarkers to support precision medicine. Hair has emerged as a promising, non-invasive biological matrix for biomarker research. Hair analysis has been explored to detect trace elements, abused drugs, antipsychotics, cortisol, neurotransmitters, and to assess gene expression, with results often consistent with blood, urine, and post-mortem tissues. Its advantages include ease of sampling and the ability to provide long-term information, while limitations involve individual variability and methodological inconsistencies. This review summarizes current evidence on hair-based biomarkers in SCZ, critically evaluating their potential and challenges. By integrating molecular, metabolic, and genetic findings, we highlight the value of hair as a complementary tool for advancing biomarker discovery and personalized approaches in SCZ.<\/jats:p>","DOI":"10.3390\/ijms26178718","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:27:12Z","timestamp":1757500032000},"page":"8718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Potential of Hair Matrix for Biomarker Analysis in Schizophrenia"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5631-9633","authenticated-orcid":false,"given":"Enric","family":"Rubio-Contreras","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Practice, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1295-6822","authenticated-orcid":false,"given":"Nora","family":"Guasch-Capella","sequence":"additional","affiliation":[{"name":"Barcelona Cl\u00ednic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Cl\u00ednic of Barcelona, University of Barcelona, 08036 Barcelona, Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2035-5979","authenticated-orcid":false,"given":"Albert","family":"Mart\u00ednez-Pinte\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Practice, University of Barcelona, 08036 Barcelona, Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-9887","authenticated-orcid":false,"given":"David","family":"Olivares-Berjaga","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Practice, University of Barcelona, 08036 Barcelona, Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Mor\u00e9n","sequence":"additional","affiliation":[{"name":"Barcelona Cl\u00ednic Schizophrenia Unit (BCSU), Department of Psychiatry, Institute of Neuroscience, Hospital Cl\u00ednic of Barcelona, University of Barcelona, 08036 Barcelona, Spain"},{"name":"August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Biomedical Research Networking Center in Mental Health (CIBERSAM), 28029 Madrid, Spain"},{"name":"Department of Fundamental and Clinical Nursing, Faculty of Nursing, University of Barcelona, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41582-023-00904-0","article-title":"Schizophrenia: From neurochemistry to circuits, symptoms and treatments","volume":"20","author":"Howes","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0140-6736(21)01730-X","article-title":"Schizophrenia","volume":"399","author":"Jauhar","year":"2022","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamapsychiatry.2019.3360","article-title":"Schizophrenia\u2014An Overview","volume":"77","author":"McCutcheon","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.psc.2020.02.010","article-title":"Neurodevelopmental Factors in Schizophrenia","volume":"43","author":"Sawa","year":"2020","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1017\/S1092852924000622","article-title":"What is schizophrenia\u2014Symptomatology","volume":"30","author":"Striebel","year":"2024","journal-title":"CNS Spectr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/schbul\/sbv002","article-title":"The Promise of Biological Markers for Treatment Response in First-Episode Psychosis: A Systematic Review","volume":"41","author":"Fond","year":"2015","journal-title":"Schizophr. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e601","DOI":"10.1038\/tp.2015.91","article-title":"Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset","volume":"5","author":"Chan","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.schres.2018.01.008","article-title":"Patterns in adolescent cannabis use predict the onset and symptom structure of schizophrenia-spectrum disorder","volume":"197","author":"Shahzade","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.psychres.2015.09.029","article-title":"Psychosocial functioning of individuals with schizophrenia in community housing facilities and the psychiatric hospital in Zurich","volume":"230","author":"Jaeger","year":"2015","journal-title":"Psychiatry Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1017\/S0033291710002023","article-title":"Early detection of psychosis: Positive effects on 5-year outcome","volume":"41","author":"Larsen","year":"2011","journal-title":"Psychol. Med."},{"key":"ref_11","first-page":"130","article-title":"Early detection of schizophrenia: Current evidence and future perspectives","volume":"5","author":"Maurer","year":"2006","journal-title":"World Psychiatry Off. J. World Psychiatr. Assoc. (WPA)"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Walker, E.F. (2002). The Role of Endogenous and Exogenous Risk Factors in the Genesis of Schizophrenia. The Effects of Parental Dysfunction on Children, Springer US.","DOI":"10.1007\/978-1-4615-1739-9_1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jpsychires.2023.01.004","article-title":"The use of biochemical indexes in hair for clinical studies of psychiatric diseases: What can we learn about mental disease from hair?","volume":"158","author":"Ren","year":"2023","journal-title":"J. Psychiatr. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.biopsych.2014.07.025","article-title":"Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses","volume":"78","author":"Maekawa","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpsychires.2015.08.007","article-title":"The relationship between cortisol, stress and psychiatric illness: New insights using hair analysis","volume":"70","author":"Papadopoulos","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Fi\u0161ar, Z. (2023). Biological hypotheses, risk factors, and biomarkers of schizophrenia. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 120.","DOI":"10.1016\/j.pnpbp.2022.110626"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Berdeville, C.H.D.S.F., Silva-Amaral, D., Dalgalarrondo, P., Banzato, C.E.M., and Martins-de-Souza, D. (2025). A scoping review of protein biomarkers for schizophrenia: State of progress, underlying biology, and methodological considerations. Neurosci. Biobehav. Rev., 168.","DOI":"10.1016\/j.neubiorev.2024.105949"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/wps.21078","article-title":"Candidate biomarkers in psychiatric disorders: State of the field","volume":"22","author":"Moeller","year":"2023","journal-title":"World Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2025.05.026","article-title":"Molecular signatures and emerging therapeutic targets in schizophrenia: A biomarker-centric perspective in psychiatric disorders","volume":"282","author":"Hakami","year":"2025","journal-title":"Schizophr. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.schres.2019.03.009","article-title":"Candidate metabolic biomarkers for schizophrenia in CNS and periphery: Do any possible associations exist?","volume":"226","author":"Cao","year":"2020","journal-title":"Schizophr. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1038\/s41380-023-02059-2","article-title":"Biomarkers in the cerebrospinal fluid of patients with psychotic disorders compared to healthy controls: A systematic review and meta-analysis","volume":"28","author":"Jeppesen","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2457295","DOI":"10.1080\/20008066.2025.2457295","article-title":"The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder","volume":"16","author":"Shkreli","year":"2025","journal-title":"Eur. J. Psychotraumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.psychres.2018.04.036","article-title":"Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia","volume":"265","author":"Mohammadi","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/jamapsychiatry.2023.0791","article-title":"Evaluation of Brain-Body Health in Individuals with Common Neuropsychiatric Disorders","volume":"80","author":"Tian","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.schres.2017.09.021","article-title":"A systematic review of metabolite biomarkers of schizophrenia","volume":"195","author":"Davison","year":"2018","journal-title":"Schizophr. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Perkovic, M., Erjavec, G., Strac, D., Uzun, S., Kozumplik, O., and Pivac, N. (2017). Theranostic Biomarkers for Schizophrenia. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18040733"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1177\/0960327120903487","article-title":"Determination of thallium in urine, blood, and hair in illicit opioid users in Iran","volume":"39","author":"Molavi","year":"2020","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_28","first-page":"633","article-title":"Concentrations of cadmium in blood and urine and their contents in the hair of children from Katowice Murcki","volume":"55","author":"Bibrzycka","year":"2002","journal-title":"Wiadomosci Lekarskie"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"M1","DOI":"10.1530\/EJE-15-0313","article-title":"Clinical applications of cortisol measurements in hair","volume":"173","author":"Wester","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.forsciint.2011.10.024","article-title":"Society of Hair Testing guidelines for drug testing in hair","volume":"218","author":"Cooper","year":"2012","journal-title":"Forensic Sci. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.psychres.2012.05.028","article-title":"Assessing illicit drug use among adults with schizophrenia","volume":"200","author":"Desmarais","year":"2012","journal-title":"Psychiatry Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kogler, L., Wang, R., Luther, T., Hofer, A., Frajo-Apor, B., and Derntl, B. (2025). Cortisol in schizophrenia spectrum disorders: A comprehensive meta-analysis. Front. Neuroendocrinol., 77.","DOI":"10.1016\/j.yfrne.2025.101186"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/nutrit\/nuz059","article-title":"Trace elements in schizophrenia: A systematic review and meta-analysis of 39 studies (N = 5151 participants)","volume":"78","author":"Saghazadeh","year":"2020","journal-title":"Nutr. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/schbul\/sbt099","article-title":"Neurocognitive Functioning of Individuals with Schizophrenia: Using and Not Using Drugs","volume":"40","author":"Bahorik","year":"2014","journal-title":"Schizophr. Bull."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"107049","DOI":"10.1016\/j.psyneuen.2024.107049","article-title":"Associations of schizophrenia with the activities of the HPA and HPG axes and their interactions characterized by hair-based biomarkers","volume":"165","author":"Qi","year":"2024","journal-title":"Psychoneuroendocrinology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"121878","DOI":"10.1016\/j.jchromb.2019.121878","article-title":"LC-MS determination of catecholamines and related metabolites in red deer urine and hair extracted using magnetic multi-walled carbon nanotube poly(styrene-co-divinylbenzene) composite","volume":"1136","author":"Murtada","year":"2020","journal-title":"J. Chromatogr. B"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e100042","DOI":"10.1136\/gpsych-2018-100042","article-title":"Correlation of hair risperidone concentration and serum level among patients with schizophrenia","volume":"32","author":"Sun","year":"2019","journal-title":"Gen. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e1229","DOI":"10.1038\/tp.2017.182","article-title":"Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes","volume":"7","author":"Maekawa","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/mp.2013.67","article-title":"Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients","volume":"18","author":"Robicsek","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"141523","DOI":"10.1016\/j.chemosphere.2024.141523","article-title":"Analytical methods and biomonitoring results in hair for the assessment of exposure to endocrine-disrupting chemicals: A literature review","volume":"353","author":"Robin","year":"2024","journal-title":"Chemosphere"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"164341","DOI":"10.1016\/j.scitotenv.2023.164341","article-title":"Human hair as a noninvasive matrix to assess exposure to micro-organic contaminants: State of the art review","volume":"892","author":"Zhang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, Y., Guo, J., Xing, S., Yu, H., and Huan, T. (2021). Global-Scale Metabolomic Profiling of Human Hair for Simultaneous Monitoring of Endogenous Metabolome, Short- and Long-Term Exposome. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.674265"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.forsciint.2004.07.024","article-title":"Results of hair analyses for drugs of abuse and comparison with self-reports and urine tests","volume":"156","author":"Musshoff","year":"2006","journal-title":"Forensic Sci. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1024\/1661-8157\/a002238","article-title":"Haaranalyse zum retrospektiven und prospektiven Konsum-Monitoring: Substanzmissbrauch, Abstinenz- und Compliancekontrolle","volume":"105","author":"Binz","year":"2016","journal-title":"Praxis"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1039\/c1cs15021a","article-title":"Hair analysis as a biomonitor for toxicology, disease and health status","volume":"40","author":"Kempson","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Wada, Y., Maekawa, M., Ohnishi, T., Balan, S., Matsuoka, S., Iwamoto, K., Iwayama, Y., Ohba, H., Watanabe, A., and Hisano, Y. (2020). Peroxisome proliferator-activated receptor \u03b1 as a novel therapeutic target for schizophrenia. eBioMedicine, 62.","DOI":"10.1016\/j.ebiom.2020.103130"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1871527321666220316122605","article-title":"Hair Cortisol Concentration as a Biomarker of Symptoms of Depressionin the Perinatal Period","volume":"22","author":"Mlili","year":"2023","journal-title":"CNS Neurol. Disord.\u2014Drug Targets"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1017\/neu.2020.35","article-title":"Hair cortisol concentration in anxiety disorders: Exploration of relationships with symptom severity and inflammatory markers","volume":"33","author":"Elnazer","year":"2021","journal-title":"Acta Neuropsychiatr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12032-022-01848-z","article-title":"Metabolomic profiling identifies hair as a robust biological sample for identifying women with cervical cancer","volume":"40","author":"Ran","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Faresj\u00f6, \u00c5., Theodorsson, E., Stomby, A., Quist, H., Jones, M.P., \u00d6stgren, C.J., Dahlqvist, P., and Faresj\u00f6, T. (2024). Higher hair cortisol levels associated with previous cardiovascular events and cardiovascular risks in a large cross-sectional population study. BMC Cardiovasc. Disord., 24.","DOI":"10.1186\/s12872-024-04221-2"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e2587","DOI":"10.1002\/hup.2587","article-title":"Hair analysis for the detection of drug use\u2014Is there potential for evasion?","volume":"32","author":"Marrinan","year":"2017","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0379-0738(99)00146-2","article-title":"Potential problems with the interpretation of hair analysis results","volume":"107","author":"Wennig","year":"2000","journal-title":"Forensic Sci. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"138274","DOI":"10.1016\/j.jhazmat.2025.138274","article-title":"Retrospective prediction of environmental emerging contaminants exposure using human hair: Insights into suitability, reliability, and availability","volume":"492","author":"Liao","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4088\/JCP.10m06068yel","article-title":"Increased Systemic Cortisol Metabolism in Patients with Schizophrenia and Bipolar Disorder: A Mechanism for Increased Stress Vulnerability?","volume":"72","author":"Steen","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Arinami, H., Watanabe, Y., Suzuki, Y., Tajiri, M., Tsuneyama, N., and Someya, T. (2023). Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-28449-8"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jtemb.2018.10.009","article-title":"Comparison of serum essential trace metals between patients with schizophrenia and healthy controls","volume":"51","author":"Cao","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1176\/appi.ps.201700082","article-title":"Clinical Consensus Recommendations for Urine Testing of Adherence to Antipsychotics Among People with Serious Mental Illness","volume":"69","author":"Cohen","year":"2018","journal-title":"Psychiatr. Serv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/phar.2689","article-title":"The effect of antipsychotic treatment on hormonal, inflammatory, and metabolic biomarkers in healthy volunteers: A systematic review and meta-analysis","volume":"42","author":"Burghardt","year":"2022","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15622975.2024.2366235","article-title":"Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: Focus on antipsychotics","volume":"25","author":"Hart","year":"2024","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1177\/0004867412455232","article-title":"Drugs of abuse and increased risk of psychosis development","volume":"46","author":"Gururajan","year":"2012","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.neubiorev.2011.04.007","article-title":"Cannabis use in young people: The risk for schizophrenia","volume":"35","author":"Casadio","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Tom\u00e1\u0161kov\u00e1, A., \u0160lamberov\u00e1, R., and \u010cern\u00e1, M. (2020). Influence of Prenatal Methamphetamine Abuse on the Brain. Epigenomes, 4.","DOI":"10.3390\/epigenomes4030014"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"20140182","DOI":"10.1098\/rsta.2014.0182","article-title":"The elements of life and medicines","volume":"373","author":"Chellan","year":"2015","journal-title":"Philos. Trans. R. Soc. A Math. Phys. Eng. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wang, B., Fang, T., and Chen, H. (2023). Zinc and Central Nervous System Disorders. Nutrients, 15.","DOI":"10.3390\/nu15092140"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s12011-021-02733-y","article-title":"Are Essential Trace Elements Effective in Modulation of Mental Disorders? Update and Perspectives","volume":"200","author":"Shayganfard","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0946-672X(97)80046-6","article-title":"Observations on the Use of Plasma, Hair and Tissue to Evaluate Trace Element Status in Cancer","volume":"11","author":"Borella","year":"1997","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00406-022-01482-w","article-title":"Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia","volume":"272","author":"Schmitt","year":"2022","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.pnpbp.2010.08.020","article-title":"In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia","volume":"34","author":"Bojarski","year":"2010","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.schres.2023.07.024","article-title":"Impaired calcium channel function and pronounced hippocampal atrophy in a schizophrenia patient with cognitive impairment carrying Presenilin-2 Ser130Leu mutation: A case report and literature review","volume":"258","author":"Zhang","year":"2023","journal-title":"Schizophr. Res."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Vidal-Dom\u00e8nech, F., Riquelme, G., Pinacho, R., Rodriguez-Mias, R., Vera, A., Monje, A., Ferrer, I., Callado, L.F., Meana, J.J., and Vill\u00e9n, J. (2020). Calcium-binding proteins are altered in the cerebellum in schizophrenia. PLoS ONE, 15.","DOI":"10.1101\/2020.03.02.972810"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"115297","DOI":"10.1016\/j.bbr.2024.115297","article-title":"HINT1 promotes neuronal apoptosis and triggers schizophrenia-like behavior in rats","volume":"477","author":"Kang","year":"2025","journal-title":"Behav. Brain Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1176\/appi.ajp.161.1.109","article-title":"Apoptotic Proteins in the Temporal Cortex in Schizophrenia: High Bax\/Bcl-2 Ratio Without Caspase-3 Activation","volume":"161","author":"Jarskog","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41398-021-01385-9","article-title":"Glutamate and microglia activation as a driver of dendritic apoptosis: A core pathophysiological mechanism to understand schizophrenia","volume":"11","author":"Parellada","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpsychires.2022.04.013","article-title":"Subcortical brain iron deposition in individuals with schizophrenia","volume":"151","author":"Sonnenschein","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1038\/s41380-023-01979-3","article-title":"Perturbed iron biology in the prefrontal cortex of people with schizophrenia","volume":"28","author":"Lotan","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1080\/1028415X.2021.1943996","article-title":"Perinatal iron deficiency as an early risk factor for schizophrenia","volume":"25","author":"Maxwell","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41537-022-00307-y","article-title":"Hair zinc levels and psychosis risk among adolescents","volume":"8","author":"Tabata","year":"2022","journal-title":"Schizophrenia"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12011-008-8230-8","article-title":"Zinc, Manganese, Calcium, Copper, and Cadmium Level in Scalp Hair Samples of Schizophrenic Patients","volume":"127","author":"Rahman","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.nimb.2022.11.011","article-title":"Levels of a select group of trace elements in scalp hair of schizophrenics by PIXE","volume":"534","author":"Pradeep","year":"2023","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. B Beam Interact. Mater. Atoms."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1176\/appi.ajp.2017.17020223","article-title":"Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis","volume":"175","author":"Starzer","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/1874473710666171020104524","article-title":"Long-term Administration of Antipsychotic Drugs in Schizophrenia and Influence of Substance and Drug Abuse on the Disease Outcome","volume":"10","author":"Werner","year":"2018","journal-title":"Curr. Drug Abus. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1001\/jamapsychiatry.2015.1737","article-title":"Premature Mortality Among Adults with Schizophrenia in the United States","volume":"72","author":"Olfson","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1093\/brain\/awq153","article-title":"Impulsivity-related brain volume deficits in schizophrenia-addiction comorbidity","volume":"133","author":"Schiffer","year":"2010","journal-title":"Brain"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1192\/bjp.165.1.13","article-title":"Schizophrenia and Substance Abuse","volume":"165","author":"Smith","year":"1994","journal-title":"Br. J. Psychiatry"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S0033291713000548","article-title":"Under-reporting of drug use among individuals with schizophrenia: Prevalence and predictors","volume":"44","author":"Bahorik","year":"2014","journal-title":"Psychol. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1176\/ps.44.2.176","article-title":"Cocaine Use by Schizophrenic Outpatients Who Receive Depot Neuroleptic Medication","volume":"44","author":"Stone","year":"1993","journal-title":"Psychiatr. Serv."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/08039480903274423","article-title":"Using brief self-reports and clinician scales to screen for substance use disorders in psychotic patients","volume":"64","author":"Linaker","year":"2010","journal-title":"Nord. J. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0920-9964(97)00015-7","article-title":"Detecting comorbid substance misuse among people with schizophrenia in the community: A study comparing the results of questionnaires with analysis of hair and urine","volume":"25","author":"McPhillips","year":"1997","journal-title":"Schizophr. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1176\/appi.ps.54.6.891","article-title":"Detection of Illicit Substance Use Among Persons with Schizophrenia by Radioimmunoassay of Hair","volume":"54","author":"Swartz","year":"2003","journal-title":"Psychiatr. Serv."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/ajad.12529","article-title":"Long lasting effects of chronic heavy cannabis abuse","volume":"26","author":"Nestoros","year":"2017","journal-title":"Am. J. Addict."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1192\/bjp.bp.107.046649","article-title":"Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis","volume":"192","author":"Morgan","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e032711","DOI":"10.1136\/bmjopen-2019-032711","article-title":"Risks of psychosis in methamphetamine users: Cross-sectional study in Thailand","volume":"9","author":"Lamyai","year":"2019","journal-title":"BMJ Open"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/adc.2006.100156","article-title":"Methamphetamine detection in maternal and neonatal hair: Implications for fetal safety","volume":"92","author":"Rokach","year":"2007","journal-title":"Arch. Dis. Child.\u2014Fetal Neonatal Ed."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1017\/S1092852924002244","article-title":"How antipsychotics work in schizophrenia: A primer on mechanisms","volume":"30","author":"Meyer","year":"2025","journal-title":"CNS Spectr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.biopsych.2024.05.014","article-title":"New Drug Treatments for Schizophrenia: A Review of Approaches to Target Circuit Dysfunction","volume":"96","author":"Howes","year":"2024","journal-title":"Biol. Psychiatry"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/14656566.2021.1882996","article-title":"Improving adherence to pharmacological treatment for schizophrenia: A systematic assessment","volume":"22","author":"Curto","year":"2021","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1176\/appi.ajp.2018.17091001","article-title":"20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia","volume":"175","author":"Tiihonen","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1176\/appi.ajp.20240738","article-title":"Antipsychotic Drugs: A Concise Review of History, Classification, Indications, Mechanism, Efficacy, Side Effects, Dosing, and Clinical Application","volume":"181","author":"Leucht","year":"2024","journal-title":"Am. J. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12024-007-0010-9","article-title":"Dose\u2013hair concentration relationship and pigmentation effects in patients on low-dose clozapine","volume":"3","author":"Kronstrand","year":"2007","journal-title":"Forensic Sci. Med. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/01.ftd.0000211811.27558.b5","article-title":"Hair Analysis for Drug Detection","volume":"28","author":"Kintz","year":"2006","journal-title":"Ther. Drug Monit."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.4088\/JCP.19cs13169","article-title":"Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft f\u00fcr Neuropsychopharmakologie und Pharmakopsychiatrie","volume":"81","author":"Schoretsanitis","year":"2020","journal-title":"J. Clin. Psychiatry"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0379-0738(99)00172-3","article-title":"Clozapine dose\u2013concentration relationships in plasma, hair and sweat specimens of schizophrenic patients","volume":"107","author":"Cirimele","year":"2000","journal-title":"Forensic Sci. Int."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/dta.2754","article-title":"Segmental analysis of antidepressant and antipsychotic drugs in the hair of schizophrenic patients","volume":"12","author":"Wang","year":"2019","journal-title":"Drug Test. Anal."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Cobo-Golpe, M., de-Castro-R\u00edos, A., Cruz, A., P\u00e1ramo, M., L\u00f3pez-Rivadulla, M., and Lendoiro, E. (2020). Determination of antipsychotic drugs in nails and hair by liquid chromatography tandem mass spectrometry and evaluation of their incorporation into keratinized matrices. J. Pharm. Biomed. Anal., 189.","DOI":"10.1016\/j.jpba.2020.113443"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Yang, H., Liu, C., Zhu, C., Zheng, Y., Li, J., Zhu, Q., Wang, H., Fang, X., Liu, Q., and Liang, M. (2023). Determination of ten antipsychotics in blood, hair and nails: Validation of a LC\u2013MS\/MS method and forensic application of keratinized matrix analysis. J. Pharm. Biomed. Anal., 234.","DOI":"10.1016\/j.jpba.2023.115557"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/j.jchromb.2009.06.035","article-title":"Time resolved analysis of risperidone and 9-hydroxy-risperidone in hair using LC\/MS-MS","volume":"877","author":"Schneider","year":"2009","journal-title":"J. Chromatogr. B"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"110337","DOI":"10.1016\/j.forsciint.2020.110337","article-title":"A different insight in hair analysis: Simultaneous measurement of antipsychotic drugs and metabolites in the protein and melanin fraction of hair from criminal justice patients","volume":"312","author":"Baumgartner","year":"2020","journal-title":"Forensic Sci. Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"119888","DOI":"10.1016\/j.cca.2024.119888","article-title":"Cortisol: Biosensing and detection strategies","volume":"562","author":"Balasamy","year":"2024","journal-title":"Clin. Chim. Acta"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.schres.2019.01.011","article-title":"Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders","volume":"213","author":"Aas","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0924-977X(99)00017-6","article-title":"HPA axis and cytokines dysregulation in schizophrenia: Potential implications for the antipsychotic treatment","volume":"10","author":"Altamura","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zhu, X., Zhu, Y., Huang, J., Zhou, Y., Tong, J., Zhang, P., Luo, X., Chen, S., Tian, B., and Tan, S. (2022). Abnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-20808-1"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.psyneuen.2016.12.017","article-title":"Stress-related and basic determinants of hair cortisol in humans: A meta-analysis","volume":"77","author":"Stalder","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.psyneuen.2014.07.013","article-title":"Morning cortisol levels in schizophrenia and bipolar disorder: A meta-analysis","volume":"49","author":"Girshkin","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"113244","DOI":"10.1016\/j.physbeh.2020.113244","article-title":"Hair cortisol concentrations in mental disorders: A systematic review","volume":"229","author":"Mourikis","year":"2021","journal-title":"Physiol. Behav."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e2412","DOI":"10.1002\/brb3.2412","article-title":"Hair cortisol, social support, personality traits, and clinical course: Differences in schizophrenia and bipolar disorder","volume":"11","author":"Yang","year":"2021","journal-title":"Brain Behav."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Yang, F., Cao, X., Sun, X., Wen, H., Qiu, J., and Xiao, H. (2020). Hair Cortisol Is Associated with Social Support and Symptoms in Schizophrenia. Front. Psychiatry, 11.","DOI":"10.3389\/fpsyt.2020.572656"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mhp.2019.01.002","article-title":"Decoding the impact of adverse childhood experiences on the progression of schizophrenia","volume":"13","author":"Hirt","year":"2019","journal-title":"Ment. Health Prev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/eip.13238","article-title":"Hair cortisol levels in schizophrenia and metabolic syndrome","volume":"16","author":"Smit","year":"2022","journal-title":"Early Interv. Psychiatry"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00737-024-01434-4","article-title":"Hair cortisol concentrations in pregnant women with bipolar, depressive, or schizophrenic spectrum disorders","volume":"27","author":"Andersen","year":"2024","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/1516-4446-2014-1634","article-title":"Hair cortisol in drug-na\u00efve first-episode individuals with psychosis","volume":"38","author":"Andrade","year":"2016","journal-title":"Rev. Bras. Psiquiatr."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.schres.2019.08.012","article-title":"Hair cortisol concentrations as an indicator of potential HPA axis hyperactivation in risk for psychosis","volume":"212","author":"Clamor","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1017\/thg.2016.50","article-title":"Hair Cortisol and Its Association with Psychological Risk Factors for Psychiatric Disorders: A Pilot Study in Adolescent Twins","volume":"19","author":"Rietschel","year":"2016","journal-title":"Twin Res. Hum. Genet."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.psyneuen.2016.03.010","article-title":"Perceived stress and hair cortisol: Differences in bipolar disorder and schizophrenia","volume":"69","author":"Streit","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Brandt, J.M., Hemager, N., Ellersgaard, D., Gregersen, M., S\u00f8ndergaard, A., Ohland, J., S\u00f8borg Spang, K., Christiani, C., Burton, B.K., and Greve, A. (2023). Hair cortisol concentrations and daily life stress in 7-year-old children at familial high-risk of schizophrenia or bipolar disorder. The Danish High Risk and Resilience Study\u2014VIA 7. Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 125.","DOI":"10.1016\/j.pnpbp.2023.110750"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Mikulska, J., Juszczyk, G., Gawro\u0144ska-Grzywacz, M., and Herbet, M. (2021). HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation. Brain Sci., 11.","DOI":"10.3390\/brainsci11101298"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1017\/S1092852918001013","article-title":"Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: Dopamine, serotonin, and glutamate","volume":"23","author":"Stahl","year":"2018","journal-title":"CNS Spectr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.neubiorev.2015.01.007","article-title":"In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: Application to schizophrenia","volume":"51","author":"Wijtenburg","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/jasms.3c00326","article-title":"Novel LC-MS\/MS Method for Simultaneous Determination of Monoamine Neurotransmitters and Metabolites in Human Samples","volume":"35","author":"Kumar","year":"2024","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10337-015-3021-9","article-title":"Determination of Tyramine in Hair Samples by GC\u2013MS","volume":"79","author":"Gao","year":"2016","journal-title":"Chromatographia"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Cuevas-Diaz Duran, R., Martinez-Ledesma, E., Garcia-Garcia, M., Bajo Gauzin, D., Sarro-Ram\u00edrez, A., Gonzalez-Carrillo, C., Rodr\u00edguez-Sardin, D., Fuentes, A., and Cardenas-Lopez, A. (2024). The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25052542"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e10695","DOI":"10.15252\/emmm.201910695","article-title":"Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology","volume":"11","author":"Ide","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Matsuura, A., Ishima, T., Fujita, Y., Iwayama, Y., Hasegawa, S., Kawahara-Miki, R., Maekawa, M., Toyoshima, M., Ushida, Y., and Suganuma, H. (2018). Dietary glucoraphanin prevents the onset of psychosis in the adult offspring after maternal immune activation. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-20538-3"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijdevneu.2011.02.013","article-title":"Synaptic changes in the brain of subjects with schizophrenia","volume":"29","author":"Faludi","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1155\/2013\/510402","article-title":"Biomarkers in Schizophrenia: A Brief Conceptual Consideration","volume":"35","author":"Weickert","year":"2013","journal-title":"Dis. Markers"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.bbi.2012.02.002","article-title":"Analysis of cortisol in hair\u2014State of the art and future directions","volume":"26","author":"Stalder","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e202406401","DOI":"10.1002\/anie.202406401","article-title":"Imaging Neurotransmitters with Small-Molecule Fluorescent Probes","volume":"63","author":"Bade","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_137","first-page":"196","article-title":"Communication networks in the brain: Neurons, receptors, neurotransmitters, and alcohol","volume":"31","author":"Lovinger","year":"2008","journal-title":"Alcohol Res. Health J. Natl. Inst. Alcohol Abus. Alcohol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"002","DOI":"10.1055\/s-0038-1673630","article-title":"Inherited Disorders of Neurotransmitters: Classification and Practical Approaches for Diagnosis and Treatment","volume":"50","author":"Brennenstuhl","year":"2019","journal-title":"Neuropediatrics"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"6495","DOI":"10.1093\/hmg\/ddu369","article-title":"Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies","volume":"23","author":"Shimamoto","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Vincenti, M., and Kintz, P. (2015). New Challenges and Perspectives in Hair Analysis. Hair Analysis in Clinical and Forensic Toxicology, Elsevier.","DOI":"10.1016\/B978-0-12-801700-5.00012-1"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1039\/D0AN01265C","article-title":"Cheating on forensic hair testing? Detection of potential biomarkers for cosmetically altered hair samples using untargeted hair metabolomics","volume":"145","author":"Eisenbeiss","year":"2020","journal-title":"Analyst"},{"key":"ref_142","first-page":"59","article-title":"Underivatized Amino Acid Analyses Using Liquid Chromatography-Tandem Mass Spectrometry in Scalp Hair of Children with Autism Spectrum Disorder","volume":"15","author":"Rashaid","year":"2021","journal-title":"Int. J. Chem. Mol. Eng."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.schres.2020.11.053","article-title":"Markers of copper transport in the cingulum bundle in schizophrenia","volume":"228","author":"Schoonover","year":"2021","journal-title":"Schizophr. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/15622975.2018.1523562","article-title":"Impaired copper transport in schizophrenia results in a copper-deficient brain state: A new side to the dysbindin story","volume":"21","author":"Schoonover","year":"2020","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2741\/s129","article-title":"Myelin copper and the cuprizone model of schizophrenia","volume":"3","author":"Konradi","year":"2011","journal-title":"Front. Biosci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1176\/ajp.136.7.937","article-title":"CSF copper in schizophrenia","volume":"136","author":"Tyrer","year":"1979","journal-title":"Am. J. Psychiatry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/BTER:98:2:109","article-title":"Plasma Manganese, Selenium, Zinc, Copper, and Iron Concentrations in Patients with Schizophrenia","volume":"98","author":"Yanik","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_148","first-page":"435","article-title":"Zinc and copper in patients with schizophrenia","volume":"8","author":"Gillin","year":"1982","journal-title":"L\u2019Encephale"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.genhosppsych.2018.04.004","article-title":"Zinc in schizophrenia: A meta-analysis","volume":"53","author":"Joe","year":"2018","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Petrilli, M.A., Kranz, T.M., Kleinhaus, K., Joe, P., Getz, M., Johnson, P., Chao, M.V., and Malaspina, D. (2017). The Emerging Role for Zinc in Depression and Psychosis. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00414"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Baj, J., Forma, A., Sitarz, E., Karaku\u0142a, K., Flieger, W., Sitarz, M., Grochowski, C., Maciejewski, R., and Karakula-Juchnowicz, H. (2020). Beyond the Mind\u2014Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249566"},{"key":"ref_152","first-page":"1315","article-title":"Cerebrospinal fluid zinc concentrations in ex-heroin addicts and patients with schizophrenia: Some preliminary observations","volume":"17","author":"Potkin","year":"1982","journal-title":"Biol. Psychiatry"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archneurpsyc.1951.02320030063007","article-title":"Studies on the iron content of cerebrospinal fluid in different psychotic conditions","volume":"65","author":"Lehmann","year":"1951","journal-title":"Arch. Neurol. Psychiatry"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000468355","article-title":"Plasma Magnesium in Chronic Schizophrenia","volume":"14","author":"Yassa","year":"1979","journal-title":"Int. Pharmacopsychiatry"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/00207459408986045","article-title":"Decrease of Serum Iron in Acutely Psychotic Schizophrenic Patients","volume":"78","author":"Wiser","year":"1994","journal-title":"Int. J. Neurosci."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Kim, S.-W., Stewart, R., Park, W.-Y., Jhon, M., Lee, J.-Y., Kim, S.-Y., Kim, J.-M., Amminger, P., Chung, Y.-C., and Yoon, J.-S. (2018). Latent Iron Deficiency as a Marker of Negative Symptoms in Patients with First-Episode Schizophrenia Spectrum Disorder. Nutrients, 10.","DOI":"10.3390\/nu10111707"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4161\/pri.21767","article-title":"Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia","volume":"7","author":"Berridge","year":"2013","journal-title":"Prion"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00441-014-1806-z","article-title":"Calcium signalling and psychiatric disease: Bipolar disorder and schizophrenia","volume":"357","author":"Berridge","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_159","first-page":"37","article-title":"CSF calcium: Clinical correlates in affective illness and schizophrenia","volume":"14","author":"Jimerson","year":"1979","journal-title":"Biol. Psychiatry"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"549S","DOI":"10.1080\/07315724.2004.10719401","article-title":"The Influence of Some Antipsychotics on Erythrocyte Magnesium and Plasma Magnesium, Calcium, Copper and Zinc in Patients with Paranoid Schizophrenia","volume":"23","author":"Nechifor","year":"2004","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_161","first-page":"1157","article-title":"Calcium balance and regulation in schizophrenic patients treated with second generation antipsychotics","volume":"39","year":"2005","journal-title":"Psychiatr. Pol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4103\/1947-2714.139283","article-title":"The role of lead and cadmium in psychiatry","volume":"6","author":"Orisakwe","year":"2014","journal-title":"N. Am. J. Med. Sci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"125179","DOI":"10.1016\/j.envpol.2024.125179","article-title":"Association between the levels of toxic heavy metals and schizophrenia in the population of Guangxi, China: A case-control study","volume":"363","author":"Shen","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_164","first-page":"245","article-title":"Essential trace metals and heavy metals in newly diagnosed schizophrenic patients and those on anti-psychotic medication","volume":"15","author":"Arinola","year":"2010","journal-title":"J. Res. Med. Sci. Off. J. Isfahan Univ. Med. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00702-004-0160-9","article-title":"Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis","volume":"111","author":"Michel","year":"2004","journal-title":"J. Neural Transm."},{"key":"ref_166","first-page":"28","article-title":"Pfeiffer; Scott LaMola Zinc and manganese in the schizophrenias","volume":"14","author":"Carl","year":"1983","journal-title":"J. Orthomol. Med."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Liu, T., Lu, Q.-B., Yan, L., Guo, J., Feng, F., Qiu, J., and Wang, J. (2015). Comparative Study on Serum Levels of 10 Trace Elements in Schizophrenia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133622"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000070010","article-title":"Is the Arginine-Nitric Oxide Pathway Involved in the Pathogenesis of Schizophrenia?","volume":"47","author":"Yanik","year":"2003","journal-title":"Neuropsychobiology"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Kaya, B., Akda\u011f, N., Fad\u0131ll\u0131o\u011flu, E., Taycan, S.E., Emre, M.H., Unal, S., Sayal, A., Erdo\u011fan, H., and Polat, R. (2012). \u015eizofreni hastalar\u0131nda kanda glukoz-6-fosfat dehidrogenaz aktivitesi ve element d\u00fczeyleri\/Elements levels and glucose-6-phosphate dehydrogenase activity in blood of patients with schizophrenia. Dusunen Adam J. Psychiatry Neurol. Sci.","DOI":"10.5350\/DAJPN2012250301"},{"key":"ref_170","first-page":"780","article-title":"Manganese and copper levels in human urine","volume":"6","author":"Kanabrocki","year":"1965","journal-title":"J. Nucl. Med. Off. Publ. Soc. Nucl. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.schres.2013.06.013","article-title":"Quantification of endocannabinoids in postmortem brain of schizophrenic subjects","volume":"148","author":"Muguruza","year":"2013","journal-title":"Schizophr. Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/pcn.12072","article-title":"Comorbid substance use disorder in schizophrenia: A selective overview of neurobiological and cognitive underpinnings","volume":"67","author":"Thoma","year":"2013","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3109\/15563650.2012.744996","article-title":"Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis","volume":"50","author":"Thornton","year":"2012","journal-title":"Clin. Toxicol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/schbul\/sbae097","article-title":"Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients with Schizophrenia and Cannabis Use Disorder","volume":"51","author":"Brunette","year":"2025","journal-title":"Schizophr. Bull."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mpr.1350","article-title":"Meta-analysis of self-reported substance use compared with laboratory substance assay in general adult mental health settings","volume":"21","author":"Large","year":"2012","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/oxfordjournals.schbul.a033339","article-title":"Patterns of Current and Lifetime Substance Use in Schizophrenia","volume":"24","author":"Fowler","year":"1998","journal-title":"Schizophr. Bull."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.forsciint.2012.01.002","article-title":"Screening and quantification of antipsychotic drugs in human brain tissue by liquid chromatography\u2013tandem mass spectrometry: Application to postmortem diagnostics of forensic interest","volume":"219","author":"Sampedro","year":"2012","journal-title":"Forensic Sci. Int."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/dta.1337","article-title":"The analysis of antipsychotic drugs in human matrices using LC-MS(\/MS)","volume":"4","author":"Saar","year":"2012","journal-title":"Drug Test. Anal."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cca.2014.12.008","article-title":"Advances in detection of antipsychotics in biological matrices","volume":"441","author":"Patteet","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/JCP.0b013e318204d9e2","article-title":"High Correlation Between Serum and Cerebrospinal Fluid Olanzapine Concentrations in Patients with Schizophrenia or Schizoaffective Disorder Medicating With Oral Olanzapine as the Only Antipsychotic Drug","volume":"31","author":"Skogh","year":"2011","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Dziurkowska, E., and Wesolowski, M. (2021). Cortisol as a Biomarker of Mental Disorder Severity. J. Clin. Med., 10.","DOI":"10.3390\/jcm10215204"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nbd.2010.04.017","article-title":"An inverse relationship between cortisol and BDNF levels in schizophrenia: Data from human postmortem and animal studies","volume":"39","author":"Issa","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Pearson, A., De Vries, A., Middleton, S.D., Gillies, F., White, T.O., Armstrong, I.R., Andrew, R., Seckl, J.R., and MacLullich, A.M. (2010). Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls. BMC Res. Notes, 3.","DOI":"10.1186\/1756-0500-3-33"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.psyneuen.2019.03.014","article-title":"Meta-analysis of blood cortisol levels in individuals with first-episode psychosis","volume":"104","author":"Hubbard","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpsychires.2014.01.017","article-title":"Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders","volume":"52","author":"Steen","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.pnpbp.2010.08.013","article-title":"SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders","volume":"34","author":"Steen","year":"2010","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/archpsyc.1982.04290090001001","article-title":"Increased Brain Dopamine and Dopamine Receptors in Schizophrenia","volume":"39","author":"Mackay","year":"1982","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/brain\/102.2.347","article-title":"Increased dopamine concentration in limbic areas of brain from patients dying with schizophrenia","volume":"102","author":"Bird","year":"1979","journal-title":"Brain"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1176\/ajp.148.11.1474","article-title":"Dopamine in schizophrenia: A review and reconceptualization","volume":"148","author":"Davis","year":"1991","journal-title":"Am. J. Psychiatry"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/10673220902979896","article-title":"A Critique of the Dopamine Hypothesis of Schizophrenia and Psychosis","volume":"17","author":"Moncrieff","year":"2009","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.schres.2023.05.012","article-title":"CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance","volume":"257","author":"Orhan","year":"2023","journal-title":"Schizophr. Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/pcn.12984","article-title":"Plasma levels of dopamine metabolite correlate with mismatch negativity in patients with schizophrenia","volume":"74","author":"Shiga","year":"2020","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0920-9964(91)90032-M","article-title":"Dopamine and norepinephrine activity in schizophrenia","volume":"4","author":"Kelley","year":"1991","journal-title":"Schizophr. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/archpsyc.1978.01770250099010","article-title":"Dopamine Excretion and Vulnerability to Drug-Induced Parkinsonism: Schizophrenic Patients","volume":"35","author":"Crowley","year":"1978","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pscychresns.2017.11.014","article-title":"Dopamine in high-risk populations: A comparison of subjects with 22q11.2 deletion syndrome and subjects at ultra high-risk for psychosis","volume":"272","author":"Vingerhoets","year":"2018","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/schbul\/14.2.297","article-title":"The Role of Serotonin in Schizophrenia","volume":"14","author":"Bleich","year":"1988","journal-title":"Schizophr. Bull."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Quednow, B.B., Geyer, M.A., and Halberstadt, A.L. (2020). Serotonin and schizophrenia. Handbook of Behavioral Neuroscience, Elsevier.","DOI":"10.1016\/B978-0-444-64125-0.00039-6"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0165-1781(95)02782-3","article-title":"Serotonin in violent patients with schizophrenia","volume":"59","author":"Kunz","year":"1995","journal-title":"Psychiatry Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41398-022-02000-1","article-title":"Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients","volume":"12","author":"Shang","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/archpsyc.1981.01780310047004","article-title":"Increased Whole Blood Serotonin Concentrations in Chronic Schizophrenic Patients","volume":"38","author":"DeLisi","year":"1981","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1176\/ajp.132.2.184","article-title":"Elevated blood serotonin concentrations in unmediated chronic schizophrenic patients: A preliminary study","volume":"132","author":"Garelis","year":"1975","journal-title":"Am. J. Psychiatry"},{"key":"ref_202","first-page":"117","article-title":"Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia","volume":"31","author":"Emanuele","year":"2010","journal-title":"Neuro Endocrinol. Lett."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/nyas.12547","article-title":"The glutamate hypothesis of schizophrenia: Evidence from human brain tissue studies","volume":"1338","author":"Hu","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/pcn.12823","article-title":"Glutamate hypothesis in schizophrenia","volume":"73","author":"Uno","year":"2019","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/0269881114563634","article-title":"Glutamate and dopamine in schizophrenia: An update for the 21st century","volume":"29","author":"Howes","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Madeira, C., Alheira, F.V., Calcia, M.A., Silva, T.C.S., Tannos, F.M., Vargas-Lopes, C., Fisher, M., Goldenstein, N., Brasil, M.A., and Vinogradov, S. (2018). Blood Levels of Glutamate and Glutamine in Recent Onset and Chronic Schizophrenia. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00713"},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Nagai, T., Kirihara, K., Tada, M., Koshiyama, D., Koike, S., Suga, M., Araki, T., Hashimoto, K., and Kasai, K. (2017). Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-02267-1"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000364828","article-title":"Peripheral Glutamate Levels in Schizophrenia: Evidence from a Meta-Analysis","volume":"70","author":"Song","year":"2014","journal-title":"Neuropsychobiology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0920-9964(99)00029-8","article-title":"Tyrosine transport is regulated differently in patients with schizophrenia","volume":"40","author":"Wiesel","year":"1999","journal-title":"Schizophr. Res."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Zaki, J.K., Tomasik, J., McCune, J., Scherman, O.A., and Bahn, S. (2023). Discovery of Urinary Metabolite Biomarkers of Psychiatric Disorders Using Two-Sample Mendelian Randomization. medRxiv.","DOI":"10.1101\/2023.09.26.23296078"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.schres.2016.04.050","article-title":"Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia","volume":"177","author":"Pinacho","year":"2016","journal-title":"Schizophr. Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.schres.2011.01.018","article-title":"The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia","volume":"128","author":"Madrigal","year":"2011","journal-title":"Schizophr. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/17\/8718\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:41:30Z","timestamp":1760035290000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/17\/8718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,7]]},"references-count":212,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ijms26178718"],"URL":"https:\/\/doi.org\/10.3390\/ijms26178718","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,7]]}}}