{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:09:07Z","timestamp":1793394547431,"version":"4.5.0"},"reference-count":231,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004747","name":"John Paul II Catholic University of Lublin","doi-asserted-by":"publisher","award":["Publication fund"],"award-info":[{"award-number":["Publication fund"]}],"id":[{"id":"10.13039\/501100004747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is a complex gynecological condition affecting 10% of women globally, characterized by the growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain, infertility, reduced quality of life, and a risk of cancer. This review examines the multifaceted aspects of endometriosis, including its causes, diagnostic approaches, and management strategies. Genetic and environmental factors, hormonal influences, and immunological dysregulation are addressed as potential drivers of disease progression. Treatment options, including pharmacological interventions (hormone therapy, pain management) and surgical interventions, are assessed for their effectiveness in alleviating symptoms and improving outcomes. Emerging therapies, such as small-molecule inhibitors and anti-angiogenic agents, are also explored. Additionally, the psychological impact of endometriosis is addressed, emphasizing the need for holistic care. This review highlights the importance of continued research to unravel the precise mechanisms underlying endometriosis and to develop targeted therapies for improved patient care.<\/jats:p>","DOI":"10.3390\/ijms26188878","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:07:15Z","timestamp":1757668035000},"page":"8878","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Understanding Endometriosis: A Broad Review of Its Causes, Management, and Impact"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1212-1278","authenticated-orcid":false,"given":"Pawe\u0142","family":"Czubak","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, The John Paul II Catholic University of Lublin, ul. Konstantyn\u00f3w 1i, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Herda","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Analytical Chemistry, The John Paul II Catholic University of Lublin, ul. Konstantyn\u00f3w 1i, 20-708 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-2748","authenticated-orcid":false,"given":"Iwona","family":"Niewiadomska","sequence":"additional","affiliation":[{"name":"Institute of Psychology, The John Paul II Catholic University of Lublin, 20-950 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lechos\u0142aw","family":"Putowski","sequence":"additional","affiliation":[{"name":"Chair and Department of Gynaecology and Gynaecological Endocrinology, Medical University of Lublin, Aleje Rac\u0142awickie 23 (SPSW), 20-037 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-9111","authenticated-orcid":false,"given":"Miros\u0142aw","family":"\u0141a\u0144cut","sequence":"additional","affiliation":[{"name":"Experimental Research Center, The John Paul II Catholic University of Lublin, ul. 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