{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:33:45Z","timestamp":1789094025426,"version":"build-2803163510"},"reference-count":140,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute on Aging of the National Institutes of Health","award":["RF1AG072510"],"award-info":[{"award-number":["RF1AG072510"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) causes progressive cognitive decline and neuronal loss, partly due to the buildup of amyloid-\u03b2 (A\u03b2) plaques and tau tangles. Despite years of research, treatments targeting these hallmark pathologies have yielded only modest clinical success, prompting interest in regenerative approaches to restore the brain\u2019s ability to repair itself. One such approach focuses on adult hippocampal neurogenesis, the process by which neural stem cells (NSCs) produce new neurons throughout life. In AD, this process is impaired, worsening cognitive deficits. In this review, we examine the molecular pathways that control adult neurogenesis, including transcriptional, epigenetic, inflammatory, and metabolic mechanisms, and how they become dysregulated in AD. We also highlight various therapeutic strategies aimed at boosting neurogenesis, such as pharmacological treatments, stem cell therapy, gene therapy, and epigenetic modulation. Preclinical studies indicate that enhancing neurogenesis can improve cognition and reduce brain pathology in AD models. Several of these treatments are now being tested in clinical trials. Ultimately, promoting neurogenesis may offer a promising avenue to complement current AD therapies and help restore lost neural function.<\/jats:p>","DOI":"10.3390\/ijms26188926","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:33:02Z","timestamp":1758007982000},"page":"8926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Boosting Neurogenesis as a Strategy in Treating Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Abena","family":"Dwamena","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Garrison Institute on Aging, Center of Excellence for Translational Neuroscience and Therapeutics, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-2395","authenticated-orcid":false,"given":"Rashini","family":"Beragama-Arachchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Garrison Institute on Aging, Center of Excellence for Translational Neuroscience and Therapeutics, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0392-4458","authenticated-orcid":false,"given":"Hongmin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Neuroscience, Garrison Institute on Aging, Center of Excellence for Translational Neuroscience and Therapeutics, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00401-024-02839-2","article-title":"Amyloid-\u03b2 oligomers increase the binding and internalization of tau oligomers in human synapses","volume":"149","author":"Kadamangudi","year":"2024","journal-title":"Acta Neuropathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid \u03b2 protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e70194","DOI":"10.1002\/alz.70194","article-title":"Inhibition of hippocampal mossy fiber plasticity and episodic memory by human A\u03b2 oligomers is prevented by enhancing cAMP signaling in Alzheimer\u2019s mice","volume":"21","author":"Jin","year":"2025","journal-title":"Alzheimers Dement."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"de la Cueva, M., Antequera, D., Ordo\u00f1ez-Gutierrez, L., Wandosell, F., Camins, A., Carro, E., and Bartolome, F. (2022). Amyloid-\u03b2 impairs mitochondrial dynamics and autophagy in Alzheimer\u2019s disease experimental models. Sci. Rep., 12, Erratum in Sci. Rep. 2023, 13, 19303. https:\/\/doi.org\/10.1038\/s41598-023-46106-y.","DOI":"10.1038\/s41598-022-13683-3"},{"key":"ref_6","unstructured":"WHO (2025, August 02). Dementia. 2023 September. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/207953a0","article-title":"Post-Natal Origin of Microneurones in the Rat Brain","volume":"207","author":"Altman","year":"1965","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.887941","article-title":"Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs","volume":"197","author":"Kaplan","year":"1977","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer\u2019s disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nature25975","article-title":"Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults","volume":"555","author":"Sorrells","year":"2018","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Cafini","year":"2019","journal-title":"Nat. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.stem.2019.05.003","article-title":"Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer\u2019s Disease Patients","volume":"24","author":"Tobin","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-017-0207-7","article-title":"Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer\u2019s disease by compromising hippocampal inhibition","volume":"12","author":"Hollands","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1210951","article-title":"A Phase 3 Trial of Semagacestat for Treatment of Alzheimer\u2019s Disease","volume":"369","author":"Doody","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13195-016-0193-y","article-title":"Long-term safety and tolerability of bapineuzumab in patients with Alzheimer\u2019s disease in two phase 3 extension studies","volume":"8","author":"Ivanoiu","year":"2016","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_16","unstructured":"National Institutes of Health (2022, March 16). A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients with Prodromal to Mild Alzheimer\u2019s Disease, Available online: https:\/\/clinicaltrials.gov\/study\/NCT03289143."},{"key":"ref_17","unstructured":"National Institutes of Health (2025, September 01). A Study of Semorinemab in Patients with Moderate Alzheimer\u2019s Disease, Available online: https:\/\/www.clinicaltrials.gov\/study\/NCT03828747."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1523\/JNEUROSCI.22-03-00629.2002","article-title":"Neurogenesis in adult subventricular zone","volume":"22","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e67436","DOI":"10.7554\/eLife.67436","article-title":"Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis","volume":"10","author":"Nascimento","year":"2021","journal-title":"eLife"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: Significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and Functional Implications of Adult Neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.187336.112","article-title":"Orchestrating transcriptional control of adult neurogenesis","volume":"26","author":"Hsieh","year":"2012","journal-title":"Genes Dev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3389\/fnins.2010.00189","article-title":"Why and how physical activity promotes experience-induced brain plasticity","volume":"4","author":"Kempermann","year":"2010","journal-title":"Front. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Jiang, M., Jang, S.E., and Zeng, L. (2023). The Effects of Extrinsic and Intrinsic Factors on Neurogenesis. Cells, 12.","DOI":"10.3390\/cells12091285"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature02211","article-title":"Expression and function of orphan nuclear receptor TLX in adult neural stem cells","volume":"427","author":"Shi","year":"2004","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e110384","DOI":"10.15252\/embj.2021110384","article-title":"The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation","volume":"42","author":"Fan","year":"2023","journal-title":"EMBO J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/nn.2397","article-title":"Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh","volume":"12","author":"Favaro","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Li, Y., Ma, W., Ma, R., Wang, S., Liu, X., Guo, X., Li, W., Chen, X., Cui, Y.-L., and Song, H. (Cell Death Differ., 2025). FMRP regulation of STAT3-MYC signaling is critical for adult hippocampal neurogenesis and cognitive flexibility, Cell Death Differ., in press.","DOI":"10.1038\/s41418-025-01546-z"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e70016","DOI":"10.1002\/hipo.70016","article-title":"Loss of NFIA Impairs Adult Hippocampal Neurogenesis","volume":"35","author":"Wang","year":"2025","journal-title":"Hippocampus"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mir, S., Cai, W., Carlson, S.W., Saatman, K.E., and Andres, D.A. (2017). IGF-1 mediated Neurogenesis Involves a Novel RIT1\/Akt\/Sox2 Cascade. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-03641-9"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e72195","DOI":"10.7554\/eLife.72195","article-title":"Transcriptional regulation of neural stem cell expansion in the adult hippocampus","volume":"11","author":"Guo","year":"2022","journal-title":"eLife"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15282","DOI":"10.1073\/pnas.0704089104","article-title":"Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation","volume":"104","author":"Sun","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e15092","DOI":"10.7554\/eLife.15092","article-title":"Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body \u03b2-hydroxybutyrate","volume":"5","author":"Sleiman","year":"2016","journal-title":"eLife"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chen, D., Zhang, Y., Zhang, M., Chang, J., Zeng, Z., Kou, X., and Chen, N. (2020). Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt\/\u03b2-Catenin Signaling in Aged Rats. Front. Aging Neurosci., 12.","DOI":"10.3389\/fnagi.2020.00105"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1\u03b1\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neurobiolaging.2012.05.023","article-title":"Environmental enrichment restores neurogenesis and rapid acquisition in aged rats","volume":"34","author":"Speisman","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/mp.2011.26","article-title":"Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor","volume":"16","author":"Anacker","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Rafa-Zab\u0142ocka, K., Kreiner, G., Bagi\u0144ska, M., and Nalepa, I. (2018). Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment. Front. Neurosci., 12.","DOI":"10.3389\/fnins.2018.00637"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Leschik, J., Gentile, A., Cicek, C., P\u00e9ron, S., Tevosian, M., Beer, A., Radyushkin, K., Bludau, A., Ebner, K., and Neumann, I. (2022). Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis. Prog. Neurobiol., 217.","DOI":"10.1016\/j.pneurobio.2022.102333"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Blanco-Luquin, I., Acha, B., Urd\u00e1noz-Casado, A., G\u00f3mez-Orte, E., Roldan, M., P\u00e9rez-Rodr\u00edguez, D.R., Cabello, J., and Mendioroz, M. (2022). NXN Gene Epigenetic Changes in an Adult Neurogenesis Model of Alzheimer\u2019s Disease. Cells, 11.","DOI":"10.3390\/cells11071069"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e107100","DOI":"10.15252\/embj.2020107100","article-title":"De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis","volume":"40","author":"Zocher","year":"2021","journal-title":"EMBO J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12967-024-05041-w","article-title":"Mitochondrial metabolism in neural stem cells and implications for neurodevelopmental and neurodegenerative diseases","volume":"22","author":"Garone","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"13145","DOI":"10.1073\/pnas.0806192105","article-title":"The amyloid \u03b2-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae","volume":"105","author":"Alikhani","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Atlante, A., and Valenti, D. (2023). Mitochondrial Complex I and \u03b2-Amyloid Peptide Interplay in Alzheimer\u2019s Disease: A Critical Review of New and Old Little Regarded Findings. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115951"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1007\/s12035-024-04468-y","article-title":"Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer\u2019s Disease: An Educational Literature Review","volume":"62","author":"Moawad","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/s40001-025-02699-w","article-title":"The role of mitochondrial dysfunction in the pathogenesis of Alzheimer\u2019s disease and future strategies for targeted therapy","volume":"30","author":"Li","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"281","DOI":"10.5483\/BMBRep.2023-0167","article-title":"Integrative analysis of microRNA-mediated mitochondrial dysfunction in hippocampal neural progenitor cell death in relation with Alzheimer\u2019s disease","volume":"57","author":"Han","year":"2024","journal-title":"BMB Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1038\/s41467-017-02221-9","article-title":"Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a","volume":"8","author":"Spinelli","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1001\/archneur.62.10.noc50112","article-title":"Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults","volume":"62","author":"Fishel","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nn2055","article-title":"Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons","volume":"11","author":"Stranahan","year":"2008","journal-title":"Nat. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Guo, Z., Chen, Y., Mao, Y.-F., Zheng, T., Jiang, Y., Yan, Y., Yin, X., and Zhang, B. (2017). Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer\u2019s rat model. Sci. Rep., 7.","DOI":"10.1038\/srep45971"},{"key":"ref_53","first-page":"222","article-title":"Safety and efficacy of intranasal insulin in patients with Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"9","author":"Hendi","year":"2023","journal-title":"J. Clin. Transl. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.celrep.2015.07.044","article-title":"Amyloid-\u03b2 Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a","volume":"12","author":"Yang","year":"2015","journal-title":"Cell Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1212\/01.wnl.0000171450.97464.49","article-title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD","volume":"65","author":"Dickerson","year":"2005","journal-title":"Neurology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e20220391","DOI":"10.1084\/jem.20220391","article-title":"Augmenting neurogenesis rescues memory impairments in Alzheimer\u2019s disease by restoring the memory-storing neurons","volume":"219","author":"Mishra","year":"2022","journal-title":"J. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chen, Z.R., Huang, J.B., Yang, S.L., and Hong, F.F. (2022). Role of Cholinergic Signaling in Alzheimer\u2019s Disease. Molecules, 27.","DOI":"10.3390\/molecules27061816"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.isci.2019.11.016","article-title":"Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis","volume":"22","author":"Poeta","year":"2019","journal-title":"iScience"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12035-020-02120-z","article-title":"Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer\u2019s Disease","volume":"58","author":"Stazi","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/s41593-022-01176-5","article-title":"Adult-born dentate granule cells promote hippocampal population sparsity","volume":"25","author":"McHugh","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1173215","article-title":"A functional role for adult hippocampal neurogenesis in spatial pattern separation","volume":"325","author":"Clelland","year":"2009","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/acel.12641","article-title":"Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers","volume":"16","author":"Mathews","year":"2017","journal-title":"Aging Cell"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1002\/alz.14179","article-title":"The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer\u2019s disease","volume":"20","author":"Tari","year":"2024","journal-title":"Alzheimers Dement."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kang, E., Wen, Z., Song, H., Christian, K.M., and Ming, G.L. (2016). Adult Neurogenesis and Psychiatric Disorders. Cold Spring Harb. Perspect. Biol., 8.","DOI":"10.1101\/cshperspect.a019026"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41586-018-0262-4","article-title":"Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus","volume":"559","author":"Anacker","year":"2018","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1523\/JNEUROSCI.16-06-02027.1996","article-title":"Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation","volume":"16","author":"Kuhn","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-022-04912-w","article-title":"Molecular landscapes of human hippocampal immature neurons across lifespan","volume":"607","author":"Zhou","year":"2022","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Reyes, R.E., Nava-Mesa, M.O., Vargas-S\u00e1nchez, K., Ariza-Salamanca, D., and Mora-Mu\u00f1oz, L. (2017). Involvement of Astrocytes in Alzheimer\u2019s Disease from a Neuroinflammatory and Oxidative Stress Perspective. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00427"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbr.2012.12.032","article-title":"Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice","volume":"242","author":"Kohman","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000330363","article-title":"Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer\u2019s disease","volume":"9","author":"Biscaro","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ghosal, K., Stathopoulos, A., and Pimplikar, S.W. (2010). APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011866"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","article-title":"Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer\u2019s disease model","volume":"187","author":"Kitazawa","year":"2011","journal-title":"J. Immunol."},{"key":"ref_75","first-page":"1537","article-title":"Microglia and Astrocytes in Alzheimer\u2019s Disease: Significance and Summary of Recent Advances","volume":"15","author":"Deng","year":"2024","journal-title":"Aging Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e975","DOI":"10.1038\/cddis.2013.503","article-title":"Oligomeric amyloid \u03b2 induces IL-1\u03b2 processing via production of ROS: Implication in Alzheimer\u2019s disease","volume":"4","author":"Parajuli","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.freeradbiomed.2024.07.020","article-title":"The crosstalk between oxidative stress and DNA damage induces neural stem cell senescence by HO-1\/PARP1 non-canonical pathway","volume":"223","author":"Li","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2010.11.028","article-title":"Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K\/Akt-dependant manner","volume":"8","author":"Orozco","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Oguchi, T., Ono, R., Tsuji, M., Shozawa, H., Somei, M., Inagaki, M., Mori, Y., Yasumoto, T., Ono, K., and Kiuchi, Y. (2017). Cilostazol Suppresses A\u03b2-induced Neurotoxicity in SH-SY5Y Cells through Inhibition of Oxidative Stress and MAPK Signaling Pathway. Front. Aging Neurosci., 9.","DOI":"10.3389\/fnagi.2017.00337"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Coli\u00e9, S., Sarroca, S., Palenzuela, R., Garcia, I., Matheu, A., Corpas, R., Dotti, C.G., Esteban, J.A., Sanfeliu, C., and Nebreda, A.R. (2017). Neuronal p38\u03b1 mediates synaptic and cognitive dysfunction in an Alzheimer\u2019s mouse model by controlling \u03b2-amyloid production. Sci. Rep., 7.","DOI":"10.1038\/srep45306"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.18632\/aging.102994","article-title":"Elevated p38MAPK activity promotes neural stem cell aging","volume":"12","author":"Arrizabalaga","year":"2020","journal-title":"Aging"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Amoroso, R., Maccallini, C., and Bellezza, I. (2023). Activators of Nrf2 to Counteract Neurodegenerative Diseases. Antioxidants, 12.","DOI":"10.3390\/antiox12030778"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40035-022-00279-0","article-title":"Brain-derived neurotrophic factor in Alzheimer\u2019s disease and its pharmaceutical potential","volume":"11","author":"Gao","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Tang, S., Luo, W., Cheng, C., Shen, L., Wu, X., and Xiao, X. (2025). BDNF gene therapy rescues neuronal function via unique and common transcriptional responses in A\u03b2 and tau-driven Alzheimer\u2019s disease mouse models. Biochem. Biophys. Rep., 43.","DOI":"10.1016\/j.bbrep.2025.102089"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41398-024-02904-0","article-title":"Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats","volume":"14","author":"Nicolas","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Codd, L.N., Blackmore, D.G., Vukovic, J., and Bartlett, P.F. (2020). Exercise reverses learning deficits induced by hippocampal injury by promoting neurogenesis. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-76176-1"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Huang, Y., Sun, W., Gao, F., Ma, H., Yuan, T., Liu, Z., Liu, H., Hu, J., Bai, J., and Zhang, X. (2023). Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats. Biology, 12.","DOI":"10.3390\/biology12060760"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"110903","DOI":"10.1016\/j.brainresbull.2024.110903","article-title":"Prolonged stress response induced by chronic stress and corticosterone exposure causes adult neurogenesis inhibition and astrocyte loss in mouse hippocampus","volume":"208","author":"Shin","year":"2024","journal-title":"Brain Res. Bull."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12974-021-02243-7","article-title":"Galantamine prevents and reverses neuroimmune induction and loss of adult hippocampal neurogenesis following adolescent alcohol exposure","volume":"18","author":"Macht","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cbi.2008.04.004","article-title":"Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis","volume":"175","author":"Kotani","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jns.2014.09.021","article-title":"Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia","volume":"347","author":"Kwon","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Sahin, F., Gunel, A., Atasoy, B.T., Guler, U., Salih, B., Kuzu, I., Taspinar, M., Cinar, O., and Kahveci, S. (2025). Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases. Sci. Rep., 15.","DOI":"10.1038\/s41598-024-84479-w"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbi.2021.02.011","article-title":"Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model","volume":"95","author":"Ma","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1038\/s12276-023-01073-2","article-title":"Trametinib activates endogenous neurogenesis and recovers neuropathology in a model of Alzheimer\u2019s disease","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Shi, Y., Lv, J., Chen, L., Luo, G., Tao, M., Pan, J., Hu, X., Sheng, J., Zhang, S., and Zhou, M. (2021). Phosphodiesterase-4D Knockdown in the Prefrontal Cortex Alleviates Memory Deficits and Synaptic Failure in Mouse Model of Alzheimer\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.722580"},{"key":"ref_98","first-page":"2008","article-title":"Polypharmacological Potential of Phosphodiesterase 5 Inhibitors for the Treatment of Neurocognitive Disorders","volume":"15","author":"Kumar","year":"2024","journal-title":"Aging Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1017\/S1461145711000836","article-title":"The phosphodiesterase-4 inhibitor rolipram reverses A\u03b2-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats","volume":"15","author":"Wang","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neuropharm.2011.05.009","article-title":"The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents","volume":"61","author":"Hutson","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/ejn.15089","article-title":"Roflumilast protects against spatial memory impairments and exerts anti-inflammatory effects after transient global cerebral ischemia","volume":"53","author":"Bonato","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3233\/JAD-231391","article-title":"Sildenafil as a Candidate Drug for Alzheimer\u2019s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons","volume":"98","author":"Gohel","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"ref_103","first-page":"726","article-title":"Sildenafil and risk of Alzheimer disease: A systematic review and meta-analysis","volume":"17","author":"Chua","year":"2025","journal-title":"Aging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"137027","DOI":"10.1016\/j.neulet.2022.137027","article-title":"Fluoxetine increased adult neurogenesis is mediated by 5-HT3 receptor","volume":"795","author":"Crespo","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Bougea, A., Angelopoulou, E., Vasilopoulos, E., Gourzis, P., and Papageorgiou, S. (2024). Emerging Therapeutic Potential of Fluoxetine on Cognitive Decline in Alzheimer\u2019s Disease: Systematic Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126542"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1523\/JNEUROSCI.0529-11.2011","article-title":"The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer\u2019s disease","volume":"31","author":"McClean","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13195-024-01666-7","article-title":"evoke and evoke+: Design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer\u2019s disease","volume":"17","author":"Cummings","year":"2025","journal-title":"Alzheimers Res. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13063-019-3259-x","article-title":"Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer\u2019s disease: Study protocol for a randomised controlled trial (ELAD study)","volume":"20","author":"Femminella","year":"2019","journal-title":"Trials"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e089799","DOI":"10.1002\/alz.089799","article-title":"Evaluation of Novel GLP-1 analogue in the treatment of Alzheimer\u2019s disease","volume":"20","author":"Edison","year":"2024","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nbt.2565","article-title":"Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits","volume":"31","author":"Liu","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Ji, Q., Lv, Y., Hu, B., Su, Y., Shaikh, I.I., and Zhu, X. (2024). Study on the therapeutic potential of induced neural stem cells for Alzheimer\u2019s disease in mice. Biol. Res., 57.","DOI":"10.1186\/s40659-024-00568-0"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/alz.12651","article-title":"Results and insights from a phase I clinical trial of Lomecel-B for Alzheimer\u2019s disease","volume":"19","author":"Brody","year":"2023","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Nato, G., Corti, A., Parmigiani, E., Jachetti, E., Lecis, D., Colombo, M.P., Delia, D., Buffo, A., and Magrassi, L. (2021). Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing. Sci. Rep., 11.","DOI":"10.1038\/s41598-020-79502-9"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5966\/sctm.2016-0201","article-title":"Preventing Pluripotent Cell Teratoma in Regenerative Medicine Applied to Hematology Disorders","volume":"6","author":"Bedel","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1038\/s41380-023-02135-7","article-title":"Hippocampal delivery of neurotrophic factor-\u03b11\/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer\u2019s Disease male mice","volume":"28","author":"Xiao","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_116","unstructured":"(2021). A Phase I Study to Assess the Safety, Tolerability and Preliminary Efficacy of AAV2-BDNF [Adeno-Associated Virus (AAV)-Based, Vector-Mediated Delivery of Human Brain Derived Neurotrophic Factor] in Subjects with Early Alzheimer\u2019s Disease and Mild Cognitive Impairment, The Ohio State University."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrd3366","article-title":"Potential therapeutic uses of BDNF in neurological and psychiatric disorders","volume":"10","author":"Nagahara","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Roussel-Gervais, A., Sgroi, S., Cambet, Y., Lemeille, S., Seredenina, T., Krause, K.H., and Jaquet, V. (2023). Genetic knockout of NTRK2 by CRISPR\/Cas9 decreases neurogenesis and favors glial progenitors during differentiation of neural progenitor stem cells. Front. Cell Neurosci., 17.","DOI":"10.3389\/fncel.2023.1289966"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/s41586-024-07972-2","article-title":"CRISPR\u2013Cas9 screens reveal regulators of ageing in neural stem cells","volume":"634","author":"Ruetz","year":"2024","journal-title":"Nature"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zeng, Q., Long, Z., Feng, M., Zhao, Y., Luo, S., Wang, K., Wang, Y., Yang, G., and He, G. (2019). Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt\/\u03b2-Catenin Signaling Pathway in the APP\/PS1\/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer\u2019s Disease. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00062"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Nakatsuka, D., Izumi, T., Tsukamoto, T., Oyama, M., Nishitomi, K., Deguchi, Y., Niidome, K., Yamakawa, H., Ito, H., and Ogawa, K. (2021). Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP\/PS1 Transgenic Mouse Model. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.782375"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Chang, Z., Xu, W., Jiang, S., Liu, X., Zhu, H., Wang, P., Gao, B., Gong, K., Guo, G., and Sun, K. (2022). Effects of 5-Aza on neurogenesis contribute to learning and memory in the mouse hippocampus. Biomed. Pharmacother., 154.","DOI":"10.1016\/j.biopha.2022.113623"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e8587","DOI":"10.15252\/emmm.201708587","article-title":"Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator","volume":"10","author":"Chatterjee","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1038\/s41467-025-58496-w","article-title":"Tip60 HAT activators as therapeutic modulators for Alzheimer\u2019s disease","volume":"16","author":"Bhatnagar","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Chen, Y.A., Lu, C.H., Ke, C.C., Chiu, S.J., Jeng, F.S., Chang, C.W., Yang, B.H., and Liu, R.S. (2021). Mesenchymal Stem Cell-Derived Exosomes Ameliorate Alzheimer\u2019s Disease Pathology and Improve Cognitive Deficits. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060594"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-022-02393-2","article-title":"Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e101143","DOI":"10.1136\/gpsych-2023-101143","article-title":"Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer\u2019s disease: A phase I\/II clinical trial","volume":"36","author":"Xie","year":"2023","journal-title":"Gen. Psychiatr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCRESAHA.123.323054","article-title":"The Discovery of Extracellular Vesicles and Their Emergence as a Next-Generation Therapy","volume":"135","author":"Rai","year":"2024","journal-title":"Circ. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2403199","DOI":"10.1002\/adma.202403199","article-title":"Immunogenicity of Extracellular Vesicles","volume":"36","author":"Xia","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in Early Alzheimer\u2019s Disease","volume":"388","author":"Swanson","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1038\/s41380-024-02833-w","article-title":"Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"30","author":"Kokkali","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"302","DOI":"10.4103\/1673-5374.379038","article-title":"5-Bromo-2\u2032-deoxyuridine labeling: Historical perspectives, factors influencing the detection, toxicity, and its implications in the neurogenesis","volume":"19","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Cha, D.J., Mengel, D., Mustapic, M., Liu, W., Selkoe, D.J., Kapogiannis, D., Galasko, D., Rissman, R.A., Bennett, D.A., and Walsh, D.M. (2019). miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer\u2019s Patients. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01208"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.stem.2021.05.001","article-title":"Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer\u2019s disease","volume":"28","author":"Walgrave","year":"2021","journal-title":"Cell Stem Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s41418-019-0409-3","article-title":"Impaired adult neurogenesis is an early event in Alzheimer\u2019s disease neurodegeneration, mediated by intracellular A\u03b2 oligomers","volume":"27","author":"Scopa","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/s41467-021-21649-8","article-title":"A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy","volume":"12","author":"Lybrand","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41392-023-01433-4","article-title":"Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Maddaloni, G., Migliarini, S., Napolitano, F., Giorgi, A., Nazzi, S., Biasci, D., De Felice, A., Gritti, M., Cavaccini, A., and Galbusera, A. (2018). Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-30291-2"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Gao, M., Yao, H., Dong, Q., Zhang, H., Yang, Z., Yang, Y., Zhu, J., Xu, M., and Xu, R. (2016). Tumourigenicity and Immunogenicity of Induced Neural Stem Cell Grafts Versus Induced Pluripotent Stem Cell Grafts in Syngeneic Mouse Brain. Sci. Rep., 6.","DOI":"10.1038\/srep29955"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/s41467-024-45265-4","article-title":"Aneuploid embryonic stem cells drive teratoma metastasis","volume":"15","author":"Xiao","year":"2024","journal-title":"Nat. Commun."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/18\/8926\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:45:04Z","timestamp":1760035504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/18\/8926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,13]]},"references-count":140,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ijms26188926"],"URL":"https:\/\/doi.org\/10.3390\/ijms26188926","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,13]]}}}