{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:24:55Z","timestamp":1782743095838,"version":"3.54.5"},"reference-count":141,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Immunonutrition is a nutritional strategy where the bioactive properties of nutrients from the diet are used to modulate metabolic pathways, inflammation signals, and oxidative stress regulators. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic degenerative disease with increasing prevalence over the past decade. In MASLD, where inflammation and oxidative stress play key roles in the progression of liver disease, immunonutrition becomes even more important. The impact of different dietary patterns has been studied in the MASLD context; however, current guidelines emphasize the Mediterranean Diet, which, in terms of included food groups, provides a high level of immunonutrients. Nonetheless, adherence, monitoring, and implementation based on geographic areas, availability, and economic factors make this type of diet ultimately less accessible. The main benefit of the diet pattern is in maintaining the positive effects of new pharmacological treatments, alongside physical activity, which are crucial to prevent recurrence. A diet strategy designed for MASLD needs to be adapted to local food availability and should promote the inclusion of immunonutrients. In the treatment of MASLD, dietary recommendations should be individualized based on the sociodemographic, clinical, and nutritional characteristics of the patients.<\/jats:p>","DOI":"10.3390\/ijms26188928","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T07:33:02Z","timestamp":1758007982000},"page":"8928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immunonutrition: Another Player on the MASLD Field"],"prefix":"10.3390","volume":"26","author":[{"given":"Iv\u00e1n","family":"L\u00f3pez-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Hepatology and Transplants Unit, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6514-7869","authenticated-orcid":false,"given":"Misael","family":"Uribe","sequence":"additional","affiliation":[{"name":"Gastroenterology and Obesity Unit, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ju\u00e1rez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Translational Research Unit, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"ref_1","first-page":"186","article-title":"Immunonutrition, Evidence and Experiences","volume":"40","author":"Amarelle","year":"2022","journal-title":"Nutr. Hosp."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF02722634","article-title":"Immunonutrition","volume":"69","author":"Singh","year":"2002","journal-title":"Indian J. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2023.02.003","article-title":"The Global Burden of Metabolic Disease: Data from 2000 to 2019","volume":"35","author":"Chew","year":"2023","journal-title":"Cell Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A Multisociety Delphi Consensus Statement on New Fatty Liver Disease Nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of Metabolic Dysfunction-Associated Steatotic Liver Disease","volume":"31","author":"Younossi","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-physiol-021115-105331","article-title":"Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease","volume":"78","author":"Haas","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.tem.2022.07.001","article-title":"Immune-Metabolic Interactions in Homeostasis and the Progression to NASH","volume":"33","author":"Hoogerland","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_8","first-page":"691","article-title":"MASLD: A Systemic Metabolic Disorder with Cardiovascular and Malignant Complications","volume":"7","author":"Targher","year":"2024","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.clnesp.2024.12.011","article-title":"Preoperative Immunonutrition and Postoperative Outcomes in Patients with Cancer Undergoing Major Abdominal Surgery: Retrospective Cohort Study","volume":"65","author":"Chona","year":"2025","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ncp.10102","article-title":"Immunonutrition in Critical Illness: What Is the Role?","volume":"33","author":"McCarthy","year":"2018","journal-title":"Nutr. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.surg.2023.08.005","article-title":"Immunonutrition in Patients Who Underwent Major Abdominal Surgery: A Comprehensive Systematic Review and Component Network Metanalysis Using GRADE and CINeMA Approaches","volume":"174","author":"Ricci","year":"2023","journal-title":"Surgery"},{"key":"ref_12","first-page":"e36923","article-title":"Effect of Immunonutrition on the Liver Function Status of End-Stage Liver Disease Patients Waiting\/Referred for Liver Transplant: A Randomized Controlled Trial","volume":"15","author":"Beevi","year":"2023","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-Alcoholic Fatty Liver Disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.7150\/ijms.47103","article-title":"Vitamin C: A Review on Its Role in the Management of Metabolic Syndrome","volume":"17","author":"Wong","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Liu, Y.-X., Yu, J.-H., Sun, J.-H., Ma, W.-Q., Wang, J.-J., and Sun, G.-J. (2023). Effects of Omega-3 Fatty Acids Supplementation on Serum Lipid Profile and Blood Pressure in Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Foods, 12.","DOI":"10.3390\/foods12040725"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12944-024-02108-x","article-title":"Updated Mechanisms of MASLD Pathogenesis","volume":"23","author":"Li","year":"2024","journal-title":"Lipids Health Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Feng, J., MengHuan, L., TingTing, Y., XueJie, Y., and HaiNing, G. (2025). Research Progress on AMPK in the Pathogenesis and Treatment of MASLD. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1558041"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1111\/jgh.16272","article-title":"AMPK\/MTOR Pathway Significance in Healthy Liver and Non-alcoholic Fatty Liver Disease and Its Progression","volume":"38","author":"Marinho","year":"2023","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1053\/j.sult.2016.08.003","article-title":"Hepatic Steatosis: Etiology, Patterns, and Quantification","volume":"37","author":"Idilman","year":"2016","journal-title":"Semin. Ultrasound CT MRI"},{"key":"ref_20","first-page":"388","article-title":"Immune-Enhancing Nutrition in Surgical Critical Care","volume":"109","author":"Pollock","year":"2012","journal-title":"Mo. Med."},{"key":"ref_21","first-page":"55","article-title":"Are Immunonutrition a Novel Therapy for Liver Diseases?","volume":"4","year":"2022","journal-title":"Medicon Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Chen, H., Chen, Z., Bai, X., Li, Z., Huang, S., Lu, D., Li, J., Wang, Y., Han, L., and Xia, K. (2025). Metabolic and Hepatic Biomarkers Associated with MASLD in the Chinese Population. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-17219-3"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Raczy\u0144ska, A., Leszczy\u0144ska, T., Skotnicki, P., and Koronowicz, A. (2025). The Impact of Immunomodulatory Components Used in Clinical Nutrition\u2014A Narrative Review. Nutrients, 17.","DOI":"10.3390\/nu17050752"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"de Jong, J.C.W., van Rooijen, K.S., Stigter, E.C.A., G\u00fclers\u00f6nmez, M.C., de Zoete, M.R., Top, J., Baars, M.J.D., Vercoulen, Y., Kuipers, F., and van Mil, S.W.C. (2024). Dietary Cystine Restriction Increases the Proliferative Capacity of the Small Intestine of Mice. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0290493"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.13653","article-title":"The SPARC Protein: An Overview of Its Role in Lung Cancer and Pulmonary Fibrosis and Its Potential Role in Chronic Airways Disease","volume":"174","author":"Wong","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"110700","DOI":"10.1016\/j.nut.2019.110700","article-title":"Change of Some Oxidative Stress Parameters after Supplementation with Whey Protein Isolate in Patients with Type 2 Diabetes","volume":"73","author":"Derosa","year":"2020","journal-title":"Nutrition"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mazzolini, G., Atorrasagasti, C., Onorato, A., Peixoto, E., Schlattjan, M., Sowa, J.-P., Sydor, S., Gerken, G., and Canbay, A. (2018). SPARC Expression Is Associated with Hepatic Injury in Rodents and Humans with Non-Alcoholic Fatty Liver Disease. Sci. Rep., 8.","DOI":"10.1038\/s41598-017-18981-9"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1157\/13083906","article-title":"Las C\u00e9lulas Estrelladas Del H\u00edgado: Su Importancia En Condiciones Normales y Patol\u00f3gicas","volume":"29","author":"Sarem","year":"2006","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s13105-022-00913-5","article-title":"The Role of SPARC (Secreted Protein Acidic and Rich in Cysteine) in the Pathogenesis of Obesity, Type 2 Diabetes, and Non-Alcoholic Fatty Liver Disease","volume":"79","author":"Atorrasagasti","year":"2023","journal-title":"J. Physiol. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e220073","DOI":"10.1530\/JOE-22-0073","article-title":"SerpinA3N Deficiency Attenuates Steatosis and Enhances Insulin Signaling in Male Mice","volume":"256","author":"Tran","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Rague, J. (2022). N-Acetylcysteine. History of Modern Clinical Toxicology, Elsevier.","DOI":"10.1016\/B978-0-12-822218-8.00002-8"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hang, W., Shu, H., Wen, Z., Liu, J., Jin, Z., Shi, Z., Chen, C., and Wang, D.W. (2021). N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.636204"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100343","DOI":"10.1016\/j.phanu.2023.100343","article-title":"The Efficacy of N-Acetylcysteine in Improving Liver Function: A Systematic Review and Meta-Analysis of Controlled Clinical Trials","volume":"24","author":"Adeli","year":"2023","journal-title":"PharmaNutrition"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/j.eclnm.2008.07.015","article-title":"Basics in Clinical Nutrition: Immunonutrition\u2014Nutrients Which Influence Immunity: Effect and Mechanism of Action","volume":"4","author":"Grimble","year":"2009","journal-title":"E-Spen Eur. E J. Clin. Nutr. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Cervantes, J., S\u00e1nchez-Machado, D.I., Campas-Baypoli, O.N., Cant\u00fa-Soto, E.U., and de la Mora-L\u00f3pez, G.S. (2021). Influence of Other Nutrients (e.g., l-Arginine, Taurine, and Choline) on Liver Diseases. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases, Elsevier.","DOI":"10.1016\/B978-0-12-816488-4.00003-6"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12970-021-00472-y","article-title":"Effect of Food Sources of Nitrate, Polyphenols, L-Arginine and L-Citrulline on Endurance Exercise Performance: A Systematic Review and Meta-Analysis of Randomised Controlled Trials","volume":"18","author":"Blake","year":"2021","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jhep.2014.09.015","article-title":"Arginase 2 Deficiency Results in Spontaneous Steatohepatitis: A Novel Link between Innate Immune Activation and Hepatic de Novo Lipogenesis","volume":"62","author":"Navarro","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1038\/s12276-023-01102-0","article-title":"Lactobacillus Plantarum Ameliorates NASH-Related Inflammation by Upregulating l-Arginine Production","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12986-020-00477-5","article-title":"Low-Arginine and Low-Protein Diets Induce Hepatic Lipid Accumulation through Different Mechanisms in Growing Rats","volume":"17","author":"Otani","year":"2020","journal-title":"Nutr. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12944-015-0124-0","article-title":"Investigation into the Antioxidant Role of Arginine in the Treatment and the Protection for Intralipid-Induced Non-Alcoholic Steatohepatitis","volume":"14","year":"2015","journal-title":"Lipids Health Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ije\/dyx234","article-title":"Dietary Glutamine, Glutamate and Mortality: Two Large Prospective Studies in US Men and Women","volume":"47","author":"Ma","year":"2018","journal-title":"Int. J. Epidemiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kapalka, G.M. (2010). Substances Involved in Neurotransmission. Nutritional and Herbal Therapies for Children and Adolescents, Elsevier.","DOI":"10.1016\/B978-0-12-374927-7.00004-2"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., and Newsholme, P. (2018). Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients, 10.","DOI":"10.20944\/preprints201809.0459.v1"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e92244","DOI":"10.5812\/hepatmon.92244","article-title":"Metabolomic Biomarkers in the Diagnosis of Non-Alcoholic Fatty Liver Disease","volume":"19","author":"Chashmniam","year":"2019","journal-title":"Hepat. Mon."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Li, J., Ghazwani, M., Liu, K., Huang, Y., Chang, N., Fan, J., He, F., Li, L., Bu, S., and Xie, W. (2017). Regulation of Hepatic Stellate Cell Proliferation and Activation by Glutamine Metabolism. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182679"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41419-022-05409-0","article-title":"Targeting Glutamine Metabolism in Hepatic Stellate Cells Alleviates Liver Fibrosis","volume":"13","author":"Yin","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2017.12.022","article-title":"Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells","volume":"154","author":"Du","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_48","first-page":"92","article-title":"Efecto de La Glutamina En El Estr\u00e9s Oxidativo y La Inflamaci\u00f3n En Un Modelo de Rata Con Insuficiencia Hep\u00e1tica Fulminante","volume":"33","author":"Schemitt","year":"2016","journal-title":"Nutr. Hosp."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3892\/etm.2013.1434","article-title":"Effects of Glutamine on Oxidative Stress and Nuclear Factor-\u039aB Expression in the Livers of Rats with Nonalcoholic Fatty Liver Disease","volume":"7","author":"Lin","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000282083","article-title":"The Role of Cytokines in Non-Alcoholic Fatty Liver Disease","volume":"28","author":"Tilg","year":"2010","journal-title":"Dig. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1017\/S1368980021004948","article-title":"Association of Dietary Intake of Branched-Chain Amino Acids with Long-Term Risks of CVD, Cancer and All-Cause Mortality","volume":"25","author":"Xu","year":"2022","journal-title":"Public Health Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12937-023-00861-w","article-title":"Dietary Intakes of Branched-Chain Amino Acids and Plasma Lipid Profiles among Filipino Women in Korea: The Filipino Women\u2019s Diet and Health Study (FiLWHEL)","volume":"22","author":"Okekunle","year":"2023","journal-title":"Nutr. J."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cuomo, P., Capparelli, R., Iannelli, A., and Iannelli, D. (2022). Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084325"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.metabol.2016.12.013","article-title":"Branched-Chain Amino Acids Alleviate Hepatic Steatosis and Liver Injury in Choline-Deficient High-Fat Diet Induced NASH Mice","volume":"69","author":"Honda","year":"2017","journal-title":"Metabolism"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00726-014-1894-9","article-title":"Branched Chain Amino Acid Metabolism Profiles in Progressive Human Nonalcoholic Fatty Liver Disease","volume":"47","author":"Lake","year":"2015","journal-title":"Amino Acids"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"E299","DOI":"10.1152\/ajpendo.00307.2022","article-title":"Branched-Chain Amino Acids Alter Cellular Redox to Induce Lipid Oxidation and Reduce de Novo Lipogenesis in the Liver","volume":"324","author":"Surugihalli","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_57","first-page":"76","article-title":"The Polyphenols, Naturally Occurring Compounds with Beneficial Effects on Cardiovascular Disease","volume":"27","author":"Miguel","year":"2012","journal-title":"Nutr. Hosp."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Safer, A.-M., Afzal, M., Nomani, M., and Mousa, S.A. (2013). Green Tea Extract in the Management of Hepatic Fibrosis. Tea in Health and Disease Prevention, Elsevier.","DOI":"10.1016\/B978-0-12-384937-3.00076-8"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Rana, A., Samtiya, M., Dhewa, T., Mishra, V., and Aluko, R.E. (2022). Health Benefits of Polyphenols: A Concise Review. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14264"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Rafiei, H., Omidian, K., and Bandy, B. (2019). Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an In Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function. Nutrients, 11.","DOI":"10.3390\/nu11030541"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e2202934119","DOI":"10.1073\/pnas.2202934119","article-title":"A Gut Microbial Metabolite of Dietary Polyphenols Reverses Obesity-Driven Hepatic Steatosis","volume":"119","author":"Osborn","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"106994","DOI":"10.1016\/j.prostaglandins.2025.106994","article-title":"The Effect of Highly Bioavailable Forms of Curcumin on Lipoprotein(a) Plasma Levels: A Systematic Review and Meta-Analysis of Randomized Clinical Studies","volume":"178","author":"Fogacci","year":"2025","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"102801","DOI":"10.1016\/j.arr.2025.102801","article-title":"Effect of Curcumin on Cardiometabolic Diseases in the Elderly: A Systematic Review of Randomized Controlled Trials","volume":"110","author":"Rajabinasab","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1007\/s10787-025-01739-5","article-title":"From Bench to Bedside: Exploring Curcumin-Driven Signaling Pathways in Immune Cells for Cancer Management","volume":"33","author":"Goleij","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ciuca, M.D., and Racovita, R.C. (2023). Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24108874"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lukkunaprasit, T., Tansawet, A., Boonmanunt, S., Sobhonslidsuk, A., McKay, G.J., Attia, J., and Thakkinstian, A. (2023). An Updated Meta-Analysis of Effects of Curcumin on Metabolic Dysfunction-Associated Fatty Liver Disease Based on Available Evidence from Iran and Thailand. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33023-3"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2021.06.026","article-title":"Polyphenols in the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease: An Update of Preclinical and Clinical Studies","volume":"44","author":"Bayram","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_68","first-page":"1523","article-title":"Green Tea Polyphenols Attenuate Hepatic Steatosis, and Reduce Insulin Resistance and Inflammation in High-Fat Diet-Induced Rats","volume":"44","author":"Xia","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5599997","DOI":"10.1155\/2021\/5599997","article-title":"Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS\/MAPK Signaling Pathway","volume":"2021","author":"Wu","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Du, Y., Paglicawan, L., Soomro, S., Abunofal, O., Baig, S., Vanarsa, K., Hicks, J., and Mohan, C. (2021). Epigallocatechin-3-Gallate Dampens Non-Alcoholic Fatty Liver by Modulating Liver Function, Lipid Profile and Macrophage Polarization. Nutrients, 13.","DOI":"10.3390\/nu13020599"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"102843","DOI":"10.1016\/j.ctim.2022.102843","article-title":"Curcumin as Adjuvant Treatment in Patients with Non-Alcoholic Fatty Liver (NAFLD) Disease: A Systematic Review and Meta-Analysis","volume":"68","author":"Ngu","year":"2022","journal-title":"Complement. Ther. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1021\/acs.jafc.3c01067","article-title":"Curcumin Alleviates High-Fat Diet-Induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats","volume":"71","author":"Wu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ajcnut.2024.05.017","article-title":"Curcumin Supplementation Alleviates Hepatic Fat Content Associated with Modulation of Gut Microbiota-Dependent Bile Acid Metabolism in Patients with Nonalcoholic Simple Fatty Liver Disease: A Randomized Controlled Trial","volume":"120","author":"He","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chen, Q., Zhao, L., Mei, L., Zhao, X., Han, P., Liu, J., Meng, C., Li, R., Zhong, R., and Wang, K. (2023). Vitamin C and Vitamin D3 Alleviate Metabolic-Associated Fatty Liver Disease by Regulating the Gut Microbiota and Bile Acid Metabolism via the Gut-Liver Axis. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1163694"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Dosed\u011bl, M., Jirkovsk\u00fd, E., Mac\u00e1kov\u00e1, K., Kr\u010dmov\u00e1, L., Javorsk\u00e1, L., Pourov\u00e1, J., Mercolini, L., Remi\u00e3o, F., Nov\u00e1kov\u00e1, L., and Mlad\u011bnka, P. (2021). Vitamin C\u2014Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients, 13.","DOI":"10.3390\/nu13020615"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Hon, S.L. (2024). Vitamin C (Ascorbic Acid). Encyclopedia of Toxicology, Elsevier.","DOI":"10.1016\/B978-0-12-824315-2.00981-7"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1053\/jhep.2003.50132","article-title":"Dietary Habits and Their Relations to Insulin Resistance and Postprandial Lipemia in Nonalcoholic Steatohepatitis","volume":"37","author":"Musso","year":"2003","journal-title":"Hepatology"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Lee, S.-W., Lee, Y.-J., Baek, S.-M., Kang, K.-K., Kim, T.-U., Yim, J.-H., Kim, H.-Y., Han, S.-H., Choi, S.-K., and Park, S.-J. (2022). Mega-Dose Vitamin C Ameliorates Nonalcoholic Fatty Liver Disease in a Mouse Fast-Food Diet Model. Nutrients, 14.","DOI":"10.3390\/nu14112195"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"He, Z., Li, X., Yang, H., Wu, P., Wang, S., Cao, D., Guo, X., Xu, Z., Gao, J., and Zhang, W. (2021). Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.745609"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Fatima, G., Dzupina, A., Mahdi, A.A., Fedacko, J., Magomedova, A., and Yousif, N.G. (2025). Role of Vitamin-E as a Vital Nutrient in Health and Diseases. Indian J. Clin. Biochem., 1\u201314.","DOI":"10.1007\/s12291-025-01309-0"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.18295\/2075-0528.1566","article-title":"The Role of Vitamin e in Human Health and Some Diseases","volume":"14","author":"Rizvi","year":"2014","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/iub.1991","article-title":"Role of Vitamin E in Nonalcoholic Fatty Liver Disease","volume":"71","author":"Nagashimada","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"102866","DOI":"10.1016\/j.ctim.2022.102866","article-title":"Comparison of Delta-Tocotrienol and Alpha-Tocopherol Effects on Hepatic Steatosis and Inflammatory Biomarkers in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blind Active-Controlled Trial","volume":"70","author":"Pervez","year":"2022","journal-title":"Complement. Ther. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD Practice Guidance on the Clinical Assessment and Management of Nonalcoholic Fatty Liver Disease","volume":"77","author":"Rinella","year":"2023","journal-title":"Hepatology"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Lahmi, A., Oryan, S., Eidi, A., and Rohani, A.H. (2024). Comparative Effects of Thymol and Vitamin E on Nonalcoholic Fatty Liver Disease in Male Wistar Rats. Braz. J. Biol., 84.","DOI":"10.1590\/1519-6984.268781"},{"key":"ref_87","first-page":"144","article-title":"Zinc and Its Importance for Human Health: An Integrative Review","volume":"18","author":"Roohani","year":"2013","journal-title":"J. Res. Med. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1002\/efd2.17","article-title":"Zinc Nutrition and Human Health: Overview and Implications","volume":"3","author":"Sangeetha","year":"2022","journal-title":"eFood"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12576-017-0571-7","article-title":"Zinc Status Is Associated with Inflammation, Oxidative Stress, Lipid, and Glucose Metabolism","volume":"68","author":"Olechnowicz","year":"2018","journal-title":"J. Physiol. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Cooper-Capetini, V., De Vasconcelos, D., Martins, A., Hirabara, S., Donato, J., Carpinelli, A., and Abdulkader, F. (2017). Zinc Supplementation Improves Glucose Homeostasis in High Fat-Fed Mice by Enhancing Pancreatic \u03b2-Cell Function. Nutrients, 9.","DOI":"10.3390\/nu9101150"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.numecd.2022.01.035","article-title":"J-Shaped Relationship between Serum Zinc Levels and the Severity of Hepatic Necro-Inflammation in Patients with MAFLD","volume":"32","author":"Chen","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"100105","DOI":"10.1016\/j.metop.2021.100105","article-title":"The Role of Zinc in the Prevention and Treatment of Nonalcoholic Fatty Liver Disease","volume":"11","author":"Barbara","year":"2021","journal-title":"Metab. Open"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Rezaei, S.M.A., Mohammadi, F., Eftekhari, M.H., Ejtehadi, F., Ghaem, H., and Mohammadipoor, N. (2023). The Effects of Zinc Supplementation on the Metabolic Factors in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. BMC Nutr., 9.","DOI":"10.1186\/s40795-023-00776-z"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/ps\/79.7.961","article-title":"Human Requirement for N-3 Polyunsaturated Fatty Acids","volume":"79","author":"Simopoulos","year":"2000","journal-title":"Poult. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11745-003-1074-0","article-title":"Dietary Intakes and Food Sources of Omega-6 and Omega-3 Polyunsaturated Fatty Acids","volume":"38","author":"Meyer","year":"2003","journal-title":"Lipids"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Yang, J., Fern\u00e1ndez-Galilea, M., Mart\u00ednez-Fern\u00e1ndez, L., Gonz\u00e1lez-Muniesa, P., P\u00e9rez-Ch\u00e1vez, A., Mart\u00ednez, J.A., and Moreno-Aliaga, M.J. (2019). Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation. Nutrients, 11.","DOI":"10.3390\/nu11040872"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev-nutr-061021-030223","article-title":"Nonalcoholic Fatty Liver Disease and Omega-3 Fatty Acids: Mechanisms and Clinical Use","volume":"43","author":"Spooner","year":"2023","journal-title":"Annu. Rev. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mam.2018.03.001","article-title":"Omega-3 Fatty Acids and Non-Alcoholic Fatty Liver Disease: Evidence of Efficacy and Mechanism of Action","volume":"64","author":"Scorletti","year":"2018","journal-title":"Mol. Asp. Med."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Kumar, N.G., Contaifer, D., Madurantakam, P., Carbone, S., Price, E.T., Van Tassell, B., Brophy, D.F., and Wijesinghe, D.S. (2019). Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health. Nutrients, 11.","DOI":"10.3390\/nu11122974"},{"key":"ref_100","first-page":"E673","article-title":"Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association","volume":"140","author":"Wilson","year":"2019","journal-title":"Circulation"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/1440-1681.13750","article-title":"Omega-3 Polyunsaturated Fatty Acids in the Treatment of Non-alcoholic Fatty Liver Disease: An Umbrella Systematic Review and Meta-analysis","volume":"50","author":"Musazadeh","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/j.gastro.2014.04.046","article-title":"No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial","volume":"147","author":"Sanyal","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jhep.2014.08.036","article-title":"Effects of N-3 Fish Oil on Metabolic and Histological Parameters in NASH: A Double-Blind, Randomized, Placebo-Controlled Trial","volume":"62","author":"Argo","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/sj.ejcn.1601475","article-title":"Modulation of the Immune Response Mediated by Dietary Nucleotides","volume":"56","author":"Gil","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1113\/JP280908","article-title":"NAD+ and NAFLD\u2014Caution, Causality and Careful Optimism","volume":"600","author":"Dall","year":"2022","journal-title":"J. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2019.03.064","article-title":"Nicotinamide Riboside Protects against Liver Fibrosis Induced by CCl4 via Regulating the Acetylation of Smads Signaling Pathway","volume":"225","author":"Jiang","year":"2019","journal-title":"Life Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jhep.2022.03.017","article-title":"Endoplasmic Reticulum-Mitochondria Miscommunication Is an Early and Causal Trigger of Hepatic Insulin Resistance and Steatosis","volume":"77","author":"Beaulant","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Li, Y., Tian, X., Yu, Q., Bao, T., Dai, C., Jiang, L., Niu, K., Yang, J., Wang, S., and Wu, X. (2024). Alleviation of Hepatic Insulin Resistance and Steatosis with NMN via Improving Endoplasmic Reticulum\u2013Mitochondria Miscommunication in the Liver of HFD Mice. Biomed. Pharmacother., 175.","DOI":"10.1016\/j.biopha.2024.116682"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.32778","article-title":"Nicotinamide Riboside and Pterostilbene Reduces Markers of Hepatic Inflammation in NAFLD: A Double-blind, Placebo-controlled Clinical Trial","volume":"78","author":"Dellinger","year":"2023","journal-title":"Hepatology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.7150\/thno.53652","article-title":"NAD+-Boosting Therapy Alleviates Nonalcoholic Fatty Liver Disease via Stimulating a Novel Exerkine Fndc5\/Irisin","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"e147193","DOI":"10.1172\/jci.insight.147193","article-title":"SIRT3 Is Required for Liver Regeneration but Not for the Beneficial Effect of Nicotinamide Riboside","volume":"6","author":"Mukherjee","year":"2021","journal-title":"JCI Insight"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3350\/cmh.2023.0555","article-title":"Evaluating the Therapeutic Efficacy of NAD Supplementation in Management of Metabolic Dysfunction-Associated Steatotic Liver Disease: Key Considerations","volume":"30","author":"Lu","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ueg2.12443","article-title":"Dietary Strategies in Non-alcoholic Fatty Liver Disease Patients: From Evidence to Daily Clinical Practice, a Systematic Review","volume":"11","author":"Hadefi","year":"2023","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.gastrohep.2021.06.006","article-title":"Efecto de La Dieta Mediterr\u00e1nea Sobre Indicadores Histol\u00f3gicos y Pruebas de Imagen En Enfermedad de H\u00edgado Graso No Alcoh\u00f3lico","volume":"45","author":"Saavedra","year":"2022","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_116","first-page":"2518","article-title":"Mediterranean diet is associated with liver histology in patients with non-alcoholic fatty liver disease","volume":"32","author":"Aller","year":"2015","journal-title":"Nutr. Hosp."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Miryan, M., Darbandi, M., Moradi, M., Najafi, F., Soleimani, D., and Pasdar, Y. (2023). Relationship between the Mediterranean Diet and Risk of Hepatic Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Analysis of the RaNCD Cohort. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1062008"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific Association for the Study of the Liver Clinical Practice Guidelines for the Diagnosis and Management of Metabolic Associated Fatty Liver Disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","article-title":"EASL\u2013EASD\u2013EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","volume":"81","author":"Tacke","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"101903","DOI":"10.1016\/j.aohep.2025.101903","article-title":"Updated Recommendations for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by the Latin American Working Group","volume":"30","author":"Diaz","year":"2025","journal-title":"Ann. Hepatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/joim.13333","article-title":"The Mediterranean Diet and Health: A Comprehensive Overview","volume":"290","author":"Willett","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_123","first-page":"E56","article-title":"Effects of the Mediterranean Diet on the Components of Metabolic Syndrome","volume":"63","author":"Dayi","year":"2022","journal-title":"J. Prev. Med. Hyg."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Nani, A., Murtaza, B., Sayed Khan, A., Khan, N.A., and Hichami, A. (2021). Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms. Molecules, 26.","DOI":"10.3390\/molecules26040985"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/advances\/nmab086","article-title":"Effects of Dietary Patterns on Biomarkers of Inflammation and Immune Responses: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"13","author":"Koelman","year":"2022","journal-title":"Adv. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jand.2022.12.005","article-title":"Increased Adherence to a Mediterranean Diet Is Associated With Reduced Low-Grade Inflammation after a 12.7-Year Period: Results From the Moli-Sani Study","volume":"123","author":"Bonaccio","year":"2023","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jn\/nxx045","article-title":"Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults","volume":"148","author":"Bettermann","year":"2018","journal-title":"J. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Tsigalou, C., Konstantinidis, T., Paraschaki, A., Stavropoulou, E., Voidarou, C., and Bezirtzoglou, E. (2020). Mediterranean Diet as a Tool to Combat Inflammation and Chronic Diseases. An Overview. Biomedicines, 8.","DOI":"10.3390\/biomedicines8070201"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Zelicha, H., Kloting, N., Kaplan, A., Yaskolka Meir, A., Rinott, E., Tsaban, G., Chassidim, Y., Bluher, M., Ceglarek, U., and Isermann, B. (2022). The Effect of High-Polyphenol Mediterranean Diet on Visceral Adiposity: The DIRECT PLUS Randomized Controlled Trial. BMC Med., 20.","DOI":"10.1186\/s12916-022-02525-8"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1136\/gutjnl-2020-323106","article-title":"Effect of Green-Mediterranean Diet on Intrahepatic Fat: The DIRECT PLUS Randomised Controlled Trial","volume":"70","author":"Rinott","year":"2021","journal-title":"Gut"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.clnu.2022.06.037","article-title":"The Effectiveness and Acceptability of Mediterranean Diet and Calorie Restriction in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis","volume":"41","author":"Haigh","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5802\/crbiol.164","article-title":"The Milpa, from Mesoamerica to Present Days, a Multicropping Traditional Agricultural System Serving Agroecology","volume":"347","author":"Manicacci","year":"2024","journal-title":"C. R. Biol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Huerta-\u00c1lvarez, A., Arellano, M., Ch\u00e1vez-M\u00e9ndez, C.A., Carpinteyro-Espin, P., Palacios-Reyes, C., and P\u00e9rez-Escobar, J. (2025). Milpa Diet for MASLD in Mesoamerican Populations: Feasibility, Advantages, and Future Perspectives. Life, 15.","DOI":"10.3390\/life15050812"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","article-title":"Antioxidants and Antioxidant Methods: An Updated Overview","volume":"94","author":"Gulcin","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Vel\u00e1zquez, O.A., Luna-Vital, D.A., Morales-Hernandez, N., Contreras, J., Villase\u00f1or-Tapia, E.C., Fragoso-Medina, J.A., and Mojica, L. (2023). Nutritional, Bioactive Components and Health Properties of the Milpa Triad System Seeds (Corn, Common Bean and Pumpkin). Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1169675"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Luo, J., Wei, Y., Fan, Z., Li, B., Li, L., Chai, Y., Xing, Z., Qiu, Y., Lu, W., and Fang, Z. (2025). Gut Microbiota as a Metabolic Mediator to Prevent or Attenuate MASLD. Crit. Rev. Food Sci. Nutr., 1\u201317.","DOI":"10.1080\/10408398.2025.2545525"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41575-025-01089-1","article-title":"Gut Microbiome in Metabolic Dysfunction-Associated Steatotic Liver Disease and Associated Hepatocellular Carcinoma","volume":"22","author":"Lau","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Chen, J., and Vitetta, L. (2020). Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155214"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/febs.17327","article-title":"Ruminococcus Gnavus in the Gut: Driver, Contributor, or Innocent Bystander in Steatotic Liver Disease?","volume":"292","author":"Meadows","year":"2025","journal-title":"FEBS J."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Barber, T.M., Kabisch, S., Pfeiffer, A.F.H., and Weickert, M.O. (2023). The Effects of the Mediterranean Diet on Health and Gut Microbiota. Nutrients, 15.","DOI":"10.3390\/nu15092150"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13073-022-01015-z","article-title":"The Effects of the Green-Mediterranean Diet on Cardiometabolic Health Are Linked to Gut Microbiome Modifications: A Randomized Controlled Trial","volume":"14","author":"Rinott","year":"2022","journal-title":"Genome Med."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/18\/8928\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:45:05Z","timestamp":1760035505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/18\/8928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,13]]},"references-count":141,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ijms26188928"],"URL":"https:\/\/doi.org\/10.3390\/ijms26188928","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,13]]}}}