{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T12:30:23Z","timestamp":1763469023273,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lead is a naturally occurring metal found in numerous compounds used in everyday life. Toxicity from lead is a well-known public health problem. Its effects are implicated in multiple tissues, encompassing the gastrointestinal, renal, cardiovascular, and neurological systems. Endocannabinoid receptors are involved in each of these systems, but the effects of lead on the receptors themselves are not well elucidated. In the neurological system, lead has varying interactions with neurotransmitters and downstream regulators implicated in neuronal transmissions influenced by endocannabinoid receptor function. Lead\u2019s effect is likely indirect on endocannabinoid receptor function; however, its influence on neuronal function is likely inhibitory to the receptor\u2019s functioning. Lead has also been implicated in oxidative stress states, which would influence endocannabinoid receptors\u2019 function. The literature clearly supports lead having a negative impact on the overall function of endocannabinoid receptors, setting the stage for pathological states related to diminished neurosynaptic function and, in embryology, altered neuronal development, especially of the neural tube.<\/jats:p>","DOI":"10.3390\/ijms26188994","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T08:56:46Z","timestamp":1758013006000},"page":"8994","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Putative Effects of Lead on the Endocannabinoid System: A Literature Review and Summary"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5365-3334","authenticated-orcid":false,"given":"Gersham J.","family":"Rainone","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-2325","authenticated-orcid":false,"given":"Phillip Mitchell","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6636-8161","authenticated-orcid":false,"given":"Peter","family":"Pressman","sequence":"additional","affiliation":[{"name":"Institute of Medicine & Department of Sociology, University of Maine, Orono, ME 04469, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-3179","authenticated-orcid":false,"given":"Andrew Wallace","family":"Hayes","sequence":"additional","affiliation":[{"name":"Center for Environmental\/Occupational Risk Analysis & Management, College of Public Health, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/intox-2015-0009","article-title":"Lead toxicity: A review","volume":"8","author":"Wani","year":"2015","journal-title":"Interdiscip. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1289\/ehp.877559","article-title":"Metal toxicity in the central nervous system","volume":"75","author":"Clarkson","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hayes, A.W., and Kobets, T. (2024). Hayes\u2019 Principles and Methods of Toxicology, CRC Press. [7th ed.].","DOI":"10.1201\/9781003390008"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/REVEH.2009.24.1.15","article-title":"Neurotoxic effects and biomarkers of lead exposure: A review","volume":"24","author":"Sanders","year":"2009","journal-title":"Rev. Environ. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.med.55.091902.103653","article-title":"Lead poisoning","volume":"55","author":"Needleman","year":"2004","journal-title":"Annu. Rev. Med."},{"key":"ref_6","first-page":"40","article-title":"Lead hazards for pregnant women and children: Part 2: More can still be done to reduce the chance of exposure to lead in at-risk populations","volume":"108","author":"Cleveland","year":"2008","journal-title":"Am. J. Nurs."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"A599","DOI":"10.1289\/ehp.021100599","article-title":"The prevalence of lead-based paint hazards in U.S. housing","volume":"110","author":"Jacobs","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12403-023-00564-x","article-title":"In Utero Exposure to Lead is Associated with Neural Tube Defects via Disturbing the Expression of Endocannabinoid Retrograde Signaling-Related Genes","volume":"16","author":"Tian","year":"2024","journal-title":"Expo. Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1037\/pne0000225","article-title":"Low-level Lead Exposure Impairs Fronto-executive Functions: A Call to Update the DSM-5 with Lead Poisoning as a Neurodevelopmental Disorder","volume":"13","author":"Neuwirth","year":"2020","journal-title":"Psychol. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tips.2006.12.004","article-title":"The emerging functions of endocannabinoid signaling during CNS development","volume":"28","author":"Harkany","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0166-2236(99)01491-5","article-title":"The endogenous cannabinoid system and brain development","volume":"23","author":"Berrendero","year":"2000","journal-title":"Trends Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0009-3084(00)00189-4","article-title":"2-Arachidonoylglycerol and the cannabinoid receptors","volume":"108","author":"Sugiura","year":"2000","journal-title":"Chem. Phys. Lipids"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nn2042","article-title":"Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum","volume":"11","author":"Maccarrone","year":"2008","journal-title":"Nat. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","article-title":"Cannabinoid receptor localization in brain","volume":"87","author":"Herkenham","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.neuroscience.2005.01.026","article-title":"CB1 cannabinoid receptors are enriched in the perisynaptic annulus and on preterminal segments of hippocampal GABAergic axons","volume":"136","author":"Szabadits","year":"2005","journal-title":"Neuroscience"},{"key":"ref_16","first-page":"607","article-title":"Review of the Endocannabinoid System","volume":"6","author":"Lu","year":"2021","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1046\/j.1460-9568.2003.02599.x","article-title":"Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain","volume":"17","author":"Mato","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1523\/JNEUROSCI.2126-10.2010","article-title":"Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding","volume":"30","author":"Keimpema","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International Union of Pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rosati, L., Chianese, T., Mileo, A., De Falco, M., and Capaldo, A. (2023). Cocaine Effects on Reproductive Behavior and Fertility: An Overview. Vet. Sci., 10.","DOI":"10.3390\/vetsci10080484"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.conb.2008.08.007","article-title":"Wiring and firing neuronal networks: Endocannabinoids take center stage","volume":"18","author":"Harkany","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2012.09.020","article-title":"Endocannabinoid signaling and synaptic function","volume":"76","author":"Castillo","year":"2012","journal-title":"Neuron"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1073\/pnas.0803545105","article-title":"Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning","volume":"105","author":"Mulder","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/physrev.00019.2008","article-title":"Endocannabinoid-mediated control of synaptic transmission","volume":"89","author":"Kano","year":"2009","journal-title":"Physiol. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.conb.2014.03.017","article-title":"Endocannabinoid-mediated retrograde modulation of synaptic transmission","volume":"29","author":"Kano","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1113\/jphysiol.2011.220855","article-title":"Endocannabinoids at the synapse a decade after the dies mirabilis (29 March 2001): What we still do not know","volume":"590","author":"Alger","year":"2012","journal-title":"J. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuron.2009.06.021","article-title":"Activity-dependent regulation of synapses by retrograde messengers","volume":"63","author":"Regehr","year":"2009","journal-title":"Neuron"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.biopsych.2015.07.028","article-title":"An Introduction to the Endogenous Cannabinoid System","volume":"79","author":"Lu","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/35069076","article-title":"Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses","volume":"410","author":"Wilson","year":"2001","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/42015","article-title":"A second endogenous cannabinoid that modulates long-term potentiation","volume":"388","author":"Stella","year":"1997","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1523\/JNEUROSCI.4134-09.2011","article-title":"Concerted action of CB1 cannabinoid receptor and deleted in colorectal cancer in axon guidance","volume":"31","author":"Argaw","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-319-20825-1_3","article-title":"Distribution of the Endocannabinoid System in the Central Nervous System","volume":"231","author":"Hu","year":"2015","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/18\/8994\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:46:09Z","timestamp":1760035569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/18\/8994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":32,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["ijms26188994"],"URL":"https:\/\/doi.org\/10.3390\/ijms26188994","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2025,9,16]]}}}