{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:44:49Z","timestamp":1791236689482,"version":"4.1.0"},"reference-count":109,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Slovak Research and Development Agency","award":["APVV-23-0031"],"award-info":[{"award-number":["APVV-23-0031"]}]},{"name":"Slovak Research and Development Agency","award":["VEGA-1\/0253\/25"],"award-info":[{"award-number":["VEGA-1\/0253\/25"]}]},{"name":"Slovak Research and Development Agency","award":["VEGA 1\/0232\/25"],"award-info":[{"award-number":["VEGA 1\/0232\/25"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) includes two distinct diseases: ulcerative colitis (UC) and Crohn\u2019s disease, affecting people worldwide regardless of age and gender. It appears that a combination of many factors, primarily genetic background, environmental, host immune response, and a state of reduced microbial diversity are associated with IBD. Gut modulation by probiotics application represents one of the potential strategies for the prevention or treatment of IBD. The gut microbiota has the ability to influence host physiology either directly or through microbial metabolites. This review summarizes human randomized clinical trials that evaluate the usefulness of various probiotics in relation to the treatment, prevention, and maintenance of disease remission.<\/jats:p>","DOI":"10.3390\/ijms26189065","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:10:19Z","timestamp":1758118219000},"page":"9065","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Probiotics in IBD: Evidence and Perspectives on Patient Health and Disease Management"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-373X","authenticated-orcid":false,"given":"Em\u00edlia","family":"Hijov\u00e1","sequence":"first","affiliation":[{"name":"Center of Clinical and Preclinical Research-MediPark, Pavol Jozef \u0160af\u00e1rik University in Ko\u0161ice, 04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1053\/j.gastro.2020.09.056","article-title":"Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues","volume":"160","author":"Lee","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/ibd\/izab029","article-title":"Human intestinal macrophages are involved in the pathology of both ulcerative colitis and Crohn disease","volume":"27","author":"Dharmasiri","year":"2021","journal-title":"Inflamm. 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