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Thermal information is collected by thermoreceptors present in the viscera and driven across sensory neurons of the nodose ganglia (NG), which in turn send it to the hypothalamus. While transient receptor potential channels (TRPs) are traditionally considered for thermal transduction, TREK channels belonging to the two-pore domain K+ channels family are emerging as thermosensors, but their role in the NG remains understudied. Patch-clamp recordings revealed that increasing the temperature to physiological levels causes a hyperpolarization of the membrane potential followed by a depolarization and, despite physiological temperature increased the firing rate, we have demonstrated that TREK channels might be taking part in the excitability control by counteracting TRPs\u2019 effects. In fact, single-channel experiments revealed an increase in TREK channel open probability and a subsequent rise in their activity in NG neurons. All this indicates that TREK channels, mainly TREK1, may be responsible along with TRPs for the maintenance of the membrane potential at physiological temperature in NG neurons.<\/jats:p>","DOI":"10.3390\/ijms26189119","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T14:45:46Z","timestamp":1758206746000},"page":"9119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increasing Temperature Activates TREK Potassium Currents in Vagal Afferent Neurons from the Nodose Ganglion"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-8018","authenticated-orcid":false,"given":"Lola","family":"Rueda-Ruzafa","sequence":"first","affiliation":[{"name":"Department of Functional Biology and Health Sciences, University of Vigo, 36310 Vigo, Spain"},{"name":"Neuroscience Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-6345","authenticated-orcid":false,"given":"Ana","family":"Campos-R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Functional Biology and Health Sciences, University of Vigo, 36310 Vigo, Spain"},{"name":"Neuroscience Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rivas-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Functional Biology and Health Sciences, University of Vigo, 36310 Vigo, Spain"},{"name":"CINBIO, University of Vigo, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-6845","authenticated-orcid":false,"given":"Manuela","family":"Rodr\u00edguez-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Department of Functional Biology and Health Sciences, University of Vigo, 36310 Vigo, Spain"},{"name":"Neuroscience Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36310 Vigo, Spain"},{"name":"CINBIO, University of Vigo, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-3718","authenticated-orcid":false,"given":"Salvador","family":"Herrera-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Functional Biology and Health Sciences, University of Vigo, 36310 Vigo, Spain"},{"name":"Neuroscience Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Lamas","sequence":"additional","affiliation":[{"name":"Department of Functional Biology and Health Sciences, University of Vigo, 36310 Vigo, Spain"},{"name":"Neuroscience Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: A heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"033409","DOI":"10.1117\/1.NPh.11.3.033409","article-title":"Vertebrate behavioral thermoregulation: Knowledge and future directions","volume":"11","author":"Cutler","year":"2024","journal-title":"Neurophotonics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1523\/JNEUROSCI.1696-08.2008","article-title":"TRPA1 Channels Mediate Cold Temperature Sensing in Mammalian Vagal Sensory Neurons: Pharmacological and Genetic Evidence","volume":"28","author":"Fajardo","year":"2008","journal-title":"J. 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