{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:00:34Z","timestamp":1791846034443,"version":"4.3.4"},"reference-count":76,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Green tea, long consumed across Southeast Asia, is highly esteemed for its medicinal properties and is often favored over conventional treatments in Eastern cultures. Its health benefits are largely attributed to its minimal processing, which preserves pharmacologically active compounds, particularly catechins, a key class of polyphenols, with epigallocatechin-gallate (EGCG) being the most abundant and bioactive. These compounds exhibit antioxidant, anti-cancer, antimicrobial, and antiangiogenic properties. Beyond systemic health, EGCG has diverse applications in dermatology, including the treatment of viral warts, psoriasis, lichen sclerosus, acne, vaginal dryness, alopecia, and UV-induced skin damage. Emerging research also highlights its promise in aesthetic medicine for mitigating skin oxidative stress, improving skin brightness and neutralizing free radicals, responsible for wrinkles, hyperpigmentation, and loss of elasticity. The aim of this review is to examine the most recent literature on the wide-ranging clinical applications of Epigallocatechin-gallate (EGCG) and to assess its potential use as a daily foundational supplement to enhance both physical and mental well-being, focusing on the dermatological benefits.<\/jats:p>","DOI":"10.3390\/ijms26189253","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T17:08:17Z","timestamp":1758560897000},"page":"9253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6432-8585","authenticated-orcid":false,"given":"Emanuele","family":"Rovaldi","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Medical and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-5790","authenticated-orcid":false,"given":"Violante","family":"Di Donato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Sapienza of Roma, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Paolino","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, IRCCS, Ospedale San Raffaele, 20132 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Bruno","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Medei","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ospedale Santa Maria, University Sapienza of Perugia, 05100 Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3828-0883","authenticated-orcid":false,"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-1755","authenticated-orcid":false,"given":"Norbert","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Azzella","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-1364","authenticated-orcid":false,"given":"Andras","family":"Banvolgyi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-951X","authenticated-orcid":false,"given":"Carmen","family":"Cantisani","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Medical and Cardiovascular Sciences, \u201cSapienza\u201d University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0025-6196(11)61193-2","article-title":"Reading the tea leaves: Anticarcinogenic properties of (\u2212)-epigallocatechin-3-gallate","volume":"82","author":"Carlson","year":"2007","journal-title":"Mayo Clin. 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