{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:20:45Z","timestamp":1789734045123,"version":"4.0.1"},"reference-count":14,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To evaluate the effect of sodium\u2013glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1RAs), and their combination on atrial fibrillation (AF) recurrence after catheter ablation in patients with type 2 diabetes mellitus (T2DM). In a prospective cohort study, patients with T2DM undergoing AF ablation were stratified into three groups: SGLT2i-users, GLP-1RAs-users, and combined SGLT2i\/GLP-1RAs users. Diabetics under SGLT2i\/GLP-1RAs therapy had worse glycemic control (HbA1c &gt; 7%). AF recurrence was assessed over 12 months using implantable continuous monitoring (ICM). Secondary outcomes included the inflammatory\/oxidative stress markers measured at the 12-month follow-up. At the follow-up end, patients treated with SGLT2i\/GLP-1RAs versus monotherapy patients showed significantly lower AF recurrence and serum inflammatory\/oxidative stress markers, despite having higher HbA1c levels (p &lt; 0.05). Combined SGLT2i\/GLP-1RAs therapy reduced AF recurrence following catheter ablation and inflammatory\/oxidative stress in T2DM patients.<\/jats:p>","DOI":"10.3390\/ijms26199285","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T15:54:54Z","timestamp":1758642894000},"page":"9285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of Combined Therapy with SGLT2i and GLP-1RAs on Atrial Fibrillation Recurrence After Catheter Ablation in Diabetic Cohorts: One-Year Outcomes from Continuous Monitoring"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5099-3790","authenticated-orcid":false,"given":"Celestino","family":"Sardu","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Centre, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3960-9270","authenticated-orcid":false,"given":"Raffaele","family":"Marfella","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"},{"name":"Pollution and Cardiovascular Diseases Research Centre, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.hroo.2020.04.006","article-title":"Catheter ablation of atrial fibrillation in patients with diabetes mellitus","volume":"1","author":"Wang","year":"2020","journal-title":"Heart Rhythm O2"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1093\/europace\/euv214","article-title":"Catheter ablation of atrial fibrillation in patients with diabetes mellitus: A systematic review and meta-analysis","volume":"17","author":"Anselmino","year":"2015","journal-title":"Europace"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e031269","DOI":"10.1161\/JAHA.123.031269","article-title":"Impact of Sodium-Glucose Cotransporter 2 Inhibitor on Recurrence After Catheter Ablation for Atrial Fibrillation in Patients With Diabetes: A Propensity-Score Matching Study and Meta-Analysis","volume":"12","author":"Zhao","year":"2023","journal-title":"J. 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Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"132359","DOI":"10.1016\/j.ijcard.2024.132359","article-title":"Effectiveness of sodium-glucose co-transporter 2 inhibitors on atrial fibrillation recurrence after catheter ablation: A systemic review and meta-analysis","volume":"413","author":"Zhang","year":"2024","journal-title":"Int. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jacep.2022.08.004","article-title":"Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors on Outcomes After Catheter Ablation for Atrial Fibrillation","volume":"8","author":"Kishima","year":"2022","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.jacep.2023.06.008","article-title":"Impact of SGLT2 Inhibitors on AF Recurrence After Catheter Ablation in Patients with Type 2 Diabetes","volume":"9","author":"Kumar","year":"2023","journal-title":"JACC Clin. 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Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023","volume":"46","author":"Aleppo","year":"2023","journal-title":"Diabetes Care"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/19\/9285\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:47:55Z","timestamp":1760035675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/19\/9285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":14,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ijms26199285"],"URL":"https:\/\/doi.org\/10.3390\/ijms26199285","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]}}}