{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:43:30Z","timestamp":1791362610801,"version":"4.3.1"},"reference-count":130,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Autoimmune diseases are characterized by immune response dysregulation against self-components, leading to chronic inflammation and tissue damage. Vitamin C (VitC), a water-soluble vitamin with established functions in antioxidant defence and collagen synthesis, has also been of interest based on its potential immunomodulatory effects. This review discusses the role of VitC in the course and progression of (A) autoimmune diseases (multiple sclerosis, rheumatoid arthritis, Sj\u00f6gren\u2019s disease, type 1 diabetes, Hashimoto\u2019s thyroiditis, pernicious anaemia, antiphospholipid syndrome), (B) other immune-mediated diseases (Crohn\u2019s disease, periodontitis), and (C) Alzheimer\u2019s disease, a neurodegenerative disorder with autoimmune features. Results from clinical, observational, and experimental trials show that VitC deficiency is common in many of these diseases and may contribute to increased oxidative stress and immune disequilibrium. Supplementation has been associated with improved antioxidant levels, control of inflammatory mediators, and, in some cases, clinical outcomes like disease activity decrease or symptom load. Although findings vary across conditions and few large, randomized trials are available, the overall evidence indicates that maintaining good VitC status can be useful in maintaining immune homeostasis and reducing inflammation. VitC should be viewed as an adjunct to be employed safely, perhaps and ideally within larger treatment regimens, but not in place of effective therapies. Further research, including large-scale clinical trials, will be required to determine more clearly optimal dosing, timing of treatment, and patient population most likely to benefit. By integration of current knowledge, this review recognizes both promise in VitC for treatment of autoimmune\/immune-mediated disease and promise in its potential use within future treatment regimens.<\/jats:p>","DOI":"10.3390\/ijms26199375","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:48:28Z","timestamp":1758804508000},"page":"9375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Vitamin C in Selected Autoimmune and Immune-Mediated Diseases: Exploring Potential Therapeutic Benefits"],"prefix":"10.3390","volume":"26","author":[{"given":"Martyna","family":"Mochol","sequence":"first","affiliation":[{"name":"Department of Periodontology, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Jablonowski","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Walther-Rathenau-Str. 42a, D-17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-1208","authenticated-orcid":false,"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ras\u0142awska-Socha","sequence":"additional","affiliation":[{"name":"Department of Preclinical Conservative Dentistry and Preclinical Endodontics, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-9792","authenticated-orcid":false,"given":"Agnieszka","family":"Chamarczuk","sequence":"additional","affiliation":[{"name":"Department of Preclinical Conservative Dentistry and Preclinical Endodontics, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-3362","authenticated-orcid":false,"given":"Mariusz","family":"Lipski","sequence":"additional","affiliation":[{"name":"Department of Preclinical Conservative Dentistry and Preclinical Endodontics, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3044-8079","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Mazurek-Mochol","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Pomeranian Medical University in Szczecin, Powsta\u0144c\u00f3w Wlkp 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Carr, A.C., and Maggini, S. (2017). Vitamin C and immune function. Nutrients, 9.","DOI":"10.3390\/nu9111211"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hemil\u00e4, H. (2017). Vitamin C and Infections. Nutrients, 9.","DOI":"10.3390\/nu9040339"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1017\/S0007114507832971","article-title":"Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses","volume":"98","author":"Maggini","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000090495","article-title":"Immune-enhancing role of vitamin C and zinc and effect on clinical conditions","volume":"50","author":"Wintergerst","year":"2006","journal-title":"Ann. Nutr. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1093\/ajcn\/69.6.1086","article-title":"Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans","volume":"69","author":"Carr","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1177\/0300060518777044","article-title":"Intravenous vitamin C in the treatment of allergies: An interim subgroup analysis of a long-term observational study","volume":"46","author":"Vollbracht","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"ref_7","first-page":"983","article-title":"Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-\/radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany","volume":"25","author":"Vollbracht","year":"2011","journal-title":"In Vivo"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Vollbracht, C., and Kraft, K. (2021). Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue. Nutrients, 13.","DOI":"10.3390\/nu13041154"},{"key":"ref_9","first-page":"1","article-title":"Plausibility and Feasibility of Intravenous High-Dose Vitamin C in Long COVID Related Fatigue","volume":"12","author":"Vollbracht","year":"2021","journal-title":"J. Basic Clin. Pharm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"CR215","DOI":"10.12659\/MSM.882621","article-title":"Intravenous Vitamin C in the Treatment of Shingles: Results of a Multicenter Prospective Cohort Study","volume":"18","author":"Schencking","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12640-015-9584-2","article-title":"Evaluation of Delta-Aminolevulinic Dehydratase Activity, Oxidative Stress Biomarkers, and Vitamin D Levels in Patients with Multiple Sclerosis","volume":"29","author":"Polachini","year":"2016","journal-title":"Neurotox. Res."},{"key":"ref_12","first-page":"167156","article-title":"Serum Metabolic Profile in Multiple Sclerosis Patients","volume":"2011","author":"Tavazzi","year":"2011","journal-title":"Mult. Scler. Int."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Jim\u00e9nez, F.J., Alonso-Navarro, H., Salgado-C\u00e1mara, P., Garc\u00eda-Mart\u00edn, E., and Ag\u00fandez, J.A.G. (2024). Antioxidant Therapies in the Treatment of Multiple Sclerosis. Biomolecules, 14.","DOI":"10.3390\/biom14101266"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kocot, J., Luchowska-Kocot, D., Kie\u0142czykowska, M., Musik, I., and Kurzepa, J. (2017). Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders. Nutrients, 9.","DOI":"10.3390\/nu9070659"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/0502-514","article-title":"Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival","volume":"8","author":"Sotiriou","year":"2002","journal-title":"Nat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e0054","DOI":"10.37039\/1982.8551.20250054","article-title":"Supplementation and therapeutic use of vitamin C in multiple sclerosis","volume":"84","author":"Oliani","year":"2025","journal-title":"Rev. Bras. Oftalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103267","DOI":"10.1016\/j.msard.2021.103267","article-title":"Plasma circulating vitamin C levels and risk of multiple sclerosis: A two-sample Mendelian randomization analysis","volume":"56","author":"Peng","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/ije\/27.5.845","article-title":"Nutritional factors in the aetiology of multiple sclerosis: A case- control study in Montreal, Canada","volume":"27","author":"Ghadirian","year":"1998","journal-title":"Int. J. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ensci.2018.01.007","article-title":"A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis","volume":"10","author":"Rousta","year":"2018","journal-title":"eNeurologicalSci"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1021\/acs.jproteome.2c00460","article-title":"Multifaceted Analysis of Cerebrospinal Fluid and Serum from Progressive Multiple Sclerosis Patients: Potential Role of Vitamin C and Metal Ion Imbalance in the Divergence of Primary Progressive Multiple Sclerosis and Secondary Progressive Multiple Sclerosis","volume":"22","author":"Pomary","year":"2023","journal-title":"J. Proteome Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.105.2.1023","article-title":"Differentiation of axon-related Schwann cells in vitro. I. Ascorbic acid regulates basal lamina assembly and myelin formation","volume":"105","author":"Eldridge","year":"1987","journal-title":"J. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2165\/00023210-200620060-00001","article-title":"Antioxidants in multiple sclerosis: Do they have a role in therapy?","volume":"20","author":"Carlson","year":"2006","journal-title":"CNS Drugs"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102793","DOI":"10.1016\/j.pmedr.2024.102793","article-title":"Association between rheumatoid arthritis and serum vitamin C levels in Adults: Based on the National health and Nutrition Examination survey database","volume":"44","author":"Zhang","year":"2024","journal-title":"Prev. Med. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ma, G., Zhang, S., Luo, Y., Zhang, C., Xu, W., and Wang, L. (2024). The association between composite dietary antioxidant index and rheumatoid arthritis: Evidence from NHANES 2001\u20132020. BMC Rheumatol., 8.","DOI":"10.1186\/s41927-024-00447-x"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.reuma.2024.02.001","article-title":"The relationship between dietary inflammatory index scores and rheumatoid arthritis disease activity","volume":"20","author":"Baygin","year":"2024","journal-title":"Reum. Clin."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5582\/bst.2024.01037","article-title":"Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance","volume":"18","author":"Zhang","year":"2024","journal-title":"Biosci. Trends"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s12964-024-01756-x","article-title":"Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies","volume":"22","author":"Yin","year":"2024","journal-title":"Cell Commun. Signal. CCS"},{"key":"ref_28","first-page":"1463","article-title":"Effects of Vitamin C and Vitamin E in rheumatoid arthritis\u2014A randomized, open label, and comparative study in a tertiary care hospital","volume":"12","author":"Gomathi","year":"2022","journal-title":"Natl. J. Physiol. Pharm. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nutos.2021.09.003","article-title":"Vitamin C reduces interleukin-6 plasma concentration: A systematic review and meta-analysis of randomized clinical trials","volume":"40","author":"Gholizadeh","year":"2021","journal-title":"Clin. Nutr. Open Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"105392","DOI":"10.1016\/j.jff.2022.105392","article-title":"High fiber multigrain supplementation improved disease activity score, circulating inflammatory and oxidative stress biomarkers in rheumatoid arthritis (RA) patients: A randomized human clinical trial","volume":"100","author":"Latif","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10067-024-07285-9","article-title":"The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: A comprehensive review","volume":"44","author":"Hijjawi","year":"2025","journal-title":"Clin. Rheumatol."},{"key":"ref_32","unstructured":"ClinicalTrials.gov (2025, September 17). Vitamin C Supplementation Intervention. Identifier: NCT04036110, Available online: https:\/\/www.clinicaltrials.gov\/study\/NCT04036110."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12967-025-06174-2","article-title":"Wnt signaling as a translational target in rheumatoid and psoriatic arthritis","volume":"23","author":"Riitano","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Choi, H.K., Kim, G.-J., Yoo, H.-S., Song, D.H., Chung, K.-H., Lee, K.-J., Koo, Y.T., and An, J.H. (2019). Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt\/\u03b2-Catenin\/ATF4 Signaling Pathways. Nutrients, 11.","DOI":"10.3390\/nu11030506"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ruggiero, M., Cianciulli, A., Calvello, R., Porro, C., De Nuccio, F., Kashyrina, M., Miraglia, A., Lofrumento, D.D., and Panaro, M.A. (2024). Ser9p-GSK3\u03b2 Modulation Contributes to the Protective Effects of Vitamin C in Neuroinflammation. Nutrients, 16.","DOI":"10.3390\/nu16081121"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Rharass, T., Lantow, M., Gbankoto, A., Weiss, D.G., Pan\u00e1kov\u00e1, D., and Lucas, S. (2017). Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT\/\u03b2-catenin\/ROS signaling dependent manner. J. Biomed. Sci., 24.","DOI":"10.1186\/s12929-017-0385-1"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Rodriguez-Trillo, A., Mosquera, N., Pena, C., Rivas-Tob\u00edo, F., Mera-Varela, A., Gonzalez, A., and Conde, C. (2020). Non-Canonical WNT5A Signaling Through RYK Contributes to Aggressive Phenotype of the Rheumatoid Fibroblast-Like Synoviocytes. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.555245"},{"key":"ref_38","first-page":"148","article-title":"Sj\u00f6gren\u2019s syndrome: Towards precision medicine","volume":"38","author":"Laigle","year":"2022","journal-title":"Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Horai, Y., Kurushima, S., Shimizu, T., Nakamura, H., and Kawakami, A. (2025). A Review of the Current Clinical Aspects of Sj\u00f6gren\u2019s Disease: Geographical Difference, Classification\/Diagnostic Criteria, Recent Advancements in Diagnostic Methods, and Molecular Targeted Therapy. J. Clin. Med., 14.","DOI":"10.3390\/jcm14155577"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hyon, J.Y., and Han, S.B. (2022). Dry Eye Disease and Vitamins: A Narrative Literature Review. Appl. Sci., 12.","DOI":"10.3390\/app12094567"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bu, J., Liu, Y., Zhang, R., Lin, S., Zhuang, J., Sun, L., Zhang, L., He, H., Zong, R., and Wu, Y. (2024). Potential New Target for Dry Eye Disease\u2014Oxidative Stress. Antioxidants, 13.","DOI":"10.3390\/antiox13040422"},{"key":"ref_42","first-page":"216","article-title":"Mediterranean diet and risk of Sj\u00f6gren\u2019s syndrome","volume":"38","author":"Machowicz","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Nesvold, M.B., Jensen, J.L., Hove, L.H., Singh, P.B., Young, A., Palm, \u00d8., Andersen, L.F., Carlsen, M.H., and Iversen, P.O. (2018). Dietary Intake, Body Composition, and Oral Health Parameters among Female Patients with Primary Sj\u00f6gren\u2019s Syndrome. Nutrients, 10.","DOI":"10.3390\/nu10070866"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3946320241263034","DOI":"10.1177\/03946320241263034","article-title":"Exploring the relationship between oxidative stress status and inflammatory markers during primary Sj\u00f6gren\u2019s syndrome: A new approach for patient monitoring","volume":"38","author":"Benchabane","year":"2024","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2147\/OPTH.S106455","article-title":"A randomized, double-blind, placebo-controlled study of oral antioxidant supplement therapy in patients with dry eye syndrome","volume":"10","author":"Hou","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Cong, Y., Zhang, Y., Han, Y., Wu, Y., Wang, D., and Zhang, B. (2024). Recommendations for nutritional supplements for dry eye disease: Current advances. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1388787"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"DES163","DOI":"10.1167\/iovs.17-23402","article-title":"Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease","volume":"59","author":"Dogru","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13075-024-03459-7","article-title":"A non-invasive model for diagnosis of primary Sjogren\u2019s disease based on salivary biomarkers, serum autoantibodies, and Schirmer\u2019s test","volume":"26","author":"Zhang","year":"2024","journal-title":"Arthritis Res. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/aos.14892","article-title":"Oxidative and antioxidative stress markers in dry eye disease: A systematic review and meta-analysis","volume":"100","author":"Navel","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sun, H., Karp, J., Sun, K.M., and Weaver, C.M. (2022). Decreasing Vitamin C Intake, Low Serum Vitamin C Level and Risk for US Adults with Diabetes. Nutrients, 14.","DOI":"10.3390\/nu14193902"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.2337\/dc13-0750","article-title":"Vitamin C Further Improves the Protective Effect of Glucagon-Like Peptide-1 on Acute Hypoglycemia-Induced Oxidative Stress, Inflammation, and Endothelial Dysfunction in Type 1 Diabetes","volume":"36","author":"Ceriello","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3945\/ajcn.2009.27602","article-title":"Poor vitamin C status is associated with increased carotid intima-media thickness, decreased microvascular function, and delayed myocardial repolarization in young patients with type 1 diabetes","volume":"90","author":"Odermarsky","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.yexmp.2013.08.007","article-title":"Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow","volume":"95","author":"Sangani","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.2337\/dc07-0318","article-title":"Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes","volume":"30","author":"Ceriello","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Mattila, M., Hakola, L., Niinist\u00f6, S., Tapanainen, H., Takkinen, H.-M., Ahonen, S., Ilonen, J., Toppari, J., Veijola, R., and Knip, M. (2021). Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children: A Birth Cohort Study. Nutrients, 13.","DOI":"10.3390\/nu13030928"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Juhl, B., Lauszus, F.F., and Lykkesfeldt, J. (2017). Poor Vitamin C Status Late in Pregnancy Is Associated with Increased Risk of Complications in Type 1 Diabetic Women: A Cross-Sectional Study. Nutrients, 9.","DOI":"10.3390\/nu9030186"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ejim.2004.07.009","article-title":"Vitamin C treatment reduces transcapillary escape rate of albumin in type 1 diabetes","volume":"15","author":"Juhl","year":"2004","journal-title":"Eur. J. Intern. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e00424","DOI":"10.14309\/crj.0000000000000424","article-title":"Vitamin C Deficiency: An Under-Recognized Condition in Crohn\u2019s Disease","volume":"7","author":"Gordon","year":"2020","journal-title":"ACG Case Rep. J."},{"key":"ref_59","first-page":"e55295","article-title":"Vitamin C Deficiency Masquerading as Vasculitis in a Patient With Crohn\u2019s Disease","volume":"16","author":"Verma","year":"2024","journal-title":"Cureus"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Mortezaei, K., Gonzales, S.A.B., Kreitenberg, A., and Arkfeld, D.G. (2025). Scurvy in a Patient with Crohn\u2019s Disease: A Case Report. Curr. Rheumatol. Rev.","DOI":"10.2174\/0115733971355926250805052920"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e43688","DOI":"10.1097\/MD.0000000000043688","article-title":"When a diet is followed too strictly. Scurvy\u2014An old disease in a modern gut: A case report","volume":"104","author":"Guarino","year":"2025","journal-title":"Medicine"},{"key":"ref_62","first-page":"348","article-title":"Original contribution Antioxidant vitamin supplementation in Crohn\u2019s disease decreases oxidative stress a randomized controlled trial","volume":"98","author":"Aghdassi","year":"2003","journal-title":"Am. J. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S235","DOI":"10.1016\/S0399-8320(09)73159-8","article-title":"Nutritional consequences and nutrition therapy in Crohn\u2019s disease","volume":"33","author":"Filippi","year":"2009","journal-title":"Gastroenterol. Clin. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.3748\/wjg.v19.i39.6540","article-title":"Concepts of oxidative stress and antioxidant defense in Crohn\u2019s disease","volume":"19","author":"Alzoghaibi","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/01.MIB.0000206541.15963.c3","article-title":"Nutritional deficiencies in patients with Crohn\u2019s disease in remission","volume":"12","author":"Filippi","year":"2006","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0261-5614(90)90045-T","article-title":"The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn\u2019s disease","volume":"9","author":"Animashaun","year":"1990","journal-title":"Clin. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1007\/BF01303168","article-title":"Multiple vitamin status in Crohn\u2019s disease. Correlation with disease activity","volume":"38","author":"Kuroki","year":"1993","journal-title":"Dig. Dis. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/pgmj.59.697.690","article-title":"Nutritional disturbances in Crohn\u2019s disease","volume":"59","author":"Harries","year":"1983","journal-title":"Postgrad. Med. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/ncp.10800","article-title":"High-dose vitamin C therapy for symptomatic deficiency in a patient with myasthenia gravis and Crohn\u2019s disease","volume":"37","author":"Murphree","year":"2021","journal-title":"Nutr. Clin. Pract."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1556\/1886.2019.00016","article-title":"Immunomodulatory and Antimicrobial Effects of Vitamin C","volume":"9","author":"Mousavi","year":"2019","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/ajcn\/67.5.919","article-title":"Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission","volume":"67","author":"Geerling","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1586\/egh.11.29","article-title":"Existing dietary guidelines for Crohn\u2019s disease and ulcerative colitis","volume":"5","author":"Brown","year":"2011","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1056\/NEJMra1510030","article-title":"Graves\u2019 Disease","volume":"375","author":"Smith","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(17)30703-1","article-title":"Hypothyroidism","volume":"390","author":"Chaker","year":"2017","journal-title":"Lancet"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e432","DOI":"10.1002\/edm2.432","article-title":"The interplay between vitamin C and thyroid","volume":"6","author":"Far","year":"2023","journal-title":"Endocrinol. Diabetes Metab."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s40618-018-0944-7","article-title":"Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis","volume":"42","author":"Karimi","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_77","first-page":"34","article-title":"Role of Antioxidants on Thyroid Hormones in Wister Rats","volume":"3","author":"Peepre","year":"2014","journal-title":"Int. J. Sci. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/EDE.0b013e3181d6201d","article-title":"Nitrate Intake and the Risk of Thyroid Cancer and Thyroid Disease","volume":"21","author":"Ward","year":"2010","journal-title":"Epidemiology"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Shen, J., Zhang, H., Jiang, H., Lin, H., He, J., Fan, S., Yu, D., Yang, L., Tang, H., and Lin, E. (2024). The effect of micronutrient on thyroid cancer risk: A Mendelian randomization study. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1331172"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Wu, J., Jia, C., Wang, Q., and Li, X. (2024). Association between vitamin C intake and thyroid function among U.S. adults: A population-based study. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1462251"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Zhang, W., Liu, E., and Que, H. (2024). Association of circulating vitamin levels with thyroid diseases: A Mendelian randomization study. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1360851"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Sarandi, E., Tsoukalas, D., Rudofsky, G., Fragoulakis, V., Liapi, C., Paramera, E., Papakonstantinou, E., Krasagakis, S.K., and Tsatsakis, A. (2025). Identifying the metabolic profile of Hashimoto\u2019s thyroiditis from the METHAP clinical study. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-89600-1"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1017\/S0007114524001715","article-title":"Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007\u20132012","volume":"132","author":"Chen","year":"2024","journal-title":"Br. J. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1902\/jop.2010.100319","article-title":"Salivary Stress Markers, Stress, and Periodontitis: A Pilot Study","volume":"82","author":"Rai","year":"2011","journal-title":"J. Periodontol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/jcpe.13094","article-title":"The influence of an anti-inflammatory diet on gingivitis. A randomized controlled trial","volume":"46","author":"Woelber","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Ustianowski, \u0141., Ustianowska, K., Gurazda, K., Rusi\u0144ski, M., Ostrowski, P., and Pawlik, A. (2023). The Role of Vitamin C and Vitamin D in the Pathogenesis and Therapy of Periodontitis\u2014Narrative Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076774"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1017\/S0007114508147377","article-title":"Low dietary intake of \u03b2-carotene, \u03b1-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort","volume":"101","author":"Helmersson","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Tada, A., and Miura, H. (2019). The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review. Int. J. Environ. Res. Public Health, 16.","DOI":"10.20944\/preprints201906.0007.v1"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1600-051X.2007.01053.x","article-title":"Java project on periodontal diseases: The relationship between vitamin C and the severity of periodontitis","volume":"34","author":"Amaliya","year":"2007","journal-title":"J. Clin. Periodontol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"S903","DOI":"10.4103\/jpbs.jpbs_94_22","article-title":"Assessment of Vitamin C Levels in Periodontal Patients: A Cross-Sectional Study in Palestine","volume":"14","author":"Assaf","year":"2022","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Munday, M.-R., Rodricks, R., Fitzpatrick, M., Flood, V.M., and Gunton, J.E. (2020). A Pilot Study Examining Vitamin C Levels in Periodontal Patients. Nutrients, 12.","DOI":"10.3390\/nu12082255"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"de Jong, T.M.H., Stamatelou, E., Rosema, N.A.M., Jansen, I.D.C., Brandt, B.W., Angelakis, A., Loos, B.G., van der Velden, U., and Danser, M.M. (2024). Effect of Daily Vitamin C Supplementation with or Without Flavonoids on Periodontal, Microbial, and Systemic Conditions Before and After Periodontal Therapy: A Case Series from an RCT. J. Clin. Med., 13.","DOI":"10.3390\/jcm13247571"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Li, W., Song, J., and Chen, Z. (2022). The association between dietary vitamin C intake and periodontitis: Result from the NHANES (2009\u20132014). BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02416-7"},{"key":"ref_94","first-page":"115","article-title":"Vitamin C and Its Role in Periodontal Diseases\u2014The Past and the Present: A Narrative Review","volume":"18","year":"2020","journal-title":"Oral Health Prev. Dent."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Buzatu, R., Luca, M.M., and Bumbu, B.A. (2024). Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25168598"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/cid.12647","article-title":"Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic periodontitis","volume":"20","author":"Li","year":"2018","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Isola, G., Polizzi, A., Muraglie, S., Leonardi, R., and Lo Giudice, A. (2019). Assessment of Vitamin C and Antioxidant Profiles in Saliva and Serum in Patients with Periodontitis and Ischemic Heart Disease. Nutrients, 11.","DOI":"10.3390\/nu11122956"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Hoffbrand, A.V., Higgs, D.R., Keeling, D.M., and Mehta, A.B. (2015). Megaloblastic Anaemia. Postgraduate Haematology, John Wiley & Sons.","DOI":"10.1002\/9781118853771"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/JBM.S25620","article-title":"Optimal management of pernicious anemia","volume":"3","author":"Andres","year":"2012","journal-title":"J. Blood Med."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Esposito, G., Dottori, L., Pivetta, G., Ligato, I., Dilaghi, E., and Lahner, E. (2022). Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency. Nutrients, 14.","DOI":"10.3390\/nu14081672"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"E166","DOI":"10.1002\/ajh.26484","article-title":"Transfusion-dependent anemia secondary to vitamin C deficiency","volume":"97","author":"Angeli","year":"2022","journal-title":"Am. J. Hematol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Sano, K., Imoto, N., Koketsu, H., Kubo, A., Ito, R., Nakashima, M., and Kurahashi, S. (2025). Vitamin C Deficiency Megaloblastic Anemia Mimicking Hemolytic Anemia: A Case Report. Intern. Med.","DOI":"10.2169\/internalmedicine.5013-24"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Taylor, L., McCaddon, A., and Wolffenbuttel, B.H.R. (2024). Creating a Framework for Treating Autoimmune Gastritis\u2014The Case for Replacing Lost Acid. Nutrients, 16.","DOI":"10.3390\/nu16050662"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3748\/wjg.v23.i4.563","article-title":"Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review","volume":"23","author":"Cavalcoli","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Nocella, C., Bartimoccia, S., Cammisotto, V., D\u2019amico, A., Pastori, D., Frati, G., Sciarretta, S., Rosa, P., Felici, C., and Riggio, O. (2021). Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process. Antioxidants, 10.","DOI":"10.3390\/antiox10111790"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1182\/blood.V93.10.3401.410k36_3401_3407","article-title":"Ongoing prothrombotic state in patients with antiphospholipid antibodies: A role for increased lipid peroxidation","volume":"93","author":"Ferro","year":"1999","journal-title":"Blood"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1046\/j.1365-2141.2001.03028.x","article-title":"Increased lipid peroxidation correlates with platelet activation but not with markers of endothelial cell and blood coagulation activation in patients with antiphospholipid antibodies","volume":"114","author":"Martinuzzo","year":"2001","journal-title":"Br. J. Haematol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1182\/blood.V90.10.3931","article-title":"Enhanced lipid peroxidation in patients positive for antiphospholipid antibodies","volume":"90","author":"Iuliano","year":"1997","journal-title":"Blood"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e15104","DOI":"10.14814\/phy2.15104","article-title":"Oral vitamin C restores endothelial function during acute inflammation in young and older adults","volume":"9","author":"Lefferts","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Xu, Z., and Liu, Z. (2022). Impact of Neutrophil Extracellular Traps on Thrombosis Formation: New Findings and Future Perspective. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.910908"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Bozonet, S.M., and Carr, A.C. (2019). The Role of Physiological Vitamin C Concentrations on Key Functions of Neutrophils Isolated from Healthy Individuals. Nutrients, 11.","DOI":"10.3390\/nu11061363"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1538-7836.2003.00108.x","article-title":"Enhanced monocyte expression of tissue factor by oxidative stress in patients with antiphospholipid antibodies: Effect of antioxidant treatment","volume":"1","author":"Ferro","year":"2003","journal-title":"J. Thromb. Haemost. JTH"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Isola, S., Gammeri, L., Furci, F., Gangemi, S., Pioggia, G., and Allegra, A. (2024). Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25137284"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"109848","DOI":"10.1016\/j.clim.2023.109848","article-title":"Natural supplements in antiphospholipid syndrome: A case for further study","volume":"258","author":"Kello","year":"2024","journal-title":"Clin. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"\u0160tok, U., Blokar, E., Lenassi, M., Holcar, M., Frank-Bertoncelj, M., Erman, A., Resnik, N., Sodin-\u0160emrl, S., \u010cu\u010dnik, S., and Pirkmajer, K.P. (2020). Characterization of Plasma-Derived Small Extracellular Vesicles Indicates Ongoing Endothelial and Platelet Activation in Patients with Thrombotic Antiphospholipid Syndrome. Cells, 9.","DOI":"10.3390\/cells9051211"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Tian, W., Shi, D., Zhang, Y., Wang, H., Tang, H., Han, Z., Wong, C.C.L., Cui, L., Zheng, J., and Chen, Y. (2024). Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. Commun. Biol., 7.","DOI":"10.1038\/s42003-024-05789-3"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Bonisoli, G.L., Argentino, G., Friso, S., and Tinazzi, E. (2025). Extracellular Vesicles Analysis as Possible Signatures of Antiphospholipid Syndrome Clinical Features. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26072834"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2174\/1567205018666211202141650","article-title":"\u03b2-Amyloid is an Immunopeptide and Alzheimer\u2019s is an Autoimmune Disease","volume":"18","author":"Weaver","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/alz.12789","article-title":"Alzheimer\u2019s disease as an innate autoimmune disease (AD2): A new molecular paradigm","volume":"19","author":"Weaver","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1073858420908189","article-title":"Alzheimer\u2019s Disease: From Amyloid to Autoimmune Hypothesis","volume":"26","author":"Arshavsky","year":"2020","journal-title":"Neuroscientist"},{"key":"ref_121","first-page":"498","article-title":"Alzheimer\u2019s Disease: New Concepts on the Role of Autoimmunity and NLRP3 Inflammasome in the Pathogenesis of the Disease","volume":"19","author":"Severini","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Hamid, M., Mansoor, S., Amber, S., and Zahid, S. (2022). A quantitative meta-analysis of vitamin C in the pathophysiology of Alzheimer\u2019s disease. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.970263"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Appiah, D., Ingabire-Gasana, E., Appiah, L., and Yang, J. (2024). The Relation of Serum Vitamin C Concentrations with Alzheimer\u2019s Disease Mortality in a National Cohort of Community-Dwelling Elderly Adults. Nutrients, 16.","DOI":"10.3390\/nu16111672"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"He, X., Lin, Y., Wu, X., Li, M., Zhong, T., Zhang, Y., and Weng, X. (2025). Vitamin C intake and cognitive function in older U.S. adults: Nonlinear dose\u2013response associations and effect modification by smoking status. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1585863"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s40520-024-02893-6","article-title":"Association of antioxidants intake in diet and supplements with risk of Alzheimer\u2019s disease: A systematic review and dose-response meta-analysis of prospective cohort studies","volume":"37","author":"Hu","year":"2025","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"100226","DOI":"10.1016\/j.ahr.2025.100226","article-title":"Unraveling the molecular mechanisms of vitamin C in Alzheimer\u2019s disease: Oxidative stress, homocysteine metabolism, and amyloid\/tau interactions","volume":"5","author":"Sharma","year":"2025","journal-title":"Aging Health Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3233\/JAD-2011-101971","article-title":"Vitamin C restores behavioral deficits and amyloid-\u03b2 oligomerization without affecting plaque formation in a mouse model of Alzheimer\u2019s disease","volume":"26","author":"Murakami","year":"2011","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1007\/s11064-012-0860-8","article-title":"Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer\u2019s Disease","volume":"37","author":"Arlt","year":"2012","journal-title":"Neurochem. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-2012-120349","article-title":"Dietary Intakes of Vitamin E, Vitamin C, and \u03b2-Carotene and Risk of Alzheimer\u2019s Disease: A Meta-Analysis","volume":"31","author":"Li","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3233\/JAD-2012-111853","article-title":"A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer\u2019s disease","volume":"29","author":"Harrison","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/19\/9375\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:49:36Z","timestamp":1760035776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/19\/9375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":130,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ijms26199375"],"URL":"https:\/\/doi.org\/10.3390\/ijms26199375","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]}}}