{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:06:52Z","timestamp":1758931612744,"version":"3.44.0"},"reference-count":27,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>Assessment of liver fibrosis stage is important in the management of patients with metabolic dysfunction-associated steatotic liver disease (MASLD). However, non-invasive methods to determine the changes in liver fibrosis stage are unknown. We investigated whether Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP), a serum fibrosis marker, can evaluate the changes in liver fibrosis stage. We observed the course of liver fibrosis stage and five serum fibrosis markers of 196 MASLD patients who had a paired biopsy performed. The changes in fibrosis markers, including WFA+-M2BP, were compared according to the changes in fibrosis stage. Factors associated with improvement of fibrosis stage were examined in a multivariate analysis. The changes in WFA+-M2BP (\u0394WFA+-M2BP) were significantly correlated with changes in fibrosis stage (p &lt; 0.01). The median of \u0394WFA+-M2BP was \u22120.21, \u22120.08, \u22120.04, and 0.19 in 2 fibrosis stage regression group, 1 fibrosis stage regression group, fibrosis stage unchanged group, and fibrosis stage progression group, respectively (p &lt; 0.01). However, other non-invasive markers did not reflect changes in fibrosis. \u0394WFA+-M2BP was a significant factor for the regression of liver fibrosis stage in multivariate analysis (odds ratio: 3.54, 95% confidence interval: 1.55\u20138.12, p &lt; 0.01). Time-course changes in WFA+-M2BP levels indicate the changes in liver fibrosis.<\/jats:p>","DOI":"10.3390\/ijms26199410","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:39:37Z","timestamp":1758883177000},"page":"9410","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimation the Change in Liver Fibrosis Stage with Serial Measurement of Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-1672","authenticated-orcid":false,"given":"Tsuguru","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Hepatology, Sendai Kousei Hospital, Aoba-ku, Sendai 980-0873, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Kooka","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sendai Kousei Hospital, Aoba-ku, Sendai 980-0873, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sendai Kousei Hospital, Aoba-ku, Sendai 980-0873, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Hepatology, Sendai Kousei Hospital, Aoba-ku, Sendai 980-0873, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrinol. 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