{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:35:59Z","timestamp":1787600159729,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP19577056"],"award-info":[{"award-number":["AP19577056"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>Cichorium intybus, commonly known as chicory, is acknowledged as a substitute for coffee and is widely utilized in medicinal applications to treat various ailments. Chicory extract is commonly used in the management of diabetes; however, the specific bioactive components remain unidentified. The present study displayed the antidiabetic potential of chicory using a comprehensive approach integrating in vitro, network pharmacology, and in silico techniques. The methanolic extract demonstrated significant \u03b1-glucosidase inhibitory activity in the initial experiment, indicating potential for the management of postprandial hyperglycemia. Based on this, chicory\u2019s major metabolites were identified and examined for their interactions with (type 2 diabetes) T2D targets using network pharmacology. The core genes and pathways involved in the disease were mapped to understand the multitarget mechanisms of the extract. A molecular docking study validated the binding affinity and interactions of leading bioactive compounds with T2D protein targets. The findings indicate that chicory metabolites may serve as promising candidates for the development of natural antidiabetic agents.<\/jats:p>","DOI":"10.3390\/ijms26199497","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:38:55Z","timestamp":1759246735000},"page":"9497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["\u03b1-Glucosidase Inhibition-Guided Network Pharmacology and Molecular Docking Reveal the Antidiabetic Potential of Cichorium intybus as a Functional Food"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-7556","authenticated-orcid":false,"given":"Abdul Bari","family":"Shah","sequence":"first","affiliation":[{"name":"College of Pharmacy, Korea University, Sejong 30019, Republic of Korea"},{"name":"Interdisciplinary Major Program in Innovative Pharmaceutical Sciences, Korea University, Sejong 30019, Republic of Korea"},{"name":"Research Institute for Natural Products & Technology, Almaty 050046, Kazakhstan"},{"name":"The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-8978","authenticated-orcid":false,"given":"Aizhamal","family":"Baiseitova","sequence":"additional","affiliation":[{"name":"Research Institute for Natural Products & Technology, Almaty 050046, Kazakhstan"},{"name":"The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, Kazakhstan"},{"name":"Division of Applied Life Science (BK21 Plus), IALS, Gyeongsang National University, Jinju 52828, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulpan","family":"Amzeyeva","sequence":"additional","affiliation":[{"name":"Research Institute for Natural Products & Technology, Almaty 050046, Kazakhstan"},{"name":"The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, Kazakhstan"},{"name":"Kazakh-China Joint Research Center for Natural Veterinary Drug, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-7212","authenticated-orcid":false,"given":"Xiaofei","family":"Shang","sequence":"additional","affiliation":[{"name":"Kazakh-China Joint Research Center for Natural Veterinary Drug, Almaty 050040, Kazakhstan"},{"name":"Lanzhou Institute of Husbandry and Pharmaceutical Sciences, CAAS, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-7253","authenticated-orcid":false,"given":"Janar","family":"Jenis","sequence":"additional","affiliation":[{"name":"The Research Center for Medicinal Plants, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, Almaty 050040, Kazakhstan"},{"name":"Kazakh-China Joint Research Center for Natural Veterinary Drug, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"ref_1","first-page":"224","article-title":"Chemical Constituents and Their Pharmacological Activities of Plants from Cichorium Genus","volume":"12","author":"Aisa","year":"2020","journal-title":"Chin. 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