{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:46:08Z","timestamp":1779093968752,"version":"3.51.4"},"reference-count":12,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis was characterized for more than 20 years as a microbial infection that results in blood leukocyte alterations, tachycardia, tachypnea, and fever (or hypothermia) [...]<\/jats:p>","DOI":"10.3390\/ijms26199551","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:38:55Z","timestamp":1759246735000},"page":"9551","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Special Issue \u201cMolecular Mechanisms and Pathophysiology of Sepsis\u201d"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-5689","authenticated-orcid":false,"given":"Vlad","family":"P\u0103dureanu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: Signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4161\/viru.24906","article-title":"Dysregulation of the angiopoietin\u2013Tie-2 axis in sepsis and ARDS","volume":"4","author":"Parikh","year":"2013","journal-title":"Virulence"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pasare, M.A., Prepeliuc, C.S., Grigoriu, M.G., Miftode, I.L., and Miftode, E.G. (2025). Biomarkers as Beacons: Illuminating Sepsis-Associated Hepato-Renal Injury. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26104825"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Hao, D., Xue, J.Y., Wang, Q., Guo, L., and Li, X.A. (2024). The Role of Scavenger Receptor BI in Sepsis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413441"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mpakosi, A., Cholevas, V., Meletiadis, J., Theodoraki, M., and Sokou, R. (2024). Neonatal Fungemia by Non-Candida Rare Opportunistic Yeasts: A Systematic Review of Literature. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179266"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Taha, S., Bindayna, K., Aljishi, M., Sultan, A., and Almansour, N. (2025). Transcriptomic Profiling Reveals Distinct Immune Dysregulation in Early-Stage Sepsis Patients. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26146647"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Harvey, B.I., Yoniles, A.M., Monsivais, A., Du, J., Zadorozny, L., Yu, Q., and Wang, M. (2025). Sex-Specific Differences in LPS-Induced Rapid Myocardial Dysfunction. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26135963"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.3390\/ijms26051844","article-title":"Profiling of miRNAs Contained in Circulating Extracellular Vesicles and Associated with Sepsis Development in Burn Patients: A Proof-of-Concept Study","volume":"26","author":"Schiavello","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Halimi, F., Vanderhaeghen, T., Timmermans, S., Croubels, S., Libert, C., and Vandewalle, J. (2024). Comparative Analysis of Hepatic Gene Expression Profiles in Murine and Porcine Sepsis Models. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011079"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10673","DOI":"10.3390\/ijms251910673","article-title":"C5a Induces Inflammatory Signaling and Apoptosis in PC12 Cells through C5aR-Dependent Signaling: A Potential Mechanism for Adrenal Damage in Sepsis","volume":"25","author":"Mrozewski","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Agnello, L., and Ciaccio, M. (2023). Biomarkers of Sepsis. Diagnostics, 13.","DOI":"10.3390\/diagnostics13030435"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/19\/9551\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:56:19Z","timestamp":1759247779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/19\/9551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":12,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ijms26199551"],"URL":"https:\/\/doi.org\/10.3390\/ijms26199551","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}