{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:46:11Z","timestamp":1783655171404,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003627","name":"Rural Development Administration","doi-asserted-by":"publisher","award":["PJ01669005"],"award-info":[{"award-number":["PJ01669005"]}],"id":[{"id":"10.13039\/501100003627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002471","name":"Dongguk University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002471","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Osteoarthritis (OA) is primarily a degenerative disease triggered by joint inflammation and oxidative stress. While Aster glehni is an edible and traditionally medicinal herb, the beneficial effect of A. glehni on OA progression remains unknown. This study aimed to investigate the effect of A. glehni extract (AGE) and its primary biological compound\u20143,5-dicaffeoylquinic acid (3,5-DCQA)\u2014on inflammation and oxidative stress in chondrocytes. AGE effectively inhibited the expression of interleukin (IL)-6, cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-1, and MMP-13 in chondrocytes stimulated by IL-1\u03b2 for 24 h. In contrast, 3,5-DCQA did not inhibit IL-6, COX-2, and MMP expressions under the same conditions. However, when chondrocytes were stimulated by IL-1\u03b2 for a short duration (6 h), 3,5-DCQA suppressed IL-6, COX-2, and MMP expressions. The inhibition of IL-6, COX-2, and MMP expressions by AGE was associated with the p38 kinase and nuclear factor-\u03baB signaling pathways, but not ERK and JNK signaling pathways. Furthermore, AGE prevented cell apoptosis and reduced intracellular reactive oxygen species levels in chondrocytes induced by hydrogen peroxide (H2O2). AGE restored the decreased superoxide dismutase 1 and catalase mRNA expressions caused by H2O2. Collectively, AGE may protect against cartilage deterioration by inhibiting inflammation and oxidative stress, making it a promising therapeutic agent for alleviating OA.<\/jats:p>","DOI":"10.3390\/ijms26199691","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:05:06Z","timestamp":1759763106000},"page":"9691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Edible Herb Aster glehni Alleviates Inflammation and Oxidative Stress in Chondrocytes by Regulating p38 and NF-\u03baB Signaling Pathways with Partial Involvement of Its Major Component, 3,5-Dicaffeoylqunic Acid"],"prefix":"10.3390","volume":"26","author":[{"given":"Jihyeon","family":"Baek","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ran","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Agriculture Environment Research, Gyongsangbuk-do Agricultural Research and Extension Services, Daegu 41404, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Jin","family":"Jeong","sequence":"additional","affiliation":[{"name":"KMF Co., Ltd., Daegu 41605, Republic of Korea"},{"name":"Department of Food Science and Technology, Keimyung University, Daegu 42601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Young","family":"Oh","sequence":"additional","affiliation":[{"name":"KMF Co., Ltd., Daegu 41605, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Sook","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Agro-Food Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeng-Ran","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Agro-Food Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Seung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Seong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, College of Life Science and Biotechnology, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/BOR.0000000000000479","article-title":"Epidemiology of osteoarthritis: Literature update","volume":"30","author":"Vina","year":"2018","journal-title":"Curr. 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