{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:09:47Z","timestamp":1792019387983,"version":"4.4.0"},"reference-count":24,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"crossref","award":["CSCL35.01\/24-25"],"award-info":[{"award-number":["CSCL35.01\/24-25"]}],"id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"crossref","award":["NCSX01.02\/23-25"],"award-info":[{"award-number":["NCSX01.02\/23-25"]}],"id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["IJMS"],"abstract":"<jats:p>Avicennia marina, commonly known as the grey mangrove, is a salt-tolerant species widely distributed in coastal and estuarine ecosystems. Traditionally, it has been used in folk medicine to treat skin diseases, rheumatism, and ulcers due to its anti-inflammatory and antimicrobial properties. However, comprehensive studies on the chemical constituents and their pharmacological effects remain limited. The dried powder of the aerial parts of A. marina (3.6 kg) was successfully extracted three times with methanol (20 L \u00d7 3, each for 2 h) using a multifunctional ultrasonic cleaner operated at 25 \u00b0C with a 50% amplitude setting. In this study, the methanolic extract of the aerial parts of A. marina led to the isolation of eight compounds, including two previously unreported iridoid glycosides\u2014avicenosides A and B (1 and 2)\u2014and six known compounds: techtochrysin (3), 7,4\u2032-di-O-methyl-apigenin (4), luteolin (5), kaempferol (6), trans-caffeic acid (7), and 3,4-dihydroxybenzoic acid (8). Their chemical structures were elucidated using nuclear magnetic resonance (NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and compared with previously published data. Moreover, the absolute configuration of the sugar moieties in the new compounds was also identified. All isolated compounds were evaluated for their cytotoxicity against HepG2 and A549 cancer cell lines. The results indicate potential cytotoxicity of the secondary metabolites from A. marina and provide evidence of their promising role as lead compounds for the development of novel anticancer agents.<\/jats:p>","DOI":"10.3390\/ijms26199694","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:05:06Z","timestamp":1759763106000},"page":"9694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chemical Constituents from the Vietnamese Mangrove Avicennia marina: Two New Iridoid Glycosides and Their Cytotoxicity Against Cancer Cell Lines"],"prefix":"10.3390","volume":"26","author":[{"given":"Ngo Van","family":"Hieu","sequence":"first","affiliation":[{"name":"Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"},{"name":"Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-2606","authenticated-orcid":false,"given":"Le Ba","family":"Vinh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Yersin University of Da Lat, Lamdong 670000, Vietnam"},{"name":"Faculty of Science and Technology, University of Bergen, 5007 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Thi","family":"Mai","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"},{"name":"Institute for Biotechnology and Environment, NhaTrang University, Northern Nha Trang Ward, Khanh Hoa 57000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Ngoc","family":"Hung","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Tien","family":"Dat","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Ha","family":"Phuong","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Ph\u01b0\u01a1ng","family":"Anh","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Thanh","family":"Tuan","sequence":"additional","affiliation":[{"name":"Department of Education Quality Assurance and Testing, Thai Binh University of Medicine and Pharmacy, Hung Yen 160000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1715-4455","authenticated-orcid":false,"given":"Nguyen Viet","family":"Phong","sequence":"additional","affiliation":[{"name":"Department of Biology Education, Teachers College and Institute for Phylogenomics and Evolution, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Thi Thu","family":"Hien","sequence":"additional","affiliation":[{"name":"Center for Training, Research in Toxicology and Radiology, Vietnam Military Medical University, Ha Dong Ward, Hanoi 10000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Le","family":"Tuan Anh","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"},{"name":"Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-environ-101718-033302","article-title":"The state of the world\u2019s mangrove forests: Past, present, and future","volume":"44","author":"Friess","year":"2019","journal-title":"Annu. 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