{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:23:58Z","timestamp":1790198638576,"version":"4.1.0"},"reference-count":99,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT 156205"],"award-info":[{"award-number":["PJT 156205"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT 178412"],"award-info":[{"award-number":["PJT 178412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fonds de recherche du Qu\u00e9bec (FRQ) through the research center grant for the CHU de Qu\u00e9bec\u2013Universit\u00e9 Laval Research Center","award":["30641"],"award-info":[{"award-number":["30641"]}]},{"name":"Universit\u00e9 Laval Studentship (Citizens of the World Doctoral Commitment Scholarship) as well as a Vanier Canada Graduate Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>P2Y2 receptors are a subclass of G protein-coupled receptors activated by the extracellular nucleotides ATP and UTP. These receptors are widely expressed in multiple tissues\u2014including the brain, lungs, heart, and kidneys\u2014and play pivotal roles in inflammation, wound healing, and cell migration. Through coupling with various G proteins, P2Y2 receptors initiate diverse intracellular signaling pathways that mediate calcium mobilization, cytokine release, and cytoskeletal reorganization. Recent studies highlight their dual roles in health and disease. In physiological contexts, P2Y2 receptors contribute to immune modulation and tissue repair. In pathological conditions, they are implicated in Alzheimer\u2019s disease by promoting non-amyloidogenic processing of amyloid precursor protein and in dry eye disease by enhancing mucin secretion while modulating ocular inflammation. They also influence chloride secretion and mucosal hydration in cystic fibrosis and contribute to inflammatory regulation and epithelial repair in inflammatory bowel disease. Additionally, P2Y2 receptors modulate breast cancer progression by regulating cell adhesion, migration, and matrix remodeling. Their involvement in blood pressure regulation via epithelial sodium channel modulation and their facilitative role in HIV-1 entry further underscore their clinical significance. These multifaceted functions position P2Y2 receptors as promising therapeutic targets for diverse diseases, warranting further investigation for translational applications.<\/jats:p>","DOI":"10.3390\/ijms26199815","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:50:16Z","timestamp":1760107816000},"page":"9815","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["P2Y2 Receptor Signaling in Health and Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Fatemeh","family":"Salarpour","sequence":"first","affiliation":[{"name":"D\u00e9partement de Microbiologie-Infectiologie et D\u2019immunologie, Centres PROTEO et ARThrite, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 0A6, Canada"},{"name":"Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Qu\u00e9bec Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2922-1600","authenticated-orcid":false,"given":"Jean","family":"S\u00e9vigny","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie-Infectiologie et D\u2019immunologie, Centres PROTEO et ARThrite, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 0A6, Canada"},{"name":"Axe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Qu\u00e9bec Universit\u00e9 Laval, Qu\u00e9bec City, QC G1V 4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature13085","article-title":"Nucleotide signalling during inflammation","volume":"509","author":"Idzko","year":"2014","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/JLB.2RU0421-226RR","article-title":"Physiologic roles of P2 receptors in leukocytes","volume":"112","author":"Alberto","year":"2022","journal-title":"J. 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