{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:13:38Z","timestamp":1790205218808,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["2019-08380"],"award-info":[{"award-number":["2019-08380"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","award":["2021-02825"],"award-info":[{"award-number":["2021-02825"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. Over the past two decades, multiple studies have established the importance of miRNAs in regulating a variety of biological processes, one of which includes regenerative repair. Although many miRNAs have been shown to regulate the expression of genes that are required for regeneration, few studies have extrapolated these findings from cell culture to in vivo animal models or reported comparative work between regenerating and non-regenerating systems. Here, we review the most current literature highlighting the role of distinct miRNAs in regulating the repair of different tissues, focusing on the heart, limb and spinal cord. In exploring existing work, we emphasize the importance of using animal models to provide foundational knowledge that could potentially lead to future therapeutic strategies to allow for functional regenerative repair in humans.<\/jats:p>","DOI":"10.3390\/ijms262010043","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:04:02Z","timestamp":1760537042000},"page":"10043","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["MicroRNAs in Tissue Regeneration: Lessons from Animal Models"],"prefix":"10.3390","volume":"26","author":[{"given":"Sarah E.","family":"Walker","sequence":"first","affiliation":[{"name":"Department Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Piazza","sequence":"additional","affiliation":[{"name":"Department Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5007-2921","authenticated-orcid":false,"given":"Robert L.","family":"Carlone","sequence":"additional","affiliation":[{"name":"Department Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaynor E.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department Biological Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tremblay, A. (1744). M\u00e9moires Pour Servir \u00e0 L\u2019histoire D\u2019un Genre de Polypes D\u2019eau Douce, \u00e0 Bras en Forme de Cornes, Jean & Herman Verbeek.","DOI":"10.5962\/bhl.title.64073"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1387\/ijdb.120086bg","article-title":"Hydra, a fruitful model system for 270 years","volume":"56","author":"Galliot","year":"2012","journal-title":"Int. J. Dev. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tree.2009.08.005","article-title":"Evolution of animal regeneration: Re-emergence of a field","volume":"25","author":"Bely","year":"2010","journal-title":"Trends Ecol. Evol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF02161491","article-title":"Experimental studies of the regeneration of planaria maculata","volume":"7","author":"Morgan","year":"1898","journal-title":"Arch. F\u00fcr Entwickelungsmechanik Der Org."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/BF01380539","article-title":"Regenerationsversuche mit Hofstenia giselae Steinb. (Turbellaria acoela)","volume":"158","year":"1967","journal-title":"Wilhelm Roux\u2019Archiv Entwicklungsmechanik Org."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.tig.2013.07.003","article-title":"The zebrafish as a model for complex tissue regeneration","volume":"29","author":"Gemberling","year":"2014","journal-title":"Trends Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/dvdy.520","article-title":"Axolotl: A resourceful vertebrate model for regeneration and beyond","volume":"251","author":"Yavuz","year":"2022","journal-title":"Dev. Dyn."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2014.10.003","article-title":"In vivo activation of a conserved microRNA program induces mammalian heart regeneration","volume":"15","author":"Aguirre","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_9","first-page":"601","article-title":"Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: A cross-species comparison between salamander and rat","volume":"7","author":"Tsai","year":"2014","journal-title":"Dis. Models Mech."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1242\/dev.126649","article-title":"Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration","volume":"142","author":"Beauchemin","year":"2015","journal-title":"Development"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.ajpath.2015.04.001","article-title":"miRNA control of tissue repair and regeneration","volume":"185","author":"Sen","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sabin, K.Z., Jiang, P., Gearhart, M.D., Stewart, R., and Echeverri, K. (2019). AP-1cFos\/JunB\/miR-200a regulate the pro-regenerative glial cell response during axolotl spinal cord regeneration. Commun. Biol., 2.","DOI":"10.1038\/s42003-019-0335-4"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"dev200033","DOI":"10.1242\/dev.200033","article-title":"Regulation of stem cell identity by miR-200a during spinal cord regeneration","volume":"149","author":"Walker","year":"2022","journal-title":"Development"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.ydbio.2009.08.008","article-title":"miR-196 is an essential early-stage regulator of tail regeneration, upstream of key spinal cord patterning events","volume":"334","author":"Sehm","year":"2009","journal-title":"Dev. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/j.celrep.2019.05.005","article-title":"Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation","volume":"27","author":"Torrini","year":"2019","journal-title":"Cell Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.devcel.2023.02.007","article-title":"A small noncoding RNA links ribosome recovery and translation control to dedifferentiation during salamander limb regeneration","volume":"58","author":"Subramanian","year":"2023","journal-title":"Dev. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-018-0045-7","article-title":"Regulation of microRNA function in animals","volume":"20","author":"Gebert","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41576-023-00611-y","article-title":"microRNAs in action: Biogenesis, function and regulation","volume":"24","author":"Shang","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.oraloncology.2012.07.003","article-title":"Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA","volume":"49","author":"Chang","year":"2013","journal-title":"Oral Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/mt.2012.269","article-title":"Therapeutic effects of microRNA-582-5p and -3p on the inhibition of bladder cancer progression","volume":"21","author":"Uchino","year":"2013","journal-title":"Mol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9688","DOI":"10.1093\/nar\/gkt680","article-title":"Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1215704","article-title":"Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in zebrafish","volume":"336","author":"Bazzini","year":"2012","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/embor.2012.82","article-title":"Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells","volume":"13","author":"Filipowicz","year":"2012","journal-title":"EMBO Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1126\/science.1215691","article-title":"miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay","volume":"336","author":"Djuranovic","year":"2012","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1126\/science.1146067","article-title":"MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F","volume":"317","author":"Mathonnet","year":"2007","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1073\/pnas.0801102105","article-title":"MicroRNA-repressed mRNAs contain 40S but not 60S components","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.molcel.2012.09.024","article-title":"MicroRNAs mediate gene silencing via multiple different pathways in drosophila","volume":"48","author":"Fukaya","year":"2012","journal-title":"Mol. Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1073\/pnas.1113350109","article-title":"Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish","volume":"109","author":"Mishima","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature13007","article-title":"Poly(A)-tail profiling reveals an embryonic switch in translational control","volume":"508","author":"Subtelny","year":"2014","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/febs.16422","article-title":"The intricate balance between microRNA-induced mRNA decay and translational repression","volume":"290","author":"Naeli","year":"2023","journal-title":"FEBS J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Xu, W., San Lucas, A., Wang, Z., and Liu, Y. (2014). Identifying microRNA targets in different gene regions. BMC Bioinform., 15.","DOI":"10.1186\/1471-2105-15-S7-S4"},{"key":"ref_34","first-page":"7215","article-title":"Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5\u2032UTR of RUNX3","volume":"15","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shakyawar, S., Southekal, S., and Guda, C. (2022). mintRULS: Prediction of miRNA-mRNA Target Site Interactions Using Regularized Least Square Method. Genes, 13.","DOI":"10.3390\/genes13091528"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1101\/gr.139758.112","article-title":"Analysis of CDS-located miRNA target sites suggests that they can effectively inhibit translation","volume":"23","author":"Hausser","year":"2013","journal-title":"Genome Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Bandyopadhyay, S., Ghosh, D., Mitra, R., and Zhao, Z. (2015). MBSTAR: Multiple instance learning for predicting specific functional binding sites in microRNA targets. Sci. Rep., 5.","DOI":"10.1038\/srep08004"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Sticht, C., De La Torre, C., Parveen, A., and Gretz, N. (2018). miRWalk: An online resource for prediction of microRNA binding sites. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206239"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1093\/bioinformatics\/bty424","article-title":"DeepMirTar: A deep-learning approach for predicting human miRNA targets","volume":"34","author":"Wen","year":"2018","journal-title":"Bioinformatics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1101\/gad.1424106","article-title":"mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes","volume":"20","author":"Rehwinkel","year":"2006","journal-title":"Genes Dev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Jonas","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.cell.2005.11.023","article-title":"Animal microRNAs confer robustness to gene expression and have a significant impact on 3\u2032UTR evolution","volume":"123","author":"Stark","year":"2005","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.1080372","article-title":"Vertebrate microRNA genes","volume":"299","author":"Lim","year":"2003","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4161\/rna.8.4.16019","article-title":"MicroRNA-9","volume":"8","author":"Simkin","year":"2011","journal-title":"RNA Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Morgan, T.H., and Moszkowski, M. (1901). Regeneration, Macmillan.","DOI":"10.5962\/bhl.title.87895"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jez.1401870208","article-title":"Response of the adult newt ventricle to injury","volume":"187","author":"Oberpriller","year":"1974","journal-title":"J. Exp. Zool."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00429-002-0249-6","article-title":"Cell cycle reentry of ventricular and atrial cardiomyocytes and cells within the epicardium following amputation of the ventricular apex in the axolotl, Amblystoma mexicanum: Confocal microscopic immunofluorescent image analysis of bromodeoxyuridine-labeled nuclei","volume":"205","author":"Flink","year":"2002","journal-title":"Anat. Embryol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2014.03.035","article-title":"A proliferative burst during preadolescence establishes the final cardiomyocyte number","volume":"157","author":"Naqvi","year":"2014","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.devcel.2022.01.012","article-title":"Heart regeneration: 20 years of progress and renewed optimism","volume":"57","author":"Garbern","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_53","first-page":"I141","article-title":"The relationship of myocardial infarct size and prognosis","volume":"53","author":"Caulfield","year":"1976","journal-title":"Circulation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/j.2040-4603.2015.tb00658.x","article-title":"Physiological implications of myocardial scar structure","volume":"5","author":"Richardson","year":"2015","journal-title":"Compr. Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.7100922","article-title":"Mice regrow the tips of their foretoes","volume":"217","author":"Borgens","year":"1982","journal-title":"Science"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0022-3468(74)80220-4","article-title":"Trapped fingers and amputated finger tips in children","volume":"9","author":"Illingworth","year":"1974","journal-title":"J. Pediatr. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.64.1.1","article-title":"Nonoperative management of distal fingertip amputations in children","volume":"64","author":"Rosenthal","year":"1979","journal-title":"Pediatrics"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Yuan, B., Hu, D., Gu, S., Xiao, S., and Song, F. (2023). The global burden of traumatic amputation in 204 countries and territories. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1258853"},{"key":"ref_60","unstructured":"GBD 2021 Diabetes Collaborators (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet, 402, 203\u2013234. Erratum in Lancet 2023, 402, 1132."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF00575834","article-title":"Forelimb regeneration from different levels of amputation in the newt, Notophthalmus viridescens: Length, rate, and stages","volume":"173","author":"Iten","year":"1973","journal-title":"Wilhelm Roux\u2019Archiv Entwicklungsmechanik Org."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/reg2.32","article-title":"The axolotl limb blastema: Cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods","volume":"2","author":"McCusker","year":"2015","journal-title":"Regeneration"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature08152","article-title":"Cells keep a memory of their tissue origin during axolotl limb regeneration","volume":"460","author":"Kragl","year":"2009","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2013.11.007","article-title":"Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species","volume":"14","author":"Wang","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"20609","DOI":"10.1073\/pnas.1118017108","article-title":"Mouse digit tip regeneration is mediated by fate-restricted progenitor cells","volume":"108","author":"Lehoczky","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Holman, E.C., Campbell, L.J., Hines, J., and Crews, C.M. (2012). Microarray analysis of microRNA expression during axolotl limb regeneration. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0041804"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, Q., and Lu, B. (2024). The mRNA and microRNA Landscape of the Blastema Niche in Regenerating Newt Limbs. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179225"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1021\/acs.jproteome.8b00778","article-title":"Integrative Analysis of MicroRNAome, Transcriptome, and Proteome during the Limb Regeneration of Cynops orientalis","volume":"18","author":"Yu","year":"2019","journal-title":"J. Proteome Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrn1326","article-title":"Regeneration beyond the glial scar","volume":"5","author":"Silver","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1002\/dvdy.22438","article-title":"Cellular response after crush injury in adult zebrafish spinal cord","volume":"239","author":"Hui","year":"2010","journal-title":"Dev. Dyn."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1749-8104-6-1","article-title":"Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts","volume":"6","author":"Zukor","year":"2011","journal-title":"Neural Dev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13064-021-00152-2","article-title":"Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis","volume":"16","author":"Penailillo","year":"2021","journal-title":"Neural Dev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"101917","DOI":"10.1016\/j.gde.2022.101917","article-title":"Spinal cord regeneration- the origins of progenitor cells for functional rebuilding","volume":"75","author":"Walker","year":"2022","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1242\/dev.01155","article-title":"Cell lineage tracing during Xenopus tail regeneration","volume":"131","author":"Gargioli","year":"2004","journal-title":"Development"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8104-7-13","article-title":"Spinal cord regeneration in Xenopus tadpoles proceeds through activation of Sox2-positive cells","volume":"7","author":"Gaete","year":"2012","journal-title":"Neural Dev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"8510","DOI":"10.1523\/JNEUROSCI.1189-08.2008","article-title":"Motor neuron regeneration in adult zebrafish","volume":"28","author":"Reimer","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s004270050265","article-title":"Neurogenesis during caudal spinal cord regeneration in adult newts","volume":"209","author":"Benraiss","year":"1999","journal-title":"Dev. Genes Evol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1126\/science.1077804","article-title":"Ectoderm to mesoderm lineage switching during axolotl tail regeneration","volume":"298","author":"Echeverri","year":"2002","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ydbio.2017.03.004","article-title":"Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish","volume":"424","author":"Berberoglu","year":"2017","journal-title":"Dev. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Wang, L., Song, L., Yi, C., Zhou, J., Yong, Z., Hu, Y., Pan, X., Qiao, N., Cai, H., and Zhao, W. (2025). Divergent stem cell mechanisms governing the primary body axis and appendage regeneration in the axolotl. bioRxiv.","DOI":"10.1101\/2025.02.11.637618"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s10571-020-00982-4","article-title":"Context-dependent role of miR-124 in retinoic acid-induced growth cone attraction of regenerating motorneurons","volume":"42","author":"Walker","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00018-024-05117-2","article-title":"MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6\/calcium activity pathway","volume":"81","author":"Shen","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1083\/jcb.200304021","article-title":"RhoA\/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability","volume":"162","author":"Medina","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0896-6273(03)00754-2","article-title":"Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow","volume":"40","author":"Zhang","year":"2003","journal-title":"Neuron"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Roloff, F., Scheiblich, H., Dewitz, C., Dempewolf, S., Stern, M., and Bicker, G. (2015). Enhanced neurite outgrowth of human model (NT2) neurons by small-molecule inhibitors of Rho\/ROCK signaling. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118536"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ydbio.2013.09.011","article-title":"miR-128 regulates non-myocyte hyperplasia, deposition of extracellular matrix and Islet1 expression during newt cardiac regeneration","volume":"383","author":"Witman","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/dvdy.24342","article-title":"MicroRNA dysregulation in response to RAR\u03b22 inhibition reveals a negative feedback loop between microRNAs 1, 133a, and RAR\u03b22 during tail and spinal cord regeneration in the adult newt","volume":"244","author":"Lepp","year":"2014","journal-title":"Dev. Dyn."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/dvdy.24210","article-title":"RAR\u03b22 expression is induced by the down-regulation of microRNA 133a during caudal spinal cord regeneration in the adult newt","volume":"243","author":"Lepp","year":"2015","journal-title":"Dev. Dyn."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/dmm.004077","article-title":"Remodeling and homeostasis of the extracellular matrix: Implications for fibrotic diseases and cancer","volume":"4","author":"Cox","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/s12276-023-01050-9","article-title":"MicroRNA: Trends in clinical trials of cancer diagnosis and therapy strategies","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"King, B.L., and Yin, V.P. (2016). A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb\/Appendage Regeneration. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157106"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e1662","DOI":"10.1002\/wrna.1662","article-title":"microRNA-based diagnostic and therapeutic applications in cancer medicine","volume":"12","author":"Sempere","year":"2021","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Lee, J., Li, Z., Brower-Sinning, R., and John, B. (2007). Regulatory circuit of human microRNA biogenesis. PLoS Comput. Biol., 3.","DOI":"10.1371\/journal.pcbi.0030067"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"149328","DOI":"10.1016\/j.brainres.2024.149328","article-title":"Upstream regulation of microRNA-9 through a complex cellular machinery during neurogenesis","volume":"1848","author":"Kuriakose","year":"2025","journal-title":"Brain Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Urrutia, E., Bustamante Montes, L.P., Ladr\u00f3n de Guevara Cervantes, D., P\u00e9rez-Plasencia, C., and Campos-Parra, A.D. (2019). Crosstalk between long non-coding RNAs, micro-RNAs and mRNAs: Deciphering molecular mechanisms of master regulators in cancer. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00669"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Sebastian-delaCruz, M., Gonzalez-Moro, I., Olazagoitia-Garmendia, A., Castellanos-Rubio, A., and Santin, I. (2021). The role of lncRNAs in gene expression regulation through mRNA stabilization. Noncoding RNA, 7.","DOI":"10.3390\/ncrna7010003"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1756-6606-4-40","article-title":"Regulation of chemotropic guidance of nerve growth cones by microRNA","volume":"4","author":"Han","year":"2011","journal-title":"Mol. Brain"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.celrep.2016.12.093","article-title":"miR-182 regulates Slit2-mediated axon guidance by modulation the local translation of a specific mRNA","volume":"18","author":"Bellon","year":"2017","journal-title":"Cell Rep."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/20\/10043\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T04:17:39Z","timestamp":1760674659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/20\/10043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":100,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ijms262010043"],"URL":"https:\/\/doi.org\/10.3390\/ijms262010043","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}