{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:33:38Z","timestamp":1790224418798,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Determination of the multifaceted activity of selected flavone C-monoglucosides, namely orientin (OR), homoorientin (hOR), vitexin (VT), and isovitexin (iVT) in comparison to quercetin (Q) was addressed. Their antioxidant activity was characterized by the peak oxidation potentials (Epa) provided by the differential pulse voltammetry (DPV) method, whereas their inhibitory activity towards angiotensin converting enzyme (ACE), acetylcholinesterase (AChE), and advanced glycation end-products (AGEs) formation was measured in a model system. The relationship between the multifaceted activity of flavone C-monoglucosides and their Epa was evaluated. The rank of the antioxidant activity in comparison to quercetin was Q &gt; hOR \u2248 OR &gt; iVT \u2248 VT, whereas the order of the ACE inhibitory activity was Q &gt; hOR &gt; OR &gt; VT &gt; iVT. The correlation between IC50 for ACE inhibition and Epa values was r = 0.787. This finding was confirmed by the negative correlation between ACE inhibitory activity and antioxidant activity of these compounds (r = \u22120.838). The order of the AChE enzyme inhibitory activity was hOR &gt; OR &gt; iVT &gt; VT &gt; Q, whereas the rank of anti-AGEs activity was hOR &gt; OR &gt; iVT &gt; Q &gt; VT &gt; AG (aminoquanidine), and the weak positive correlation between IC50 and Epa was noted (r = 0.546 for BSA (bovine serum albumin)\/glucose system and r = 0.580 for BSA\/methylglyoxal system). In contrast, the anti-AGEs activity was negatively correlated with IC50 values for ACE inhibition (r = \u22120.669), whereas no correlation was found between the ACE and AChE inhibitory activities. The results expand our knowledge of the multifaceted activity of flavone C-monoglucosides.<\/jats:p>","DOI":"10.3390\/ijms262010124","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:29:17Z","timestamp":1760711357000},"page":"10124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifaceted Biological Activity of Selected Flavone C-Monoglucosides"],"prefix":"10.3390","volume":"26","author":[{"given":"Danuta","family":"Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Warmia and Mazury in Olsztyn, Plac \u0141\u00f3dzki 4, 10-721 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-6677","authenticated-orcid":false,"given":"Henryk","family":"Zieli\u0144ski","sequence":"additional","affiliation":[{"name":"Team of Chemistry and Biodynamics of Food, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tryli\u0144skiego 18, 10-683 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"140501","DOI":"10.1016\/j.electacta.2022.140501","article-title":"Reactivity of flavonoids toward superoxide radical: An electrochemical approach","volume":"421","year":"2022","journal-title":"Electrochim. Acta"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Speisky, H., Shahidi, F., Costa de Camargo, A., and Fuentes, J. (2022). Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties. Antioxidants, 11.","DOI":"10.3390\/antiox11010133"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/1040869059096","article-title":"Dietary polyphenols and the prevention of diseases","volume":"45","author":"Scalbert","year":"2005","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2174\/138527212800194791","article-title":"Advances in C-glycosylflavonoid research","volume":"6","author":"Oualid","year":"2012","journal-title":"Curr. Org. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1039\/c1np00044f","article-title":"Flavonoids and their glycosides, including anthocyanins","volume":"28","author":"Veitch","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.biotechadv.2014.04.006","article-title":"Advance on biotechnology for glycosylation of high-value flavonoids","volume":"32","author":"Xiao","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1080\/10408398.2015.1067595","article-title":"Advance on the Flavonoid C-glycosides and Health Benefits","volume":"56","author":"Xiao","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_8","first-page":"1874","article-title":"Dietary flavonoid aglycones and their glycosides: Which show better biological significance?","volume":"57","author":"Xiao","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.foodchem.2013.10.096","article-title":"First evidence of C and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties","volume":"149","author":"Barreca","year":"2014","journal-title":"Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0031-9422(01)00156-X","article-title":"Acylated flavone C-glycosides from Cucumis sativus","volume":"58","author":"Lombardo","year":"2001","journal-title":"Phytochemistry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0031-9422(97)00801-7","article-title":"6-Hydroxy-3,5,7,4\u2032-tetramethoxyflavone 6-rhamnoside from roots of Pterocarpus marsupim","volume":"48","author":"Yadaw","year":"1998","journal-title":"Phytochemistry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/mnfr.200500258","article-title":"Antioxidants in thermally treated buckwheat groats","volume":"50","author":"Michalska","year":"2006","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.scienta.2007.07.018","article-title":"A time-course of flavonoids in the sprouts of tartary (Fagopyrum tataricum Gaertn.) buckwheats","volume":"115","author":"Kim","year":"2007","journal-title":"Sci. Hortic."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S575","DOI":"10.1111\/j.1365-2621.2005.tb08331.x","article-title":"Antioxidant properties of flavone C-glycosides from Atractylodes japonica leaves in human low-density lipoprotein oxidation","volume":"70","author":"Kim","year":"2005","journal-title":"J. Food Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.foodchem.2007.06.016","article-title":"Inhibitory Effect of Mung Bean Extract and its Constituents Vitexin and Isovitexin on the Formation of Advanced Glycation End products","volume":"106","author":"Peng","year":"2008","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.chroma.2004.12.086","article-title":"Determination of flavone C-glucosides in antioxidant of bamboo leaves (AOB) fortified foods by reversed-phase high-performance liquid chromatography with ultraviolet diode array detection","volume":"1065","author":"Zhang","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.chroma.2006.11.015","article-title":"Preparative separation of vitexin and isovitexin from pigeonpea extracts with macroporous resins","volume":"1139","author":"Fu","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.foodchem.2010.06.051","article-title":"Antioxidant activity of flavone C-glucosides determined by updated analytical strategies","volume":"124","year":"2011","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2008.02.047","article-title":"Methodological aspects about in vitro evaluation of antioxidant properties","volume":"613","author":"Magalhaes","year":"2008","journal-title":"Anal. Chim. Acta"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1111\/1541-4337.12566","article-title":"Natural phenolic antioxidants electrochemistry: Towards a new food science methodology","volume":"19","author":"Enache","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.foodchem.2016.11.017","article-title":"Electrochemical methods as a tool for determining the antioxidant capacity of food and beverages: A review","volume":"221","year":"2017","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1016\/S1452-3981(23)12902-6","article-title":"Electrochemistry as a Tool for Studying Antioxidant Properties","volume":"8","author":"Sochor","year":"2013","journal-title":"Inter. J. Electroch. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, D., Zieli\u0144ski, H., and Pisku\u0142a, M.K. (2022). An Electrochemical Determination of the Total Reducing Capacity of Wheat, Spelt, and Rye Breads. Antioxidants, 11.","DOI":"10.3390\/antiox11081438"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1021\/jf900494d","article-title":"Plant Food-Derived Angiotensin I Converting Enzyme Inhibitory Peptides","volume":"57","author":"Guang","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4103\/IJMR.2010_132_05_531","article-title":"Strategies for initial management of hypertension","volume":"132","author":"Gupta","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1021\/acs.jafc.8b00313","article-title":"Quantitative structure-activity relationship modeling coupled with molecular docking analysis in screening of angiotensin I-converting enzyme inhibitory peptides from qula casein hydrolysates obtained by two-enzyme combination hydrolysis","volume":"66","author":"Lin","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2621.2000.tb16049.x","article-title":"Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins","volume":"65","author":"Fujita","year":"2000","journal-title":"J. Food Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1021\/jf001119u","article-title":"Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate","volume":"49","author":"Kim","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00002093-200304000-00002","article-title":"The magnitude of dementia occurrence in the world","volume":"17","author":"Wimo","year":"2003","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u2019s disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000085382","article-title":"Natural products and derivatives affecting neurotransmission relevant to Alzheimer\u2019s and Parkinson\u2019s disease","volume":"14","author":"Houghton","year":"2005","journal-title":"Neurosignals"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.tins.2007.02.004","article-title":"Neuronal death: Where does the end begin?","volume":"30","author":"Conforti","year":"2007","journal-title":"Trends Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S1995-7645(11)60203-4","article-title":"In vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from southern Africa","volume":"4","author":"Adewusi","year":"2011","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1039\/C0NP00027B","article-title":"Natural products as a source of Alzheimer\u2019s drug leads","volume":"28","author":"Williams","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ajcnut.2023.04.013","article-title":"Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12 years of follow-up among adults in the Framingham Heart Study","volume":"118","author":"Oei","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112466","DOI":"10.1016\/j.exger.2024.112466","article-title":"Quercetin ameliorates cognitive deficit, expression of amyloid precursor gene, and pro-inflammatory cytokines in an experimental models of Alzheimer\u2019s disease in Wistar rats","volume":"193","author":"Safarzadeh","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.diabres.2004.09.004","article-title":"Advanced glycation endproducts--role in pathology of diabetic complications","volume":"67","author":"Ahmed","year":"2005","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/mnfr.200790017","article-title":"The Health Risks of Dietary Advanced Glycation end-products","volume":"51","author":"Buetler","year":"2007","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1111\/1541-4337.12593","article-title":"Dietary advanced glycation end-products: Perspectives linking food processing with health implications","volume":"19","author":"Zhang","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.fitote.2005.03.021","article-title":"Ilex paraguariensis extracts inhibit AGE formation more efficiently than green tea","volume":"76","author":"Lunceford","year":"2005","journal-title":"Fitoterapia"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.freeradbiomed.2009.11.019","article-title":"Rutin metabolites: Novel inhibitors of nonoxidative advanced glycation end products","volume":"48","author":"Pashikanti","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.fct.2013.11.020","article-title":"Effects of C-glycosylation on anti-diabetic, anti-Alzheimer\u2019s disease and anti-inflammatory potential of apigenin","volume":"64","author":"Choi","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/elan.200302800","article-title":"Electrochemical oxidation of quercetin","volume":"15","author":"Brett","year":"2003","journal-title":"Electroanalysis"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1590\/S0103-50532006000100020","article-title":"Electrochemical oxidation of quercetin in hydro-alcoholic solution","volume":"17","author":"Timbola","year":"2006","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0891-5849(00)00178-7","article-title":"The use of cyclic voltammetry for the evaluation of antioxidant capacity","volume":"6","author":"Chevion","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, D., Zieli\u0144ski, H., Laparra-Llopis, J.M., Honke, J., and Gim\u00e9nez-Bastida, J.A. (2021). Caffeic acid modulates processes associated with intestinal inflammation. Nutrients, 13.","DOI":"10.3390\/nu13020554"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8673","DOI":"10.1039\/C5AY01619C","article-title":"Electro-oxidation of captopril at a gold electrode and its determination in pharmaceuticals and human fluids","volume":"7","author":"Shetti","year":"2015","journal-title":"Anal. Methods"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1016\/S0024-3205(02)02034-9","article-title":"Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts","volume":"71","author":"Lopez","year":"2002","journal-title":"Life Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.foodchem.2018.06.044","article-title":"Antioxidant capacity of mango fruit (Mangifera indica). An electrochemical study as an approach to the spectrophotometric methods","volume":"266","year":"2018","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.foodchem.2006.05.067","article-title":"The use of photochemiluminescence for the measurement of the integral antioxidant capacity of baobab products","volume":"102","author":"Besco","year":"2007","journal-title":"Food Chem."},{"key":"ref_51","first-page":"68","article-title":"Cyclic voltammetry study of plasma antioxidant capacity\u2013comparison with the DPPH and TAS spectrophotometric methods","volume":"588","author":"Martinez","year":"2006","journal-title":"J. Electrochem. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Alam, M.W., Najeeb, J., Naeem, S., Usman, S.M., Nahvi, I., Alismail, F., Abuzir, A., Farhan, M., and Allah Nawaz, A. (2022). Electrochemical methodologies for investigating the antioxidant potential of plant and fruit extracts: A review. Antioxidants, 11.","DOI":"10.3390\/antiox11061205"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zlati\u0107, G., Arapovi\u0107, A., Martinovi\u0107, I., Martinovi\u0107 Bevanda, A., Bo\u0161kovi\u0107, P., Prki\u0107, A., Paut, A., and Vuku\u0161i\u0107, T. (2022). Antioxidant Capacity of Herzegovinian Wildflowers Evaluated by UV\u2013VIS and Cyclic Voltammetry Analysis. Molecules, 27.","DOI":"10.3390\/molecules27175466"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.foodchem.2018.10.078","article-title":"Evaluation of total polyphenol content of wines by means of voltammetric techniques: Cyclic voltammetry vs. differential pulse voltammetry","volume":"276","author":"Valderrama","year":"2019","journal-title":"Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1007\/s10800-023-01933-9","article-title":"Evaluation of antioxidant capacity in different food matrices through differential pulse voltammetry and its correlation with spectrophotometric methods","volume":"53","year":"2023","journal-title":"J. Appl. Electrochem."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Terao, J. (2023). Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health. Antioxidants, 12.","DOI":"10.3390\/antiox12020258"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0891-5849(95)02227-9","article-title":"Structure-antioxidant activity relationships of flavonoids and phenolic acids","volume":"20","author":"Miller","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1179\/135100004225005994","article-title":"Reducing power: The measure of antioxidant activities or reductant compounds","volume":"9","author":"Cheng","year":"2004","journal-title":"Redox Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Sarian, M.N., Ahmed, Q.U., Mat So\u2019ad, S.Z., Alhassan, A.M., Murugesu, S., Perumal, V., Mohamad, S.N.A.S., Khatib, A., and Latip, J. (2017). Antioxidant and Antidiabetic Effects of Flavonoids: A Structure-Activity Relationship Based Study. Biomed. Res. Int.","DOI":"10.1155\/2017\/8386065"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.aca.2005.02.056","article-title":"\u2018\u2018Electrochemical Index\u201d as a screening method to determine \u2018\u2018total polyphenolics\u201d in foods: A proposal","volume":"539","author":"Blasco","year":"2005","journal-title":"Anal. Chim. Acta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.foodchem.2008.05.041","article-title":"ACE inhibitory and antihypertensive properties of a bovine casein hydrolysate","volume":"12","author":"Miguel","year":"2009","journal-title":"Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.procbio.2007.02.006","article-title":"Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis","volume":"42","author":"Je","year":"2007","journal-title":"Proc. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.procbio.2004.08.010","article-title":"Production of angiotensin I-converting enzyme inhibitory peptides from soybean protein with Monascus purpureus acid proteinase","volume":"40","author":"Kuba","year":"2005","journal-title":"Proc. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.foodchem.2012.09.015","article-title":"Antioxidant and antihypertensive properties of liquid and solid state fermented lentils","volume":"136","author":"Torino","year":"2013","journal-title":"Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00217-010-1411-7","article-title":"ACE inhibitory and antihypertensive properties of apricot almond meal hydrolysate","volume":"232","author":"Wang","year":"2011","journal-title":"Eur. Food Res. Technol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00217-013-2118-3","article-title":"Effects of sweeping frequency ultrasound treatment on enzymatic preparations of ACE-inhibitory peptides from zein","volume":"238","author":"Ren","year":"2014","journal-title":"Eur. Food Res. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/1541-4337.12051","article-title":"Food-originating ACE inhibitors, including antihypertensive peptides, as preventive food components in blood pressure reduction","volume":"13","author":"Iwaniak","year":"2014","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1078\/0944-7113-00003","article-title":"Search for potential Angiotensin Converting Enzyme (ACE)-inhibitors from plants","volume":"8","author":"Franck","year":"2001","journal-title":"Phytomedicine"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, H., Honke, J., Topolska, J., B\u0105czek, N., Pisku\u0142a, M.K., Wiczkowski, W., and Wronkowska, M. (2020). ACE inhibitory properties and phenolics profile of fermented flours and of baked and digested biscuits from buckwheat. Foods, 9.","DOI":"10.3390\/foods9070847"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2174\/138920110793262114","article-title":"Hypertension, nitric oxide, oxidants, and dietary polyphenols","volume":"11","author":"Galleano","year":"2010","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jamcollsurg.2011.09.023","article-title":"Perfecting the plate: Adding cardioprotective compounds to the diet","volume":"214","author":"Cordova","year":"2012","journal-title":"J. Am. Coll. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1021\/jf900612n","article-title":"Modulation of inflammatory genes by natural dietary bioactive compounds","volume":"57","author":"Pan","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Guerrero, L., Castillo, J., Quinones, M., Garcia-Vallve, S., Arola, L., Pujadas, G., and Muguerza, B. (2012). Inhibition of angiotensin-converting enzyme activity by flavonoids: Structure-activity relationship studies. PLoS ONE., 7.","DOI":"10.1371\/journal.pone.0049493"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, D., Starowicz, M., Wronkowska, M., and Zieli\u0144ski, H. (2025). Angiotensin-converting enzyme inhibitory activity of selected phenolic acids, flavonoids, their O-glucosides, and low-molecular-weight phenolic metabolites in relation to their oxidation potentials. Metabolites, 15.","DOI":"10.3390\/metabo15070443"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1752-153X-6-78","article-title":"Bioactivity comparison of extracts from various parts of common and tartary buckwheats: Evaluation of the antioxidant- and angiotensin converting enzyme inhibitory activities","volume":"6","author":"Tsai","year":"2012","journal-title":"Chem. Cent. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11832","DOI":"10.1021\/jf404641v","article-title":"Angiotensin-Converting Enzyme Inhibitory Effects by Plant Phenolic Compounds: A Study of Structure Activity Relationships","volume":"61","author":"Shukor","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1211\/jpp.58.8.0016","article-title":"Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells","volume":"58","author":"Persson","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"105701","DOI":"10.1016\/j.jff.2023.105701","article-title":"Angiotensin I-converting enzyme (ACE) inhibition and biological activities of green and black tea samples from Azorean Camellia sinensis","volume":"107","author":"Paiva","year":"2023","journal-title":"J. Funct. Foods."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.fct.2009.12.004","article-title":"Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey","volume":"48","author":"Orhan","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fphar.2010.00138","article-title":"Traditional used plants against cognitive decline and Alzheimer\u2019s disease","volume":"1","author":"Eckert","year":"2010","journal-title":"Front. Pharmacol."},{"key":"ref_81","first-page":"454","article-title":"Expert consensus document on angiotensin-converting enzyme inhibitors in cardiovascular disease. The Task Force on ACE-inhibitors of the European Society of Cardiology","volume":"25","author":"Swedberg","year":"2004","journal-title":"Eur. Heart J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1021\/jf048550u","article-title":"Inhibitory effect of naturally occuring flavonoids on the formation of advanced glycation endproducts","volume":"53","author":"Wu","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.foodchem.2005.05.043","article-title":"Use of an electrochemical method to evaluate the antioxidant activity of herb extracts from the Labiatae family","volume":"97","author":"Cosio","year":"2006","journal-title":"Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.foodchem.2005.06.006","article-title":"A rapid, simple and sensitive fluorescence method for the assay of angiotensin-I converting enzyme","volume":"97","author":"Sentandreu","year":"2006","journal-title":"Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jep.2005.08.049","article-title":"Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine","volume":"102","author":"Eldeen","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, D., Starowicz, M., Wronkowska, M., and Zieli\u0144ski, H. (2025). Multifaceted Biological Activity of Rutin, Quercetin, and Quercetin\u2019s Glucosides. Molecules, 30.","DOI":"10.3390\/molecules30122555"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1600475","DOI":"10.1002\/mnfr.201600475","article-title":"Buckwheat bioactive compounds, their derived phenolic metabolites and their health benefits","volume":"61","author":"Piskula","year":"2017","journal-title":"Mol. Nutr. Food Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/20\/10124\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:13:59Z","timestamp":1761106439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/20\/10124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":87,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["ijms262010124"],"URL":"https:\/\/doi.org\/10.3390\/ijms262010124","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]}}}