{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:05:12Z","timestamp":1791270312232,"version":"4.1.0"},"reference-count":58,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biomedical Research Institute grant, Kyungpook National University Hospital","award":["2022"],"award-info":[{"award-number":["2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesity is a major global health issue linked to metabolic disorders, chronic inflammation, and systemic complications, with high-fat diets (HFDs) playing a key role by disrupting intestinal balance and promoting oxidative stress. This study investigates Protaetia brevitarsis-derived protein hydrolysate (PBPH), an insect-derived bioactive peptide extract, as a potential intervention to counteract HFD-induced metabolic disturbances. Female ICR mice were divided into three groups: control diet, HFD, and HFD + PBPH, with PBPH (obtained by alcalase hydrolysis and ultrafiltration) administered daily for eight weeks. Researchers assessed adipokine levels, inflammatory cytokines, antioxidant enzymes, and apoptotic markers using qPCR, ELISA, histology, and immunohistochemistry. PBPH supplementation significantly improved metabolic parameters by lowering leptin, adipsin, resistin, IL-1\u03b2, TNF-\u03b1, and IL-6, while restoring antioxidant balance and reducing pro-apoptotic signals. Histological analyses confirmed preserved intestinal tissue and reduced inflammation. Overall, this study highlights PBPH\u2019s promising therapeutic role in addressing obesity-related metabolic dysfunctions through its multifaceted effects on inflammation, oxidative stress, and apoptosis. It underscores the potential of insect-derived peptides as sustainable, innovative dietary interventions for improving metabolic health.<\/jats:p>","DOI":"10.3390\/ijms262110352","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:53:25Z","timestamp":1761296005000},"page":"10352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-Oxidative and Anti-Inflammatory Effect of Protaetia Brevitarsis-Derived Protein Hydrolysates in Adipose Tissues of Obese Mice"],"prefix":"10.3390","volume":"26","author":[{"given":"Jun-Koo","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Jeon","sequence":"additional","affiliation":[{"name":"Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-2357","authenticated-orcid":false,"given":"Jae-Wook","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil Hyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Gyun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-9814","authenticated-orcid":false,"given":"Yun-Sok","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Chun","sequence":"additional","affiliation":[{"name":"Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-8634","authenticated-orcid":false,"given":"Syng-ook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Keimyung University, Daegu 42403, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-3049","authenticated-orcid":false,"given":"Bum Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(11)60813-1","article-title":"The global obesity pandemic: Shaped by global drivers and local environments","volume":"378","author":"Swinburn","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.2147\/DMSO.S216791","article-title":"How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases","volume":"12","author":"Kopp","year":"2019","journal-title":"Diabetes Metab. 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