{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:24:17Z","timestamp":1761643457772,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chitosan (CHT) and hyaluronic acid (HA) are biomaterials with diverse properties. While each has been individually employed for the treatment of oral lesions, there is a need for further evidence regarding their combined properties. This study compares the effects on the properties and biocompatibility of chitosan sponges, CHT crosslinked with oxidized hyaluronic acid (OHA) (oxidized at 1:1 and 1:2 ratios, respectively), and CHT crosslinked with oxidized hyaluronic acid and polyethylene glycol diglycidyl ether (PEGDE). Spectroscopy revealed reduced free amino groups and the amide I\/II ratio in CHT sponges crosslinked with OHA. SEM confirmed the porous network morphology with an average pore size ranging from 155 to 213 \u03bcm. TGA indicated the scaffolds\u2019 decomposition temperature (Td) increased from 253\u00b0 to 308\u00b0, with the CHT-OHA 1:2 sponge exhibiting the highest thermal stability. Compression testing highlighted that the chitosan sponges crosslinked with AHO and PEGDE at a 1:2 ratio displayed a higher elastic modulus than the other studied scaffolds. The MTS assay confirmed that the fabricated biomaterials were not cytotoxic. This study demonstrates the enhanced properties and biocompatibility of CHT-OHA and CHT-OHA-PEGDE sponges, highlighting their potential for oral lesion treatment.<\/jats:p>","DOI":"10.3390\/ijms262110383","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:51:42Z","timestamp":1761526302000},"page":"10383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidized Hyaluronic Acid-Based Sponges: A Promising Biomaterial for Oral Mucosa Lesion Application"],"prefix":"10.3390","volume":"26","author":[{"given":"Clara Alicia","family":"Mu\u00f1oz-Trejo","sequence":"first","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, Calle 61 A #492 A Centro, M\u00e9rida C.P. 97000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-4290","authenticated-orcid":false,"given":"Martha Gabriela","family":"Chuc-Gamboa","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Yucat\u00e1n, Calle 61 A #492 A Centro, M\u00e9rida C.P. 97000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-7794","authenticated-orcid":false,"given":"Juan V.","family":"Cauich-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Unidad de Materiales, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, Calle 43 No. 130, Chuburn\u00e1 de Hidalgo, M\u00e9rida C.P. 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-0559","authenticated-orcid":false,"given":"Rossana Faride","family":"Vargas-Coronado","sequence":"additional","affiliation":[{"name":"Unidad de Materiales, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, Calle 43 No. 130, Chuburn\u00e1 de Hidalgo, M\u00e9rida C.P. 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Mar\u00eda","family":"Escobar-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Ciencias B\u00e1sicas, Facultad de Estomatolog\u00eda, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. 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