{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:07:47Z","timestamp":1792112867220,"version":"4.4.0"},"reference-count":183,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Nowadays, nonalcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disorder worldwide. From the clinical point of view, it evolves from steatosis to nonalcoholic steatohepatitis, which can lead to cirrhosis and finally to hepatocellular carcinoma. The mechanisms involved in its progression to more pathological stages and NAFLD pathogenesis are not completely understood. The research concerning NAFLD has become urgent and important because the age of NAFLD diagnosis is progressively decreasing, and its relationship with cancer risk is already well known. Because NAFLD ultimately leads to disability and imposes a major socioeconomic burden, timely diagnosis and effective treatment of NAFLD is particularly important. In the development of NAFLD, noncoding RNAs (ncRNAs) represented by microRNAs, long noncoding RNAs, circular RNAs, and piRNAs are epigenetic factors that play important regulatory roles. In the current review, we present updated information regarding the role of miRNAs, lncRNAs, circRNAs, and piRNAs, aiming to develop a good understanding of their regulatory functions in hepatic metabolism and concerning their potential use as biomarkers for early NAFLD\/NASH diagnosis and as therapeutic targets.<\/jats:p>","DOI":"10.3390\/ijms262110402","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:51:42Z","timestamp":1761526302000},"page":"10402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["miRNAs, lncRNAs, circRNAs and piRNAs in Nonalcoholic Fatty Liver Disease: Past, Present and Future"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4920-4760","authenticated-orcid":false,"given":"Roxana Liana","family":"Lucaciu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-142X","authenticated-orcid":false,"given":"Olga Hilda","family":"Orasan","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-3161","authenticated-orcid":false,"given":"Adriana Corina","family":"Hangan","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Pharmacy, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-5364","authenticated-orcid":false,"given":"Mihaela","family":"Iancu","sequence":"additional","affiliation":[{"name":"Medical Informatics and Biostatistics, Faculty of Nursing and Health Science, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Cozma","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0400-7296","authenticated-orcid":false,"given":"Sorina Cezara","family":"Coste","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidonia","family":"Gog-Bogdan","sequence":"additional","affiliation":[{"name":"Department of Sugery and ATI, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Sevastre","sequence":"additional","affiliation":[{"name":"Department of Paraclinics, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-5775","authenticated-orcid":false,"given":"Lucia Maria","family":"Procopciuc","sequence":"additional","affiliation":[{"name":"Medical Biochemistry, Department of Molecular Sciences, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lucaciu, R.L., Coste, S.C., Hangan, A.C., Iancu, M., Orasan, O.H., Cozma, A., Gog-Bogdan, S., and Procopciuc, L.M. (2025). Pathogenesis and clinical management of metabolic dysfunction-associated steatotic liver disease. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26125717"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Vulf, M., Shunkina, D., Komar, A., Bograya, M., Zatolokin, P., Kirienkova, N.G., Kozlov, I., and Litvinova, L. (2021). Analysis of miRNAs profiles in serum of patients with steatosis and steatohepatitis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.736677"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s00018-018-2860-6","article-title":"Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease","volume":"75","author":"Ipsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/er.2018-00064","article-title":"Molecular actions of PPAR\u03b1 in lipid metabolism and inflammation","volume":"39","author":"Bougarne","year":"2018","journal-title":"Endocr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1002\/hep.30097","article-title":"Acetyl-CoA carboxylase inhibition reverses NAFLD and hepatic insulin resistance but promotes hypertriglyceridemia in rodents","volume":"68","author":"Goedeke","year":"2018","journal-title":"Hepatology"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Francisco, V., Jesus Sanz, M., Real, J.T., Marques, P., Capuozzo, M., Ait Eldjoudi, D.A., and Gualillo, O. (2022). Adipokines in non-alcoholic fatty liver disease: Are we on the road toward new biomarkers and therapeutic targets?. Biology, 11.","DOI":"10.3390\/biology11081237"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101581","DOI":"10.1016\/j.molmet.2022.101581","article-title":"MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives","volume":"65","author":"Hochreuter","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_8","first-page":"26","article-title":"miR-122 promotes hepatic lipogenesis via inhibiting the LKB1\/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease","volume":"25","author":"Long","year":"2019","journal-title":"Metabolism"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yepmo, M., Potier, J.B., Pinget, M., Grabarz, A., Bouzakri, K., and Dumond Bourie, A. (2022). Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1035159"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Peng, Y., Liu, A., Zhu, Q., Liu, X., Cai, B., Yan, Z., Gao, J., Zhu, R., and Wang, C. (2025). Advances in the regulation of lipid metabolism by non-coding RNAs. Animals, 15.","DOI":"10.3390\/ani15172621"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-0031-1276643","article-title":"Genetics of alcoholic and nonalcoholic fatty liver disease","volume":"31","author":"Anstee","year":"2011","journal-title":"Semin. Liver Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bpg.2011.02.007","article-title":"Genetics and epigenetics in the fibrogenic evolution of chronic liver diseases","volume":"25","author":"Zimmer","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature11233","article-title":"Landscape of transcription in human cells","volume":"489","author":"Djebali","year":"2012","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00018-017-2626-6","article-title":"Interaction and cross-talk between non-coding RNAs","volume":"75","author":"Yamamura","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"04856","DOI":"10.3892\/ijmm.2021.4856","article-title":"Role of long noncoding RNAs and related epigenetic mechanisms in liver fibrosis","volume":"47","author":"Ganguly","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21037\/tgh.2019.09.06","article-title":"Genetic and epigenetic disease modifiers: Non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD)","volume":"6","author":"Choudhary","year":"2021","journal-title":"Transl. Gastroenterol. Hepatol."},{"key":"ref_17","first-page":"939","article-title":"Synthesis and caracterization of some cobalt (II) complexes with amino acids having biological activities","volume":"60","author":"Rusu","year":"2009","journal-title":"Rev. Chim."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Iancu, M., Coste, S.C., Cozma, A., Or\u0103\u0219an, O.H., Lucaciu, R.L., Hangan, A.C., Para, I., Gog Bogdan, S., and Procopciuc, L.M. (2025). Metabolic characteristics, cytokine gene polymorphisms as potential risk factors for higher liver fibrosis stage in MASLD patients: A hospital-based study. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26083730"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/physrev.00006.2010","article-title":"MicroRNAs in development and disease","volume":"91","author":"Sayed","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gori, M., Arciello, M., and Balsano, C. (2014). MicroRNAs in nonalcoholic fatty liver disease: Novel biomarkers and prognostic tools during the transition from steatosis to hepatocarcinoma. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/741465"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jcp.21993","article-title":"Genomic organization of microRNAs","volume":"222","author":"Olena","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tig.2006.01.003","article-title":"Genomics of microRNA","volume":"22","author":"Kim","year":"2006","journal-title":"Trends Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jhep.2017.09.003","article-title":"Genetics and epigenetics of NAFLD and NASH: Clinical impact","volume":"68","author":"Eslam","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lin, H.Y., Yang, Y.L., Wang, P.W., Wang, F.S., and Huang, Y.H. (2020). The Emerging Role of MicroRNAs in NAFLD: Highlight of microRNA-29a in modulating oxidative stress, inflammation, and beyond. Cells, 9.","DOI":"10.3390\/cells9041041"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1002\/jcp.30699","article-title":"The role of exosomal miRNA in nonalcoholic fatty liver disease","volume":"237","author":"Mahmoudi","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1440-1746.2009.05949.x","article-title":"Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-\u03b1 expression, a novel mechanism for the pathogenesis of NAFLD","volume":"25","author":"Zheng","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1007\/s13277-012-0396-1","article-title":"MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular carcinoma cells","volume":"33","author":"Li","year":"2012","journal-title":"Tumor Biol."},{"key":"ref_28","first-page":"2201","article-title":"Role and mechanisms of action of microRNA21 as regards the regulation of the WNT\/\u03b2catenin signaling pathway in the pathogenesis of nonalcoholic fatty liver disease","volume":"44","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1136\/gutjnl-2015-310822","article-title":"Stress-activated miR-21\/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption","volume":"65","author":"Calo","year":"2016","journal-title":"Gut"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Pillai, S.S., Lakhani, H.V., Zehra, M., Wang, J., Dilip, A., Puri, N., O\u2019Hanlon, K., and Sodhi, K. (2020). Predicting nonalcoholic fatty liver disease through a panel of plasma biomarkers and microRNAs in female West Virginia population. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186698"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2748","DOI":"10.1038\/cddis.2017.172","article-title":"miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice","volume":"8","author":"Rodrigues","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/hep.31428","article-title":"An endoplasmic reticulum stress-microRNA-26a feedback circuit in NAFLD","volume":"73","author":"Xu","year":"2021","journal-title":"Hepatology"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhao, W., Cheng, L., Quek, C., Bellingham, S.A., and Hill, A.F. (2019). Novel miR-29b target regulation patterns are revealed in two different cell lines. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-53868-x"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yang, Y.L., Wang, P.W., Wang, F.S., Lin, H.Y., and Huang, Y.H. (2020). miR-29a Modulates GSK3\u03b2\/SIRT1-linked mitochondrial proteostatic stress to ameliorate mouse non-alcoholic steatohepatitis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186884"},{"key":"ref_36","first-page":"3","article-title":"New microRNA biomarkers for drug-induced steatosis and their potential to predict the contribution of drugs to non-alcoholic fatty liver disease","volume":"8","author":"Conde","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/j.celrep.2018.01.074","article-title":"Genetic ablation of mir-33 increases food intake, enhances adipose tissue expansion, and promotes obesity and insulin resistance","volume":"22","author":"Price","year":"2018","journal-title":"Cell Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1189123","article-title":"MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis","volume":"328","author":"Kristo","year":"2010","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1038\/ncomms3883","article-title":"MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice","volume":"4","author":"Horie","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1039\/D0FO02286A","article-title":"The role of microRNA-33 as a key regulator in hepatic lipogenesis signaling and a potential serological biomarker for NAFLD with excessive dietary fructose consumption in C57BL\/6N mice","volume":"12","author":"Pan","year":"2021","journal-title":"Food Funct."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Erhartova, D., Cahova, M., Dankova, H., Heczkova, M., Mikova, I., Sticova, E., Spicak, J., Seda, O., and Trunecka, P. (2019). Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0224820"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"36677","DOI":"10.1074\/jbc.M111.270561","article-title":"MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2036.2010.04366.x","article-title":"Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease","volume":"32","author":"Estep","year":"2010","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/gutjnl-2014-306996","article-title":"Circulating microRNA signature in non-alcoholic fatty liver disease: From serum non-coding RNAs to liver histology and disease pathogenesis","volume":"64","author":"Pirola","year":"2015","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1136\/gutjnl-2018-318146","article-title":"miRNAs and NAFLD: From pathophysiology to therapy","volume":"68","author":"Gjorgjieva","year":"2019","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/oby.21950","article-title":"miRNA Signatures of insulin resistance in obesity","volume":"25","author":"Jones","year":"2017","journal-title":"Obesity"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/db16-0731","article-title":"Circulating microRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes","volume":"66","author":"Willeit","year":"2017","journal-title":"Diabetes"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e780","DOI":"10.1038\/cddis.2013.301","article-title":"Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXR\u03b1 expression and cholesterol homeostasis","volume":"4","author":"Adlakha","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1053\/j.gastro.2021.08.030","article-title":"Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity","volume":"161","author":"Azzimato","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"eaaw9709","DOI":"10.1126\/scitranslmed.aaw9709","article-title":"Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance","volume":"12","author":"Azzimato","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Lin, X., Jia, J., Du, T., Li, W., Wang, X., Wei, J., Lin, X., Zeng, H., Yao, L., and Chen, X. (2015). Overexpression of miR-155 in the liver of transgenic mice alters the expression profiling of hepatic genes associated with lipid metabolism. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118417"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Csak, T., Bala, S., Lippai, D., Kodys, K., Catalano, D., Iracheta-Vellve, A., and Szabo, G. (2015). MicroRNA-155 deficiency attenuates liver steatosis and fibrosis without reducing inflammation in a mouse model of steatohepatitis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129251"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41374-021-00626-1","article-title":"Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH","volume":"101","author":"Bala","year":"2021","journal-title":"Lab. Investig."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1440-1746.2011.06864.x","article-title":"Transition from hepatic steatosis to steatohepatitis: Unique microRNA patterns and potential downstream functions and pathways","volume":"27","author":"Jin","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbagrm.2012.06.001","article-title":"The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes","volume":"1819","author":"Hou","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1582-4934.2011.01282.x","article-title":"Functional analysis of microRNAs in human hepatocellular cancer stem cells","volume":"16","author":"Meng","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.taap.2012.04.018","article-title":"Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet","volume":"262","author":"Tryndyak","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbrc.2012.03.025","article-title":"MiR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients","volume":"421","author":"Wang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Dongiovanni, P., Meroni, M., Longo, M., Fargion, S., and Fracanzani, A.L. (2018). miRNA signature in NAFLD: A turning point for a non-invasive diagnosis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123966"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/hep4.1501","article-title":"Differential associations of circulating microRNAs with pathogenic factors in NAFLD","volume":"4","author":"Ezaz","year":"2020","journal-title":"Hepatol. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00109-019-01796-8","article-title":"Skeletal muscle miR-34a\/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis","volume":"97","author":"Afonso","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Oses, M., Margareto Sanchez, J., Portillo, M.P., Aguilera, C.M., and Labayen, I. (2019). Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: A systematic review. Nutrients, 11.","DOI":"10.3390\/nu11122890"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/jgh.12268","article-title":"Expression of genes for miRNAsprocessing enzymes is altered in advanced nonalcoholic fatty liver disease","volume":"28","author":"Sharma","year":"2013","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ccr.2011.01.001","article-title":"Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a\/b-3p as therapeutic target for hepatocellular carcinoma","volume":"19","author":"Hou","year":"2011","journal-title":"Cancer Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1245\/s10434-012-2482-4","article-title":"MicroRNA-200a and -200b mediated hepatocellular carcinoma cell migration through the epithelial to mesenchymal transition markers","volume":"20","author":"Hung","year":"2013","journal-title":"Ann. Surg. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/carcin\/bgs381","article-title":"Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma","volume":"34","author":"Zhang","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1136\/gutjnl-2011-300717","article-title":"MicroRNA-221\/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis","volume":"61","author":"Ogawa","year":"2012","journal-title":"Gut"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hep.25747","article-title":"Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model","volume":"56","author":"Callegari","year":"2012","journal-title":"Hepatology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/mc.21864","article-title":"Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance","volume":"52","author":"Karakatsanis","year":"2013","journal-title":"Mol. Carcinog."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8822859","DOI":"10.1155\/2020\/8822859","article-title":"Noncoding RNAs nonalcoholic fatty liver disease: Potential diagnosis and prognosis biomarkers","volume":"2020","author":"Khalifa","year":"2020","journal-title":"Dis. Markers"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/hep.30301","article-title":"LXRalpha promotes hepatosteatosis in part through activation of microRNA-378 transcription and inhibition of Ppargc1beta expression","volume":"69","author":"Zhang","year":"2019","journal-title":"Hepatology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.metabol.2018.03.023","article-title":"A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet","volume":"85","author":"Zhang","year":"2018","journal-title":"Metabolism"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jhep.2018.08.026","article-title":"MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-kBTNFa pathway","volume":"70","author":"Zhang","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1530\/JOE-19-0180","article-title":"microRNA-375 regulates glucose metabolism-related signaling for insulin secretion","volume":"244","author":"Dumortier","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/1440-1681.12940","article-title":"Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting adipoR2 in non-alcoholic fatty liver disease","volume":"45","author":"Lei","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.gene.2018.08.052","article-title":"Preliminary screening and functional analysis of circular RNAs associated with hepatic stellate cell activation","volume":"677","author":"Zhou","year":"2018","journal-title":"Gene"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhang, P., Wu, S., He, Y., Li, X., Zhu, Y., Lin, X., Chen, L., Zhao, Y., Niu, L., and Zhang, S. (2022). LncRNA-mediated adipogenesis in different adipocytes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137488"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.bbagrm.2014.06.006","article-title":"Regulation of histone methylation by noncoding RNAs","volume":"1839","author":"Joh","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_80","first-page":"1025","article-title":"Non-coding transcript variants of protein-coding genes\u2014What are they good for?","volume":"15","author":"Dhamija","year":"2018","journal-title":"RNA Biol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Jalali, S., Jayaraj, G.G., and Scaria, V. (2012). Integrative transcriptome analysis suggest processing of a subset of long non-coding RNAs to small RNAs. Biol. Direct, 7.","DOI":"10.1186\/1745-6150-7-25"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1261\/rna.053561.115","article-title":"Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells","volume":"22","author":"Rahim","year":"2016","journal-title":"RNA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Functional classification and experimental dissection of long noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.celrep.2019.12.011","article-title":"Targeting the oncogenic long non-codingRNA SLNCR1 by blocking its sequence-specific binding to theandrogen receptor","volume":"30","author":"Schmidt","year":"2020","journal-title":"Cell Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1146\/annurev-pharmtox-010715-103209","article-title":"Nuclear receptors as therapeutic targets in liver disease: Are we there yet?","volume":"56","author":"Rudraiah","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.livres.2017.09.001","article-title":"Long non-coding RNA in liver metabolism and disease: Current status","volume":"1","author":"Zhao","year":"2017","journal-title":"Liver Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.gastrohep.2023.09.014","article-title":"long non-coding RNAs as modulators and therapeutic targets in non-alcoholic fatty liver disease (NAFLD)","volume":"47","author":"Tao","year":"2024","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"104472","DOI":"10.1016\/j.yexmp.2020.104472","article-title":"Long non-coding RNA H19 in the liver-gut axis: A diagnostic marker and therapeutic target for liver diseases","volume":"115","author":"Li","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Liu, J., Tang, T., Wang, G.D., and Liu, B. (2019). LncRNA-H19 promotes hepatic lipogenesis by directly regulating miR-130a\/PPAR\u03b3axis in non-alcoholic fatty liver disease. Biosci. Rep., 39.","DOI":"10.1042\/BSR20181722"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/jcmm.14818","article-title":"Long non-coding RNA (lncRNA) H19 induces hepatic steatosis through activating MLXIPL and mTORC1 networks in hepatocytes","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/hep.29034","article-title":"A liver specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis","volume":"66","author":"Atanasovska","year":"2017","journal-title":"Hepatology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"349","DOI":"10.7150\/ijbs.16635","article-title":"Identification of a novel human long non-coding RNA that regulates hepatic lipid metabolism by inhibiting SREBP-1c","volume":"13","author":"Li","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Coste, S.C., Or\u0103san, O.H., Cozma, A., Negrean, V., Sitar-T\u0103ut, A.V., Filip, G.A., Hangan, A.C., Lucaciu, R.L., Iancu, M., and Procopciuc, L.M. (2024). Metabolic dysfunction associated steatotic liver disease: The associations between inflammatory markers, TLR4, and cytokines IL-17A\/F, and their connections to the degree of steatosis and the risk of fibrosis. Biomedicines, 12.","DOI":"10.3390\/biomedicines12092144"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"22011","DOI":"10.1074\/jbc.M116.715953","article-title":"Runt-related transcription factor (RUNX1) binds to p50 in macrophages and enhances TLR4-triggered inflammation and septic shock","volume":"291","author":"Luo","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kaur, S., Rawal, P., Siddiqui, H., Rohilla, S., Sharma, S., Tripathi, D.M., Baweja, S., Hassan, M., Vlaic, S., and Guthke, R. (2019). Increased expression of RUNX1 in liver correlates with NASH activity score in patients with non-alcoholic steatohepatitis (NASH). Cells, 8.","DOI":"10.3390\/cells8101277"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41467-018-03072-8","article-title":"Ultraconserved element uc. 372 drives hepatic lipid accumulation by suppressing miR-195\/miR4668 maturation","volume":"9","author":"Guo","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1002\/jcb.26107","article-title":"Long noncoding RNA lncARSR promotes doxorubicin resistance in hepatocellular carcinoma via modulating PTEN-PI3K\/Akt pathway","volume":"118","author":"Li","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bbrc.2018.03.127","article-title":"Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt\/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis","volume":"499","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12967-020-02225-y","article-title":"Long noncoding RNA lncARSR promotes nonalcoholic fatty liver disease and hepatocellular carcinoma by promoting YAP1 and activating the IRS2\/AKT pathway","volume":"18","author":"Chi","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"11411","DOI":"10.1096\/fj.201900643RRR","article-title":"Long noncoding RNA FLRL2 alleviated nonalcoholic fatty liver disease through Arntl-Sirt1 pathway","volume":"33","author":"Chen","year":"2019","journal-title":"FASEB J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1159\/000495384","article-title":"ATP citrate lyase and LncRNA NONMMUT010685 play crucial role in nonalcoholic fatty liver disease based on analysis of microarray data","volume":"51","author":"Ma","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1194\/jlr.M003335","article-title":"Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice","volume":"51","author":"Wang","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"S345","DOI":"10.1016\/S0168-8278(18)30910-3","article-title":"RIPK1 depletion exacerbates progression of liver fibrosis in high fat diet induced non-alcoholic steatohepatitis (NASH) in mice","volume":"68","author":"Farooq","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Negishi, M., Wongpalee, S.P., Sarkar, S., Park, J., Lee, K.Y., Shibata, Y., Suzuki, Y., Sugano, S., and Dutta, A. (2014). A new lncRNA, APTR, associates with and represses the CDKN1A\/p21 promoter by recruiting polycomb proteins. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095216"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3904\/kjim.2010.25.4.364","article-title":"Increased expression of cyclooxygenase-2 is associated with the progression to cirrhosis","volume":"25","author":"Jeong","year":"2010","journal-title":"Korean J. Intern. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3892\/mmr.2017.6161","article-title":"Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride","volume":"15","author":"Tang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"He, Z., Yang, D., Fan, X., Zhang, M., Li, Y., Gu, X., and Yang, M. (2020). The roles and mechanisms of lncRNAs in liver fibrosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041482"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1412794","DOI":"10.1080\/16546628.2017.1412794","article-title":"Up-regulated HOTAIR induced by fatty acids inhibits PTEN expression and increases triglycerides accumulation in HepG2 cells","volume":"61","author":"Li","year":"2017","journal-title":"Food Nutr. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"110190","DOI":"10.1016\/j.cellsig.2021.110190","article-title":"LncRNA HOTAIR regulates the lipid accumulation in nonalcoholic fatty liver disease via miR-130b-3p\/ROCK1 axis","volume":"90","author":"Guo","year":"2022","journal-title":"Cell. Signal."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00109-017-1586-5","article-title":"NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6","volume":"95","author":"Yu","year":"2017","journal-title":"J. Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kim, Y.A., Park, K.K., and Lee, S.J. (2020). lncRNAs act as a link between chronic liver disease and hepatocellular carcinoma. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082883"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2147\/OTT.S116319","article-title":"Long noncoding RNA NEAT1 promotes cell proliferation and invasion by regulating hnRNP A2 expression in hepatocellular carcinoma cells","volume":"10","author":"Mang","year":"2017","journal-title":"OncoTargets Ther."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Huang, R., Duan, X., Fan, J., Li, G., and Wang, B. (2019). Role of noncoding RNA in development of nonalcoholic fatty liver disease. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/8690592"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/jcb.26317","article-title":"Down-regulation of lncRNA-NEAT1 alleviated the non-alcoholic fatty liver disease via mTOR\/S6K1 signaling pathway","volume":"119","author":"Wang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1080\/21691401.2019.1604536","article-title":"Long non-coding RNA NEAT1 promotes steatosis via enhancement of estrogen receptor alpha-mediated AQP7 expression in HepG2 cells","volume":"47","author":"Fu","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1684\/ecn.2019.0432","article-title":"lncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506\/GLI3","volume":"30","author":"Jin","year":"2019","journal-title":"Eur. Cytokine Netw."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Wen, H., Peng, B., Weng, J., and Zeng, F. (2020). Downregulated microRNA-129-5p by long non-coding RNA NEAT1 upregulates PEG3 expression to aggravate non-alcoholic steatohepatitis. Front. Genet., 11.","DOI":"10.3389\/fgene.2020.563265"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.trsl.2017.09.001","article-title":"Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells","volume":"190","author":"Leti","year":"2017","journal-title":"Transl. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1038\/s41467-018-05383-2","article-title":"Long noncoding RNA licensing of obesity linked hepatic lipogenesis and NAFLD pathogenesis","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2147\/DMSO.S248692","article-title":"The long noncoding RNA Blnc1 protects against diet-induced obesity by promoting mitochondrial function in white fat","volume":"13","author":"Tang","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12986-021-00552-5","article-title":"A compresive review of long non-coding RNAs in the pathogenesis and development of non-alcoholic fatty liver disease","volume":"18","author":"Shabgah","year":"2021","journal-title":"Nutr. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1093\/nar\/gkw341","article-title":"A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice","volume":"44","author":"Qin","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Yan, C., Chen, J., and Chen, N. (2016). Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. Sci. Rep., 6.","DOI":"10.1038\/srep22640"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.3748\/wjg.v28.i35.5111","article-title":"Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease","volume":"28","author":"Zaiou","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"73282","DOI":"10.18632\/oncotarget.19931","article-title":"Potential applications of MEG3 in cancer diagnosis and prognosis","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41420-022-00889-7","article-title":"LncRNA MEG3 up-regulates SIRT6 by ubiquitinating EZH2 and alleviates nonalcoholic fatty liver disease","volume":"8","author":"Zou","year":"2022","journal-title":"Cell Death Discov."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Cheng, X., Shihabudeen Haider Ali, M.S., Moran, M., Viana, M.P., Schlichte, S.L., Zimmerman, M.C., Khalimonchuk, O., Feinberg, M.W., and Sun, X. (2021). Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity. Redox Biol., 40.","DOI":"10.1016\/j.redox.2021.101863"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41419-018-1068-x","article-title":"lncRNAMEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212","volume":"9","author":"Yu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1194\/jlr.RA120000664","article-title":"The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice","volume":"61","author":"Ma","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1586\/17474124.2014.894880","article-title":"Metformin in the treatment of nonalcoholic fatty liver disease: Safety, efficacy and mechanism","volume":"8","author":"Rouabhia","year":"2014","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"18169","DOI":"10.1002\/jcp.28450","article-title":"Inhibition of lncRNA HULC improves hepatic fibrosis and hepatocyte apoptosis by inhibiting the MAPK signaling pathway in rats with nonalcoholic fatty liver disease","volume":"234","author":"Shen","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"26359","DOI":"10.18632\/oncotarget.4560","article-title":"Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC","volume":"6","author":"Gandhy","year":"2015","journal-title":"Oncotarget"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"73271","DOI":"10.18632\/oncotarget.19154","article-title":"An emerging function of circRNA-miRNAs-mRNA axis in human diseases","volume":"8","author":"Rong","year":"2017","journal-title":"Oncotarget"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Zhao, X., Cai, Y., and Xu, J. (2019). Circular RNAs: Biogenesis, mechanism, and function in human cancers. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163926"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circRNA biogenesis","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Wu, Y.L., Li, H.F., Chen, H.H., and Lin, H. (2022). Emergent roles of circular RNAs in metabolism and metabolic disorders. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031032"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s12967-020-02637-w","article-title":"Circular RNA expression profiles and features in NAFLD mice: A study using RNA-seq data","volume":"18","author":"Yuan","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cell.2020.08.009","article-title":"Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output","volume":"183","author":"Zhao","year":"2020","journal-title":"Cell"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"396019","DOI":"10.1155\/2017\/3960197","article-title":"circRNA_0046367 prevents hepatoxicity of lipid peroxidation: An inhibitory role against hepatic steatosis","volume":"2017","author":"Guo","year":"2017","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Li, J., Qi, J., Tang, Y., Liu, H., Zhou, K., Dai, Z., Yuan, L., and Sun, C. (2021). A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p\/miR-320a and ABCA1\/CPT1 axis. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-01108-8"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Liu, C.H., Jiang, W., Zeng, Q., Wu, D., Li, H., Zhou, L., Bai, L., and Tang, H. (2023). CircRNA-PI4KB induces hepatic lipid deposition in non-alcoholic fatty liver disease by transporting miRNA-122 to extra-hepatocytes. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021297"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Sulaiman, S.A., Muhsin, N.I.A., and Jamal, R. (2019). Regulatory non-coding RNAs network in non-alcoholic fatty liver disease. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00279"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"66455","DOI":"10.18632\/oncotarget.12186","article-title":"CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis","volume":"7","author":"Jin","year":"2016","journal-title":"Oncotarget"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41419-020-2293-7","article-title":"Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy","volume":"11","author":"Jin","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1159\/000495556","article-title":"Thymosin-\u03b24 mediates hepatic stellate cell activation by interfering with CircRNA-0067835\/miR-155\/FoxO3 signaling pathway","volume":"51","author":"Zhu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1159\/000495589","article-title":"Comprehensive circular RNA profiling reveals the regulatory role of the CircRNA-0067835\/miR-155 pathway in temporal lobe epilepsy","volume":"51","author":"Gong","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gene.2017.07.078","article-title":"Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation","volume":"629","author":"Chen","year":"2017","journal-title":"Gene"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"6412916","DOI":"10.1155\/2020\/6412916","article-title":"Understanding the role of exercise in nonalcoholicfatty liver disease: ERS-linked molecular pathways","volume":"2020","author":"Zou","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"36202","DOI":"10.1074\/jbc.M113.498634","article-title":"MicroRNA-22 is a master regulator of bone morphogenetic protein-7\/6 homeostasis in the kidney","volume":"288","author":"Long","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1080\/10717544.2022.2030428","article-title":"Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p\/PTEN\/AKT pathway in human liver fibrosis","volume":"29","author":"Ma","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1038\/s41467-022-34287-5","article-title":"Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.7150\/thno.42423","article-title":"Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p\/FBXW7 axis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"23996","DOI":"10.18632\/aging.104081","article-title":"Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179\/miR-188-3p\/GPX4 signaling","volume":"12","author":"Yang","year":"2020","journal-title":"Aging"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-022-09714-4","article-title":"hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p\/KAT2B","volume":"39","author":"Ma","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41419-021-04090-z","article-title":"Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1\/AMPK signaling through targeting miR-206","volume":"12","author":"Chen","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Zheng, Q., Liu, C.H., Wu, D., Jiang, W., Zhang, N., and Tang, H. (2023). LncRNA and circRNA in patients with non-alcoholic fatty liver disease: A systematic review. Biomolecules, 13.","DOI":"10.3390\/biom13030560"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41576-018-0073-3","article-title":"PIWI-interacting RNAs: Small RNAs with big functions","volume":"20","author":"Ozata","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_158","first-page":"3829","article-title":"Analysis of piRNA expression spectra in a non-alcoholic fatty liver disease mouse model induced by a methionine- and choline-deficient diet","volume":"19","author":"Ma","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.12659\/MSM.914222","article-title":"The combination of piR-823 and eukaryotic initiation Factor 3 B (EIF3B) activates hepatic stellate cells via upregulating TGF-\u03b21 in liver fibrogenesis","volume":"24","author":"Tang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e12293","DOI":"10.1002\/jev2.12293","article-title":"Distinct non-coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages","volume":"11","author":"Pantazi","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Ma, D., Zhou, X., Wang, Y., Dai, L., Yuan, J., Peng, J., Zhang, X., and Wang, C. (2022). Changes in the small noncoding RNAome during M1 and M2 macrophage polarization. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.799733"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a continuum: From obesity to metabolic syndrome and diabetes","volume":"12","author":"Valerio","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American association for the study of liver diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Zailaie, S.A., Khoja, B.B., Siddiqui, J.J., Mawardi, M.H., Heaphy, E., Aljagthmi, A., and Sergi, C.M. (2024). Investigating the role of non-coding RNA in non-alcoholic fatty liver disease. Non-Coding RNA, 10.","DOI":"10.3390\/ncrna10010010"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"22522","DOI":"10.1021\/acsomega.2c01801","article-title":"Identify functional lncRNAs in nonalcoholic fatty liver disease by constructing a ceRNA network","volume":"7","author":"Xue","year":"2022","journal-title":"ACS Omega"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/obr.12765","article-title":"Adipose may actively delay progression of NAFLD by releasing tumor-suppressing, anti-fibrotic miR-122 into circulation","volume":"20","author":"Baranova","year":"2019","journal-title":"Obes. Rev."},{"key":"ref_167","first-page":"907","article-title":"Anti-tumor effect of Euonymus Europaeus on Ehrlich tumor cells in vivo","volume":"62","author":"Sevastre","year":"2014","journal-title":"Farmacia"},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Martinou, E., Pericleous, M., Stefanova, I., Kaur, V., and Angelidi, A.M. (2022). Diagnostic modalities of non-alcoholic fatty liver disease: From biochemical biomarkers to multi-omics non-invasive approaches. Diagnostics, 12.","DOI":"10.3390\/diagnostics12020407"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Xin, S., Zhan, Q., Chen, X., Xu, J., and Yu, Y. (2020). Efficacy of serum miRNA test as a non-invasive method to diagnose nonalcoholic steatohepatitis: A systematic review and meta-analysis. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01334-8"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/cpt.2244","article-title":"Exploring the use of serum-derived small extracellular vesicles as liquid biopsy to study the induction of hepatic cytochromes P450 and organic anion transporting polypeptides","volume":"110","author":"Rodrigues","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Newman, L.A., Useckaite, Z., Johnson, J., Sorich, M.J., Hopkins, A.M., and Rowland, A. (2022). Selective isolation of liver-derived extracellular vesicles redefines performance of miRNA biomarkers for non-alcoholic fatty liver disease. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010195"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S2468-1253(20)30252-1","article-title":"A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: A prospective derivation and global validation study","volume":"5","author":"Harrison","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41573-020-0075-7","article-title":"Advances in oligonucleotide drug delivery","volume":"19","author":"Roberts","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.ymthe.2020.06.015","article-title":"Delivery of oligonucleotides to the liver with GalNAc: From research to registered therapeutic drug","volume":"28","author":"Debacker","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"113888","DOI":"10.1016\/j.addr.2021.113888","article-title":"Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41392-021-00569-5","article-title":"Targeting circular RNAs as a therapeutic approach: Current strategies and challenges","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tips.2022.01.008","article-title":"The potential of long noncoding RNA therapies","volume":"43","author":"Mercer","year":"2022","journal-title":"Trends Pharm. Sci."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-pathol-042320-115255","article-title":"Long noncoding RNAs and human liver disease","volume":"17","author":"DiStefano","year":"2021","journal-title":"Annu. Rev. Pathol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ebiom.2018.07.036","article-title":"Circular RNAs: Promising biomarkers for human diseases","volume":"34","author":"Zhang","year":"2018","journal-title":"eBioMedicine"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Coste, S.C., Or\u0103san, O.H., Cozma, A., Negrean, V., Alexescu, T.G., Perne, M.G., Ciulei, G., Hangan, A.C., Lucaciu, R.L., and Iancu, M. (2024). Allelic, genotypic, and haplotypic analysis of cytokine IL17A, IL17F, and toll-like receptor TLR4 gene polymorphisms in metabolic-dysfunction-associated steatotic liver disease: Insights from an exploratory study. Life, 14.","DOI":"10.3390\/life14101327"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"101122","DOI":"10.1016\/j.molmet.2020.101122","article-title":"Non-alcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans","volume":"50","author":"Pafili","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease\u2014A global public health perspective","volume":"70","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/hep.31050","article-title":"Lipotoxic hepatocyte-derived exosomal microRNA 192-5p activates macrophages through Rictor\/Akt\/Forkhead Box Transcription Factor O1 signaling in nonalcoholic fatty liver disease","volume":"72","author":"Liu","year":"2020","journal-title":"Hepatology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/21\/10402\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:20:15Z","timestamp":1761643215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/21\/10402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,26]]},"references-count":183,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["ijms262110402"],"URL":"https:\/\/doi.org\/10.3390\/ijms262110402","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,26]]}}}