{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:59:19Z","timestamp":1765609159436,"version":"build-2065373602"},"reference-count":161,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oxidative stress observed in schizophrenia and other psychiatric disorders can induce neuronal damage and modulate intracellular signaling, ultimately leading to neuronal death by apoptosis or necrosis. The aim of this study was to estimate in vitro the possible antioxidant properties of curcumin, the natural polyphenolic antioxidant, and its protective effects against lipid peroxidation induced by the atypical antipsychotic Ziprasidone. Curcumin (5 \u00b5g\/mL, 12.5 \u00b5g\/mL, 25 \u00b5g\/mL, 50 \u00b5g\/mL) was added to human plasma and incubated for 1 and 24 h, alone and in the presence of Ziprasidone (40 ng\/mL, 139 ng\/mL, 250 ng\/mL). Control plasma samples were incubated for 1 and 24 h. The concentration of thiobarbituric acid-reactive substances (TBARSs; lipid peroxidation marker) was determined by the spectrophotometric method according to Rice-Evans. Curcumin at the tested concentrations significantly inhibited lipid peroxidation in human plasma by about 60%. Ziprasidone (40 ng\/mL, 139 ng\/mL, 250 ng\/mL) significantly increased TBARS levels, but in the presence of the studied curcumin concentrations, its pro-oxidative effects were reduced by about 56%. Our results confirm that Ziprasidone in vitro may induce lipid peroxidation in human plasma, whereas curcumin protects against lipid peroxidation in human plasma caused by the antipsychotic Ziprasidone.<\/jats:p>","DOI":"10.3390\/ijms262110430","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T09:16:07Z","timestamp":1761642967000},"page":"10430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin as an Antioxidant Against Ziprasidone Induced Lipid Peroxidation in Human Plasma: Potential Relevance to Cortico Subcortical Circuit Function"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-4528","authenticated-orcid":false,"given":"Anna","family":"Dietrich-Muszalska","sequence":"first","affiliation":[{"name":"Department of Biological Psychiatry, Medical University of \u0141\u00f3d\u017a, 90-419 \u0141\u00f3d\u017a, Poland"},{"name":"Department of Biological Psychiatry, Centre for Mental Health and Addiction, Medical University of \u0141\u00f3d\u017a, 90-419 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1978-6018","authenticated-orcid":false,"given":"Piotr","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Division of Ecology and Environmental Protection, Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toru\u0144, 85-094 Bydgoszcz, Poland"},{"name":"Department of Biotechnology, Institute of Biological Sciences, Faculty of Biological Sciences, University of Zielona G\u00f3ra, 65-516 Zielona G\u00f3ra, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-2494","authenticated-orcid":false,"given":"Bogdan","family":"Kontek","sequence":"additional","affiliation":[{"name":"Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of \u0141\u00f3d\u017a, Pomorska 141\/143, 90-236 \u0141\u00f3d\u017a, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-9700","authenticated-orcid":false,"given":"Edward Jacek","family":"Gorzela\u0144czyk","sequence":"additional","affiliation":[{"name":"Institute of Philosophy, Kazimierz Wielki University in Bydgoszcz, 85-064 Bydgoszcz, Poland"},{"name":"Faculty of Mathematics and Computer Science, Adam Mickiewicz University in Pozna\u0144, 61-614 Pozna\u0144, Poland"},{"name":"Medically Assisted Recovery Association \u201cMAR\u201d, 85-067 Bydgoszcz, Poland"},{"name":"Oskar Bielawski Greater Poland Neuropsychiatric Center in Ko\u015bcian, 64-000 Ko\u015bcian, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Trofin, D.-M., Sardaru, D.-P., Trofin, D., Onu, I., Tutu, A., Onu, A., Onit\u0103, C., Galaction, A.I., and Matei, D.V. 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