{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:53:04Z","timestamp":1761652384013,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006181","name":"Bahia State Research Support Foundation","doi-asserted-by":"publisher","award":["005\/2019"],"award-info":[{"award-number":["005\/2019"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Brazilian Coordination for the Improvement of Higher Education Personnel"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sickle cell anemia (SCA) is characterized by hematological events that lead to vaso-occlusion and the onset of clinical manifestations. Fetal hemoglobin (HbF) has been shown to positively influence the clinical outcomes of individuals with SCA. Genetic polymorphisms are known to modulate clinical phenotypes by increasing HbF levels, with the BCL11A gene being an important marker in this regard for future therapies. However, while the BCL11A gene plays a role in the regulation of several genes during hematopoiesis, its various effects are not yet fully understood. The study aimed to investigate association between laboratory biomarkers in the presence of rs766432 and rs6732518 polymorphisms in the BCL11A gene. Hematological and biochemical markers were analyzed using automated methods, while genetic markers were identified by PCR-RFLP techniques. Elevated HbF levels were significantly associated with the presence of rs766432 and rs6732518 polymorphisms. High concentrations of HDL were associated with rs766432 polymorphism, and elevated levels of alpha-1antitrypsin were linked to the rs6732518 polymorphism. No correlation was found between HbF and HDL concentrations. The low sample size represents a major constraint, making the results only suggestive. In conclusion, polymorphisms in the BCL11A gene are important for variations in HbF levels and may have a pleiotropic effect by influencing laboratory parameters unrelated to HbF levels.<\/jats:p>","DOI":"10.3390\/ijms262110458","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:47:19Z","timestamp":1761652039000},"page":"10458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleiotropic Effects of Polymorphisms in the BCL11A Gene on Laboratory Parameters in Sickle Cell Anemia"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4408-2680","authenticated-orcid":false,"given":"Antonio Mateus","family":"Oliveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Sa\u00fade Global e Doen\u00e7as Negligenciadas, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz Bahia, Salvador 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u00e9llen","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Sa\u00fade Global e Doen\u00e7as Negligenciadas, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz Bahia, Salvador 40296-710, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Sa\u00fade Global e Doen\u00e7as Negligenciadas, Instituto Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz\u2014Fiocruz Bahia, Salvador 40296-710, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isa","family":"Lyra","sequence":"additional","affiliation":[{"name":"Hospital do Sub\u00farbio, Salvador 40720-460, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-890X","authenticated-orcid":false,"given":"Elis\u00e2ngela Vit\u00f3ria","family":"Adorno","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Anemias, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador 40170-110, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynara","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Anemias, Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal da Bahia, Salvador 40170-110, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilda","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Sa\u00fade Global e 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