{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:12:13Z","timestamp":1777943533584,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The present work investigates the electrochemical behavior of the Zr2.5Nb alloy in a biomedical context, emphasizing the influence of electrochemical oxidation treatment on its stability in simulated physiological environments. The alloy samples were oxidized in 1 M H2SO4 under controlled voltages (200\u2013275 V) and times (1 min), identifying 200 V\u20131 min as the optimal condition for obtaining a uniform porous oxide layer with an average pore diameter of ~90 nm. The corrosion resistance was evaluated using open circuit potential (OCP) and electrochemical impedance spectroscopy (EIS) in Ringer\u2019s solution and Ringer\u2019s solution containing 40 g\/L H2O2 to simulate physiological and inflammatory conditions. Electrochemical tests revealed that electrochemically oxidized samples exhibited a polarization resistance up to 14.78 M\u03a9\u00b7cm2, about 26 times higher than that of the untreated alloy (0.56 M\u03a9\u00b7cm2). After 77 h of immersion, the oxidized alloy maintained a high resistance (17.54 M\u03a9\u00b7cm2), confirming long-term stability. Scanning Electron Microscopy (SEM\u2013EDX) and X-Ray Diffraction (XRD) analyses highlighted significant increases in oxygen content and the transformation from the monoclinic baddeleyite to the cubic arkelite phase of ZrO2, contributing to enhanced corrosion resistance. These findings demonstrate that controlled electrochemical oxidation significantly improves the durability of Zr2.5Nb alloy in oxidative environments, supporting its potential for long-term biomedical implant applications.<\/jats:p>","DOI":"10.3390\/ijms262110537","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:38:22Z","timestamp":1761759502000},"page":"10537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Monitoring and Evaluation of Corrosion at the Interface of Zirconium Alloy Biomaterials Under Simulated Oxidative Biological Environment"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-3960","authenticated-orcid":false,"given":"Lidia","family":"Benea","sequence":"first","affiliation":[{"name":"Competences Centre\u2014Interfaces-Tribocorrosion-Electrochemical Systems (CC-ITES), \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasca Street, 800008 Gala\u021bi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veaceslav","family":"Neaga","sequence":"additional","affiliation":[{"name":"Competences Centre\u2014Interfaces-Tribocorrosion-Electrochemical Systems (CC-ITES), \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasca Street, 800008 Gala\u021bi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta","family":"Bogatu","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Centre in the Field of Eco-Nano Technology and Advance Materials CC-ITI, Faculty of Engineering, \u201cDun\u0103rea de Jos\u201d University of Gala\u021bi, 47 Domneasca Street, 800008 Gala\u021bi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1452-6615","authenticated-orcid":false,"given":"Elena Roxana","family":"Axente","sequence":"additional","affiliation":[{"name":"Center for Research and Technology Transfer in the Medico-Pharmaceutical Field, \u201cDun\u0103rea de Jos\u201d University, 800008 Gala\u021bi, Romania"},{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 800008 Gala\u021bi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","unstructured":"Erwin, A.V. 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